{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T16:15:54Z","timestamp":1790957754785,"version":"4.1.0"},"reference-count":22,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmaceutical and Biomedical Analysis"],"published-print":{"date-parts":[[2022,5]]},"DOI":"10.1016\/j.jpba.2022.114732","type":"journal-article","created":{"date-parts":[[2022,3,17]],"date-time":"2022-03-17T21:49:28Z","timestamp":1647553768000},"page":"114732","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"special_numbering":"C","title":["Identification and characterization of higenamine metabolites in human urine by quadrupole-orbitrap LC-MS\/MS for doping control"],"prefix":"10.1016","volume":"214","author":[{"given":"Xuxiao","family":"Zhao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuling","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiaoling","family":"Fei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaoqian","family":"Luan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinzhai","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youxuan","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianghai","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jpba.2022.114732_bib1","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.jep.2016.12.033","article-title":"Applications of higenamine in pharmacology and medicine","volume":"196","author":"Zhang","year":"2017","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jpba.2022.114732_bib2","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/bs.irn.2017.02.010","article-title":"Interactions of commonly used chinese medicinal herbs","volume":"135","author":"Singh","year":"2017","journal-title":"Int. Rev. Neurobiol."},{"issue":"1","key":"10.1016\/j.jpba.2022.114732_bib3","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/s40256-013-0006-7","article-title":"Tolerability and pharmacokinetics of ranolazine following single and multiple sustained-release doses in Chinese healthy adult volunteers: a randomized, open-label, Latin square design, phase I study","volume":"13","author":"Tan","year":"2013","journal-title":"Am. J. Cardiovasc. Drugs"},{"issue":"11","key":"10.1016\/j.jpba.2022.114732_bib4","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1038\/aps.2012.37","article-title":"Population pharmacokinetics and pharmacodynamics of bivalirudin in young healthy Chinese volunteers","volume":"33","author":"Zhang","year":"2012","journal-title":"Acta Pharmacol. Sin."},{"issue":"4","key":"10.1016\/j.jpba.2022.114732_bib5","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1007\/s13318-016-0371-0","article-title":"Population pharmacokinetic modeling of olmesartan, the active metabolite of olmesartan medoxomil, in patients with hypertension","volume":"42","author":"Kodati","year":"2017","journal-title":"Eur. J. Drug Metab. Pharmacokinet."},{"key":"10.1016\/j.jpba.2022.114732_bib6","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1186\/1476-511X-12-148","article-title":"Acute oral intake of a higenamine-based dietary supplement increases circulating free fatty acids and energy expenditure in human subjects","volume":"12","author":"Lee","year":"2013","journal-title":"Lipids Health Dis."},{"issue":"10","key":"10.1016\/j.jpba.2022.114732_bib7","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1177\/0960327114565490","article-title":"Clinical safety assessment of oral higenamine supplementation in healthy, young men","volume":"34","author":"Bloomer","year":"2015","journal-title":"Hum. Exp. Toxicol."},{"issue":"10","key":"10.1016\/j.jpba.2022.114732_bib8","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1111\/j.1745-7254.2008.00859.x","article-title":"Identification of higenamine in Radix Aconiti Lateralis Preparata as a beta2-adrenergic receptor agonist1","volume":"29","author":"Bai","year":"2008","journal-title":"Acta Pharmacol. Sin."},{"issue":"2","key":"10.1016\/j.jpba.2022.114732_bib9","doi-asserted-by":"crossref","first-page":"285","DOI":"10.3390\/nu12020285","article-title":"Potential risk of higenamine misuse in sports: evaluation of lotus plumule extract products and a human study","volume":"12","author":"Yen","year":"2020","journal-title":"Nutrients"},{"key":"10.1016\/j.jpba.2022.114732_bib10","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1023\/A:1008681612399","article-title":"A case of positive doping associated with a botanical food supplement","volume":"21","author":"Ros","year":"1999","journal-title":"Pharm. World Sci."},{"issue":"7","key":"10.1016\/j.jpba.2022.114732_bib11","doi-asserted-by":"crossref","first-page":"e847","DOI":"10.7205\/MILMED-D-14-00647","article-title":"A case of paraspinal muscle rhabdomyolysis in a 22-year-old male after ingesting a supplement containing higenamine","volume":"180","author":"Jeter","year":"2015","journal-title":"Mil. Med."},{"key":"10.1016\/j.jpba.2022.114732_bib12","unstructured":"World Anti-Doping Agency, World Anti-doping Code International Standard 2022 Prohibited List. https:\/\/www.wada-ama.org\/en\/resources\/science-medicine\/2022-prohibited-list-documents."},{"issue":"9","key":"10.1016\/j.jpba.2022.114732_bib13","first-page":"1871","article-title":"Quality consistency evaluation of Fuzi formula granules using determination of multi-component contents by HPLC-MS\/MS method","volume":"43","author":"Tang","year":"2018","journal-title":"Zhongguo Zhong Yao Za Zhi"},{"key":"10.1016\/j.jpba.2022.114732_bib14","doi-asserted-by":"crossref","first-page":"3812180","DOI":"10.1155\/2020\/3812180","article-title":"Identification of active compounds of mahuang fuzi xixin decoction and their mechanisms of action by lc-ms\/ms and network pharmacology","author":"Liang","year":"2020","journal-title":"Evid. Based Complement Altern. Med."},{"issue":"12","key":"10.1016\/j.jpba.2022.114732_bib15","doi-asserted-by":"crossref","first-page":"1953","DOI":"10.1002\/jssc.201300012","article-title":"Simultaneous quantitation of seven alkaloids in processed Fuzi decoction by rapid resolution liquid chromatography coupled with tandem mass spectrometry","volume":"36","author":"Guo","year":"2013","journal-title":"J. Sep. Sci."},{"issue":"11\u201312","key":"10.1016\/j.jpba.2022.114732_bib16","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1016\/j.jchromb.2011.02.019","article-title":"Determination of higenamine in human plasma and urine using liquid chromatography coupled to positive electrospray ionization tandem mass spectrometry","volume":"879","author":"Feng","year":"2011","journal-title":"J. Chromatogr. B Anal. Technol. Biomed. Life Sci."},{"issue":"10","key":"10.1016\/j.jpba.2022.114732_bib17","first-page":"1036","article-title":"Determination of higenamine in Chinese herbal medicine, condiments, and topical medicine by QuEChERS combined with liquid chromatography-tandem mass spectrometry","volume":"37","author":"Wang","year":"2019","journal-title":"Se Pu"},{"key":"10.1016\/j.jpba.2022.114732_bib18","doi-asserted-by":"crossref","first-page":"1788","DOI":"10.1002\/dta.2258","article-title":"Determination of higenamine and coclaurine levels in human urine after the administration of a throat lozenge containing Nandina domestica fruit","author":"Okano","year":"2017","journal-title":"Drug Test. Anal."},{"issue":"6","key":"10.1016\/j.jpba.2022.114732_bib19","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1002\/dta.2331","article-title":"Analysis for higenamine in urine by means of ultra-high-performance liquid chromatography-tandem mass spectrometry: interpretation of results","volume":"10","author":"Grucza","year":"2018","journal-title":"Drug Test. Anal."},{"issue":"4","key":"10.1016\/j.jpba.2022.114732_bib20","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1002\/dta.2756","article-title":"A pharmacokinetics study of orally administered higenamine in rats using LC-MS\/MS for doping control analysis","volume":"12","author":"Wang","year":"2020","journal-title":"Drug Test. Anal."},{"issue":"1","key":"10.1016\/j.jpba.2022.114732_bib21","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.jfda.2019.09.002","article-title":"Determination of higenamine in multi-matrix by gas chromatography-mass spectrometry combined with derivatization technology","volume":"28","author":"Feng","year":"2020","journal-title":"J. Food Drug Anal."},{"key":"10.1016\/j.jpba.2022.114732_bib22","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1002\/dta.2701","article-title":"The risk of higenamine adverse analytical findings following oral administration of plumula nelumbinis capsules","author":"Yan","year":"2019","journal-title":"Drug Test. Anal."}],"container-title":["Journal of Pharmaceutical and Biomedical Analysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0731708522001534?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0731708522001534?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T09:20:11Z","timestamp":1760001611000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0731708522001534"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5]]},"references-count":22,"alternative-id":["S0731708522001534"],"URL":"https:\/\/doi.org\/10.1016\/j.jpba.2022.114732","relation":{},"ISSN":["0731-7085"],"issn-type":[{"value":"0731-7085","type":"print"}],"subject":[],"published":{"date-parts":[[2022,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Identification and characterization of higenamine metabolites in human urine by quadrupole-orbitrap LC-MS\/MS for doping control","name":"articletitle","label":"Article Title"},{"value":"Journal of Pharmaceutical and Biomedical Analysis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpba.2022.114732","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"114732"}}