{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T18:04:35Z","timestamp":1789841075387,"version":"4.0.1"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmaceutical and Biomedical Analysis"],"published-print":{"date-parts":[[2023,10]]},"DOI":"10.1016\/j.jpba.2023.115610","type":"journal-article","created":{"date-parts":[[2023,7,29]],"date-time":"2023-07-29T19:32:43Z","timestamp":1690659163000},"page":"115610","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Efficacy evaluation and metabolomics analysis of Huanglian Jiedu decoction in combination with donepezil for Alzheimer's disease treatment"],"prefix":"10.1016","volume":"235","author":[{"given":"Manfei","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuebing","family":"Yue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.jpba.2023.115610_bib1","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1111\/ene.13439","article-title":"Alzheimer's disease","volume":"25","author":"Lane","year":"2018","journal-title":"Eur. J. Neurol."},{"key":"10.1016\/j.jpba.2023.115610_bib2","doi-asserted-by":"crossref","unstructured":"2021 Alzheimer's disease facts and figures, Alzheimers Dement 17(3) (2021) 327\u2013406.","DOI":"10.1002\/alz.12328"},{"key":"10.1016\/j.jpba.2023.115610_bib3","doi-asserted-by":"crossref","unstructured":"2022 Alzheimer's disease facts and figures, Alzheimers Dement 18(4) (2022) 700\u2013789.","DOI":"10.1002\/alz.12638"},{"issue":"6","key":"10.1016\/j.jpba.2023.115610_bib4","doi-asserted-by":"crossref","first-page":"1989","DOI":"10.3390\/ijms21061989","article-title":"Biochemical markers in Alzheimer's disease","volume":"21","author":"Rabbito","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"6","key":"10.1016\/j.jpba.2023.115610_bib5","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/j.jalz.2016.02.010","article-title":"Neuroinflammation in Alzheimer's disease: current evidence and future directions","volume":"12","author":"Calsolaro","year":"2016","journal-title":"Alzheimers Dement."},{"issue":"3","key":"10.1016\/j.jpba.2023.115610_bib6","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.3233\/JAD-170819","article-title":"Alzheimer's disease, oligomers, and inflammation","volume":"62","author":"Forloni","year":"2018","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.jpba.2023.115610_bib7","article-title":"The impact of systemic inflammation on Alzheimer's disease pathology","volume":"12","author":"Xie","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jpba.2023.115610_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.113208","article-title":"Signal pathways in the treatment of Alzheimer's disease with traditional Chinese medicine","volume":"152","author":"Ding","year":"2022","journal-title":"Biomed. Pharm."},{"key":"10.1016\/j.jpba.2023.115610_bib9","doi-asserted-by":"crossref","first-page":"931","DOI":"10.2147\/DDDT.S357061","article-title":"Involvement of Huanglian Jiedu decoction on microglia with abnormal sphingolipid metabolism in Alzheimer's disease","volume":"16","author":"Qi","year":"2022","journal-title":"Drug Des. Dev. Ther."},{"key":"10.1016\/j.jpba.2023.115610_bib10","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/2209574","article-title":"Huanglian Jiedu decoction exerts antipyretic effect by inhibiting MAPK signaling pathway","volume":"2021","author":"Li","year":"2021","journal-title":"Evid. Based Complement Altern. Med."},{"key":"10.1016\/j.jpba.2023.115610_bib11","unstructured":"Y. Gao, [The clinical observation and experimental study of Huanglian Jiedu Decoction in the treatment of Alzheimer's disease], Hubei University of Chinese Medicine, 2021."},{"issue":"07","key":"10.1016\/j.jpba.2023.115610_bib12","first-page":"47","article-title":"Effect of Huanglian Jiedu decoction in combination with butylphthalide and donepezil on Alzheimer's disease","volume":"42","author":"Ren","year":"2021","journal-title":"J. Yunnan Tradit. Chin. Med."},{"key":"10.1016\/j.jpba.2023.115610_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2019.112371","article-title":"Integrated network pharmacology analysis and serum metabolomics to reveal the cognitive improvement effect of Bushen Tiansui formula on Alzheimer's disease","volume":"249","author":"Zhang","year":"2020","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jpba.2023.115610_bib14","doi-asserted-by":"crossref","first-page":"44368","DOI":"10.1038\/srep44368","article-title":"A 'Disease Severity Index' to identify individuals with subjective memory decline who will progress to mild cognitive impairment or dementia","volume":"7","author":"Ferreira","year":"2017","journal-title":"Sci. Rep."},{"issue":"14","key":"10.1016\/j.jpba.2023.115610_bib15","first-page":"116","article-title":"Effect of Huanglian Jiedu decoction on the effect of pitavastatin treatment in Alzheimer's disease","volume":"31","author":"Zhao","year":"2018","journal-title":"Med. Equip."},{"key":"10.1016\/j.jpba.2023.115610_bib16","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/460562","article-title":"The pattern element scale: a brief tool of traditional medical subtyping for dementia","volume":"2013","author":"Shi","year":"2013","journal-title":"Evid. Based Complement Altern. Med."},{"issue":"02","key":"10.1016\/j.jpba.2023.115610_bib17","first-page":"452","article-title":"Criteria of syndrome differentiation and staging of dementia in clinical trials of Chinese medicinal products for dementia","volume":"32","author":"Ni","year":"2017","journal-title":"China J. Tradit. Chin. Med. Pharm."},{"issue":"14","key":"10.1016\/j.jpba.2023.115610_bib18","first-page":"3006","article-title":"Pharmacodynamics of Huanglian Jiedu decoction in Alzheimer's disease (AD) model rats and effect on improvement of inflammation microenvironment in brain","volume":"43","author":"Gu","year":"2018","journal-title":"Zhongguo Zhong Yao Za Zhi"},{"issue":"1","key":"10.1016\/j.jpba.2023.115610_bib19","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1186\/s13195-021-00779-7","article-title":"Huanglian Jiedu decoction remodels the periphery microenvironment to inhibit Alzheimer's disease progression based on the \"brain-gut\" axis through multiple integrated omics","volume":"13","author":"Gu","year":"2021","journal-title":"Alzheimers Res. Ther."},{"issue":"7","key":"10.1016\/j.jpba.2023.115610_bib20","doi-asserted-by":"crossref","first-page":"908","DOI":"10.2174\/1570159X18666201111104509","article-title":"Glia-driven neuroinflammation and systemic inflammation in Alzheimer's disease","volume":"19","author":"Hashioka","year":"2021","journal-title":"Curr. Neuropharmacol."},{"key":"10.1016\/j.jpba.2023.115610_bib21","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.neurobiolaging.2016.08.019","article-title":"Association of brain amyloidosis with pro-inflammatory gut bacterial taxa and peripheral inflammation markers in cognitively impaired elderly","volume":"49","author":"Cattaneo","year":"2017","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.jpba.2023.115610_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.154469","article-title":"Inhibition of inflammasome activation via sphingolipid pathway in acute lung injury by Huanglian Jiedu decoction: an integrative pharmacology approach","volume":"107","author":"Chen","year":"2022","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jpba.2023.115610_bib23","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1186\/s13020-020-00327-9","article-title":"Huanglian Jiedu decoction ameliorates DSS-induced colitis in mice via the JAK2\/STAT3 signalling pathway","volume":"15","author":"Lu","year":"2020","journal-title":"Chin. Med."},{"key":"10.1016\/j.jpba.2023.115610_bib24","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.neurobiolaging.2021.07.014","article-title":"Emerging roles of oxidative stress in brain aging and Alzheimer's disease","volume":"107","author":"Ionescu-Tucker","year":"2021","journal-title":"Neurobiol. Aging"},{"issue":"3","key":"10.1016\/j.jpba.2023.115610_bib25","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1291\/hypres.30.249","article-title":"1-Aminocyclopropanecarboxylic acid, an antagonist of N-methyl-D-aspartate receptors, causes hypotensive and antioxidant effects with upregulation of heme oxygenase-1 in stroke-prone spontaneously hypertensive rats","volume":"30","author":"Gao","year":"2007","journal-title":"Hypertens. Res."},{"issue":"2","key":"10.1016\/j.jpba.2023.115610_bib26","doi-asserted-by":"crossref","first-page":"185","DOI":"10.2174\/1567205013666151218132725","article-title":"Glutamate and mitochondria: two prominent players in the oxidative stress-induced neurodegeneration","volume":"13","author":"Cassano","year":"2016","journal-title":"Curr. Alzheimer Res."},{"issue":"3","key":"10.1016\/j.jpba.2023.115610_bib27","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1093\/jn\/134.3.489","article-title":"Glutathione metabolism and its implications for health","volume":"134","author":"Wu","year":"2004","journal-title":"J. Nutr."},{"key":"10.1016\/j.jpba.2023.115610_bib28","doi-asserted-by":"crossref","DOI":"10.1155\/2017\/6297080","article-title":"Comparison of the neuroprotective and anti-inflammatory effects of the anthocyanin metabolites, protocatechuic acid and 4-hydroxybenzoic acid","volume":"2017","author":"Winter","year":"2017","journal-title":"Oxid. Med. Cell Longev."},{"key":"10.1016\/j.jpba.2023.115610_bib29","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.trsl.2018.07.002","article-title":"Serum noncholesterol sterols in Alzheimer's disease: the Helsinki Businessmen Study","volume":"202","author":"Sittiwet","year":"2018","journal-title":"Transl. Res."},{"issue":"573","key":"10.1016\/j.jpba.2023.115610_bib30","doi-asserted-by":"crossref","first-page":"eabb1206","DOI":"10.1126\/scitranslmed.abb1206","article-title":"An epoxide hydrolase inhibitor reduces neuroinflammation in a mouse model of Alzheimer's disease","volume":"12","author":"Ghosh","year":"2020","journal-title":"Sci. Transl. Med."},{"issue":"34","key":"10.1016\/j.jpba.2023.115610_bib31","doi-asserted-by":"crossref","first-page":"34046","DOI":"10.1007\/s11356-018-3354-7","article-title":"Association of benzene exposure with insulin resistance, SOD, and MDA as markers of oxidative stress in children and adolescents","volume":"25","author":"Amin","year":"2018","journal-title":"Environ. Sci. Pollut. Res. Int."},{"issue":"8","key":"10.1016\/j.jpba.2023.115610_bib32","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.3390\/antiox10081315","article-title":"Mechanistic basis and clinical evidence for the applications of nicotinamide (Niacinamide) to control skin aging and pigmentation","volume":"10","author":"Boo","year":"2021","journal-title":"Antioxid. (Basel)"},{"issue":"2","key":"10.1016\/j.jpba.2023.115610_bib33","doi-asserted-by":"crossref","first-page":"2123","DOI":"10.3168\/jds.2020-18402","article-title":"Glutamine pretreatment protects bovine mammary epithelial cells from inflammation and oxidative stress induced by \u03b3-d-glutamyl-meso-diaminopimelic acid (iE-DAP)","volume":"104","author":"Cheng","year":"2021","journal-title":"J. Dairy Sci."},{"issue":"2","key":"10.1016\/j.jpba.2023.115610_bib34","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1111\/j.1471-4159.2012.07783.x","article-title":"Abcg2 deficiency augments oxidative stress and cognitive deficits in Tg-SwDI transgenic mice","volume":"122","author":"Zeng","year":"2012","journal-title":"J. Neurochem."}],"container-title":["Journal of Pharmaceutical and Biomedical Analysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0731708523003795?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0731708523003795?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T09:30:14Z","timestamp":1760002214000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0731708523003795"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10]]},"references-count":34,"alternative-id":["S0731708523003795"],"URL":"https:\/\/doi.org\/10.1016\/j.jpba.2023.115610","relation":{},"ISSN":["0731-7085"],"issn-type":[{"value":"0731-7085","type":"print"}],"subject":[],"published":{"date-parts":[[2023,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Efficacy evaluation and metabolomics analysis of Huanglian Jiedu decoction in combination with donepezil for Alzheimer's disease treatment","name":"articletitle","label":"Article Title"},{"value":"Journal of Pharmaceutical and Biomedical Analysis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpba.2023.115610","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"115610"}}