{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T19:33:42Z","timestamp":1789673622899,"version":"4.0.1"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmaceutical and Biomedical Analysis"],"published-print":{"date-parts":[[2024,8]]},"DOI":"10.1016\/j.jpba.2024.116201","type":"journal-article","created":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T16:22:23Z","timestamp":1715617343000},"page":"116201","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Photodegradation of indomethacin and naproxen contained within commercial products for skin \u2013 RAP"],"prefix":"10.1016","volume":"246","author":[{"given":"Marzena","family":"Jamr\u00f3giewicz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"Bray","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grzegorz","family":"Go\u0142u\u0144ski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrycja","family":"Be\u0142dzi\u0144ska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcin","family":"Zakrzewski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jpba.2024.116201_bib1","unstructured":"M7(R1) assessment and control of DNA reactive (mutagenic) impurities in pharmaceuticals to limit potential carcinogenic risk https:\/\/database.ich.org\/sites\/default\/files\/M7_R1_Guideline.pdf (2017)."},{"key":"10.1016\/j.jpba.2024.116201_bib2","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.trac.2018.12.007","article-title":"Recent breakthroughs in the stability testing of pharmaceutical compounds","volume":"111","author":"Jamr\u00f3giewicz","year":"2019","journal-title":"Trends Anal. Chem."},{"key":"10.1016\/j.jpba.2024.116201_bib3","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.jpba.2015.01.012","article-title":"Application of vibrational spectroscopy, thermal analyses and X-ray diffraction in the rapid evaluation of the stability in solid-state of ranitidine, famotidine and cimetidine","volume":"107","author":"Jamr\u00f3giewicz","year":"2015","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jpba.2024.116201_bib4","series-title":"Rapid Assessment Process: An Introduction","author":"Beebe","year":"2001"},{"key":"10.1016\/j.jpba.2024.116201_bib5","series-title":"Contemporary research methods in pharmacy and health services","first-page":"397","author":"Desselle","year":"2022"},{"key":"10.1016\/j.jpba.2024.116201_bib6","series-title":"ICH quality guidelines: an implementation guide","author":"Teasdale","year":"2017"},{"key":"10.1016\/j.jpba.2024.116201_bib7","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.trac.2017.10.027","article-title":"Analytical control strategies for mutagenic impurities: current challenges and future opportunities?","volume":"101","author":"Teasdale","year":"2017","journal-title":"Trends Anal. Chem."},{"key":"10.1016\/j.jpba.2024.116201_bib8","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1111\/j.1600-0536.1996.tb02192.x","article-title":"High dissociation constants (pKa) of basic permeants are associated within vivoskin irritation in man","volume":"34","author":"Mangia","year":"1996","journal-title":"Contact Derm."},{"issue":"2","key":"10.1016\/j.jpba.2024.116201_bib9","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1081\/GNC-120026235","article-title":"Photoreaction, phototoxicity, and photocarcinogenicity of retinoids","volume":"21","author":"Fu","year":"2003","journal-title":"J. Environ. Sci. Health C: Toxicol."},{"issue":"8","key":"10.1016\/j.jpba.2024.116201_bib10","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.3390\/pharmaceutics13081220","article-title":"Photodegradation of bexarotene and its implication for cytotoxicity","volume":"13","author":"Kryczyk-Poprawa","year":"2021","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.jpba.2024.116201_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2020.144079","article-title":"Exploring the phototransformation and assessing the in vitro and in silico toxicity of a mixture of pharmaceuticals susceptible to photolysis","volume":"756","author":"Ofrydopoulou","year":"2021","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.jpba.2024.116201_bib12","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1562\/0031-8655(2001)074<0401:POBMAA>2.0.CO;2","article-title":"Photostabilization of Butyl methoxydibenzoylmethane (Avobenzone) and Ethylhexyl methoxycinnamate by Bis-ethylhexyloxyphenol methoxyphenyl triazine (Tinosorb S), a New UV Broadband Filter.","volume":"74","author":"Chatelain","year":"2001","journal-title":"Photochem. Photobiol."},{"issue":"1","key":"10.1016\/j.jpba.2024.116201_bib13","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.jphotobiol.2009.04.007","article-title":"UVB photolysis of betamethasone and its esters: characterization of photoproducts in solution, in pig skin and in drug formulations","volume":"96","author":"Miolo","year":"2009","journal-title":"J. Photochem. Photobiol. B"},{"issue":"1-2","key":"10.1016\/j.jpba.2024.116201_bib14","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.ijpharm.2007.05.048","article-title":"Photostability and efficacy studies of topical formulations containing UV-filters combination and vitamins A, C and E","volume":"343","author":"Gaspar","year":"2007","journal-title":"Int. J. Pharm."},{"issue":"4","key":"10.1016\/j.jpba.2024.116201_bib15","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1111\/php.13075","article-title":"Photostability of terbinafine under UVA irradiation: the effect of UV absorbers","volume":"95","author":"Kryczyk-Poprawa","year":"2019","journal-title":"Photochem. Photobiol."},{"issue":"1","key":"10.1016\/j.jpba.2024.116201_bib16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1752-153X-7-181","article-title":"Photostability and toxicity of finasteride, diclofenac and naproxen under simulating sunlight exposure: evaluation of the toxicity trend and of the packaging photoprotection","volume":"7","author":"Sammartino","year":"2013","journal-title":"Chem. Cent. J."},{"key":"10.1016\/j.jpba.2024.116201_bib17","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1016\/j.chemosphere.2017.02.010","article-title":"Fast identification of microplastics in complex environmental samples by a thermal degradation method","volume":"174","author":"D\u00fcmichen","year":"2017","journal-title":"Chemosphere"},{"issue":"7","key":"10.1016\/j.jpba.2024.116201_bib18","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1002\/jps.2600790717","article-title":"Nondestructive near-infrared analysis of intact tablets for determination of degradation products","volume":"79","author":"Drennen","year":"1990","journal-title":"J. Pharm. Sci."},{"issue":"26","key":"10.1016\/j.jpba.2024.116201_bib19","doi-asserted-by":"crossref","first-page":"5735","DOI":"10.1016\/j.biomaterials.2004.01.066","article-title":"The effect of scaffold degradation rate on three-dimensional cell growth and angiogenesis","volume":"25","author":"Sung","year":"2004","journal-title":"Biomaterials"},{"issue":"5","key":"10.1016\/j.jpba.2024.116201_bib20","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/j.addr.2012.01.009","article-title":"Advances in simultaneous DSC\u2013FTIR microspectroscopy for rapid solid-state chemical stability studies: some dipeptide drugs as examples","volume":"64","author":"Lin","year":"2012","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.jpba.2024.116201_bib21","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.addr.2018.06.009","article-title":"Practical guidelines for the characterization and quality control of pure drug nanoparticles and nano-cocrystals in the pharmaceutical industry","volume":"131","author":"Peltonen","year":"2018","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.jpba.2024.116201_bib22","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.jaap.2015.05.004","article-title":"Thermal characterization of polymer-silica composites loaded with ibuprofen sodium salt","volume":"114","author":"Grochowicz","year":"2015","journal-title":"J. Anal. Appl. Pyrolysis"},{"issue":"1","key":"10.1016\/j.jpba.2024.116201_bib23","doi-asserted-by":"crossref","first-page":"10","DOI":"10.3390\/pharmaceutics12010010","article-title":"Photostability of topical agents applied to the skin: A review","volume":"12","author":"Kryczyk-Poprawa","year":"2020","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.jpba.2024.116201_bib24","doi-asserted-by":"crossref","first-page":"438","DOI":"10.3390\/pharmaceutics7040438","article-title":"Transdermal Drug Delivery: Innovative Pharmaceutical Developments Based on Disruption of the Barrier Properties of the stratum corneum","volume":"7","author":"Alkilani","year":"2015","journal-title":"Pharmaceutics"},{"issue":"4","key":"10.1016\/j.jpba.2024.116201_bib25","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1016\/j.jpba.2011.07.005","article-title":"Determination of photostability and photodegradation products of indomethacin in aqueous media","volume":"56","author":"Temussi","year":"2011","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jpba.2024.116201_bib26","unstructured":"R: A language and environment for statistical computing. R Foundation for Statistical Computing, Vienna, Austria. URL https:\/\/www.R-project.org\/."},{"issue":"4","key":"10.1016\/j.jpba.2024.116201_bib27","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1016\/j.chemosphere.2009.07.041","article-title":"Photodegradation of pharmaceuticals and personal care products during UV and UV\/H2O2 treatments","volume":"77","author":"Kim","year":"2009","journal-title":"Chemosphere"},{"key":"10.1016\/j.jpba.2024.116201_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.saa.2021.120018","article-title":"Spectroscopic evaluation on pseudopolymorphs of sodium naproxen","volume":"261","author":"Jamr\u00f3giewicz","year":"2021","journal-title":"Spectrochim. Acta A: Mol. Biomol. Spectrosc."},{"issue":"6","key":"10.1016\/j.jpba.2024.116201_bib29","article-title":"Pressure perturbation calorimetry, heat capacity and the role of water in protein stability and interactions","volume":"35","author":"Cooper","year":"2007","journal-title":"7th Int. Conf. Protein Stab."},{"issue":"2","key":"10.1016\/j.jpba.2024.116201_bib30","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1007\/s10973-007-8698-z","article-title":"Is there a relationship between protein thermal stability and the denaturation heat capacity change?","volume":"93","author":"Graziano","year":"2008","journal-title":"J. Therm. Anal. Calorim."},{"key":"10.1016\/j.jpba.2024.116201_bib31","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1007\/BF01897163","article-title":"A study of standardization of variables in cluster analysis","volume":"5","author":"Milligan","year":"1988","journal-title":"J. Classif."},{"key":"10.1016\/j.jpba.2024.116201_bib32","doi-asserted-by":"crossref","first-page":"1660","DOI":"10.1021\/tx4002513","article-title":"Caffeine and other methylxanthines as interceptors of food-borne aromatic mutagens: inhibition of Trp-P-1 and Trp-P-2 mutagenic activity","volume":"26","author":"Woziwodzka","year":"2013","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.jpba.2024.116201_bib33","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S0027-5107(00)00064-6","article-title":"The Ames Salmonella\/microsome mutagenicity assay","volume":"455","author":"Mortelmans","year":"2000","journal-title":"Mutat. Res"},{"key":"10.1016\/j.jpba.2024.116201_bib34","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/0165-1218(84)90035-1","article-title":"Mutagenicity examination of several non-steroidal anti-inflammatory drugs in bacterial systems","volume":"138","author":"Kadotani","year":"1984","journal-title":"Mutat. Res."},{"key":"10.1016\/j.jpba.2024.116201_bib35","doi-asserted-by":"crossref","first-page":"53","DOI":"10.3123\/jemsge.32.53","article-title":"Inhibitory Effect of Dimethyl Sulfoxide on the Mutagenicity of Promutagens in the Ames Test","volume":"32","author":"Hakura","year":"2010","journal-title":"Genes Environ."}],"container-title":["Journal of Pharmaceutical and Biomedical Analysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0731708524002413?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0731708524002413?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T02:54:52Z","timestamp":1740797692000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0731708524002413"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8]]},"references-count":35,"alternative-id":["S0731708524002413"],"URL":"https:\/\/doi.org\/10.1016\/j.jpba.2024.116201","relation":{},"ISSN":["0731-7085"],"issn-type":[{"value":"0731-7085","type":"print"}],"subject":[],"published":{"date-parts":[[2024,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Photodegradation of indomethacin and naproxen contained within commercial products for skin \u2013 RAP","name":"articletitle","label":"Article Title"},{"value":"Journal of Pharmaceutical and Biomedical Analysis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpba.2024.116201","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"116201"}}