{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T12:30:29Z","timestamp":1790080229419,"version":"4.0.1"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,2,26]],"date-time":"2024-02-26T00:00:00Z","timestamp":1708905600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmaceutical and Biomedical Analysis"],"published-print":{"date-parts":[[2024,5]]},"DOI":"10.1016\/j.jpba.2024.116058","type":"journal-article","created":{"date-parts":[[2024,2,17]],"date-time":"2024-02-17T16:27:38Z","timestamp":1708187258000},"page":"116058","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Pharmacodynamics and mechanism of Erigeron breviscapus granules in the treatment of ischemic stroke in mice by regulating sphingolipid metabolism based on metabolomics"],"prefix":"10.1016","volume":"242","author":[{"given":"Chengzhao","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kedi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingru","family":"Tao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weihong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Mu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sha","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taiwei","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jialin","family":"Duan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peifeng","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miaomiao","family":"Xi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jpba.2024.116058_bib1","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/S1474-4422(21)00252-0","article-title":"Global, regional, and national burden of stroke and its risk factors, 1990\u20132019: a systematic analysis for the Global Burden of Disease Study 2019","volume":"20","author":"Feigin","year":"2021","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.jpba.2024.116058_bib2","doi-asserted-by":"crossref","first-page":"e93","DOI":"10.1161\/CIR.0000000000001123","article-title":"Heart disease and stroke statistics\u20142023 update: a report from the American Heart Association","volume":"147","author":"Tsao","year":"2023","journal-title":"Circulation"},{"key":"10.1016\/j.jpba.2024.116058_bib3","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1038\/s41392-022-01064-1","article-title":"Signaling pathways involved in ischemic stroke: molecular mechanisms and therapeutic interventions","volume":"7","author":"Qin","year":"2022","journal-title":"Signal Transduct. Target Ther."},{"key":"10.1016\/j.jpba.2024.116058_bib4","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1016\/S1474-4422(15)00054-X","article-title":"Future directions of acute ischaemic stroke therapy","volume":"14","author":"Fisher","year":"2015","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.jpba.2024.116058_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.112719","article-title":"Therapeutic targets of neuroprotection and neurorestoration in ischemic stroke: Applications for natural compounds from medicinal herbs","volume":"148","author":"Zhu","year":"2022","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.jpba.2024.116058_bib6","unstructured":"Commission Chinese Pharmacopoeia, Pharmacopoeia of the People's Republic of China, China Medical Science and Technology Press, Beijing, 2020."},{"key":"10.1016\/j.jpba.2024.116058_bib7","article-title":"Advances in chemical constituents, clinical applications, pharmacology, pharmacokinetics and toxicology of Erigeron breviscapus","volume":"12","author":"Wu","year":"2021","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jpba.2024.116058_bib8","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.710692","article-title":"Protective property of Scutellarin against liver injury induced by carbon tetrachloride in mice","volume":"12","author":"Miao","year":"2021","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jpba.2024.116058_bib9","first-page":"2639","article-title":"Pharmacodynamics experiment of Erigeron breviscapus pellets, Mod","volume":"34","author":"Yang","year":"2007","journal-title":"Prev. Med."},{"key":"10.1016\/j.jpba.2024.116058_bib10","first-page":"6","article-title":"Study on the chronic toxic effect of Erigeron breviscapus pellets, Guide","volume":"8","author":"Yang","year":"2010","journal-title":"Chin. Med."},{"key":"10.1016\/j.jpba.2024.116058_bib11","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1161\/01.STR.20.1.84","article-title":"Reversible middle cerebral artery occlusion without craniectomy in rats","volume":"20","author":"Longa","year":"1989","journal-title":"Stroke"},{"key":"10.1016\/j.jpba.2024.116058_bib12","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1161\/01.STR.32.4.1005","article-title":"Therapeutic benefit of intravenous administration of bone marrow stromal cells after cerebral ischemia in rats","volume":"32","author":"Chen","year":"2001","journal-title":"Stroke"},{"key":"10.1016\/j.jpba.2024.116058_bib13","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/S0165-0270(02)00114-0","article-title":"A test for detecting long-term sensorimotor dysfunction in the mouse after focal cerebral ischemia","volume":"117","author":"Zhang","year":"2002","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.jpba.2024.116058_bib14","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/0091-3057(82)90452-X","article-title":"Tactile extinction: distinguishing between sensorimotor and motor asymmetries in rats with unilateral nigrostriatal damage","volume":"16","author":"Schallert","year":"1982","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.jpba.2024.116058_bib15","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.expneurol.2004.01.004","article-title":"Chronic behavioral testing after focal ischemia in the mouse: functional recovery and the effects of gender","volume":"187","author":"Li","year":"2004","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.jpba.2024.116058_bib16","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1016\/S0140-6736(21)00244-0","article-title":"Sphingosine 1-phosphate receptor modulators in multiple sclerosis and other conditions","volume":"398","author":"McGinley","year":"2021","journal-title":"Lancet"},{"key":"10.1016\/j.jpba.2024.116058_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2020.117542","article-title":"Potential sphingosine-1-phosphate-related therapeutic targets in the treatment of cerebral ischemia reperfusion injury","volume":"249","author":"Han","year":"2020","journal-title":"Life Sci."},{"key":"10.1016\/j.jpba.2024.116058_bib18","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1142\/S0192415X10008020","article-title":"Protective effect of Astragaloside on focal cerebral ischemia\/reperfusion injury in rats","volume":"38","author":"Yin","year":"2012","journal-title":"Am. J. Chin. Med."},{"key":"10.1016\/j.jpba.2024.116058_bib19","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1001\/jamaneurol.2023.1871","article-title":"Efficacy and safety of Butylphthalide in patients with acute ischemic stroke","volume":"80","author":"Wang","year":"2023","journal-title":"JAMA Neurol."},{"key":"10.1016\/j.jpba.2024.116058_bib20","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1016\/j.cmet.2011.08.016","article-title":"Brain energy metabolism: focus on astrocyte-neuron metabolic cooperation","volume":"14","author":"B\u00e9langer","year":"2011","journal-title":"Cell Metab."},{"key":"10.1016\/j.jpba.2024.116058_bib21","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1093\/aje\/kwz116","article-title":"Association between serum \u03b2-alanine and risk of dementia","volume":"188","author":"Hata","year":"2019","journal-title":"Am. J. Epidemiol."},{"key":"10.1016\/j.jpba.2024.116058_bib22","doi-asserted-by":"crossref","first-page":"848","DOI":"10.3390\/nu12030848","article-title":"Histidine in health and disease: metabolism, physiological importance, and use as a supplement","volume":"12","author":"Hole\u010dek","year":"2020","journal-title":"Nutrients"},{"key":"10.1016\/j.jpba.2024.116058_bib23","doi-asserted-by":"crossref","first-page":"2057","DOI":"10.1002\/rcm.4620","article-title":"Direct profiling of phospholipids and lysophospholipids in rat brain sections after ischemic stroke","volume":"24","author":"Wang","year":"2010","journal-title":"Rapid Commun. Mass Spectrom."},{"key":"10.1016\/j.jpba.2024.116058_bib24","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.neuroscience.2010.03.056","article-title":"Imaging mass spectrometry revealed the production of lyso-phosphatidylcholine in the injured ischemic rat brain","volume":"168","author":"Koizumi","year":"2010","journal-title":"Neuroscience"},{"key":"10.1016\/j.jpba.2024.116058_bib25","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1038\/nrm.2017.107","article-title":"Sphingolipids and their metabolism in physiology and disease","volume":"19","author":"Hannun","year":"2018","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.jpba.2024.116058_bib26","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.expneurol.2015.03.012","article-title":"Sphingosine kinase 1 mediates neuroinflammation following cerebral ischemia","volume":"272","author":"Zheng","year":"2015","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.jpba.2024.116058_bib27","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1038\/nri2974","article-title":"The outs and the ins of sphingosine-1-phosphate in immunity","volume":"11","author":"Spiegel","year":"2011","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.jpba.2024.116058_bib28","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.jneuroim.2017.01.015","article-title":"Sphk1 mediates neuroinflammation and neuronal injury via TRAF2\/NF-\u03baB pathways in activated microglia in cerebral ischemia reperfusion","volume":"305","author":"Su","year":"2017","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.jpba.2024.116058_bib29","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1161\/CIRCRESAHA.120.316711","article-title":"endothelial S1P1 signaling counteracts infarct expansion in ischemic stroke","volume":"128","author":"Nitzsche","year":"2021","journal-title":"Circ. Res."},{"key":"10.1016\/j.jpba.2024.116058_bib30","article-title":"Critical role of sphingosine-1-phosphate receptor-2 in the disruption of cerebrovascular integrity in experimental stroke","volume":"6","author":"Kim","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jpba.2024.116058_bib31","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1161\/ATVBAHA.107.143735","article-title":"Induction of vascular permeability by the sphingosine-1-phosphate receptor\u20132 (S1P2R) and its downstream effectors ROCK and PTEN","volume":"27","author":"Sanchez","year":"2007","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.jpba.2024.116058_bib32","doi-asserted-by":"crossref","first-page":"3133","DOI":"10.1096\/fj.201701121R","article-title":"MicroRNA-149-5p regulates blood\u2013brain barrier permeability after transient middle cerebral artery occlusion in rats by targeting S1PR2 of pericytes","volume":"32","author":"Wan","year":"2018","journal-title":"FASEB J."},{"key":"10.1016\/j.jpba.2024.116058_bib33","doi-asserted-by":"crossref","first-page":"3348","DOI":"10.1080\/21655979.2021.1947167","article-title":"Analysis of regulatory effect of miR-149-5p on Sphingosine-1-phosphate receptor 2 of pericytes and its neuroprotective molecular mechanism after acute cerebral ischemia reperfusion in rats","volume":"12","author":"Yan","year":"2021","journal-title":"Bioengineered"},{"key":"10.1016\/j.jpba.2024.116058_bib34","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1038\/jcbfm.1992.65","article-title":"Direct evidence for increased continuous histamine release in the striatum of conscious freely moving rats produced by middle cerebral artery occlusion","volume":"12","author":"Adachi","year":"1992","journal-title":"J. Cereb. Blood Flow. Metab."},{"key":"10.1016\/j.jpba.2024.116058_bib35","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1111\/j.1471-4159.1991.tb02099.x","article-title":"Changes in the metabolism of histamine arid monoamines after occlusion of the middle cerebral artery in rats","volume":"57","author":"Adachi","year":"1991","journal-title":"J. Neurochem."}],"container-title":["Journal of Pharmaceutical and Biomedical Analysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0731708524000980?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0731708524000980?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,5,9]],"date-time":"2024-05-09T21:42:32Z","timestamp":1715290952000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0731708524000980"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5]]},"references-count":35,"alternative-id":["S0731708524000980"],"URL":"https:\/\/doi.org\/10.1016\/j.jpba.2024.116058","relation":{},"ISSN":["0731-7085"],"issn-type":[{"value":"0731-7085","type":"print"}],"subject":[],"published":{"date-parts":[[2024,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pharmacodynamics and mechanism of Erigeron breviscapus granules in the treatment of ischemic stroke in mice by regulating sphingolipid metabolism based on metabolomics","name":"articletitle","label":"Article Title"},{"value":"Journal of Pharmaceutical and Biomedical Analysis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpba.2024.116058","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"116058"}}