{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T09:42:25Z","timestamp":1760002945487,"version":"build-2065373602"},"reference-count":15,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003482","name":"Hebei Province Department of Education","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003482","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008238","name":"Hebei Province Department of Science And Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008238","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmaceutical and Biomedical Analysis"],"published-print":{"date-parts":[[2022,5]]},"DOI":"10.1016\/j.jpba.2022.114715","type":"journal-article","created":{"date-parts":[[2022,3,9]],"date-time":"2022-03-09T02:13:28Z","timestamp":1646792008000},"page":"114715","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Isolation, synthesis, identification of new process-related impurities in evocalcet"],"prefix":"10.1016","volume":"214","author":[{"given":"Hongyi","family":"Yan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yabo","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongli","family":"Yue","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaowei","family":"Shi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kai","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Na","family":"Xue","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jpba.2022.114715_bib1","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1152\/physrev.2001.81.1.239","article-title":"Extracellular calcium sensing and extracellular calcium signaling","volume":"81","author":"Brown","year":"2001","journal-title":"J. Physiol. Rev."},{"key":"10.1016\/j.jpba.2022.114715_bib2","article-title":"Localization and function of the renal calcium-sensing receptor","volume":"9","author":"Daniela","year":"2016","journal-title":"Nat. Rev. Nephrol."},{"key":"10.1016\/j.jpba.2022.114715_bib3","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.bcp.2010.04.002","article-title":"Clinical utility of calcimimetics targeting the extracellular calcium-sensing receptor (CaSR)","volume":"80","author":"Brown","year":"2010","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.jpba.2022.114715_bib4","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1007\/BF00866757","article-title":"The parathyroid calcium receptor: a novel therapeutic target for treating hyperparathyroidism","volume":"10","author":"Nemeth","year":"1996","journal-title":"Pediatr. Nephrol."},{"key":"10.1016\/j.jpba.2022.114715_bib5","doi-asserted-by":"crossref","first-page":"913","DOI":"10.2215\/CJN.06040710","article-title":"Secondary hyperparathyroidism: pathogenesis, disease progression, and therapeutic options","volume":"6","author":"Cunningham","year":"2011","journal-title":"Clin. J. Am. Soc. Nephrol."},{"issue":"10","key":"10.1016\/j.jpba.2022.114715_bib6","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0204896","article-title":"Phase 2b study of evocalcet (KHK7580), a novel calcimimetic, in Japanese patients with secondary hyperparathyroidism undergoing hemodialysis: a randomized, double-blind, placebo-controlled, dose-finding study","volume":"13","author":"Akizawa","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.jpba.2022.114715_bib7","article-title":"Pharmacodynamics of evocalcet for secondary hyperparathyroidism in Japanese hemodialysis patients","volume":"31","author":"Shigematsu","year":"2018","journal-title":"Clin. Exp. Nephrol."},{"key":"10.1016\/j.jpba.2022.114715_bib8","unstructured":"International Conference Harmonization (ICH harmonized tripartite guideline, Impurities in New Drug Substances Q3A (R2), October 25, (2006)."},{"key":"10.1016\/j.jpba.2022.114715_bib9","unstructured":"Guidance for Industry: Q3B (R2) Impurities in New Drug Product, International Conference on Harmonisation, 2006."},{"key":"10.1016\/j.jpba.2022.114715_bib10","unstructured":"Guideline for Assessment and Control of DNA Reactive (mutagenic) Impurities in Pharmaceuticals to Limit Potential Carcinogenic Risk, M7, ICH, 2014."},{"key":"10.1016\/j.jpba.2022.114715_bib11","unstructured":"M. Hiroshi, T. Junko, Y. Kosuke, T. Iwao, S. Osamu, Arylalkylamines and process for production thereof, JP 2005\/009795 (May 2005)."},{"key":"10.1016\/j.jpba.2022.114715_bib12","unstructured":"M. Hiroshi, Y. Kosuke, T. Iwao, S. Osamu, Y. Tetsuya, H. Yutaka, Arylalkylamines and process for production thereof, WO 2005\/115975 A1 (May 2005)."},{"key":"10.1016\/j.jpba.2022.114715_bib13","unstructured":"H. Nagasaki T. Hatanaka Bodily taste imparting agent WO 2009\/107579 February 2009."},{"key":"10.1016\/j.jpba.2022.114715_bib14","unstructured":"M. Hiroshi, O. Junko, Y. Kosike, T. Iwao, S. Osamu, Y. Tetsuya, H. Yutaka, Arylakylamine compound and process for preparing the same, US 2014\/0080770 A1 (March 2014)."},{"key":"10.1016\/j.jpba.2022.114715_bib15","unstructured":"M. Hiroshi, K. Takao, T. Joji, U. Takeshi, M. Yuuji, Novel crystalline arylalkylamine compound and method for producing same, WO 2015\/034031 A1 (March 2015)."}],"container-title":["Journal of Pharmaceutical and Biomedical Analysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0731708522001364?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0731708522001364?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T09:18:00Z","timestamp":1760001480000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0731708522001364"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5]]},"references-count":15,"alternative-id":["S0731708522001364"],"URL":"https:\/\/doi.org\/10.1016\/j.jpba.2022.114715","relation":{},"ISSN":["0731-7085"],"issn-type":[{"type":"print","value":"0731-7085"}],"subject":[],"published":{"date-parts":[[2022,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Isolation, synthesis, identification of new process-related impurities in evocalcet","name":"articletitle","label":"Article Title"},{"value":"Journal of Pharmaceutical and Biomedical Analysis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpba.2022.114715","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"114715"}}