{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T17:35:14Z","timestamp":1787679314644,"version":"build-2784847793"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82174098"],"award-info":[{"award-number":["82174098"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81774156"],"award-info":[{"award-number":["81774156"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013088","name":"Jiangsu Provincial Qinglan Project","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013088","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFC2308200"],"award-info":[{"award-number":["2023YFC2308200"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmaceutical and Biomedical Analysis"],"published-print":{"date-parts":[[2024,11]]},"DOI":"10.1016\/j.jpba.2024.116399","type":"journal-article","created":{"date-parts":[[2024,8,6]],"date-time":"2024-08-06T13:25:29Z","timestamp":1722950729000},"page":"116399","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Integrated untargeted and targeted lipidomics discovers LPE 16:0 as a protector against respiratory syncytial virus infection"],"prefix":"10.1016","volume":"250","author":[{"given":"Bin","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zichen","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tong","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianjian","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinjun","family":"Shan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jpba.2024.116399_bib1","doi-asserted-by":"crossref","first-page":"l5021","DOI":"10.1136\/bmj.l5021","article-title":"Respiratory syncytial virus infection in adults","volume":"366","author":"Nam","year":"2019","journal-title":"BMJ"},{"key":"10.1016\/j.jpba.2024.116399_bib2","doi-asserted-by":"crossref","first-page":"2047","DOI":"10.1016\/S0140-6736(22)00478-0","article-title":"Global, regional, and national disease burden estimates of acute lower respiratory infections due to respiratory syncytial virus in children younger than 5 years in 2019: a systematic analysis","volume":"399","author":"Li","year":"2022","journal-title":"Lancet"},{"key":"10.1016\/j.jpba.2024.116399_bib3","doi-asserted-by":"crossref","first-page":"2002688","DOI":"10.1183\/13993003.02688-2020","article-title":"Burden of respiratory syncytial virus infection in community-dwelling older adults in Europe (RESCEU): an international prospective cohort study","volume":"57","author":"Korsten","year":"2021","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.jpba.2024.116399_bib4","article-title":"Licochalcone A plays dual antiviral roles by inhibiting RSV and protecting against host damage","volume":"95","author":"Li","year":"2023","journal-title":"J. Med. Virol."},{"key":"10.1016\/j.jpba.2024.116399_bib5","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.3390\/pathogens12101259","article-title":"Respiratory Syncytial Virus Vaccines: A Review of the Candidates and the Approved Vaccines","volume":"12","author":"Topalidou","year":"2023","journal-title":"Pathogens"},{"key":"10.1016\/j.jpba.2024.116399_bib6","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.1093\/cid\/ciad658","article-title":"Cost-effectiveness of Prefusion F Protein-based Vaccines Against Respiratory Syncytial Virus Disease for Older Adults in the United States","volume":"78","author":"Moghadas","year":"2023","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.jpba.2024.116399_bib7","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.730022","article-title":"Potential therapeutic applications of pulmonary surfactant lipids in the host defence against respiratory viral infections","volume":"12","author":"Ji","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jpba.2024.116399_bib8","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.aca.2020.09.060","article-title":"Recent advances in analytical strategies for mass spectrometry-based lipidomics","volume":"1137","author":"Xu","year":"2020","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.jpba.2024.116399_bib9","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1146\/annurev-pathol-050420-025929","article-title":"Lysophospholipid Mediators in Health and Disease","volume":"17","author":"Kano","year":"2022","journal-title":"Annu. Rev. Pathol."},{"key":"10.1016\/j.jpba.2024.116399_bib10","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202301976R","article-title":"Group III secreted phospholipase A(2) -driven lysophospholipid pathway protects against allergic asthma","volume":"38","author":"Hamu-Tanoue","year":"2024","journal-title":"FASEB J."},{"key":"10.1016\/j.jpba.2024.116399_bib11","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1038\/s41467-023-36575-0","article-title":"Structural basis of lysophosphatidylserine receptor GPR174 ligand recognition and activation","volume":"14","author":"Liang","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jpba.2024.116399_bib12","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1073\/pnas.1525356113","article-title":"S1PR1-mediated IFNAR1 degradation modulates plasmacytoid dendritic cell interferon-alpha autoamplification","volume":"113","author":"Teijaro","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jpba.2024.116399_bib13","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.antiviral.2018.08.010","article-title":"Transient inhibition of sphingosine kinases confers protection to influenza A virus infected mice","volume":"158","author":"Xia","year":"2018","journal-title":"Antivir. Res"},{"key":"10.1016\/j.jpba.2024.116399_bib14","article-title":"Targeting lysophospholipid acid receptor 1 and ROCK kinases promotes antiviral innate immunity","volume":"7","author":"Zhang","year":"2021","journal-title":"Sci. Adv."},{"key":"10.1016\/j.jpba.2024.116399_bib15","doi-asserted-by":"crossref","first-page":"2133","DOI":"10.1194\/jlr.M037077","article-title":"Phosphatidylglycerol provides short-term prophylaxis against respiratory syncytial virus infection","volume":"54","author":"Numata","year":"2013","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.jpba.2024.116399_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.metabol.2022.155181","article-title":"Reduced DMPC and PMPC in lung surfactant promote SARS-CoV-2 infection in obesity","volume":"131","author":"Du","year":"2022","journal-title":"Metabolism"},{"key":"10.1016\/j.jpba.2024.116399_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpba.2023.115677","article-title":"Optimization of bronchoalveolar lavage fluid volume for untargeted lipidomic method and application in influenza A virus infection","volume":"236","author":"Peng","year":"2023","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jpba.2024.116399_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpba.2020.113525","article-title":"Application of untargeted lipidomics based on UHPLC-high resolution tandem MS analysis to profile the lipid metabolic disturbances in the heart of diabetic cardiomyopathy mice","volume":"190","author":"Xu","year":"2020","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jpba.2024.116399_bib19","doi-asserted-by":"crossref","first-page":"182","DOI":"10.3389\/fimmu.2018.00182","article-title":"Respiratory Disease following Viral Lung Infection Alters the Murine Gut Microbiota","volume":"9","author":"Groves","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jpba.2024.116399_bib20","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1250350","article-title":"Novel opportunities from bioimaging to understand the trafficking and maturation of intracellular pulmonary surfactant and its role in lung diseases","volume":"14","author":"Garcia","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jpba.2024.116399_bib21","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1038\/nrm.2017.107","article-title":"Sphingolipids and their metabolism in physiology and disease","volume":"19","author":"Hannun","year":"2018","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.jpba.2024.116399_bib22","doi-asserted-by":"crossref","first-page":"612","DOI":"10.3389\/fmicb.2020.00612","article-title":"Depletion of Host and Viral Sphingomyelin Impairs Influenza Virus Infection","volume":"11","author":"Audi","year":"2020","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.jpba.2024.116399_bib23","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1038\/s41586-020-2732-8","article-title":"Plasticity of ether lipids promotes ferroptosis susceptibility and evasion","volume":"585","author":"Zou","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.jpba.2024.116399_bib24","doi-asserted-by":"crossref","first-page":"2536","DOI":"10.1038\/s41418-021-00769-0","article-title":"Peroxisome-driven ether-linked phospholipids biosynthesis is essential for ferroptosis","volume":"28","author":"Cui","year":"2021","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.jpba.2024.116399_bib25","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1073\/pnas.0909361107","article-title":"Pulmonary surfactant phosphatidylglycerol inhibits respiratory syncytial virus-induced inflammation and infection","volume":"107","author":"Numata","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jpba.2024.116399_bib26","doi-asserted-by":"crossref","first-page":"2133","DOI":"10.1194\/jlr.M037077","article-title":"Phosphatidylglycerol provides short-term prophylaxis against respiratory syncytial virus infection","volume":"54","author":"Numata","year":"2013","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.jpba.2024.116399_bib27","doi-asserted-by":"crossref","first-page":"29368","DOI":"10.1039\/C8RA05640D","article-title":"High-resolution lipidomics reveals dysregulation of lipid metabolism in respiratory syncytial virus pneumonia mice","volume":"8","author":"Shan","year":"2018","journal-title":"Rsc. Adv."},{"key":"10.1016\/j.jpba.2024.116399_bib28","doi-asserted-by":"crossref","first-page":"2927","DOI":"10.3389\/fimmu.2019.02927","article-title":"Lysophosphatidylcholine Induces NLRP3 Inflammasome-Mediated Foam Cell Formation and Pyroptosis in Human Monocytes and Endothelial Cells","volume":"10","author":"Correa","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jpba.2024.116399_bib29","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.jneuroim.2017.07.004","article-title":"Lysophosphatidylcholine activates caspase-1 in microglia via a novel pathway involving two inflammasomes","volume":"310","author":"Scholz","year":"2017","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.jpba.2024.116399_bib30","doi-asserted-by":"crossref","first-page":"219","DOI":"10.4049\/immunohorizons.2100023","article-title":"ATP Release Drives Inflammation with Lysophosphatidylcholine","volume":"5","author":"Ismaeel","year":"2021","journal-title":"Immunohorizons"},{"key":"10.1016\/j.jpba.2024.116399_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbamem.2021.183697","article-title":"Membranotropic and biological activities of the membrane fusion peptides from SARS-CoV spike glycoprotein: The importance of the complete internal fusion peptide domain","volume":"1863","author":"Basso","year":"2021","journal-title":"Biochim. Biophys. Acta Biomembr."},{"key":"10.1016\/j.jpba.2024.116399_bib32","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/j.bbrc.2015.04.042","article-title":"Lysophosphatidylethanolamine increases intracellular Ca(2+) through LPA(1) in PC-12 neuronal cells","volume":"461","author":"Lee","year":"2015","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.jpba.2024.116399_bib33","doi-asserted-by":"crossref","first-page":"4865","DOI":"10.3390\/ijms22094865","article-title":"2-Arachidonyl-lysophosphatidylethanolamine Induces Anti-Inflammatory Effects on Macrophages and in Carrageenan-Induced Paw Edema","volume":"22","author":"Park","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jpba.2024.116399_bib34","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1039\/D2MO00086E","article-title":"Graphene oxide links alterations of anti-viral signaling pathways with lipid metabolism via suppressing TLR3 in vascular smooth muscle cells","volume":"18","author":"Luo","year":"2022","journal-title":"Mol. Omics"}],"container-title":["Journal of Pharmaceutical and Biomedical Analysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0731708524004394?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0731708524004394?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T02:13:42Z","timestamp":1762308822000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0731708524004394"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11]]},"references-count":34,"alternative-id":["S0731708524004394"],"URL":"https:\/\/doi.org\/10.1016\/j.jpba.2024.116399","relation":{},"ISSN":["0731-7085"],"issn-type":[{"value":"0731-7085","type":"print"}],"subject":[],"published":{"date-parts":[[2024,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Integrated untargeted and targeted lipidomics discovers LPE 16:0 as a protector against respiratory syncytial virus infection","name":"articletitle","label":"Article Title"},{"value":"Journal of Pharmaceutical and Biomedical Analysis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpba.2024.116399","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"116399"}}