{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T11:22:37Z","timestamp":1790767357426,"version":"4.1.0"},"reference-count":106,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100014440","name":"Ministerio de Ciencia, Innovaci\u00f3n y Universidades","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014440","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmaceutical and Biomedical Analysis"],"published-print":{"date-parts":[[2021,2]]},"DOI":"10.1016\/j.jpba.2020.113681","type":"journal-article","created":{"date-parts":[[2020,11,21]],"date-time":"2020-11-21T11:05:59Z","timestamp":1605956759000},"page":"113681","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":91,"special_numbering":"C","title":["Metabolomics analysis of microbiota-gut-brain axis in neurodegenerative and psychiatric diseases"],"prefix":"10.1016","volume":"194","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9567-3731","authenticated-orcid":false,"given":"Marcela","family":"Konjevod","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matea","family":"Nikolac Perkovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"S\u00e1iz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dubravka","family":"Svob Strac","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Coral","family":"Barbas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Rojo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.jpba.2020.113681_bib0005","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1016\/j.gtc.2018.07.002","article-title":"Brain-gut axis: clinical implications","volume":"47","author":"Khlevner","year":"2018","journal-title":"Gastroenterol. Clin. North Am."},{"key":"10.1016\/j.jpba.2020.113681_bib0010","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.jneuroim.2019.01.004","article-title":"Gut microbiota in neurodegenerative disorders","volume":"328","author":"Roy Sarkar","year":"2019","journal-title":"J. Neuroimmunol."},{"issue":"1","key":"10.1016\/j.jpba.2020.113681_bib0015","doi-asserted-by":"crossref","first-page":"48","DOI":"10.5056\/jnm18087","article-title":"Brain-gut-microbiota axis in Alzheimer\u2019s disease","volume":"25","author":"Kowalski","year":"2019","journal-title":"J. Neurogastroenterol. Motil."},{"issue":"10","key":"10.1016\/j.jpba.2020.113681_bib0020","doi-asserted-by":"crossref","first-page":"4162","DOI":"10.1172\/JCI78366","article-title":"The microbiome revolution","volume":"124","author":"Blaser","year":"2014","journal-title":"J. Clin. Invest."},{"issue":"7753","key":"10.1016\/j.jpba.2020.113681_bib0025","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1038\/s41586-019-0965-1","article-title":"A new genomic blueprint of the human gut microbiota","volume":"568","author":"Almeida","year":"2019","journal-title":"Nature"},{"issue":"6285","key":"10.1016\/j.jpba.2020.113681_bib0030","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1126\/science.aad3503","article-title":"Population-level analysis of gut microbiome variation","volume":"352","author":"Falony","year":"2016","journal-title":"Science"},{"issue":"7415","key":"10.1016\/j.jpba.2020.113681_bib0035","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1038\/nature11550","article-title":"Diversity, stability and resilience of the human gut microbiota","volume":"489","author":"Lozupone","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.jpba.2020.113681_bib0040","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1146\/annurev-food-030117-012830","article-title":"Diet, microbiota, and metabolic health: trade-off between saccharolytic and proteolytic fermentation","volume":"9","author":"Korpela","year":"2018","journal-title":"Annu. Rev. Food Sci. Technol."},{"issue":"5","key":"10.1016\/j.jpba.2020.113681_bib0045","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1016\/j.cell.2019.03.036","article-title":"A forward chemical genetic screen reveals gut microbiota metabolites that modulate host physiology","volume":"177","author":"Chen","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.jpba.2020.113681_bib0050","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.3389\/fmicb.2016.01144","article-title":"Gut microbiota profiling: metabolomics based approach to unravel compounds affecting human health","volume":"7","author":"Vernocchi","year":"2016","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.jpba.2020.113681_bib0055","doi-asserted-by":"crossref","first-page":"318","DOI":"10.3389\/fcimb.2017.00318","article-title":"Secretory products of the human GI tract microbiome and their potential impact on Alzheimer\u2019s disease (AD): detection of lipopolysaccharide (LPS) in AD hippocampus","volume":"7","author":"Zhao","year":"2017","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.jpba.2020.113681_bib0060","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.bcp.2016.09.007","article-title":"Antibiotic use and microbiome function","volume":"134","author":"Ferrer","year":"2017","journal-title":"Biochem. Pharmacol."},{"issue":"10","key":"10.1016\/j.jpba.2020.113681_bib0065","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1093\/nutrit\/nuw023","article-title":"Role of gut microbiota and nutrients in amyloid formation and pathogenesis of Alzheimer disease","volume":"74","author":"Pistollato","year":"2016","journal-title":"Nutr. Rev."},{"issue":"5","key":"10.1016\/j.jpba.2020.113681_bib0070","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.tins.2013.01.005","article-title":"Gut-brain axis: how the microbiome influences anxiety and depression","volume":"36","author":"Foster","year":"2013","journal-title":"Trends Neurosci."},{"issue":"5","key":"10.1016\/j.jpba.2020.113681_bib0075","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/j.tim.2016.02.002","article-title":"Functional redundancy-induced stability of gut microbiota subjected to disturbance","volume":"24","author":"Moya","year":"2016","journal-title":"Trends Microbiol."},{"issue":"4","key":"10.1016\/j.jpba.2020.113681_bib0080","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1093\/femsre\/fuw046","article-title":"Exploring the human microbiome from multiple perspectives: factors altering its composition and function","volume":"41","author":"Rojo","year":"2017","journal-title":"FEMS Microbiol. Rev."},{"issue":"4","key":"10.1016\/j.jpba.2020.113681_bib0085","doi-asserted-by":"crossref","DOI":"10.3390\/microorganisms6040107","article-title":"Leaky gut, Leaky brain?","volume":"6","author":"Obrenovich","year":"2018","journal-title":"Microorganisms"},{"issue":"19","key":"10.1016\/j.jpba.2020.113681_bib0090","doi-asserted-by":"crossref","first-page":"2812","DOI":"10.1002\/elps.201300053","article-title":"From numbers to a biological sense: h ow the strategy chosen for metabolomics data treatment may affect final results. A practical example based on urine fingerprints obtained","volume":"34","author":"Godzien","year":"2013","journal-title":"Electrophoresis"},{"key":"10.1016\/j.jpba.2020.113681_bib0095","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.aca.2015.10.001","article-title":"From sample treatment to biomarker discovery: a tutorial for untargeted metabolomics based on GC-(EI)-Q-MS","volume":"900","author":"Mastrangelo","year":"2015","journal-title":"Anal. Chim. Acta"},{"issue":"12","key":"10.1016\/j.jpba.2020.113681_bib0100","doi-asserted-by":"crossref","first-page":"1897","DOI":"10.1007\/s13361-016-1469-y","article-title":"Untargeted metabolomics strategies-challenges and emerging directions","volume":"27","author":"Schrimpe-Rutledge","year":"2016","journal-title":"J. Am. Soc. Mass Spectrom."},{"issue":"10","key":"10.1016\/j.jpba.2020.113681_bib0105","doi-asserted-by":"crossref","DOI":"10.3390\/nu9101053","article-title":"The gut microbial metabolite trimethylamine-N-oxide is present in human cerebrospinal fluid","volume":"9","author":"Del Rio","year":"2017","journal-title":"Nutrients"},{"issue":"1","key":"10.1016\/j.jpba.2020.113681_bib0110","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1186\/s13195-018-0451-2","article-title":"The gut microbiota-derived metabolite trimethylamine N-oxide is elevated in Alzheimer\u2019s disease","volume":"10","author":"Vogt","year":"2018","journal-title":"Alzheimers Res. Ther."},{"issue":"1\u20132","key":"10.1016\/j.jpba.2020.113681_bib0115","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/S0304-3940(01)02242-X","article-title":"Kynurenic acid levels are elevated in the cerebrospinal fluid of patients with schizophrenia","volume":"313","author":"Erhardt","year":"2001","journal-title":"Neurosci. Lett."},{"issue":"2","key":"10.1016\/j.jpba.2020.113681_bib0120","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.jcmgh.2016.11.008","article-title":"Distinct microbiome-neuroimmune signatures correlate with functional abdominal pain in children with autism spectrum disorder","volume":"3","author":"Luna","year":"2017","journal-title":"Cell. Mol. Gastroenterol. Hepatol."},{"issue":"1","key":"10.1016\/j.jpba.2020.113681_bib0125","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.mehy.2012.10.010","volume":"80","author":"Brenner","year":"2013","journal-title":"Med. Hypotheses"},{"issue":"22","key":"10.1016\/j.jpba.2020.113681_bib0130","doi-asserted-by":"crossref","first-page":"2324","DOI":"10.1212\/WNL.0000000000003391","article-title":"Gram-negative bacterial molecules associate with Alzheimer disease pathology","volume":"87","author":"Zhan","year":"2016","journal-title":"Neurology"},{"issue":"3","key":"10.1016\/j.jpba.2020.113681_bib0135","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/j.nbd.2004.07.006","article-title":"Neostriatal and cortical quinolinate levels are increased in early grade Huntington\u2019s disease","volume":"17","author":"Guidetti","year":"2004","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.jpba.2020.113681_bib0140","series-title":"Microbiome and Metabolome in Diagnosis, Therapy, and Other Strategic Applications","first-page":"33","article-title":"Techniques for phenotyping the gut Microbiota metabolome","author":"Zubeldia-Varela","year":"2019"},{"issue":"10","key":"10.1016\/j.jpba.2020.113681_bib0145","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0076993","article-title":"Fecal microbiota and metabolome of children with autism and pervasive developmental disorder not otherwise specified","volume":"8","author":"De Angelis","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.jpba.2020.113681_bib0150","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.parkreldis.2016.08.019","article-title":"Short chain fatty acids and gut microbiota differ between patients with Parkinson\u2019s disease and age-matched controls","volume":"32","author":"Unger","year":"2016","journal-title":"Parkinsonism Relat. Disord."},{"issue":"7","key":"10.1016\/j.jpba.2020.113681_bib0155","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1002\/acn3.214","article-title":"A systems-level \u201cmisunderstanding\u201d: the plasma metabolome in Huntington\u2019s disease","volume":"2","author":"Rosas","year":"2015","journal-title":"Ann. Clin. Transl. Neurol."},{"issue":"sup1","key":"10.1016\/j.jpba.2020.113681_bib0160","doi-asserted-by":"crossref","first-page":"S85","DOI":"10.1080\/10715762.2016.1239821","article-title":"Quantitation of plasma thiamine, related metabolites and plasma protein oxidative damage markers in children with autism spectrum disorder and healthy controls","volume":"50","author":"Anwar","year":"2016","journal-title":"Free Radic. Res."},{"key":"10.1016\/j.jpba.2020.113681_bib0165","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1186\/s13229-016-0109-5","article-title":"Urinary metabolomics of young Italian autistic children supports abnormal tryptophan and purine metabolism","volume":"7","author":"Gevi","year":"2016","journal-title":"Mol. Autism"},{"issue":"15","key":"10.1016\/j.jpba.2020.113681_bib0170","doi-asserted-by":"crossref","first-page":"5291","DOI":"10.1007\/s00216-013-6934-x","article-title":"GC-MS-based urine metabolic profiling of autism spectrum disorders","volume":"405","author":"Emond","year":"2013","journal-title":"Anal. Bioanal. Chem."},{"issue":"Suppl 2","key":"10.1016\/j.jpba.2020.113681_bib0175","doi-asserted-by":"crossref","first-page":"46","DOI":"10.3109\/14767058.2014.954784","article-title":"The urinary metabolomics profile of an Italian autistic children population and their unaffected siblings","volume":"27","author":"Noto","year":"2014","journal-title":"J. Matern. Fetal. Neonatal. Med."},{"issue":"1","key":"10.1016\/j.jpba.2020.113681_bib0180","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1002\/mas.21553","article-title":"Mass spectrometry-based metabolomics: targeting the crosstalk between gut microbiota and brain in neurodegenerative disorders","volume":"38","author":"Luan","year":"2019","journal-title":"Mass Spectrom. Rev."},{"issue":"7","key":"10.1016\/j.jpba.2020.113681_bib0185","doi-asserted-by":"crossref","first-page":"1767","DOI":"10.1016\/j.celrep.2019.10.035","article-title":"Integrated analyses of microbiome and longitudinal metabolome data reveal microbial-host interactions on sulfur metabolism in parkinson\u2019s disease","volume":"29","author":"Hertel","year":"2019","journal-title":"Cell Rep."},{"issue":"1","key":"10.1016\/j.jpba.2020.113681_bib0190","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1021\/pr500807t","article-title":"LC-MS-based urinary metabolite signatures in idiopathic Parkinson\u2019s disease","volume":"14","author":"Luan","year":"2015","journal-title":"J. Proteome Res."},{"issue":"3","key":"10.1016\/j.jpba.2020.113681_bib0195","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1002\/acn3.724","article-title":"Metabolomics-based identification of metabolic alterations in PARK2","volume":"6","author":"Okuzumi","year":"2019","journal-title":"Ann. Clin. Transl. Neurol."},{"issue":"1","key":"10.1016\/j.jpba.2020.113681_bib0200","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.jalz.2018.07.217","article-title":"Altered bile acid profile associates with cognitive impairment in Alzheimer\u2019s disease-An emerging role for gut microbiome","volume":"15","author":"MahmoudianDehkordi","year":"2019","journal-title":"Alzheimers Dement."},{"key":"10.1016\/j.jpba.2020.113681_bib0205","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.jchromb.2014.01.041","article-title":"Identification of organic acids as potential biomarkers in the urine of autistic children using gas chromatography\/mass spectrometry","volume":"966","author":"Kaluzna-Czaplinska","year":"2014","journal-title":"J. Chromatogr. B Analyt. Technol. Biomed. Life Sci."},{"issue":"8","key":"10.1016\/j.jpba.2020.113681_bib0210","doi-asserted-by":"crossref","first-page":"2096","DOI":"10.1007\/s10620-012-2167-7","article-title":"Elevated fecal short chain fatty acid and ammonia concentrations in children with autism spectrum disorder","volume":"57","author":"Wang","year":"2012","journal-title":"Dig. Dis. Sci."},{"issue":"6","key":"10.1016\/j.jpba.2020.113681_bib0215","doi-asserted-by":"crossref","first-page":"2996","DOI":"10.1021\/pr901188e","article-title":"Urinary metabolic phenotyping differentiates children with autism from their unaffected siblings and age-matched controls","volume":"9","author":"Yap","year":"2010","journal-title":"J. Proteome Res."},{"issue":"6","key":"10.1016\/j.jpba.2020.113681_bib0220","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1038\/mp.2016.44","article-title":"Gut microbiome remodeling induces depressive-like behaviors through a pathway mediated by the host\u2019s metabolism","volume":"21","author":"Zheng","year":"2016","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.jpba.2020.113681_bib0225","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.talanta.2013.03.064","article-title":"1H-13C NMR-based urine metabolic profiling in autism spectrum disorders","volume":"114","author":"Mavel","year":"2013","journal-title":"Talanta"},{"key":"10.1016\/j.jpba.2020.113681_bib0230","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.anaerobe.2017.12.007","article-title":"Differences in fecal microbial metabolites and microbiota of children with autism spectrum disorders","volume":"49","author":"Kang","year":"2018","journal-title":"Anaerobe"},{"issue":"1","key":"10.1016\/j.jpba.2020.113681_bib0235","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1021\/acs.analchem.9b04553","article-title":"Recent developments along the analytical process for metabolomics workflows","volume":"92","author":"Gonzalez-Riano","year":"2020","journal-title":"Anal. Chem."},{"issue":"7448","key":"10.1016\/j.jpba.2020.113681_bib0240","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1038\/nature12100","article-title":"Physiology: Inflammation links ageing to the brain","volume":"497","author":"Gabuzda","year":"2013","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.jpba.2020.113681_bib0245","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.expneurol.2007.07.004","article-title":"Neuroinflammatory mechanisms in Parkinson\u2019s disease: potential environmental triggers, pathways, and targets for early therapeutic intervention","volume":"208","author":"Tansey","year":"2007","journal-title":"Exp. Neurol."},{"issue":"10","key":"10.1016\/j.jpba.2020.113681_bib0250","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1016\/j.biopsych.2008.05.019","article-title":"Depressive symptoms and metabolic syndrome: is inflammation the underlying link?","volume":"64","author":"Capuron","year":"2008","journal-title":"Biol. Psychiatry"},{"issue":"4","key":"10.1016\/j.jpba.2020.113681_bib0255","doi-asserted-by":"crossref","first-page":"3391","DOI":"10.3892\/mmr.2016.4948","article-title":"Role of neuroinflammation in neurodegenerative diseases (Review)","volume":"13","author":"Chen","year":"2016","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.jpba.2020.113681_bib0260","doi-asserted-by":"crossref","first-page":"112","DOI":"10.3389\/fncel.2014.00112","article-title":"Neuroinflammation in the pathogenesis of Alzheimer\u2019s disease. A rational framework for the search of novel therapeutic approaches","volume":"8","author":"Morales","year":"2014","journal-title":"Front. Cell. Neurosci."},{"issue":"2","key":"10.1016\/j.jpba.2020.113681_bib0265","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1038\/nm.4022","article-title":"PD-1 immune checkpoint blockade reduces pathology and improves memory in mouse models of Alzheimer\u2019s disease","volume":"22","author":"Baruch","year":"2016","journal-title":"Nat. Med."},{"key":"10.1016\/j.jpba.2020.113681_bib0270","doi-asserted-by":"crossref","first-page":"80","DOI":"10.3389\/fimmu.2019.00080","article-title":"Peripheral inflammation regulates CNS immune surveillance through the recruitment of inflammatory monocytes upon systemic alpha-synuclein administration","volume":"10","author":"Peralta Ramos","year":"2019","journal-title":"Front. Immunol."},{"issue":"11","key":"10.1016\/j.jpba.2020.113681_bib0275","doi-asserted-by":"crossref","first-page":"1905","DOI":"10.1176\/ajp.2006.163.11.1905","article-title":"Acute and longer-term outcomes in depressed outpatients requiring one or several treatment steps: a STAR*D report","volume":"163","author":"Rush","year":"2006","journal-title":"Am. J. Psychiatry"},{"issue":"9","key":"10.1016\/j.jpba.2020.113681_bib0280","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.1016\/j.psyneuen.2012.02.006","article-title":"Inflammatory biomarkers predict depressive, but not anxiety symptoms during aging: the prospective Sydney Memory and Aging Study","volume":"37","author":"Baune","year":"2012","journal-title":"Psychoneuroendocrinology"},{"issue":"3","key":"10.1016\/j.jpba.2020.113681_bib0285","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/S0197-4580(00)00124-X","article-title":"Inflammation and Alzheimer\u2019s disease","volume":"21","author":"Akiyama","year":"2000","journal-title":"Neurobiol. Aging"},{"issue":"37","key":"10.1016\/j.jpba.2020.113681_bib0290","doi-asserted-by":"crossref","first-page":"10609","DOI":"10.3748\/wjg.v21.i37.10609","article-title":"Brain-gut-microbiota axis in Parkinson\u2019s disease","volume":"21","author":"Mulak","year":"2015","journal-title":"World J. Gastroenterol."},{"issue":"12","key":"10.1016\/j.jpba.2020.113681_bib0295","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.3390\/e15041416","article-title":"Glyphosate\u2019s suppression of cytochrome P450 enzymes and amino acid biosynthesis by the gut microbiome: pathways to modern diseases","volume":"15","author":"Samsel","year":"2013","journal-title":"Entropy"},{"key":"10.1016\/j.jpba.2020.113681_bib0300","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.bbi.2015.03.016","article-title":"Altered fecal microbiota composition in patients with major depressive disorder","volume":"48","author":"Jiang","year":"2015","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.jpba.2020.113681_bib0305","doi-asserted-by":"crossref","first-page":"184","DOI":"10.3389\/fphys.2018.00184","article-title":"Interplay between peripheral and central inflammation in autism Spectrum disorders: possible nutritional and therapeutic strategies","volume":"9","author":"Cristiano","year":"2018","journal-title":"Front. Physiol."},{"key":"10.1016\/j.jpba.2020.113681_bib0310","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/1742-2094-11-4","article-title":"Association of social and cognitive impairment and biomarkers in autism spectrum disorders","volume":"11","author":"Alabdali","year":"2014","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.jpba.2020.113681_bib0315","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/j.trci.2018.06.014","article-title":"Inflammation as a central mechanism in Alzheimer\u2019s disease","volume":"4","author":"Kinney","year":"2018","journal-title":"Alzheimers Dement. (N Y)"},{"issue":"2","key":"10.1016\/j.jpba.2020.113681_bib0320","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.pneurobio.2005.06.004","article-title":"Microglia and inflammation-mediated neurodegeneration: multiple triggers with a common mechanism","volume":"76","author":"Block","year":"2005","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.jpba.2020.113681_bib0325","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.redox.2017.09.002","article-title":"Short overview on metabolomic approach and redox changes in psychiatric disorders","volume":"14","author":"Nedic Erjavec","year":"2018","journal-title":"Redox Biol."},{"key":"10.1016\/j.jpba.2020.113681_bib0330","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/2406594","article-title":"Oxidative stress and the microbiota-gut-brain axis","volume":"2018","author":"Dumitrescu","year":"2018","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.jpba.2020.113681_bib0335","doi-asserted-by":"crossref","first-page":"471","DOI":"10.3389\/fphys.2018.00471","article-title":"The microbiome-mitochondria dance in prodromal Parkinson\u2019s disease","volume":"9","author":"Cardoso","year":"2018","journal-title":"Front. Physiol."},{"key":"10.1016\/j.jpba.2020.113681_bib0340","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1016\/j.redox.2018.01.008","article-title":"13 reasons why the brain is susceptible to oxidative stress","volume":"15","author":"Cobley","year":"2018","journal-title":"Redox Biol."},{"issue":"4","key":"10.1016\/j.jpba.2020.113681_bib0345","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1212\/WNL.42.4.726","article-title":"Gastrointestinal dysfunction in Parkinson\u2019s disease: frequency and pathophysiology","volume":"42","author":"Edwards","year":"1992","journal-title":"Neurology"},{"issue":"10","key":"10.1016\/j.jpba.2020.113681_bib0350","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1124\/dmd.115.063826","article-title":"Microbiome disturbances and autism spectrum disorders","volume":"43","author":"Rosenfeld","year":"2015","journal-title":"Drug Metab. Dispos."},{"issue":"5","key":"10.1016\/j.jpba.2020.113681_bib0355","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1046\/j.1440-1746.2003.03032.x","article-title":"Intestinal barrier: an interface between health and disease","volume":"18","author":"Farhadi","year":"2003","journal-title":"J. Gastroenterol. Hepatol."},{"key":"10.1016\/j.jpba.2020.113681_bib0360","doi-asserted-by":"crossref","first-page":"392","DOI":"10.3389\/fncel.2015.00392","article-title":"Breaking down the barriers: the gut microbiome, intestinal permeability and stress-related psychiatric disorders","volume":"9","author":"Kelly","year":"2015","journal-title":"Front. Cell. Neurosci."},{"issue":"263","key":"10.1016\/j.jpba.2020.113681_bib0365","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.3009759","article-title":"The gut microbiota influences blood-brain barrier permeability in mice","volume":"6","author":"Braniste","year":"2014","journal-title":"Sci. Transl. Med."},{"issue":"Suppl 1","key":"10.1016\/j.jpba.2020.113681_bib0370","doi-asserted-by":"crossref","first-page":"4586","DOI":"10.1073\/pnas.1000097107","article-title":"Composition, variability, and temporal stability of the intestinal microbiota of the elderly","volume":"108","author":"Claesson","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"14","key":"10.1016\/j.jpba.2020.113681_bib0375","doi-asserted-by":"crossref","first-page":"2989","DOI":"10.1113\/jphysiol.2014.273995","article-title":"The microbiota-gut-brain axis in gastrointestinal disorders: stressed bugs, stressed brain or both?","volume":"592","author":"De Palma","year":"2014","journal-title":"J. Physiol."},{"issue":"12","key":"10.1016\/j.jpba.2020.113681_bib0380","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1089\/jmf.2014.7000","article-title":"The gut microbiome and the brain","volume":"17","author":"Galland","year":"2014","journal-title":"J. Med. Food"},{"issue":"4","key":"10.1016\/j.jpba.2020.113681_bib0385","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1079\/BJN2002804","article-title":"Low serum cholesteryl ester-docosahexaenoic acid levels in Alzheimer\u2019s disease: a case-control study","volume":"89","author":"Tully","year":"2003","journal-title":"Br. J. Nutr."},{"key":"10.1016\/j.jpba.2020.113681_bib0390","doi-asserted-by":"crossref","first-page":"D608","DOI":"10.1093\/nar\/gkx1089","article-title":"HMDB 4.0: the human metabolome database for 2018","volume":"46 (D1","author":"Wishart","year":"2018","journal-title":"Nucleic Acids Res."},{"issue":"6","key":"10.1016\/j.jpba.2020.113681_bib0395","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1016\/j.cell.2016.11.018","article-title":"Gut microbiota regulate motor deficits and neuroinflammation in a model of Parkinson\u2019s disease","volume":"167","author":"Sampson","year":"2016","journal-title":"Cell"},{"issue":"2","key":"10.1016\/j.jpba.2020.113681_bib0400","doi-asserted-by":"crossref","first-page":"201","DOI":"10.5056\/jnm15146","article-title":"Modulatory effects of gut microbiota on the central nervous system: how gut could play a role in neuropsychiatric health and diseases","volume":"22","author":"Yarandi","year":"2016","journal-title":"J. Neurogastroenterol. Motil."},{"issue":"7","key":"10.1016\/j.jpba.2020.113681_bib0405","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0101652","article-title":"Quantitative analyses of schizophrenia-associated metabolites in serum: serum D-lactate levels are negatively correlated with gamma-glutamylcysteine in medicated schizophrenia patients","volume":"9","author":"Fukushima","year":"2014","journal-title":"PLoS One"},{"issue":"34","key":"10.1016\/j.jpba.2020.113681_bib0410","doi-asserted-by":"crossref","first-page":"8627","DOI":"10.1073\/pnas.1801609115","article-title":"Acetyl-l-carnitine deficiency in patients with major depressive disorder","volume":"115","author":"Nasca","year":"2018","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"2","key":"10.1016\/j.jpba.2020.113681_bib0415","article-title":"Anthranilic acid: a potential biomarker and treatment target for schizophrenia","volume":"4","author":"Oxenkrug","year":"2016","journal-title":"Ann. Psychiatry Ment. Health"},{"issue":"6","key":"10.1016\/j.jpba.2020.113681_bib0420","doi-asserted-by":"crossref","first-page":"G1124","DOI":"10.1152\/ajpgi.2001.280.6.G1124","article-title":"Hepatic uptake and metabolism of benzoate: a multiple indicator dilution, perfused rat liver study","volume":"280","author":"Schwab","year":"2001","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"issue":"3","key":"10.1016\/j.jpba.2020.113681_bib0425","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/S0165-0327(98)00025-1","article-title":"The inflammatory response system and the availability of plasma tryptophan in patients with primary sleep disorders and major depression","volume":"49","author":"Song","year":"1998","journal-title":"J. Affect. Disord."},{"issue":"10","key":"10.1016\/j.jpba.2020.113681_bib0430","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1007\/s11427-016-5083-9","article-title":"Alzheimer\u2019s disease and gut microbiota","volume":"59","author":"Hu","year":"2016","journal-title":"Sci. China Life Sci."},{"issue":"Suppl 3","key":"10.1016\/j.jpba.2020.113681_bib0435","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1186\/s12918-016-0307-y","article-title":"Towards understanding brain-gut-microbiome connections in Alzheimer\u2019s disease","volume":"10","author":"Xu","year":"2016","journal-title":"BMC Syst. Biol."},{"issue":"1","key":"10.1016\/j.jpba.2020.113681_bib0440","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/2040-2392-4-16","article-title":"Decreased tryptophan metabolism in patients with autism spectrum disorders","volume":"4","author":"Boccuto","year":"2013","journal-title":"Mol. Autism"},{"issue":"6","key":"10.1016\/j.jpba.2020.113681_bib0445","doi-asserted-by":"crossref","first-page":"2504","DOI":"10.1016\/j.clnu.2018.12.024","article-title":"Dietary fat, the gut microbiota, and metabolic health - A systematic review conducted within the MyNewGut project","volume":"38","author":"Wolters","year":"2019","journal-title":"Clin. Nutr."},{"key":"10.1016\/j.jpba.2020.113681_bib0450","article-title":"Fructose promotes leaky gut, endotoxemia, and liver fibrosis through ethanol-inducible cytochrome P450-2E1-Mediated oxidative and nitrative stress","author":"Cho","year":"2019","journal-title":"Hepatology"},{"issue":"7","key":"10.1016\/j.jpba.2020.113681_bib0455","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1093\/jn\/105.7.878","article-title":"Effects of high risk and low risk diets for colon carcinogenesis on fecal microflora and steroids in man","volume":"105","author":"Reddy","year":"1975","journal-title":"J. Nutr."},{"issue":"1","key":"10.1016\/j.jpba.2020.113681_bib0460","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1186\/s12967-017-1175-y","article-title":"Influence of diet on the gut microbiome and implications for human health","volume":"15","author":"Singh","year":"2017","journal-title":"J. Transl. Med."},{"issue":"1","key":"10.1016\/j.jpba.2020.113681_bib0465","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.jad.2012.02.023","article-title":"Increased IgA and IgM responses against gut commensals in chronic depression: further evidence for increased bacterial translocation or leaky gut","volume":"141","author":"Maes","year":"2012","journal-title":"J. Affect. Disord."},{"issue":"7","key":"10.1016\/j.jpba.2020.113681_bib0470","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1179\/1476830515Y.0000000007","article-title":"Isovaleric acid in stool correlates with human depression","volume":"19","author":"Szczesniak","year":"2016","journal-title":"Nutr. Neurosci."},{"issue":"4","key":"10.1016\/j.jpba.2020.113681_bib0475","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/j.nut.2015.10.019","article-title":"Abnormal fatty acids in Canadian children with autism","volume":"32","author":"Jory","year":"2016","journal-title":"Nutrition"},{"issue":"3","key":"10.1016\/j.jpba.2020.113681_bib0480","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1007\/s10803-015-2646-8","article-title":"Brief report: whole blood serotonin levels and gastrointestinal symptoms in autism spectrum disorder","volume":"46","author":"Marler","year":"2016","journal-title":"J. Autism Dev. Disord."},{"issue":"3","key":"10.1016\/j.jpba.2020.113681_bib0485","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1179\/147683010X12611460763968","article-title":"Increased urinary excretion of a 3-(3-hydroxyphenyl)-3-hydroxypropionic acid (HPHPA), an abnormal phenylalanine metabolite of Clostridia spp. in the gastrointestinal tract, in urine samples from patients with autism and schizophrenia","volume":"13","author":"Shaw","year":"2010","journal-title":"Nutr. Neurosci."},{"key":"10.1016\/j.jpba.2020.113681_bib0490","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/9485412","article-title":"Urinary 3-(3-Hydroxyphenyl)-3-hydroxypropionic acid, 3-hydroxyphenylacetic acid, and 3-hydroxyhippuric acid are elevated in children with autism spectrum disorders","volume":"2016","author":"Xiong","year":"2016","journal-title":"Biomed Res. Int."},{"issue":"1","key":"10.1016\/j.jpba.2020.113681_bib0495","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1111\/bdi.12682","article-title":"A step ahead: exploring the gut microbiota in inpatients with bipolar disorder during a depressive episode","volume":"21","author":"Painold","year":"2019","journal-title":"Bipolar Disord."},{"issue":"10","key":"10.1016\/j.jpba.2020.113681_bib0500","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1002\/mds.26307","article-title":"Colonic bacterial composition in Parkinson\u2019s disease","volume":"30","author":"Keshavarzian","year":"2015","journal-title":"Mov. Disord."},{"issue":"12","key":"10.1016\/j.jpba.2020.113681_bib0505","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2019.e02978","article-title":"Improvised method for urinary p-cresol detection and measurement using high performance liquid chromatography\/mass spectrometry","volume":"5","author":"Nandini","year":"2019","journal-title":"Heliyon"},{"key":"10.1016\/j.jpba.2020.113681_bib0510","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/j.schres.2018.01.002","article-title":"Analysis of gut microbiota diversity and auxiliary diagnosis as a biomarker in patients with schizophrenia: a cross-sectional study","volume":"197","author":"Shen","year":"2018","journal-title":"Schizophr. Res."},{"key":"10.1016\/j.jpba.2020.113681_bib0515","first-page":"1","article-title":"Analysis of gut microbiome, nutrition and immune status in autism spectrum disorder: a case-control study in Ecuador","author":"Zurita","year":"2019","journal-title":"Gut Microbes"},{"issue":"7","key":"10.1016\/j.jpba.2020.113681_bib0520","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/j.biopsych.2003.11.018","article-title":"Hypocortisolism and increased glucocorticoid sensitivity of pro-Inflammatory cytokine production in Bosnian war refugees with posttraumatic stress disorder","volume":"55","author":"Rohleder","year":"2004","journal-title":"Biol. Psychiatry"},{"issue":"3","key":"10.1016\/j.jpba.2020.113681_bib0525","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1007\/s12640-018-9987-y","article-title":"In schizophrenia, increased plasma IgM\/IgA responses to gut commensal Bacteria Are associated with negative symptoms, neurocognitive impairments, and the deficit phenotype","volume":"35","author":"Maes","year":"2019","journal-title":"Neurotox. Res."},{"key":"10.1016\/j.jpba.2020.113681_bib0530","article-title":"Altered gut microbiota and mucosal immunity in patients with schizophrenia","author":"Xu","year":"2019","journal-title":"Brain Behav. Immun."}],"container-title":["Journal of Pharmaceutical and Biomedical Analysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0731708520315673?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0731708520315673?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T09:12:35Z","timestamp":1760001155000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0731708520315673"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2]]},"references-count":106,"alternative-id":["S0731708520315673"],"URL":"https:\/\/doi.org\/10.1016\/j.jpba.2020.113681","relation":{},"ISSN":["0731-7085"],"issn-type":[{"value":"0731-7085","type":"print"}],"subject":[],"published":{"date-parts":[[2021,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Metabolomics analysis of microbiota-gut-brain axis in neurodegenerative and psychiatric diseases","name":"articletitle","label":"Article Title"},{"value":"Journal of Pharmaceutical and Biomedical Analysis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpba.2020.113681","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"113681"}}