{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T23:11:26Z","timestamp":1772320286097,"version":"3.50.1"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100013290","name":"National Key Research and Development Program of China Stem Cell and Translational Research","doi-asserted-by":"publisher","award":["2017ZX09301005"],"award-info":[{"award-number":["2017ZX09301005"]}],"id":[{"id":"10.13039\/501100013290","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmaceutical and Biomedical Analysis"],"published-print":{"date-parts":[[2023,4]]},"DOI":"10.1016\/j.jpba.2023.115271","type":"journal-article","created":{"date-parts":[[2023,1,25]],"date-time":"2023-01-25T05:59:51Z","timestamp":1674626391000},"page":"115271","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Deciphering in vivo metabolic profile and pharmacological mechanisms of Jitongning Tablet for the treatment of Ankylosing spondylitis"],"prefix":"10.1016","volume":"227","author":[{"given":"Danmei","family":"Tian","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huadong","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Cao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sihao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wanqi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiyang","family":"Tang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Dai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wangyi","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lihua","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiefeng","family":"Tian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuanyuan","family":"Han","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinshan","family":"Tang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhaohui","family":"Song","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaohui","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinsheng","family":"Yao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jpba.2023.115271_bib1","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1016\/S0140-6736(07)60635-7","article-title":"Ankylosing spondylitis","volume":"369","author":"Braun","year":"2007","journal-title":"Lancet (Lond., Engl. )"},{"key":"10.1016\/j.jpba.2023.115271_bib2","first-page":"S65","article-title":"NSAIDs in ankylosing spondylitis","volume":"20","author":"Miceli-Richard","year":"2002","journal-title":"Clin. Exp. Rheumatol."},{"key":"10.1016\/j.jpba.2023.115271_bib3","first-page":"24","article-title":"Treatment of ankylosing spondylitis","volume":"78","author":"Clegg","year":"2006","journal-title":"J. Rheumatol."},{"key":"10.1016\/j.jpba.2023.115271_bib4","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1080\/1744666X.2019.1561281","article-title":"The advent of IL-17\u0391 blockade in ankylosing spondylitis: secukinumab, ixekizumab and beyond","volume":"15","author":"Dubash","year":"2019","journal-title":"Expert Rev. Clin. Immu"},{"key":"10.1016\/j.jpba.2023.115271_bib5","first-page":"668","article-title":"Screening of active components of Jitongning Tablet by liposome equilibrium dialysis and LC-MS analysis","volume":"48","author":"Gao","year":"2017","journal-title":"Chin. Tradit. Herb. Drugs"},{"key":"10.1016\/j.jpba.2023.115271_bib6","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1007\/s11655-012-1212-x","article-title":"The efficacy and safety of Jitongning Capsule in patients with ankylosing spondylitis","volume":"19","author":"Wang","year":"2013","journal-title":"Chin. J. Integr. Med."},{"key":"10.1016\/j.jpba.2023.115271_bib7","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.jpba.2017.03.033","article-title":"Analysis of chemical constituents in an herbal formula Jitong Ning Tablet","volume":"140","author":"Gao","year":"2017","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jpba.2023.115271_bib8","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.jpba.2019.04.001","article-title":"In vivo metabolic profiles of Bu-Zhong-Yi-Qi-Tang, a famous traditional chinese medicine prescription, in rats by ultra-high-performance liquid chromatography coupled with quadrupole time-of-flight tandem mass spectrometry","volume":"171","author":"Hu","year":"2019","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jpba.2023.115271_bib9","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/j.jep.2007.10.014","article-title":"Evaluation of the analgesic effect of alkaloid extract of Peganum harmala L.: possible mechanisms involved","volume":"115","author":"Farouk","year":"2008","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jpba.2023.115271_bib10","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/0304-3959(91)90207-E","article-title":"Differentiating analgesic and non-analgesic drug activities on rat hot plate: effect of behavioral endpoint","volume":"47","author":"Carter","year":"1991","journal-title":"Pain"},{"key":"10.1016\/j.jpba.2023.115271_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2019.152825","article-title":"Therapeutic effects of the total lignans from Vitex negundo seeds on collagen-induced arthritis in rats","volume":"58","author":"Jing","year":"2019","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jpba.2023.115271_bib12","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.intimp.2015.11.030","article-title":"MDM2 promotes rheumatoid arthritis via activation of MAPK and NF-\u03baB","volume":"30","author":"Zhang","year":"2016","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.jpba.2023.115271_bib13","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.jchromb.2015.07.044","article-title":"Characterization of chemical constituents and rats metabolites of an alkaloidal extract of Alstonia scholaris leaves by liquid chromatography coupled with mass spectrometry","volume":"1026","author":"Cao","year":"2016","journal-title":"J. Chromatogr. B"},{"key":"10.1016\/j.jpba.2023.115271_bib14","first-page":"109","article-title":"Recent advance of diterpene alkaloids in Aconitum plant","volume":"35","author":"Gao","year":"1999","journal-title":"J. Northwest Norm. Univ. (Nat. Sci. )"},{"key":"10.1016\/j.jpba.2023.115271_bib15","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0052352","article-title":"Neutral fragment filtering for rapid identification of new diester-diterpenoid alkaloids in roots of Aconitum carmichaeli by ultra-high-pressure liquid chromatography coupled with linear ion trap-orbitrap mass spectrometry","volume":"7","author":"Zhang","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.jpba.2023.115271_bib16","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.bse.2012.12.009","article-title":"Two new pyrazines from the parent roots of Aconitum carmichaelii","volume":"48","author":"Guo","year":"2013","journal-title":"Biochem. Syst. Ecol."},{"key":"10.1016\/j.jpba.2023.115271_bib17","doi-asserted-by":"crossref","first-page":"9939","DOI":"10.3390\/molecules17089939","article-title":"Alkaloids isolated from the lateral root of Aconitum carmichaelii","volume":"17","author":"Xiong","year":"2012","journal-title":"Molecules"},{"key":"10.1016\/j.jpba.2023.115271_bib18","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1016\/j.cclet.2016.05.013","article-title":"Napelline-type C20-diterpenoid alkaloid iminiums from an aqueous extract of \u201cfu zi\u201d: solvent-\/base-\/acid-dependent transformation and equilibration between alcohol iminium and aza acetal forms","volume":"27","author":"Meng","year":"2016","journal-title":"Chin. Chem. Lett."},{"key":"10.1016\/j.jpba.2023.115271_bib19","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1002\/jcph.789","article-title":"Pharmacokinetics and safety assessment of L-tetrahydropalmatine in cocaine users: a randomized, double-blind, placebo-controlled study","volume":"57","author":"Hassan","year":"2017","journal-title":"J. Clin. Pharm."},{"key":"10.1016\/j.jpba.2023.115271_bib20","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.jpba.2017.04.012","article-title":"Systematically characterize the absorbed effective substances of Wutou Decoction and their metabolic pathways in rat plasma using UHPLC-Q-TOF-MS combined with a target network pharmacological analysis","volume":"141","author":"Xu","year":"2017","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jpba.2023.115271_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpba.2020.113226","article-title":"Pharmacokinetics and tissue distribution of eighteen major alkaloids of Aconitum carmichaelii in rats by UHPLC-QQQ-MS","volume":"185","author":"Zhang","year":"2020","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jpba.2023.115271_bib22","doi-asserted-by":"crossref","first-page":"27129","DOI":"10.1038\/srep27129","article-title":"Antinociceptive effects of dehydrocorydaline in mouse models of inflammatory pain involve the opioid receptor and inflammatory cytokines","volume":"6","author":"Yin","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jpba.2023.115271_bib23","first-page":"225\/1","article-title":"Distribution assessments of coumarins from Angelicae pubescentis radix in rat cerebrospinal fluid and brain by liquid chromatography tandem mass spectrometry analysis","volume":"23","author":"Yang","year":"2018","journal-title":"Molecules"},{"key":"10.1016\/j.jpba.2023.115271_bib24","first-page":"822","article-title":"Systematic analysis of the metabolites of Angelol B by UPLC-Q-TOF-MS after oral administration to rats","volume":"17","author":"Wan","year":"2019","journal-title":"Chi. J. Nat. Med."},{"key":"10.1016\/j.jpba.2023.115271_bib25","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1002\/art.40468","article-title":"Inflammation intensity-\u00a0dependent expression of osteoinductive wnt proteins is critical for ectopic new bone formation in Ankylosing Spondylitis","volume":"70","author":"Li","year":"2018","journal-title":"Arthritis Rheuma"},{"key":"10.1016\/j.jpba.2023.115271_bib26","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.637829","article-title":"Role of the IL-\u00a023\u00a0\/IL-\u00a017 pathway in rheumatic diseases: an overview","volume":"12","author":"Schinocca","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jpba.2023.115271_bib27","doi-asserted-by":"crossref","first-page":"781","DOI":"10.17219\/acem\/146830","article-title":"Knockdown of circular RNA hsa_circ_0003307 inhibits synovial inflammation in ankylosing spondylitis by regulating the PI3K\/AKT pathway","volume":"31","author":"Fang","year":"2022","journal-title":"Adv. Clin. Exp. Med."},{"key":"10.1016\/j.jpba.2023.115271_bib28","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1038\/s41419-019-1904-7","article-title":"Extracellular IL-37 promotes osteogenic differentiation of human bone marrow mesenchymal stem cells via activation of the PI3K\/AKT signaling pathway","volume":"10","author":"Ye","year":"2019","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.jpba.2023.115271_bib29","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0042714","article-title":"Relaxin signals through a RXFP1-pERK-nNOS-NO-cGMP-dependent pathway to up-regulate matrix metalloproteinases: the additional involvement of Inos","volume":"7","author":"Chow","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.jpba.2023.115271_bib30","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1097\/MD.0b013e3181c10773","article-title":"The high prevalence of subclinical atherosclerosis in patients with ankylosing spondylitis without clinically evident cardiovascular disease","volume":"88","author":"Gonzalez-Juanatey","year":"2009","journal-title":"Medicine"},{"key":"10.1016\/j.jpba.2023.115271_bib31","first-page":"154","article-title":"Rapid analysis and identification of absorbed components and their metabolites of Yuanhu Zhitong Dropping Pill in rat plasma and brain tissue using UPLC-Q-TOF\/MS with multivariate statistical analysis","volume":"8","author":"Zhang","year":"2016","journal-title":"Chin. Herb. Med."},{"key":"10.1016\/j.jpba.2023.115271_bib32","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1080\/07853890.2021.1918345","article-title":"Multi-\u00a0target mechanism of Tripteryguim wilfordii Hook for treatment of ankylosing spondylitis based on network pharmacology and molecular docking","volume":"53","author":"Zhang","year":"2021","journal-title":"Ann. Med."},{"key":"10.1016\/j.jpba.2023.115271_bib33","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.gene.2017.09.049","article-title":"Construction and analysis of protein-\u00a0protein interaction network correlated with ankylosing spondylitis","volume":"638","author":"Kanwal","year":"2018","journal-title":"Gene"},{"key":"10.1016\/j.jpba.2023.115271_bib34","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1136\/annrheumdis-2016-209449","article-title":"A family-\u00a0based genome-\u00a0wide association study reveals an association of spondyloarthritis with MAPK14","volume":"76","author":"Costantino","year":"2017","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.jpba.2023.115271_bib35","doi-asserted-by":"crossref","first-page":"305","DOI":"10.6061\/clinics\/2013(03)OA04","article-title":"Is there a relationship between endothelial nitric oxide synthase gene polymorphisms and ankylosing spondylitis?","volume":"68","author":"Sari","year":"2013","journal-title":"Clinics"}],"container-title":["Journal of Pharmaceutical and Biomedical Analysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0731708523000407?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0731708523000407?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T09:25:34Z","timestamp":1760001934000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0731708523000407"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4]]},"references-count":35,"alternative-id":["S0731708523000407"],"URL":"https:\/\/doi.org\/10.1016\/j.jpba.2023.115271","relation":{},"ISSN":["0731-7085"],"issn-type":[{"value":"0731-7085","type":"print"}],"subject":[],"published":{"date-parts":[[2023,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Deciphering in vivo metabolic profile and pharmacological mechanisms of Jitongning Tablet for the treatment of Ankylosing spondylitis","name":"articletitle","label":"Article Title"},{"value":"Journal of Pharmaceutical and Biomedical Analysis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpba.2023.115271","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"115271"}}