{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T23:59:56Z","timestamp":1768435196673,"version":"3.49.0"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmaceutical and Biomedical Analysis"],"published-print":{"date-parts":[[2024,3]]},"DOI":"10.1016\/j.jpba.2023.115957","type":"journal-article","created":{"date-parts":[[2023,12,30]],"date-time":"2023-12-30T11:15:44Z","timestamp":1703934944000},"page":"115957","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Study on the intervention effect of Epimedium before and after suet-oil-processed on kidney yang deficiency rats based on intestinal flora and fecal metabolomics"],"prefix":"10.1016","volume":"240","author":[{"given":"Ran","family":"Huang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ziliang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ke","family":"Ding","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yawei","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yingjie","family":"Wei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaobin","family":"Jia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jpba.2023.115957_bib1","unstructured":"Liu, Y. Effect of MicroRNA on Deficiency of Kidney Yang and Intervention Effect of Yougui Pill [D]. Shaanxi University of Chinese Medicine, 2020."},{"issue":"08","key":"10.1016\/j.jpba.2023.115957_bib2","first-page":"1197","article-title":"Syndrome elements and core pathogenesis of kidney yang deficiency syndrome","volume":"27","author":"Zheng","year":"2021","journal-title":"Chin. J. Basic Med Tradit. Chin. Med"},{"issue":"1","key":"10.1016\/j.jpba.2023.115957_bib3","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.jep.2012.08.020","article-title":"Curculigo orchioides (Xian Mao) modifies the activity and protein expression of CYP3A in normal and Kidney-Yang Deficiency model rats [J]","volume":"144","author":"Wang","year":"2012","journal-title":"J. Ethnopharmacol."},{"issue":"04","key":"10.1016\/j.jpba.2023.115957_bib4","first-page":"1317","article-title":"Modeling methods and model evaluation of animal models for kidney yang deficiency syndrome","volume":"23","author":"Tang","year":"2021","journal-title":"Mod. Tradit. Chin. Med Mater. Mater. -World Sci. Technol."},{"key":"10.1016\/j.jpba.2023.115957_bib5","series-title":"Pharmacopoeia of the People's Republic of China","first-page":"340","year":"2020"},{"issue":"05","key":"10.1016\/j.jpba.2023.115957_bib6","first-page":"721","article-title":"Material basis for anti-osteoporosis efficacy of Epimedium flavonoids based on their in vivo metabolism","volume":"45","author":"Jiang","year":"2014","journal-title":"Chin. Tradit. Herb. Drugs"},{"issue":"07","key":"10.1016\/j.jpba.2023.115957_bib7","first-page":"656","article-title":"The status quo and analysis of the theoretical research on \u201cIntestine-kidney axis\u201d","volume":"18","author":"Jiao","year":"2017","journal-title":"Chin. J. Integr. Tradit. West Med Nephrol."},{"issue":"1","key":"10.1016\/j.jpba.2023.115957_bib8","first-page":"9","article-title":"Clinical study of intestinal flora imbalance in patients with kidney-yang deficiency syndrome","volume":"39","author":"Ding","year":"2007","journal-title":"J. N. Chin. Med"},{"key":"10.1016\/j.jpba.2023.115957_bib9","article-title":"Processing mechanism of herba epimedii fried with suet oil for warming kidney and enhancing yang based on metabolomics","author":"Hou","year":"2017","journal-title":"Jiangsu Univ."},{"key":"10.1016\/j.jpba.2023.115957_bib10","first-page":"1","article-title":"The processing mechanism of epimedium fried with suet oil to warm kidney and enhance yang based on UPLC-Q-TOF-MS metabolomics","author":"Wang","year":"2021","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.jpba.2023.115957_bib11","article-title":"Integrating strategies of metabolomics, network pharmacology, and experiment validation to investigate the processing mechanism of Epimedium fried with suet oil to warm kidney and enhance yang","volume":"14","author":"Sun","year":"2023","journal-title":"Front Pharm."},{"issue":"03","key":"10.1016\/j.jpba.2023.115957_bib12","first-page":"52","article-title":"Effect of Huangqin (Scutellariae Radix) and Zhizi (Gardeniae Fructus) on Intestinal Flora of Rats","volume":"42","author":"Zhu","year":"2023","journal-title":"Chin. Arch. Tradit. Chin. Med"},{"issue":"2","key":"10.1016\/j.jpba.2023.115957_bib13","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1039\/C7RA12451A","article-title":"Exploring the biomarkers and therapeutic mechanism of kidney-yang deficiency syndrome treated by You-gui pill using systems pharmacology and serum metabonomics","volume":"8","author":"Chen","year":"2018","journal-title":"RSC Adv."},{"issue":"11","key":"10.1016\/j.jpba.2023.115957_bib14","first-page":"2900","article-title":"Analysis changes of Epimedii Folium\u2019s flavonoids before and after processing based on UPLC-Q\/TOF-MS [J]","volume":"51","author":"Li","year":"2020","journal-title":"Chin. Tradit. Herb. Drugs"},{"issue":"15","key":"10.1016\/j.jpba.2023.115957_bib15","first-page":"2901","article-title":"Chinmedomics strategy to discover effective constituents and elucidate action mechanism of Nanshi capsule against kidney-yang deficiency syndrome","volume":"41","author":"Liu","year":"2016","journal-title":"China Tradit. Herba Drugs"},{"issue":"4","key":"10.1016\/j.jpba.2023.115957_bib16","doi-asserted-by":"crossref","first-page":"201","DOI":"10.3371\/CSRP.KRBA.013114","article-title":"Adjunctive pregnenolone ameliorates the cognitive deficits in recent-onset schizophrenia: an 8-week, randomized, double-blind, placebo-controlled trial","volume":"10","author":"Kreinin","year":"2017","journal-title":"Clin. Schizophr. Relat. Psychoses"},{"issue":"1","key":"10.1016\/j.jpba.2023.115957_bib17","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1210\/endrev\/bnab016","article-title":"Congenital adrenal hyperplasia-current insights in pathophysiology, diagnostics, and management","volume":"43","author":"Claahsen-van der Grinten","year":"2022","journal-title":"Endocr. Rev."},{"issue":"05","key":"10.1016\/j.jpba.2023.115957_bib18","article-title":"Study on the relationship between plasma estriol-16-glucuronide, 17-hydroxyprogresterone and labor onset during third trimester of pregnancy","volume":"51","author":"Kang","year":"2022","journal-title":"Acta Med Univ. Sci. Technol. Huazhong"},{"key":"10.1016\/j.jpba.2023.115957_bib19","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.mgene.2018.03.012","article-title":"Elucidation of bacterial species during childhood diarrhea through 16S rRNA Illumina Miseq approach [J]","volume":"16","author":"Thakur","year":"2018","journal-title":"Meta Gene"},{"issue":"1","key":"10.1016\/j.jpba.2023.115957_bib20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1746-6148-8-237","article-title":"The diversity of the fecal bacterial community and its relationship with the concentration of volatile fatty acids in the feces during subacute rumen acidosis in dairy cows","volume":"8","author":"Mao","year":"2012","journal-title":"BMC Vet. Res"},{"key":"10.1016\/j.jpba.2023.115957_bib21","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2019.01152","article-title":"Lactobacillus brevis alleviates DSS-induced colitis by reprograming intestinal microbiota and influencing serum metabolome in murine model","volume":"10","author":"Ding","year":"2019","journal-title":"Front Physiol."},{"key":"10.1016\/j.jpba.2023.115957_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.jchromb.2022.123189","article-title":"Shenqi compound ameliorates type-2 diabetes mellitus by modulating the gut microbiota and metabolites [J]","volume":"1194","author":"Zhang","year":"2022","journal-title":"J. Chromatogr. B"},{"issue":"7758","key":"10.1016\/j.jpba.2023.115957_bib23","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1038\/s41586-019-1237-9","article-title":"Multi-omics of the gut microbial ecosystem in inflammatory bowel diseases [J]","volume":"569","author":"Lloyd-Price","year":"2019","journal-title":"Nature"},{"issue":"05","key":"10.1016\/j.jpba.2023.115957_bib24","first-page":"580","article-title":"The composition and diversity of intestinal flora in rats with spleen deficiency diarrhea [J]","volume":"47","author":"Yan","year":"2021","journal-title":"J. Hunan Agric. Univ. (Nat. Sci. )"},{"issue":"Pt4","key":"10.1016\/j.jpba.2023.115957_bib25","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1099\/ijs.0.041376-0","article-title":"Description of Alloprevotella rava gen. nov., sp. nov., isolated from the human oral cavity, and reclassification of Prevotella tannerae Moore et al. 1994 as Alloprevotella tannerae gen. nov., comb. Nov","volume":"63","author":"Downes","year":"2013","journal-title":"Int J. Syst. Evol. Microbiol"},{"issue":"27","key":"10.1016\/j.jpba.2023.115957_bib26","doi-asserted-by":"crossref","first-page":"12204","DOI":"10.1073\/pnas.0909122107","article-title":"Inducible Foxp3+ regulatory T-cell development by a commensal bacterium of the intestinal microbiota","volume":"107","author":"Round","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.jpba.2023.115957_bib27","article-title":"Leveraging 16S rRNA microbiome sequencing data to identify bacterial signatures for irritable bowel syndrome","volume":"11","author":"Liu","year":"2021","journal-title":"Front Cell Infect. Microbiol"},{"issue":"06","key":"10.1016\/j.jpba.2023.115957_bib28","first-page":"1406","article-title":"Effect of Gegen Qinlian Decoction and it's different compatibility groups on gut microbiota in rats with acute enteritis based on high-throughput sequencing","volume":"45","author":"Chen","year":"2020","journal-title":"Chin. J. Chin. Mater. Med"},{"issue":"4","key":"10.1016\/j.jpba.2023.115957_bib29","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1002\/iid3.348","article-title":"The characteristics of intestinal flora of IBS-D with different syndromes","volume":"8","author":"Chao","year":"2020","journal-title":"Immun. Inflamm. Dis."},{"issue":"12","key":"10.1016\/j.jpba.2023.115957_bib30","first-page":"2777","article-title":"The role of the intestinal microflora dysbiosis in chronic kidney disease","volume":"55","author":"Li","year":"2020","journal-title":"Aata Pharm. Sin."},{"key":"10.1016\/j.jpba.2023.115957_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpba.2021.114432","article-title":"Metabolomics analysis of Semen Cuscutae protection of kidney deficient model rats using ultra high-performance liquid chromatography-quadrupole time-of-flight Mass Spectrometry","volume":"207","author":"Fan","year":"2022","journal-title":"J. Pharm. Biomed. Anal."},{"issue":"8","key":"10.1016\/j.jpba.2023.115957_bib32","first-page":"561","article-title":"Novel chinmedomics strategy for discovering effective constituents from ShenQiWan acting on ShenYangXu syndrome","volume":"14","author":"Zhou","year":"2016","journal-title":"Chin. J. Nat. Med"},{"issue":"5","key":"10.1016\/j.jpba.2023.115957_bib33","doi-asserted-by":"crossref","first-page":"287","DOI":"10.5603\/GP.2020.0049","article-title":"GC-MS as a tool for reliable non-invasive prenatal diagnosis of Smith-Lemli-Opitz syndrome but essential also for other cholesterolopathies verification","volume":"91","author":"Jezela-Stanek","year":"2020","journal-title":"Ginekol. Pol."},{"issue":"6","key":"10.1016\/j.jpba.2023.115957_bib34","doi-asserted-by":"crossref","first-page":"4251","DOI":"10.1021\/acs.analchem.9b04580","article-title":"Localization of metabolites of human kidney tissue with infrared laser-based selected reaction monitoring mass spectrometry imaging and silver-109 nanoparticle-based surface assisted laser desorption\/ionization mass spectrometry imaging","volume":"92","author":"Nizio\u0142","year":"2020","journal-title":"Anal. Chem."}],"container-title":["Journal of Pharmaceutical and Biomedical Analysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0731708523007264?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0731708523007264?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T09:35:50Z","timestamp":1760002550000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0731708523007264"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3]]},"references-count":34,"alternative-id":["S0731708523007264"],"URL":"https:\/\/doi.org\/10.1016\/j.jpba.2023.115957","relation":{},"ISSN":["0731-7085"],"issn-type":[{"value":"0731-7085","type":"print"}],"subject":[],"published":{"date-parts":[[2024,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Study on the intervention effect of Epimedium before and after suet-oil-processed on kidney yang deficiency rats based on intestinal flora and fecal metabolomics","name":"articletitle","label":"Article Title"},{"value":"Journal of Pharmaceutical and Biomedical Analysis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpba.2023.115957","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"115957"}}