{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T18:02:45Z","timestamp":1789495365775,"version":"build-2803163510"},"reference-count":18,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmaceutical and Biomedical Analysis"],"published-print":{"date-parts":[[2023,10]]},"DOI":"10.1016\/j.jpba.2023.115672","type":"journal-article","created":{"date-parts":[[2023,8,19]],"date-time":"2023-08-19T03:47:16Z","timestamp":1692416836000},"page":"115672","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Further advances in identification of pentosan polysulfate monosaccharide composition by NMR"],"prefix":"10.1016","volume":"235","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1925-0029","authenticated-orcid":false,"given":"Giorgio","family":"Eisele","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Alekseeva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabrina","family":"Bertini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0576-3846","authenticated-orcid":false,"given":"Cristina","family":"Gardini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davide","family":"Paganini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth Carolina Montatixe","family":"Fonseca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Guerrini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annamaria","family":"Naggi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jpba.2023.115672_bib1","doi-asserted-by":"crossref","first-page":"821","DOI":"10.2165\/00003495-200666060-00006","article-title":"Pentosan polysulfate","volume":"66","author":"Anderson","year":"2006","journal-title":"Drugs"},{"key":"10.1016\/j.jpba.2023.115672_bib2","first-page":"186","article-title":"Experimental and clinical pharmacology of pentosan polysulfate","volume":"17","author":"Maffrand","year":"1991","journal-title":"Semin. Thromb. Haemost."},{"key":"10.1016\/j.jpba.2023.115672_bib3","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1146\/annurev-arplant-042809-112315","article-title":"Hemicelluloses","volume":"61","author":"Scheller","year":"2010","journal-title":"Annu. Rev. Plant Biol."},{"key":"10.1016\/j.jpba.2023.115672_bib4","doi-asserted-by":"crossref","first-page":"22420","DOI":"10.1074\/jbc.M010779200","article-title":"Pentosan polysulfate as an inhibitor of extracellular HIV-1 tat*","volume":"276","author":"Rusnati","year":"2001","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.jpba.2023.115672_bib5","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0054459","article-title":"Pentosan polysulfate: a novel therapy for the mucopolysaccharidoses","volume":"8","author":"Schuchman","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.jpba.2023.115672_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2020.113867","article-title":"Pentosan polysulfate to control hepcidin expression in vitro and in vivo","volume":"175","author":"Asperti","year":"2020","journal-title":"Biochem. Pharm."},{"issue":"6","key":"10.1016\/j.jpba.2023.115672_bib7","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1055\/a-1815-2142","article-title":"Pentosan polysulfate\u2013a \"better heparin\" as potential medication for the treatment of SARS-CoV-2 infections?","volume":"122","author":"Bendas","year":"2022","journal-title":"Thromb. Haemost."},{"key":"10.1016\/j.jpba.2023.115672_bib8","first-page":"984","article-title":"Pentosan polysulfate inhibits attachment and infection by SARS-CoV-2 in vitro: insights into structural requirements for binding","volume":"122","author":"Bertini","year":"2021","journal-title":"Thromb. Haemost."},{"issue":"2","key":"10.1016\/j.jpba.2023.115672_bib9","doi-asserted-by":"crossref","first-page":"258","DOI":"10.3390\/ph15020258","article-title":"Potential anti-SARS-CoV-2 activity of pentosan polysulfate and mucopolysaccharide polysulfate","volume":"15","author":"Zhang","year":"2022","journal-title":"Pharmaceuticals"},{"key":"10.1016\/j.jpba.2023.115672_bib10","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1030879","article-title":"Anti-inflammatory actions of pentosan polysulfate sodium in a mouse model of influenza virus A\/PR8\/34-induced pulmonary inflammation","author":"Krishnan","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jpba.2023.115672_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2020.115913","article-title":"In-depth structural characterization of pentosan polysulfate sodium complex drug using orthogonal analytical tools","volume":"234","author":"Alekseeva","year":"2020","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.jpba.2023.115672_bib12","unstructured":"L. De Ferra, A. Naggi, M. Zenoni, B. Pinto, Method for the qualification of preparations of pentosan polysulfate, raw materials and production processes thereof, Patent WO 2014114723 A1."},{"key":"10.1016\/j.jpba.2023.115672_bib13","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1038\/nbt.2528","article-title":"Scientific considerations in the review and approval of generic enoxaparin in the United States","volume":"31","author":"Lee","year":"2013","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.jpba.2023.115672_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpba.2022.114589","article-title":"2D NMR peak profiling to compare chemical differences between batches of pentosan polysulfate sodium","volume":"211","author":"Chen","year":"2022","journal-title":"J. Pharmaceut. Biomed. Anal."},{"issue":"1","key":"10.1016\/j.jpba.2023.115672_bib15","doi-asserted-by":"crossref","DOI":"10.1002\/macp.201900327","article-title":"Determination of the binding situation of pyridine in xylan sulfates by means of detailed NMR studies","volume":"221","author":"Gabriel","year":"2020","journal-title":"Macromol. Chem. Phys."},{"issue":"16","key":"10.1016\/j.jpba.2023.115672_bib16","doi-asserted-by":"crossref","first-page":"4781","DOI":"10.1039\/C9AN01006H","article-title":"Bottom-up and top-down profiling of pentosan polysulfate","volume":"144","author":"Lin","year":"2019","journal-title":"Analyst"},{"issue":"38","key":"10.1016\/j.jpba.2023.115672_bib17","doi-asserted-by":"crossref","first-page":"9830","DOI":"10.1002\/chem.202100527","article-title":"A rapid and mild sulfation strategy reveals conformational preferences in therapeutically relevant sulfated xylooligosaccharides","volume":"27","author":"Vo","year":"2021","journal-title":"Chem. Eur. J."},{"key":"10.1016\/j.jpba.2023.115672_bib18","article-title":"NMR in the characterization of complex mixture drugs","volume":"32","author":"Guerrini","year":"2019"}],"container-title":["Journal of Pharmaceutical and Biomedical Analysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0731708523004417?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0731708523004417?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T09:33:39Z","timestamp":1760002419000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0731708523004417"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10]]},"references-count":18,"alternative-id":["S0731708523004417"],"URL":"https:\/\/doi.org\/10.1016\/j.jpba.2023.115672","relation":{},"ISSN":["0731-7085"],"issn-type":[{"value":"0731-7085","type":"print"}],"subject":[],"published":{"date-parts":[[2023,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Further advances in identification of pentosan polysulfate monosaccharide composition by NMR","name":"articletitle","label":"Article Title"},{"value":"Journal of Pharmaceutical and Biomedical Analysis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpba.2023.115672","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"115672"}}