{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T10:00:47Z","timestamp":1792404047785,"version":"4.4.0"},"reference-count":20,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmaceutical and Biomedical Analysis"],"published-print":{"date-parts":[[2022,4]]},"DOI":"10.1016\/j.jpba.2022.114659","type":"journal-article","created":{"date-parts":[[2022,2,11]],"date-time":"2022-02-11T11:17:47Z","timestamp":1644578267000},"page":"114659","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["Simultaneous determination of linezolid and voriconazole serum concentrations using liquid chromatography-tandem mass spectrometry"],"prefix":"10.1016","volume":"212","author":[{"given":"Qiuya","family":"Lu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoshuang","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaifeng","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengmei","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolan","family":"Bian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuefeng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.jpba.2022.114659_bib1","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1007\/s40262-019-00813-w","article-title":"Pharmacokinetics and target attainment of antibiotics in critically Ill children: a systematic review of current literature","volume":"59","author":"Hartman","year":"2020","journal-title":"Clin. Pharm."},{"issue":"8","key":"10.1016\/j.jpba.2022.114659_bib2","doi-asserted-by":"crossref","first-page":"e00583","DOI":"10.1128\/AAC.00583-19","article-title":"to Understanding antimicrobial drug dosing in critically ill patients on renal replacement therapy","volume":"63","author":"Pistolesi","year":"2019","journal-title":"Antimicrob. Agents Chemother."},{"issue":"6","key":"10.1016\/j.jpba.2022.114659_bib3","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1007\/s00134-020-06050-1","article-title":"Infection section of European society of intensive care, pharmacokinetic\/pharmacodynamic, antimicrobial therapeutic drug monitoring in critically ill adult patients: a position paper","volume":"46","author":"Abdul-Aziz","year":"2020","journal-title":"Intensive Care Med."},{"issue":"6","key":"10.1016\/j.jpba.2022.114659_bib4","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1517\/17425255.2016.1170807","article-title":"Pharmacokinetics of linezolid in critically ill patients","volume":"12","author":"Sazdanovic","year":"2016","journal-title":"Expert Opin. Drug Metab. Toxicol."},{"key":"10.1016\/j.jpba.2022.114659_bib5","doi-asserted-by":"crossref","first-page":"1759","DOI":"10.2147\/DDDT.S164515","article-title":"Linezolid: a review of its properties, function, and use in critical care","volume":"12","author":"Hashemian","year":"2018","journal-title":"Drug Des. Dev. Ther."},{"issue":"3","key":"10.1016\/j.jpba.2022.114659_bib6","doi-asserted-by":"crossref","first-page":"106","DOI":"10.3390\/metabo10030106","article-title":"Antifungal drugs","volume":"10","author":"Houst","year":"2020","journal-title":"Metabolites"},{"issue":"8","key":"10.1016\/j.jpba.2022.114659_bib7","doi-asserted-by":"crossref","first-page":"805","DOI":"10.4065\/mcp.2011.0247","article-title":"Current concepts in antifungal pharmacology","volume":"86","author":"Lewis","year":"2011","journal-title":"Mayo Clin. Proc."},{"issue":"7","key":"10.1016\/j.jpba.2022.114659_bib8","doi-asserted-by":"crossref","first-page":"649","DOI":"10.2165\/00003088-200645070-00002","article-title":"Pharmacokinetic\/pharmacodynamic profile of voriconazole","volume":"45","author":"Theuretzbacher","year":"2006","journal-title":"Clin. Pharm."},{"issue":"11","key":"10.1016\/j.jpba.2022.114659_bib9","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1016\/j.cmi.2020.05.037","article-title":"Antifungal therapeutic drug monitoring: focus on drugs without a clear recommendation","volume":"26","author":"Gomez-Lopez","year":"2020","journal-title":"Clin. Microbiol Infect."},{"key":"10.1016\/j.jpba.2022.114659_bib10","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.clinbiochem.2021.01.012","article-title":"Simultaneous quantification of plasma levels of 12 antimicrobial agents including carbapenem, anti-methicillin-resistant Staphylococcus aureus agent, quinolone and azole used in intensive care unit using UHPLC-MS\/MS method","volume":"90","author":"Kai","year":"2021","journal-title":"Clin. Biochem."},{"issue":"8","key":"10.1016\/j.jpba.2022.114659_bib11","doi-asserted-by":"crossref","first-page":"1758","DOI":"10.1111\/bcp.13262","article-title":"Population pharmacokinetics and pharmacodynamics of linezolid-induced thrombocytopenia in hospitalized patients","volume":"83","author":"Tsuji","year":"2017","journal-title":"Br. J. Clin. Pharm."},{"issue":"42","key":"10.1016\/j.jpba.2022.114659_bib12","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000008039","article-title":"Significance of monitoring plasma concentration of voriconazole in a patient with liver failure: a case report","volume":"96","author":"Liu","year":"2017","journal-title":"Medicine"},{"issue":"1","key":"10.1016\/j.jpba.2022.114659_bib13","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1186\/s12941-017-0235-8","article-title":"Voriconazole and posaconazole therapeutic drug monitoring: a retrospective study","volume":"16","author":"Yi","year":"2017","journal-title":"Ann. Clin. Microbiol Antimicrob."},{"issue":"7","key":"10.1016\/j.jpba.2022.114659_bib14","doi-asserted-by":"crossref","first-page":"493","DOI":"10.21037\/atm.2020.03.207","article-title":"Does the conventional dosage of linezolid necessitate therapeutic drug monitoring?-Experience from a prospective observational study","volume":"8","author":"Fang","year":"2020","journal-title":"Ann. Transl. Med"},{"key":"10.1016\/j.jpba.2022.114659_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2019.106078","article-title":"Therapeutic drug monitoring and safety of voriconazole in elderly patients","volume":"78","author":"Cheng","year":"2020","journal-title":"Int. Immunopharmacol."},{"issue":"1","key":"10.1016\/j.jpba.2022.114659_bib16","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1111\/bcp.13401","article-title":"Therapeutic drug monitoring of voriconazole for treatment and prophylaxis of invasive fungal infection in children","volume":"84","author":"Allegra","year":"2018","journal-title":"Br. J. Clin. Pharm."},{"key":"10.1016\/j.jpba.2022.114659_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.talanta.2020.121641","article-title":"Simultaneous determination of 8 beta-lactams and linezolid by an ultra-performance liquid chromatography method with UV detection and cross-validation with a commercial immunoassay for the quantification of linezolid","volume":"221","author":"Fage","year":"2021","journal-title":"Talanta"},{"key":"10.1016\/j.jpba.2022.114659_bib18","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/3128270","article-title":"Linezolid Inhibited Synthesis of ATP in Mitochondria: based on GC-MS Metabolomics and HPLC Method","volume":"2018","author":"Ye","year":"2018","journal-title":"Biomed. Res. Int."},{"issue":"2","key":"10.1016\/j.jpba.2022.114659_bib19","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1007\/s12291-015-0507-z","article-title":"Plasma voriconazole estimation by HPLC","volume":"31","author":"Chawla","year":"2016","journal-title":"Indian J. Clin. Biochem."},{"key":"10.1016\/j.jpba.2022.114659_bib20","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/5497427","article-title":"Determination of voriconazole plasma concentration by HPLC technique and evaluating its association with clinical outcome and adverse effects in patients with invasive aspergillosis","volume":"2021","author":"Yousefian","year":"2021","journal-title":"Can. J. Infect. Dis. Med. Microbiol."}],"container-title":["Journal of Pharmaceutical and Biomedical Analysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0731708522000802?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0731708522000802?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T09:21:43Z","timestamp":1760001703000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0731708522000802"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4]]},"references-count":20,"alternative-id":["S0731708522000802"],"URL":"https:\/\/doi.org\/10.1016\/j.jpba.2022.114659","relation":{},"ISSN":["0731-7085"],"issn-type":[{"value":"0731-7085","type":"print"}],"subject":[],"published":{"date-parts":[[2022,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Simultaneous determination of linezolid and voriconazole serum concentrations using liquid chromatography-tandem mass spectrometry","name":"articletitle","label":"Article Title"},{"value":"Journal of Pharmaceutical and Biomedical Analysis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpba.2022.114659","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"114659"}}