{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T23:30:04Z","timestamp":1780615804092,"version":"3.54.1"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmaceutical and Biomedical Analysis"],"published-print":{"date-parts":[[2024,2]]},"DOI":"10.1016\/j.jpba.2023.115830","type":"journal-article","created":{"date-parts":[[2023,10,30]],"date-time":"2023-10-30T14:10:00Z","timestamp":1698675000000},"page":"115830","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Exploring the pharmacological mechanisms of Biyan Qingdu Granula in the treatment after nasopharyngeal carcinoma radiotherapy based on UPLC\/Q-TOF MS, network pharmacology and molecular docking"],"prefix":"10.1016","volume":"239","author":[{"given":"Bojiao","family":"Yi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-1308-6308","authenticated-orcid":false,"given":"Fengyi","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keyi","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuyuan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-8160-5096","authenticated-orcid":false,"given":"Peng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8312-0678","authenticated-orcid":false,"given":"Min","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jpba.2023.115830_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.cplett.2020.138068","article-title":"Identification of potential inhibitors of SARS-CoV-2 papain-like protease from tropane alkaloids from Schizanthus porrigens: a molecular docking study","volume":"761","author":"Alfaro","year":"2020","journal-title":"Chem. Phys. Lett."},{"key":"10.1016\/j.jpba.2023.115830_bib2","unstructured":"Caixia F., Zhixi C., Shiping F., Shuzhen L., Jinkun Z., Xinhua L.: Bi-Yan-Qing Granula influence nasopharyngeal carcinoma cell line CNE-2 on cell cycle distribution and cell apoptosis. Chinese Journal of Otorhinolaryngology in Integrative Medicine 2016."},{"key":"10.1016\/j.jpba.2023.115830_bib3","unstructured":"Cai-Xia F., Zhi-Xi C., Shi-Ping F., Shu-Zhen L., Xiang-Guo Z., Jin-Kun Z., Xin-Hua L.: Radiosensitization of Bi-Yan-Qing Granules on human nasopharyngeal planted tumor and its mechanism. Drug Evaluation Research 2017."},{"issue":"3","key":"10.1016\/j.jpba.2023.115830_bib4","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1002\/j.1532-2149.2013.00378.x","article-title":"Evidence of mechanism of action of anti-inflammatory\/antinociceptive activities of acacetin","volume":"18","author":"Carballo-Villalobos","year":"2014","journal-title":"Eur. J. Pain."},{"issue":"7","key":"10.1016\/j.jpba.2023.115830_bib5","first-page":"1","article-title":"The Breakthrough Point and Advantages of Chinese Medicine Treating Nasopharyngeal Cancer","volume":"4","author":"Chen","year":"2013","journal-title":"Chin. Manip. Rehabil. Med."},{"issue":"1","key":"10.1016\/j.jpba.2023.115830_bib6","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-019-46715-6","article-title":"Insights about multi-targeting and synergistic neuromodulators in Ayurvedic herbs against epilepsy: integrated computational studies on drug-target and protein-protein interaction networks","volume":"9","author":"Choudhary","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jpba.2023.115830_bib7","unstructured":"Commission C.P.: The Pharmacopoeia of the People\u2019s Republic of China. BeiJing: China Medical Science Press; 2020."},{"key":"10.1016\/j.jpba.2023.115830_bib8","doi-asserted-by":"crossref","DOI":"10.1007\/s00432-023-05290-0","article-title":"Using network pharmacological analysis and molecular docking to investigate the mechanism of action of quercetin's suppression of oral cancer","author":"Dong","year":"2023","journal-title":"J. Cancer Res Clin. Oncol."},{"key":"10.1016\/j.jpba.2023.115830_bib9","unstructured":"Han H., Shen X.L., Cui Y., Xu H.Q., Su X.M.: Inhibitory effect of Biyan Qingdu Keli on nasopharyngeal carcinoma cells in vivo. 2009."},{"issue":"6","key":"10.1016\/j.jpba.2023.115830_bib10","doi-asserted-by":"crossref","first-page":"966","DOI":"10.7150\/jca.80456","article-title":"Advances in the mechanism of luteolin against hepatocellular carcinoma based on bioinformatics and network pharmacology","volume":"14","author":"Han","year":"2023","journal-title":"J. Cancer"},{"key":"10.1016\/j.jpba.2023.115830_bib11","article-title":"Integrated network pharmacology and experimental verification to explore the molecular mechanism of hedysarum multijugum maxim-curcumae rhizoma herb pair for treating non-small cell lung cancer","volume":"12","author":"Hu","year":"2022","journal-title":"Front Oncol."},{"issue":"7","key":"10.1016\/j.jpba.2023.115830_bib12","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1055\/s-0035-1549963","article-title":"Radiotherapy-induced hypopituitarism in nasopharyngeal carcinoma: the tip of an iceberg","volume":"123","author":"Ipekci","year":"2015","journal-title":"Exp. Clin. Endocrinol. Diabetes"},{"issue":"1","key":"10.1016\/j.jpba.2023.115830_bib13","first-page":"89","article-title":"Research on the effect of biyan qingdu granula drug-containing serum on inhibition of nasopharyngeal carcinoma cells growth in vitro","volume":"36","author":"Kang","year":"2013","journal-title":"Zhong Yao Cai"},{"key":"10.1016\/j.jpba.2023.115830_bib14","unstructured":"Lei-Lei G., Hai-Yu X.U., Lan W., Xiao-Jie Y., Wei W., Li L.I., Mo-Qi F., Ri-Xin L., Hong-Jun Y.: Vasoactivity evaluation of Yindan Xinnaotong Capsule based on everted gut sacs coupled with isolated vascular. China Journal of Traditional Chinese Medicine and Pharmacy 2018."},{"key":"10.1016\/j.jpba.2023.115830_bib15","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.jff.2017.10.047","article-title":"Antioxidant and anti-inflammatory activities of quercetin and its derivatives","volume":"40","author":"Lesjak","year":"2017","journal-title":"J. Funct. Foods"},{"key":"10.1016\/j.jpba.2023.115830_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2019.110758","article-title":"Discovery of Keap1-Nrf2 small-molecule inhibitors from phytochemicals based on molecular docking","volume":"133","author":"Li","year":"2019","journal-title":"Food Chem. Toxicol."},{"issue":"3","key":"10.1016\/j.jpba.2023.115830_bib17","doi-asserted-by":"crossref","DOI":"10.1093\/bib\/bbaa079","article-title":"Therapeutic targets and signaling mechanisms of vitamin C activity against sepsis: a bioinformatics study","volume":"22","author":"Li","year":"2021","journal-title":"Brief. Bioinform"},{"key":"10.1016\/j.jpba.2023.115830_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2021.118644","article-title":"Application of molecular docking in elaborating molecular mechanisms and interactions of supramolecular cyclodextrin","volume":"276","author":"Li","year":"2022","journal-title":"Carbohydr. Polym."},{"issue":"11","key":"10.1016\/j.jpba.2023.115830_bib19","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1007\/s12033-021-00357-0","article-title":"Cell proliferation and apoptosis-related genes affect the development of human nasopharyngeal carcinoma through PI3K\/AKT signaling pathway","volume":"63","author":"Li","year":"2021","journal-title":"Mol. Biotechnol."},{"key":"10.1016\/j.jpba.2023.115830_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.112823","article-title":"Protective effect of total Saponins from American ginseng against cigarette smoke-induced COPD in mice based on integrated metabolomics and network pharmacology","volume":"149","author":"Lin","year":"2022","journal-title":"Biomed. Pharm."},{"issue":"2","key":"10.1016\/j.jpba.2023.115830_bib21","doi-asserted-by":"crossref","first-page":"426","DOI":"10.4103\/jcrt.JCRT_750_18","article-title":"Prognostic value of the Epstein-Barr virus and tumor suppressor gene p53 gene in nasopharyngeal squamous cell carcinoma","volume":"15","author":"Liu","year":"2019","journal-title":"J. Cancer Res Ther."},{"key":"10.1016\/j.jpba.2023.115830_bib22","first-page":"416","article-title":"Src as the link between inflammation and cancer","volume":"4","author":"Liu","year":"2013","journal-title":"Front Physiol."},{"issue":"1","key":"10.1016\/j.jpba.2023.115830_bib23","doi-asserted-by":"crossref","first-page":"81","DOI":"10.7150\/ijms.48552","article-title":"Oridonin inhibits epithelial-mesenchymal transition of human nasopharyngeal carcinoma cells by negatively regulating AKT\/STAT3 signaling pathway","volume":"18","author":"Liu","year":"2021","journal-title":"Int J. Med Sci."},{"key":"10.1016\/j.jpba.2023.115830_bib24","series-title":"Traditional Chinese Medicine Treatment of Nasopharyngeal Carcinoma","author":"Mei","year":"2010"},{"issue":"3","key":"10.1016\/j.jpba.2023.115830_bib25","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23031108","article-title":"Functional Roles of JNK and p38 MAPK Signaling in Nasopharyngeal Carcinoma","volume":"23","author":"Pua","year":"2022","journal-title":"Int J. Mol. Sci."},{"key":"10.1016\/j.jpba.2023.115830_bib26","doi-asserted-by":"crossref","DOI":"10.1186\/1758-2946-6-13","article-title":"TCMSP: a database of systems pharmacology for drug discovery from herbal medicines","volume":"6","author":"Ru","year":"2014","journal-title":"J. Chemin.-."},{"key":"10.1016\/j.jpba.2023.115830_bib27","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2022.1021179","article-title":"Role of STAT3 in the pathogenesis of nasopharyngeal carcinoma and its significance in anticancer therapy","volume":"12","author":"Si","year":"2022","journal-title":"Front Oncol."},{"key":"10.1016\/j.jpba.2023.115830_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.154717","article-title":"Exploration of the anti-liver injury active components of Shaoyao Gancao decoction by network pharmacology and experiments in vivo","volume":"112","author":"Sun","year":"2023","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jpba.2023.115830_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2019.109118","article-title":"Magnoflorine inhibits human gastric cancer progression by inducing autophagy, apoptosis and cell cycle arrest by JNK activation regulated by ROS","volume":"125","author":"Sun","year":"2020","journal-title":"Biomed. Pharm."},{"key":"10.1016\/j.jpba.2023.115830_bib30","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2020.00389","article-title":"Magnoflorine suppresses MAPK and NF-\u03baB signaling to prevent inflammatory osteolysis induced by titanium particles in vivo and osteoclastogenesis via RANKL In Vitro","volume":"11","author":"Sun","year":"2020","journal-title":"Front Pharm."},{"key":"10.1016\/j.jpba.2023.115830_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.154998","article-title":"Systemic pharmacology reveal the mechanism by which the Qiangjin Zhuanggu Qufeng mixture inhibits LPS-induced pyroptosis of rat nucleus pulposus cells","volume":"119","author":"Wang","year":"2023","journal-title":"Phytomedicine"},{"issue":"04","key":"10.1016\/j.jpba.2023.115830_bib32","first-page":"209","article-title":"Zhou l: Research progress of nasopharyngeal carcinoma treated with integrated traditional Chinese and western medicine","volume":"2","author":"Wu","year":"2010","journal-title":"Res Integr. Tradit. Chin. West Med"},{"key":"10.1016\/j.jpba.2023.115830_bib33","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/9740066","article-title":"Luteolin isolated from polygonum cuspidatum is a potential compound against nasopharyngeal carcinoma","volume":"2022","author":"Xiong","year":"2022","journal-title":"Biomed. Res Int"},{"issue":"4","key":"10.1016\/j.jpba.2023.115830_bib34","doi-asserted-by":"crossref","first-page":"366","DOI":"10.4161\/cbt.8.4.7433","article-title":"Effect of DNAzymes targeting Akt1 on cell proliferation and apoptosis in nasopharyngeal carcinoma","volume":"8","author":"Yang","year":"2009","journal-title":"Cancer Biol. Ther."},{"issue":"7","key":"10.1016\/j.jpba.2023.115830_bib35","first-page":"8894","article-title":"The PK3K\/AKT and ERK\/MAPK signaling pathways correlate with nasopharyngeal carcinoma","volume":"12","author":"Yang","year":"2019","journal-title":"Int. J. Clin. Exp. Med."},{"issue":"1","key":"10.1016\/j.jpba.2023.115830_bib36","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.apsb.2011.04.007","article-title":"C-t: HPLC-MS analysis of Schisandra lignans and their metabolites in Caco-2 cell monolayer and rat everted gut sac models and in rat plasma","volume":"1","author":"Yang J-m","year":"2011","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.jpba.2023.115830_bib37","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/9214589","article-title":"Potential molecular mechanisms of ephedra herb in the treatment of nephrotic syndrome based on network pharmacology and molecular docking","volume":"2022","author":"Yao","year":"2022","journal-title":"Biomed. Res Int"},{"key":"10.1016\/j.jpba.2023.115830_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2020.153401","article-title":"Network pharmacology, molecular docking integrated surface plasmon resonance technology reveals the mechanism of Toujie Quwen Granules against coronavirus disease 2019 pneumonia","volume":"85","author":"Ye","year":"2021","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jpba.2023.115830_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.compbiomed.2021.104894","article-title":"Systematic analysis of the mechanism of Xiaochaihu decoction in hepatitis B treatment via network pharmacology and molecular docking","volume":"138","author":"Zeng","year":"2021","journal-title":"Comput. Biol. Med"},{"key":"10.1016\/j.jpba.2023.115830_bib40","article-title":"Network pharmacology databases for traditional chinese medicine: review and assessment","volume":"10","author":"Zhang","year":"2019","journal-title":"Front Pharm."},{"issue":"1","key":"10.1016\/j.jpba.2023.115830_bib41","article-title":"Metascape provides a biologist-oriented resource for the analysis of systems-level datasets","volume":"10","author":"Zhou","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jpba.2023.115830_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2023.175895","article-title":"Systems pharmacology-based mechanism exploration of Acanthopanax senticosusin for Alzheimer's disease using UPLC-Q-TOF-MS, network analysis, and experimental validation","volume":"954","author":"Zhuo","year":"2023","journal-title":"Eur. J. Pharm."}],"container-title":["Journal of Pharmaceutical and Biomedical Analysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S073170852300599X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S073170852300599X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T09:32:16Z","timestamp":1760002336000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S073170852300599X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2]]},"references-count":42,"alternative-id":["S073170852300599X"],"URL":"https:\/\/doi.org\/10.1016\/j.jpba.2023.115830","relation":{},"ISSN":["0731-7085"],"issn-type":[{"value":"0731-7085","type":"print"}],"subject":[],"published":{"date-parts":[[2024,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Exploring the pharmacological mechanisms of Biyan Qingdu Granula in the treatment after nasopharyngeal carcinoma radiotherapy based on UPLC\/Q-TOF MS, network pharmacology and molecular docking","name":"articletitle","label":"Article Title"},{"value":"Journal of Pharmaceutical and Biomedical Analysis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpba.2023.115830","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"115830"}}