{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T19:00:27Z","timestamp":1786993227779,"version":"build-2736575974"},"reference-count":16,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000038","name":"US Food and Drug Administration","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000038","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmaceutical and Biomedical Analysis"],"published-print":{"date-parts":[[2024,9]]},"DOI":"10.1016\/j.jpba.2024.116298","type":"journal-article","created":{"date-parts":[[2024,6,12]],"date-time":"2024-06-12T16:46:00Z","timestamp":1718210760000},"page":"116298","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["A multi-analyte assay of opioids in API and drug products using HPLC and HRMS"],"prefix":"10.1016","volume":"248","author":[{"given":"Ilan","family":"Geerlof-Vidavsky","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurie","family":"Balch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Stark","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diem","family":"Ngo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Connie","family":"Gryniewicz-Ruzicka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jpba.2024.116298_bib1","doi-asserted-by":"crossref","first-page":"290","DOI":"10.15585\/mmwr.mm6911a4","article-title":"Drug and opioid-involved overdose deaths \u2014 United States, 2017\u20132018","volume":"69","author":"Wilson","year":"2020","journal-title":"MMWR Morb. Mortal. Wkly Rep."},{"key":"10.1016\/j.jpba.2024.116298_bib2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.15585\/mmwr.rr7103a1","article-title":"CDC clinical practice guideline for prescribing opioids for pain \u2014 United States, 2022","volume":"71","author":"Dowell","year":"2022","journal-title":"MMWR Recomm. Rep."},{"key":"10.1016\/j.jpba.2024.116298_bib3","unstructured":"C.L. Mattson, S. Kumar, L.J. Tanz, P. Patel, Q. Luo, N. Davis, Drug Overdose Deaths in 28 States and the District of Columbia: 2020 Data from the State Unintentional Drug Overdose Reporting System, Centers for Disease Control and Prevention. SUDORS Data Brief, No 1. Atlanta, GA: Centers for Disease Control and Prevention, U.S. Department of Health and Human Services; 2022, \u3008https:\/\/www.cdc.gov\/overdose-prevention\/media\/pdfs\/SUDORS-Data-Brief-1.pdff\u3009 (accessed 22 May 2024)."},{"key":"10.1016\/j.jpba.2024.116298_bib4","unstructured":"U.S. Centers for Disease Control and Prevention, Fentanyl Facts, \u3008https:\/\/www.cdc.gov\/stop-overdose\/caring\/fentanyl-facts.html\u3009 (accessed 22 May 2024)."},{"key":"10.1016\/j.jpba.2024.116298_bib5","unstructured":"U.S. DOJ DEA, 2019 National Drug Threat Assessment, \u3008https:\/\/www.dea.gov\/sites\/default\/files\/2020-01\/2019-NDTA-final-01-14-2020_Low_Web-DIR-007-20_2019.pdf\u3009 (accessed 22 May 2024)."},{"key":"10.1016\/j.jpba.2024.116298_bib6","unstructured":"Centers for Disease Control and Prevention, Opioid Data Analysis and Resources, \u3008https:\/\/www.cdc.gov\/overdose-prevention\/data-research\/facts-stats\/sudors-dashboard-fatal-overdose-data.html\u3009 (accessed 22 May 2024)."},{"key":"10.1016\/j.jpba.2024.116298_bib7","unstructured":"H. Hedegaard, A.M. Mini\u00f1o, M.R. Spencer, M. Warner, Drug Overdose Deaths in the United States, 1999\u20132020, \u3008https:\/\/stacks.cdc.gov\/view\/cdc\/112340\u3009 (accessed 22 May 2024)."},{"key":"10.1016\/j.jpba.2024.116298_bib8","unstructured":"U.S. Food and Drug Administration, Opioid Medication, \u3008https:\/\/www.fda.gov\/drugs\/information-drug-class\/opioid-medications\u3009 (accessed 22 May 2024)."},{"key":"10.1016\/j.jpba.2024.116298_bib9","unstructured":"UN Office on Drugs and Crime, Guidance for the validation of analytical methodology and calibration of equipment used for testing of illicit drugs in seized materials and biological specimens: a commitment to quality and continuous improvement, UNITED NATIONS PUBLICATION, NY 2009, ISBN\/ISSN 978-92-1-148243-0."},{"key":"10.1016\/j.jpba.2024.116298_bib10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jchromb.2015.06.028","article-title":"Development of a multi-analyte assay for the simultaneous detection of opioids in serum and other body fluids using liquid chromatography-tandem mass spectrometry","volume":"1001","author":"Eckart","year":"2015","journal-title":"J. Chromatogr. B"},{"key":"10.1016\/j.jpba.2024.116298_bib11","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/S0731-7085(98)00290-8","article-title":"Peak fronting in reversed-phase high-performance liquid chromatography: a study of the chromatographic behavior of oxycodone hydrochloride","volume":"19","author":"Brogle","year":"1999","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jpba.2024.116298_bib12","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/S1570-0232(02)00244-1","article-title":"Linear regression for calibration lines revisited: weighting schemes for bioanalytical methods","volume":"774","author":"Almeida","year":"2002","journal-title":"J. Chromatogr. B"},{"key":"10.1016\/j.jpba.2024.116298_bib13","unstructured":"Guidelines on performance criteria for methods of analysis for the determination of pesticide residues in food and feed, Codex Alimentarius, Food and Agriculture Organization of the United Nations, World Health Organization, 2017."},{"key":"10.1016\/j.jpba.2024.116298_bib14","unstructured":"Ecological Effects Test Guidelines OCSPP 850.6100: Environmental Chemistry Methods and Associated Independent Laboratory Validation, United States Environmental Protection Agency, 2012. \u3008https:\/\/nepis.epa.gov\/Exe\/ZyPURL.cgi?Dockey=P100IR87.TXT\u3009 (accessed 22 May 2024)."},{"key":"10.1016\/j.jpba.2024.116298_bib15","doi-asserted-by":"crossref","first-page":"2672","DOI":"10.1021\/ac981179n","article-title":"Experimental comparison of the different approaches to estimate LOD and LOQ of an HPLC method","volume":"71","author":"Vial","year":"1999","journal-title":"Anal. Chem."},{"key":"10.1016\/j.jpba.2024.116298_bib16","unstructured":"U.S. Food and Drug Administration, Drug Quality Sampling and Testing Programs, \u3008https:\/\/www.fda.gov\/drugs\/science-and-research-drugs\/drug-quality-sampling-and-testing-programs\u3009 (accessed 22 May 2024)."}],"container-title":["Journal of Pharmaceutical and Biomedical Analysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0731708524003388?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0731708524003388?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,9,20]],"date-time":"2024-09-20T23:45:01Z","timestamp":1726875901000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0731708524003388"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9]]},"references-count":16,"alternative-id":["S0731708524003388"],"URL":"https:\/\/doi.org\/10.1016\/j.jpba.2024.116298","relation":{},"ISSN":["0731-7085"],"issn-type":[{"value":"0731-7085","type":"print"}],"subject":[],"published":{"date-parts":[[2024,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A multi-analyte assay of opioids in API and drug products using HPLC and HRMS","name":"articletitle","label":"Article Title"},{"value":"Journal of Pharmaceutical and Biomedical Analysis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpba.2024.116298","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"116298"}}