{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T15:58:48Z","timestamp":1783612728222,"version":"3.55.0"},"reference-count":32,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100008402","name":"Chengdu University of Traditional Chinese Medicine","doi-asserted-by":"publisher","award":["2022JJRC05"],"award-info":[{"award-number":["2022JJRC05"]}],"id":[{"id":"10.13039\/501100008402","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012542","name":"Sichuan Province Science and Technology Support Program","doi-asserted-by":"publisher","award":["2023YFS0458"],"award-info":[{"award-number":["2023YFS0458"]}],"id":[{"id":"10.13039\/100012542","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82204624"],"award-info":[{"award-number":["82204624"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmaceutical and Biomedical Analysis"],"published-print":{"date-parts":[[2024,3]]},"DOI":"10.1016\/j.jpba.2023.115944","type":"journal-article","created":{"date-parts":[[2023,12,29]],"date-time":"2023-12-29T12:04:13Z","timestamp":1703851453000},"page":"115944","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Synergistic mechanism of stir-baked curcumae radix with vinegar in dysmenorrhea rats based on UPLC-Q-TOF\/MS metabolomics"],"prefix":"10.1016","volume":"240","author":[{"given":"Jie","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayijie","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuolin","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoli","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yidian","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingying","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changjiang","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhimin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.jpba.2023.115944_bib1","article-title":"Dysmenorrhea in adolescents","volume":"52","author":"Gutman","year":"2022","journal-title":"Curr. Probl. Pedia Adolesc. Health Care"},{"key":"10.1016\/j.jpba.2023.115944_bib2","series-title":"Pharmacopoeia of the People\u2019s Republic of China","year":"2020"},{"key":"10.1016\/j.jpba.2023.115944_bib3","doi-asserted-by":"crossref","first-page":"4973128","DOI":"10.1155\/2016\/4973128","article-title":"Two traditional chinese medicines curcumae radix and curcumae rhizoma: an ethnopharmacology, phytochemistry, and pharmacology review","volume":"2016","author":"Zhou","year":"2016","journal-title":"Evid. Based Complement Altern. Med."},{"key":"10.1016\/j.jpba.2023.115944_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2020.113713","article-title":"Chemical composition and uterine smooth muscle relaxant activity of essential oils from 10 kinds of blood-activating and stasis-resolving Chinese medicinal herbs","volume":"269","author":"Ni","year":"2021","journal-title":"J. Ethnopharmacol."},{"issue":"48","key":"10.1016\/j.jpba.2023.115944_bib5","first-page":"3498","article-title":"Effect of processing with vinegar on efficacy of Curcuma longa in treatment of dysmenorrhea in rats with syndrome of liver depression and qi stagnation","volume":"13","author":"Wu","year":"2023","journal-title":"Zhong Guo Zhong Yao Za Zhi"},{"key":"10.1016\/j.jpba.2023.115944_bib6","doi-asserted-by":"crossref","first-page":"2830754","DOI":"10.1155\/2017\/2830754","article-title":"Study on quality standard of processed curcuma longa radix","volume":"2017","author":"Chen","year":"2017","journal-title":"Evid. Based Complement Altern. Med."},{"issue":"9","key":"10.1016\/j.jpba.2023.115944_bib7","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1016\/j.intimp.2009.04.012","article-title":"Zedoarondiol isolated from the rhizoma of Curcuma heyneana is involved in the inhibition of iNOS, COX-2 and pro-inflammatory cytokines via the downregulation of NF-kappaB pathway in LPS-stimulated murine macrophages","volume":"9","author":"Cho","year":"2009","journal-title":"Int Immunopharmacol."},{"issue":"10","key":"10.1016\/j.jpba.2023.115944_bib8","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1007\/BF02980264","article-title":"Inhibition of inducible prostaglandin E2 production and cyclooxygenase-2 expression by curdione from curcuma zedoaria","volume":"30","author":"Oh","year":"2007","journal-title":"Arch. Pharm. Res"},{"issue":"7","key":"10.1016\/j.jpba.2023.115944_bib9","first-page":"1318","article-title":"Effect of vinegar-processed curcumae rhizoma on bile metabolism in rats","volume":"41","author":"Gu","year":"2016","journal-title":"Zhongguo Zhong Yao Za Zhi"},{"issue":"48","key":"10.1016\/j.jpba.2023.115944_bib10","first-page":"649","article-title":"A study on the material basis and prediction of the mechanism of action of yellow silk tulip and its vinegar roasted product in the treatment of primary dysmenorrhea","volume":"03","author":"Peng","year":"2023","journal-title":"Zhong Guo Zhong Yao Za Zhi"},{"key":"10.1016\/j.jpba.2023.115944_bib11","article-title":"Different processed products of curcumae radix regulate pain-related substances in a rat model of Qi stagnation and blood stasis","volume":"11","author":"Chen","year":"2020","journal-title":"Front Pharm."},{"issue":"4","key":"10.1016\/j.jpba.2023.115944_bib12","first-page":"301","article-title":"Gut microbiota brings a novel way to illuminate mechanisms of natural products in vivo chinese herbal medicines","volume":"9","author":"Guo","year":"2017","journal-title":"CHM"},{"issue":"5","key":"10.1016\/j.jpba.2023.115944_bib13","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1007\/s13238-020-00784-w","article-title":"Role of gut microbiota in identification of novel TCM-derived active metabolites","volume":"12","author":"Lin","year":"2020","journal-title":"Protein Cell"},{"issue":"6","key":"10.1016\/j.jpba.2023.115944_bib14","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1002\/mas.21562","article-title":"Challenges and emergent solutions for LC-MS\/MS based untargeted metabolomics in diseases","volume":"37","author":"Cui","year":"2018","journal-title":"Mass Spectrom. Rev."},{"key":"10.1016\/j.jpba.2023.115944_bib15","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.jchromb.2019.04.009","article-title":"Untargeted LC\/MS-based metabolic phenotyping (metabonomics\/metabolomics): the state of the art","volume":"1117","author":"Gika","year":"2019","journal-title":"J. Chromatogr. B Anal. Technol. Biomed. Life Sci."},{"key":"10.1016\/j.jpba.2023.115944_bib16","series-title":"Pharmacopoeia of the People's Republic of China","year":"2020"},{"key":"10.1016\/j.jpba.2023.115944_bib17","unstructured":"S.F.a.D. Administration., Sichuan province traditional chinese medicine drinking piece preparation specification Sichuan Science and Technology Press, Chengdu, 2016, pp. 473\u2013473."},{"issue":"46","key":"10.1016\/j.jpba.2023.115944_bib18","first-page":"67","article-title":"HPLC fingerprinting study of yellow silk tulip before and after vinegar-roasting based on chemical pattern recognition","volume":"01","author":"Peng","year":"2023","journal-title":"Zhongyaocai"},{"key":"10.1016\/j.jpba.2023.115944_bib19","unstructured":"P.C.o.E.P.o.T.C.M.o.t.C.S.o.T.C. Medicine, Specification for the preparation of animal models of dysmenorrhea Chin J Exp tradit Med Form 24(19) (2018), pp. 20\u201320."},{"issue":"2","key":"10.1016\/j.jpba.2023.115944_bib20","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1159\/000087097","article-title":"Chronic mild stress (CMS) revisited: consistency and behavioural-neurobiological concordance in the effects of CMS","volume":"52","author":"Willner","year":"2005","journal-title":"Neuropsychobiology"},{"issue":"1","key":"10.1016\/j.jpba.2023.115944_bib21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0022-3565(25)21463-X","article-title":"In vivo studies on spinal opiate receptor systems mediating antinociception\u2161pharmacological profiles suggesting a differential association of mu,delta and kappa receptors with visceral chemical and cutaneous thermal stimuli in the rat","volume":"228","author":"Schmauss","year":"1984","journal-title":"J. Pharm. Exp. Ther."},{"key":"10.1016\/j.jpba.2023.115944_bib22","unstructured":"NTP Toxicology and Carcinogenesis Studies of Pyridine (CAS No. 110\u201386-1) in F344\/N Rats, Wistar Rats, and B6C3F1 Mice (Drinking Water Studies), Natl Toxicol Program Tech Rep Ser 470 (2000), pp. 1\u2013330."},{"key":"10.1016\/j.jpba.2023.115944_bib23","unstructured":"Toxicology and carcinogenesis studies of 4-methylimidazole (Cas No. 822\u201336-6) in F344\/N rats and B6C3F1 mice (feed studies), Natl Toxicol Program Tech Rep Ser (535) (2007), pp. 1\u2013274."},{"key":"10.1016\/j.jpba.2023.115944_bib24","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2022.969553","article-title":"Investigation of the protective mechanism of leonurine against acute myocardial ischemia by an integrated metabolomics and network pharmacology strategy","volume":"9","author":"Rong","year":"2022","journal-title":"Front. Cardiovasc. Med."},{"issue":"8","key":"10.1016\/j.jpba.2023.115944_bib25","first-page":"561","article-title":"Novel chinmedomics strategy for discovering effective constituents from ShenQiWan acting on ShenYangXu syndrome","volume":"14","author":"Zhou","year":"2016","journal-title":"Chin. J. Nat. Med."},{"key":"10.1016\/j.jpba.2023.115944_bib26","article-title":"Based on plasma metabonomics and network pharmacology exploring the therapeutic mechanism of gynura procumbens on type 2 diabetes","volume":"12","author":"Guo","year":"2021","journal-title":"Front Pharm."},{"issue":"1","key":"10.1016\/j.jpba.2023.115944_bib27","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1021\/ac202828r","article-title":"Pattern recognition approaches and computational systems tools for ultra performance liquid chromatography-mass spectrometry-based comprehensive metabolomic profiling and pathways analysis of biological data sets","volume":"84","author":"Wang","year":"2012","journal-title":"Anal. Chem."},{"key":"10.1016\/j.jpba.2023.115944_bib28","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/s12950-020-00251-7","article-title":"NLRP3 inflammasome inhibitor MCC950 attenuates primary dysmenorrhea in mice via the NF-\u03baB\/COX-2\/PG pathway","volume":"17","author":"Tang","year":"2020","journal-title":"J. Inflamm."},{"issue":"2","key":"10.1016\/j.jpba.2023.115944_bib29","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1039\/D2FO02842E","article-title":"An integrated study on the comprehensive mechanism of Schisandra chinensis polysaccharides mitigating Alzheimer's disease in rats using a UPLC-Q-TOF-MS based serum and urine metabolomics strategy","volume":"14","author":"Fu","year":"2023","journal-title":"Food Funct."},{"key":"10.1016\/j.jpba.2023.115944_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.154831","article-title":"The activities and mechanisms of intestinal microbiota metabolites of TCM herbal ingredients could be illustrated by a strategy integrating spectrum-effects, network pharmacology, metabolomics and molecular docking analysis: platycodin D as an example","volume":"115","author":"Zhong","year":"2023","journal-title":"Phytomedicine"},{"issue":"1","key":"10.1016\/j.jpba.2023.115944_bib31","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1097\/TA.0000000000002952","article-title":"Persistent metabolomic alterations characterize chronic critical illness after severe trauma","volume":"90","author":"Horn","year":"2021","journal-title":"J. Trauma Acute Care Surg."},{"key":"10.1016\/j.jpba.2023.115944_bib32","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.jep.2016.03.067","article-title":"Effects and mechanisms of Shaofu-Zhuyu decoction and its major bioactive component for cold - stagnation and blood - stasis primary dysmenorrhea rats","volume":"186","author":"Huang","year":"2016","journal-title":"J. Ethnopharmacol."}],"container-title":["Journal of Pharmaceutical and Biomedical Analysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0731708523007136?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0731708523007136?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T09:36:26Z","timestamp":1760002586000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0731708523007136"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3]]},"references-count":32,"alternative-id":["S0731708523007136"],"URL":"https:\/\/doi.org\/10.1016\/j.jpba.2023.115944","relation":{},"ISSN":["0731-7085"],"issn-type":[{"value":"0731-7085","type":"print"}],"subject":[],"published":{"date-parts":[[2024,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Synergistic mechanism of stir-baked curcumae radix with vinegar in dysmenorrhea rats based on UPLC-Q-TOF\/MS metabolomics","name":"articletitle","label":"Article Title"},{"value":"Journal of Pharmaceutical and Biomedical Analysis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpba.2023.115944","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"115944"}}