{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T02:42:08Z","timestamp":1790044928846,"version":"4.0.1"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmaceutical and Biomedical Analysis"],"published-print":{"date-parts":[[2022,9]]},"DOI":"10.1016\/j.jpba.2022.114858","type":"journal-article","created":{"date-parts":[[2022,6,2]],"date-time":"2022-06-02T12:20:20Z","timestamp":1654172420000},"page":"114858","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Biotransformation and pharmacokinetic studies of four alkaloids from Uncaria rhynchophylla in rat plasma by ultra-performance liquid chromatography with tandem mass spectrometry"],"prefix":"10.1016","volume":"218","author":[{"given":"Shuang","family":"Jiang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinrong","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhibin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunli","family":"Gan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiahui","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hesong","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fanshu","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengyang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunjuan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jpba.2022.114858_bib1","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.jep.2015.06.011","article-title":"Medicinal uses, phytochemistry and pharmacology of the genus Uncaria","volume":"173","author":"Zhang","year":"2015","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jpba.2022.114858_bib2","first-page":"268","article-title":"Pharmacopoeia of the People\u2019s Republic of China","volume":"2020","author":"China Pharmacopoeia Committee","year":"2020"},{"issue":"1","key":"10.1016\/j.jpba.2022.114858_bib3","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1177\/1469066717694044","article-title":"Chemical and biological comparison of different sections of Uncaria rhynchophylla (Gou-Teng), Eur","volume":"23","author":"Zhang","year":"2017","journal-title":"J. Mass. Spectrom. (Chichester)"},{"issue":"6","key":"10.1016\/j.jpba.2022.114858_bib4","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1016\/j.phymed.2014.01.011","article-title":"Uncaria rhynchophylla and rhynchophylline improved kainic acid-induced epileptic seizures via IL-1\u03b2 and brain-derived neurotrophic factor","volume":"21","author":"Ho","year":"2014","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jpba.2022.114858_bib5","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.jep.2018.03.015","article-title":"Ling-Yang-Gou-Teng-decoction prevents vascular dementia through inhibiting oxidative stress induced neurovascular coupling dysfunction","volume":"222","author":"Zhao","year":"2018","journal-title":"J. Ethnopharmacol."},{"issue":"7","key":"10.1016\/j.jpba.2022.114858_bib6","first-page":"495","article-title":"GTS40, an active fraction of Gou Teng-San (GTS), protects PC12 from H(2)O(2)-induced cell injury through antioxidative properties, Chin","volume":"15","author":"Chen","year":"2017","journal-title":"J. Nat. Med."},{"key":"10.1016\/j.jpba.2022.114858_bib7","doi-asserted-by":"crossref","first-page":"668","DOI":"10.3389\/fphar.2018.00668","article-title":"A Computational Systems Pharmacology Approach to Investigate Molecular Mechanisms of Herbal Formula Tian-Ma-Gou-Teng-Yin for Treatment of Alzheimer's Disease","volume":"9","author":"Wang","year":"2018","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jpba.2022.114858_bib8","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1186\/s12906-016-1030-3","article-title":"Ameliorative effects of Xue-Fu-Zhu-Yu decoction, Tian-Ma-Gou-Teng-Yin and Wen-Dan decoction on myocardial fibrosis in a hypertensive rat mode","volume":"16","author":"Zhang","year":"2016","journal-title":"Bmc. Complement. Altern. Med."},{"issue":"4","key":"10.1016\/j.jpba.2022.114858_bib9","doi-asserted-by":"crossref","first-page":"346","DOI":"10.2174\/1570161117666190704092841","article-title":"Uncaria rhynchophylla and its Major Constituents on Central Nervous System: A Review on Their Pharmacological Actions","volume":"18","author":"Yang","year":"2020","journal-title":"Curr. Vasc. Pharmacol."},{"issue":"1","key":"10.1016\/j.jpba.2022.114858_bib10","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.jep.2010.08.041","article-title":"Antihypertensive and neuroprotective activities of rhynchophylline: the role of rhynchophylline in neurotransmission and ion channel activity","volume":"132","author":"Zhou","year":"2010","journal-title":"J. Ethnopharmacol."},{"issue":"1","key":"10.1016\/j.jpba.2022.114858_bib11","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.jfda.2019.10.004","article-title":"In vitro and in vivo evaluation of the neuroprotective activity of Uncaria hirsuta Haviland","volume":"28","author":"Lin","year":"2020","journal-title":"J. Food Drug. Anal."},{"issue":"11","key":"10.1016\/j.jpba.2022.114858_bib12","doi-asserted-by":"crossref","first-page":"2365","DOI":"10.1007\/s11064-015-1730-y","article-title":"Rhynchophylline Protects Against the Amyloid \u03b2-Induced Increase of Spontaneous Discharges in the Hippocampal CA1 Region of Rats","volume":"40","author":"Shao","year":"2015","journal-title":"Neurochem. Res."},{"issue":"4","key":"10.1016\/j.jpba.2022.114858_bib13","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/j.fitote.2012.02.010","article-title":"Isorhynchophylline: A plant alkaloid with therapeutic potential for cardiovascular and central nervous system diseases","volume":"83","author":"Zhou","year":"2012","journal-title":"Fitoterapia"},{"key":"10.1016\/j.jpba.2022.114858_bib14","article-title":"Recent research progress of Uncaria spp. based on alkaloids: phytochemistry, pharmacology and structural chemistry, Eur","volume":"210","author":"Qin","year":"2021","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.jpba.2022.114858_bib15","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.fitote.2013.01.018","article-title":"A review on indole alkaloids isolated from Uncaria rhynchophylla and their pharmacological studies","volume":"86","author":"Ndagijimana","year":"2013","journal-title":"Fitoterapia"},{"issue":"7","key":"10.1016\/j.jpba.2022.114858_bib16","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1016\/j.fitote.2010.05.007","article-title":"Effect of rhynchophylline on central neurotransmitter levels in amphetamine-induced conditioned place preference rat brain","volume":"81","author":"Zhou","year":"2010","journal-title":"Fitoterapia"},{"issue":"1","key":"10.1016\/j.jpba.2022.114858_bib17","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1080\/14786419.2010.529811","article-title":"Geissoschizine methyl ether, a corynanthean-type indole alkaloid from Uncaria rhynchophylla as a potential acetylcholinesterase inhibitor","volume":"26","author":"Yang","year":"2012","journal-title":"Nat. Prod. Res."},{"issue":"1","key":"10.1016\/j.jpba.2022.114858_bib18","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1021\/np1004938","article-title":"Macrophyllionium and macrophyllines A and B, oxindole alkaloids from Uncaria macrophylla","volume":"74","author":"Wang","year":"2011","journal-title":"J. Nat. Prod."},{"issue":"2","key":"10.1016\/j.jpba.2022.114858_bib19","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1007\/s00210-003-0854-9","article-title":"In vitro vasodilator mechanisms of the indole alkaloids rhynchophylline and isorhynchophylline, isolated from the hook of Uncaria rhynchophylla (Miquel)","volume":"369","author":"Zhang","year":"2004","journal-title":"Naunyn. Schmiede Arch. Pharmacol."},{"issue":"11","key":"10.1016\/j.jpba.2022.114858_bib20","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1007\/s00210-018-1536-y","article-title":"Endothelium-independent vasodilator effect of isocorynoxeine in vitro isolated from the hook of Uncaria rhynchophylla (Miquel)","volume":"391","author":"Li","year":"2018","journal-title":"Naunyn. Schmiede Arch. Pharmacol."},{"issue":"3","key":"10.1016\/j.jpba.2022.114858_bib21","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.lfs.2004.08.012","article-title":"Protective effect of rhynchophylline and isorhynchophylline on in vitro ischemia-induced neuronal damage in the hippocampus: putative neurotransmitter receptors involved in their action","volume":"76","author":"Kang","year":"2004","journal-title":"Life Sci."},{"key":"10.1016\/j.jpba.2022.114858_bib22","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.phymed.2018.04.034","article-title":"Yokukansan contains compounds that antagonize the 5-HT(3) receptor","volume":"43","author":"Nakamura","year":"2018","journal-title":"Phytomedicine"},{"issue":"7","key":"10.1016\/j.jpba.2022.114858_bib23","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1021\/np8000305","article-title":"Alkaloids from the leaves of Uncaria rhynchophylla and their inhibitory activity on NO production in lipopolysaccharide-activated microglia","volume":"71","author":"Yuan","year":"2008","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.jpba.2022.114858_bib24","first-page":"449","article-title":"Characteristic Chromatogram: A Method of Discriminate and Quantitative Analysis for Quality Evaluation of Uncaria Stem with Hooks","author":"Hou","year":"2018","journal-title":"Planta Med. 84(6-07)"},{"key":"10.1016\/j.jpba.2022.114858_bib25","article-title":"Evidence on Integrating Pharmacokinetics to Find Truly Therapeutic Agent for Alzheimer\u2019s Disease: Comparative Pharmacokinetics and Disposition Kinetics Profiles of Stereoisomers Isorhynchophylline and Rhynchophylline in Rats","volume":"2019","author":"Zhang","year":"2019","journal-title":"Evid. Based Complement. Altern. Med."},{"key":"10.1016\/j.jpba.2022.114858_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2019.111896","article-title":"Ultrahigh-performance liquid chromatography with tandem mass spectrometry for the determination of 10 alkaloids in beagle plasma after the oral administration of the three Coptidis rhizoma extracts","volume":"239","author":"Ren","year":"2019","journal-title":"J. Ethnopharmacol."},{"issue":"10","key":"10.1016\/j.jpba.2022.114858_bib27","doi-asserted-by":"crossref","first-page":"2161","DOI":"10.1002\/jssc.201700981","article-title":"Simultaneous determination and pharmacokinetics study of four quinones in rat plasma by ultra high performance liquid chromatography with electrospray ionization tandem mass spectrometry after the oral administration of Qianzhi capsules","volume":"41","author":"Gao","year":"2018","journal-title":"J. Sep. Sci."},{"issue":"8","key":"10.1016\/j.jpba.2022.114858_bib28","doi-asserted-by":"crossref","first-page":"14849","DOI":"10.3390\/molecules200814849","article-title":"Structural Stabilities and Transformation Mechanism of Rhynchophylline and Isorhynchophylline by Ultra Performance Liquid Chromatography\/Time-of-Flight Mass Spectrometry (UPLC\/Q-TOF-MS)","volume":"20","author":"Wu","year":"2015","journal-title":"Molecules"},{"issue":"11","key":"10.1016\/j.jpba.2022.114858_bib29","doi-asserted-by":"crossref","DOI":"10.3390\/molecules23112980","article-title":"Simultaneous Determination and Pharmacokinetics Study of Six Triterpenes in Rat Plasma by UHPLC-MS\/MS after Oral Administration of Sanguisorba officinalis L. Extract","volume":"23","author":"Wu","year":"2018","journal-title":"Molecules"},{"issue":"8","key":"10.1016\/j.jpba.2022.114858_bib30","doi-asserted-by":"crossref","first-page":"3082","DOI":"10.1016\/j.xphs.2021.04.015","article-title":"Enantiomeric Separation of Dioxopromethazine and its Stereoselective Pharmacokinetics in Rats by HPLC-MS\/MS","volume":"110","author":"Lun","year":"2021","journal-title":"J. Pharm. Sci."},{"issue":"1","key":"10.1016\/j.jpba.2022.114858_bib31","doi-asserted-by":"crossref","first-page":"54","DOI":"10.2174\/1872312814666200521091236","article-title":"Pharmacokinetics of Darolutamide in Mouse - Assessment of the Disposition of the Diastereomers, Key Active Metabolite and Interconversion Phenomenon: Implications to Cancer Patients","volume":"14","author":"Saini","year":"2021","journal-title":"Drug Metab. Lett."},{"key":"10.1016\/j.jpba.2022.114858_bib32","doi-asserted-by":"crossref","DOI":"10.7717\/peerj.6665","article-title":"Pharmacokinetic comparison of quercetin, isoquercitrin, and quercetin-3-O-\u03b2-D-glucuronide in rats by HPLC-MS","volume":"7","author":"Yin","year":"2019","journal-title":"PeerJ"},{"issue":"3","key":"10.1016\/j.jpba.2022.114858_bib33","first-page":"220","article-title":"Transformation of trollioside and isoquercetin by human intestinal flora in vitro, Chin","volume":"14","author":"Yuan","year":"2016","journal-title":"J. Nat. Med."}],"container-title":["Journal of Pharmaceutical and Biomedical Analysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0731708522002795?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0731708522002795?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T09:22:23Z","timestamp":1760001743000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0731708522002795"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9]]},"references-count":33,"alternative-id":["S0731708522002795"],"URL":"https:\/\/doi.org\/10.1016\/j.jpba.2022.114858","relation":{},"ISSN":["0731-7085"],"issn-type":[{"value":"0731-7085","type":"print"}],"subject":[],"published":{"date-parts":[[2022,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Biotransformation and pharmacokinetic studies of four alkaloids from Uncaria rhynchophylla in rat plasma by ultra-performance liquid chromatography with tandem mass spectrometry","name":"articletitle","label":"Article Title"},{"value":"Journal of Pharmaceutical and Biomedical Analysis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpba.2022.114858","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"114858"}}