{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T06:14:09Z","timestamp":1791526449975,"version":"4.3.4"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmaceutical and Biomedical Analysis"],"published-print":{"date-parts":[[2021,7]]},"DOI":"10.1016\/j.jpba.2021.114110","type":"journal-article","created":{"date-parts":[[2021,5,3]],"date-time":"2021-05-03T12:55:30Z","timestamp":1620046530000},"page":"114110","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Influence of the mobile phase composition on hyphenated ultraviolet and charged aerosol detection for the impurity profiling of vigabatrin"],"prefix":"10.1016","volume":"201","author":[{"given":"Ruben","family":"Pawellek","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0364-7278","authenticated-orcid":false,"given":"Ulrike","family":"Holzgrabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10","key":"10.1016\/j.jpba.2021.114110_bib0005","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1016\/j.chroma.2010.01.007","article-title":"Review of operating principle and applications of the charged aerosol detector","volume":"1217","author":"Vehovec","year":"2010","journal-title":"J. Chromatogr. A"},{"issue":"2","key":"10.1016\/j.jpba.2021.114110_bib0010","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1080\/10408347.2012.746134","article-title":"Corona-charged aerosol detection: an analytical approach","volume":"43","author":"Ligor","year":"2013","journal-title":"Crit. Rev. Anal. Chem."},{"issue":"1","key":"10.1016\/j.jpba.2021.114110_bib0015","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.chroma.2007.11.035","article-title":"Determination of relative response factors of impurities in paclitaxel with high performance liquid chromatography equipped with ultraviolet and charged aerosol detectors","volume":"1177","author":"Sun","year":"2008","journal-title":"J. Chromatogr. A"},{"issue":"3-4","key":"10.1016\/j.jpba.2021.114110_bib0020","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1007\/s10337-015-3011-y","article-title":"Method development and validation for determination of cocaine, its main metabolites and pyrolytic products by HPLC\u2013UV\u2013CAD","volume":"79","author":"Pereira","year":"2016","journal-title":"Chromatographia"},{"key":"10.1016\/j.jpba.2021.114110_bib0025","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.jpba.2018.12.015","article-title":"Quality assessment of Astragali Radix from different production areas by simultaneous determination of thirteen major compounds using tandem UV\/charged aerosol detector","volume":"165","author":"Zhang","year":"2019","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jpba.2021.114110_bib0030","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.jpba.2017.11.078","article-title":"Impurity profiling of N, N\u2032-ethylenebis-l-cysteine diethyl ester (Bicisate)","volume":"150","author":"Wahl","year":"2018","journal-title":"J. Pharm. Biomed. Anal."},{"issue":"3","key":"10.1016\/j.jpba.2021.114110_bib0035","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1080\/10408340802038882","article-title":"Ion pairing chromatography","volume":"38","author":"Cecchi","year":"2008","journal-title":"Crit. Rev. Anal. Chem."},{"key":"10.1016\/j.jpba.2021.114110_bib0040","series-title":"Charged Aerosol Detection for Liquid Chromatography and Related Separation Techniques","author":"Gamache","year":"2017"},{"issue":"2","key":"10.1016\/j.jpba.2021.114110_bib0045","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/S0021-9673(98)01060-7","article-title":"Ion-pair reversed-phase liquid chromatography for determination of polar underivatized amino acids using perfluorinated carboxylic acids as ion pairing agent","volume":"833","author":"Petritis","year":"1999","journal-title":"J. Chromatogr. A"},{"issue":"1-2","key":"10.1016\/j.jpba.2021.114110_bib0050","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/S0021-9673(99)00863-8","article-title":"Ion-pair chromatography on a porous graphitic carbon stationary phase for the analysis of twenty underivatized protein amino acids","volume":"870","author":"Chaimbault","year":"2000","journal-title":"J. Chromatogr. A"},{"issue":"49","key":"10.1016\/j.jpba.2021.114110_bib0055","doi-asserted-by":"crossref","first-page":"8813","DOI":"10.1016\/j.chroma.2011.10.009","article-title":"Mixed-mode chromatography and its applications to biopolymers","volume":"1218","author":"Yang","year":"2011","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.jpba.2021.114110_bib0060","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.jpba.2016.05.007","article-title":"Mixed-mode chromatography in pharmaceutical and biopharmaceutical applications","volume":"128","author":"Zhang","year":"2016","journal-title":"J. Pharm. Biomed. Anal."},{"issue":"1","key":"10.1016\/j.jpba.2021.114110_bib0065","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1007\/s00216-011-5308-5","article-title":"Hydrophilic interaction liquid chromatography (HILIC)\u2014a powerful separation technique","volume":"402","author":"Buszewski","year":"2012","journal-title":"Anal. Bioanal. Chem."},{"issue":"6-7","key":"10.1016\/j.jpba.2021.114110_bib0070","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1002\/jssc.200900742","article-title":"HILIC methods in pharmaceutical analysis","volume":"33","author":"Dejaegher","year":"2010","journal-title":"J. Sep. Sci."},{"key":"10.1016\/j.jpba.2021.114110_bib0075","series-title":"European Pharmacopeia Online 10.5","author":"Council of Europe","year":"2021"},{"key":"10.1016\/j.jpba.2021.114110_bib0080","series-title":"Guideline Q2 (R1) Validation of Analytical Procedures: Text and Methodology","author":"International Council for Harmonization","year":"2005"},{"key":"10.1016\/j.jpba.2021.114110_bib0085","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.jchromb.2018.07.033","article-title":"Quantitative analysis of underivatized amino acids in the sub-to several-nanomolar range by ion-pair HPLC using a corona-charged aerosol detector (HPLC\u2013CAD)","volume":"1095","author":"Furota","year":"2018","journal-title":"J. Chromatogr. B"},{"issue":"2","key":"10.1016\/j.jpba.2021.114110_bib0090","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.jpba.2011.05.027","article-title":"Identification and control of impurities in streptomycin sulfate by high-performance liquid chromatography coupled with mass detection and corona charged-aerosol detection","volume":"56","author":"Holzgrabe","year":"2011","journal-title":"J. Pharm. Biomed. Anal."},{"issue":"2","key":"10.1016\/j.jpba.2021.114110_bib0095","first-page":"128","article-title":"Response surface methodology, Wiley Interdiscip","volume":"2","author":"Khuri","year":"2010","journal-title":"Rev. Comput. Stat."},{"key":"10.1016\/j.jpba.2021.114110_bib0100","series-title":"Response Surface Methodology: Process and Product Optimization Using Designed Experiments","author":"Myers","year":"2016"},{"issue":"2","key":"10.1016\/j.jpba.2021.114110_bib0105","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1080\/00224065.2012.11917886","article-title":"I-optimal versus D-optimal split-plot response surface designs","volume":"44","author":"Jones","year":"2012","journal-title":"J. Qual. Technol."},{"key":"10.1016\/j.jpba.2021.114110_bib0110","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.aca.2012.04.002","article-title":"Investigation of polar organic solvents compatible with corona charged aerosol detection and their use for the determination of sugars by hydrophilic interaction liquid chromatography","volume":"750","author":"Hutchinson","year":"2012","journal-title":"Anal. Chim. Acta"},{"issue":"47","key":"10.1016\/j.jpba.2021.114110_bib0115","doi-asserted-by":"crossref","first-page":"7418","DOI":"10.1016\/j.chroma.2010.09.056","article-title":"Universal response model for a corona charged aerosol detector","volume":"1217","author":"Hutchinson","year":"2010","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.jpba.2021.114110_bib0120","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.chroma.2018.09.031","article-title":"Influence of charged aerosol detector instrument settings on the ultra-high-performance liquid chromatography analysis of fatty acids in polysorbate 80","volume":"1576","author":"Schilling","year":"2018","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.jpba.2021.114110_bib0125","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.chroma.2015.05.050","article-title":"Performance of charged aerosol detection with hydrophilic interaction chromatography","volume":"1405","author":"Russell","year":"2015","journal-title":"J. Chromatogr. A"},{"issue":"6","key":"10.1016\/j.jpba.2021.114110_bib0130","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1002\/elps.200406184","article-title":"Separation of perfluorocarboxylic acids using capillary electrophoresis with UV detection","volume":"26","author":"W\u00f3jcik","year":"2005","journal-title":"Electrophoresis"},{"key":"10.1016\/j.jpba.2021.114110_bib0135","series-title":"Guideline Q3A (R2) Impurities in New Drug Products","author":"International Council for Harmonization","year":"2006"},{"key":"10.1016\/j.jpba.2021.114110_bib0140","series-title":"Knowledge Database","author":"Council of Europe","year":"2021"},{"issue":"9","key":"10.1016\/j.jpba.2021.114110_bib0145","doi-asserted-by":"crossref","first-page":"3186","DOI":"10.1021\/ac060078j","article-title":"Universal response in liquid chromatography using charged aerosol detection","volume":"78","author":"Gorecki","year":"2006","journal-title":"Anal. Chem."},{"key":"10.1016\/j.jpba.2021.114110_bib0150","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.jpba.2012.03.019","article-title":"Charged aerosol detection in pharmaceutical analysis","volume":"69","author":"Almeling","year":"2012","journal-title":"J. Pharm. Biomed. Anal."}],"container-title":["Journal of Pharmaceutical and Biomedical Analysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0731708521002211?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0731708521002211?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T09:13:07Z","timestamp":1760001187000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0731708521002211"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7]]},"references-count":30,"alternative-id":["S0731708521002211"],"URL":"https:\/\/doi.org\/10.1016\/j.jpba.2021.114110","relation":{},"ISSN":["0731-7085"],"issn-type":[{"value":"0731-7085","type":"print"}],"subject":[],"published":{"date-parts":[[2021,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Influence of the mobile phase composition on hyphenated ultraviolet and charged aerosol detection for the impurity profiling of vigabatrin","name":"articletitle","label":"Article Title"},{"value":"Journal of Pharmaceutical and Biomedical Analysis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpba.2021.114110","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"114110"}}