{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T12:22:22Z","timestamp":1768479742774,"version":"3.49.0"},"reference-count":12,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100002322","name":"CAPES","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"CNPq","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004586","name":"FAPERJ","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmaceutical and Biomedical Analysis"],"published-print":{"date-parts":[[2022,6]]},"DOI":"10.1016\/j.jpba.2022.114773","type":"journal-article","created":{"date-parts":[[2022,4,19]],"date-time":"2022-04-19T12:12:20Z","timestamp":1650370340000},"page":"114773","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Towards a holistic view of tablet quality, an extensive study on paracetamol tablets with nuclear magnetic resonance using similarity calculations, differential NMR and hierarchical cluster analysis"],"prefix":"10.1016","volume":"215","author":[{"given":"Jan","family":"Schripsema","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronald","family":"dos Santos Merlim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lais","family":"Gon\u00e7alves Parvan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helen","family":"Sant\u2019Ana dos Santos Ribeiro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leonardo","family":"Dagnino Schripsema","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seldon","family":"Aleixo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Becht","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulrike","family":"Holzgrabe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Denise","family":"Dagnino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jpba.2022.114773_bib1","article-title":"Rapid and accurate verification of drug identity, purity and quality by 1H NMR using similarity calculations and differential NMR","volume":"119","author":"dos Santos Ribeiro","year":"2021","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jpba.2022.114773_bib2","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1111\/tmi.13161","article-title":"The health consequences of falsified medicines- A study of the published literature","volume":"23","author":"Rahman","year":"2018","journal-title":"Trop. Med. Int. Heal."},{"key":"10.1016\/j.jpba.2022.114773_bib3","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1016\/j.jpba.2005.01.050","article-title":"Quantitative NMR spectroscopy--applications in drug analysis","volume":"38","author":"Holzgrabe","year":"2005","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jpba.2022.114773_bib4","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1002\/mrc.5099","article-title":"Quantitative NMR (qNMR) for pharmaceutical analysis: the pioneering work of George Hanna at the US FDA","volume":"59","author":"Jaki","year":"2021","journal-title":"Magn. Reson. Chem."},{"key":"10.1016\/j.jpba.2022.114773_bib5","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1080\/17460441.2016.1189899","article-title":"The application of absolute quantitative 1H NMR spectroscopy in drug discovery and development","volume":"11","author":"Singh","year":"2016","journal-title":"Expert Opin. Drug Disco"},{"key":"10.1016\/j.jpba.2022.114773_bib6","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1007\/s11306-019-1502-9","article-title":"Similarity and differential NMR spectroscopy in metabolomics: application to the analysis of vegetable oils with 1H and 13C NMR","volume":"15","author":"Schripsema","year":"2019","journal-title":"Metabolomics"},{"key":"10.1016\/j.jpba.2022.114773_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.jfca.2021.104000","article-title":"Metabolomics of Baobab oil - analysis and authentication of cyclopropenoid fatty acids using similarity and differential NMR spectroscopy","volume":"102","author":"Augustyn","year":"2021","journal-title":"J. Food Compos. Anal."},{"key":"10.1016\/j.jpba.2022.114773_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.talanta.2021.122928","article-title":"Differential NMR and chromatography for the detection and analysis of adulteration of vetiver essential oils","volume":"237","author":"Schripsema","year":"2022","journal-title":"Talanta"},{"key":"10.1016\/j.jpba.2022.114773_bib9","doi-asserted-by":"crossref","first-page":"3107","DOI":"10.1007\/s00216-021-03249-z","article-title":"Tracing the origin of paracetamol tablets by near-infrared, mid-infrared, and nuclear magnetic resonance spectroscopy using principal component analysis and linear discriminant analysis","volume":"413","author":"Becht","year":"2021","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.jpba.2022.114773_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.talanta.2020.121504","article-title":"Novel approach of qNMR workflow by standardization using 2H integral: application to any intrinsic calibration standard","volume":"222","author":"Monakhova","year":"2021","journal-title":"Talanta"},{"key":"10.1016\/j.jpba.2022.114773_bib11","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1007\/s10822-010-9359-z","article-title":"Tautomerism in drug discovery","volume":"24","author":"Katritzky","year":"2010","journal-title":"J. Comput. Aided Mol. Des."},{"key":"10.1016\/j.jpba.2022.114773_bib12","doi-asserted-by":"crossref","DOI":"10.1039\/C6CC01032F","article-title":"Controlled production of the elusive metastable form II of acetaminophen (paracetamol): a fully scalable templating approach in a cooling environment","volume":"52","author":"Agnew","year":"2016","journal-title":"Chem. Commun."}],"container-title":["Journal of Pharmaceutical and Biomedical Analysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0731708522001947?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0731708522001947?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T09:24:16Z","timestamp":1760001856000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0731708522001947"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6]]},"references-count":12,"alternative-id":["S0731708522001947"],"URL":"https:\/\/doi.org\/10.1016\/j.jpba.2022.114773","relation":{},"ISSN":["0731-7085"],"issn-type":[{"value":"0731-7085","type":"print"}],"subject":[],"published":{"date-parts":[[2022,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Towards a holistic view of tablet quality, an extensive study on paracetamol tablets with nuclear magnetic resonance using similarity calculations, differential NMR and hierarchical cluster analysis","name":"articletitle","label":"Article Title"},{"value":"Journal of Pharmaceutical and Biomedical Analysis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpba.2022.114773","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"114773"}}