{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,19]],"date-time":"2026-07-19T08:07:33Z","timestamp":1784448453146,"version":"3.55.0"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100017634","name":"Henan University of Chinese Medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100017634","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21807027"],"award-info":[{"award-number":["21807027"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmaceutical and Biomedical Analysis"],"published-print":{"date-parts":[[2024,11]]},"DOI":"10.1016\/j.jpba.2024.116411","type":"journal-article","created":{"date-parts":[[2024,8,12]],"date-time":"2024-08-12T18:35:18Z","timestamp":1723487718000},"page":"116411","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["A lysosome-located and rhodamine-based fluorescence probe for recognizing hydrogen polysulfide"],"prefix":"10.1016","volume":"250","author":[{"given":"Qiujuan","family":"Ma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanan","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linke","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baiyan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guojiang","family":"Mao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuangyu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gege","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"38","key":"10.1016\/j.jpba.2024.116411_bib1","doi-asserted-by":"crossref","first-page":"12519","DOI":"10.1002\/anie.201807373","article-title":"Supramolecular assemblies with near-infrared emission mediated in two stages by cucurbituril and amphiphilic calixarene for lysosome-targeted cell imaging","volume":"57","author":"Chen","year":"2018","journal-title":"Angew. Chem. Int. Ed. Engl."},{"issue":"9","key":"10.1016\/j.jpba.2024.116411_bib2","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1038\/nrm2745","article-title":"Lysosome biogenesis and lysosomal membrane proteins: trafficking meets function","volume":"10","author":"Saftig","year":"2009","journal-title":"Nat. Rev. Mol. Cell. Biol."},{"issue":"3","key":"10.1016\/j.jpba.2024.116411_bib3","doi-asserted-by":"crossref","first-page":"811","DOI":"10.3390\/ijms21030811","article-title":"Lysosomal abnormalities in cardiovascular disease","volume":"21","author":"Chi","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jpba.2024.116411_bib4","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.conb.2017.09.005","article-title":"Endo-lysosomal dysfunction: a converging mechanism in neurodegenerative diseases, Current Opinion in Neurobiology","volume":"48","author":"Wang","year":"2018","journal-title":"Curr. Opin. Neurobiol."},{"key":"10.1016\/j.jpba.2024.116411_bib5","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2021.619777","article-title":"Synaptic function and dysfunction in lysosomal storage diseases","volume":"15","author":"Rebiai","year":"2021","journal-title":"Front. Cell. Neurosci."},{"issue":"1","key":"10.1016\/j.jpba.2024.116411_bib6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ab.2011.01.044","article-title":"Sulfur signaling: is the agent sulfide or sulfane?","volume":"413","author":"Toohey","year":"2011","journal-title":"Anal. Biochem."},{"issue":"15","key":"10.1016\/j.jpba.2024.116411_bib7","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1089\/ars.2012.5041","article-title":"Polysulfides link H2S to protein thiol oxidation","volume":"19","author":"Greiner","year":"2013","journal-title":"Antioxid. Redox Signal"},{"issue":"10","key":"10.1016\/j.jpba.2024.116411_bib8","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1021\/tx100266a","article-title":"Rapid reaction of hydrogen sulfide with the neutrophil oxidant hypochlorous acid to generate polysulfides","volume":"23","author":"Nagy","year":"2010","journal-title":"Chem. Res. Toxicol."},{"issue":"4","key":"10.1016\/j.jpba.2024.116411_bib9","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1021\/tx2005234","article-title":"Small molecule signaling agents: the integrated chemistry and biochemistry of nitrogen oxides, oxides of carbon, dioxygen, hydrogen sulfide, and their derived species","volume":"25","author":"Fukuto","year":"2012","journal-title":"Chem. Res. Toxicol."},{"issue":"10","key":"10.1016\/j.jpba.2024.116411_bib10","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1089\/ars.2017.7070","article-title":"Fluorescent probes and selective inhibitors for biological studies of hydrogen sulfide-and polysulfide-mediated signaling","volume":"27","author":"Takano","year":"2017","journal-title":"Antioxid. Redox Signal."},{"issue":"11","key":"10.1016\/j.jpba.2024.116411_bib11","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1007\/s00702-016-1600-z","article-title":"Hydrogen polysulfide (H2Sn) signaling along with hydrogen sulfide (H2S) and nitric oxide (NO)","volume":"123","author":"Kimura","year":"2016","journal-title":"J. Neural Transm."},{"issue":"6","key":"10.1016\/j.jpba.2024.116411_bib12","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1021\/ic50112a009","article-title":"Optical spectra and equilibrium distribution of polysulfide ions in aqueous solution at 20\u00b0","volume":"11","author":"Giggenbach","year":"1972","journal-title":"Inorg. Chem."},{"key":"10.1016\/j.jpba.2024.116411_bib13","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1007\/s00604-004-0179-5","article-title":"Electrospray ionization mass spectrometric analysis of aqueous polysulfide solutions","volume":"146","author":"Gun","year":"2004","journal-title":"Microchim. Acta"},{"key":"10.1016\/j.jpba.2024.116411_bib14","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.freeradbiomed.2017.10.346","article-title":"Analysis of endogenous H2S and H2Sn in mouse brain by high-performance liquid chromatography with fluorescence and tandem mass spectrometric detection","volume":"113","author":"Koike","year":"2017","journal-title":"Free Radic. Biol. Med."},{"issue":"32","key":"10.1016\/j.jpba.2024.116411_bib15","doi-asserted-by":"crossref","first-page":"6692","DOI":"10.1039\/C7OB01615H","article-title":"Fluorescent probes for hydrogen polysulfides (H2Sn, n>1): from design rationale to applications","volume":"15","author":"Gupta","year":"2017","journal-title":"Org. Biomol. Chem."},{"issue":"3","key":"10.1016\/j.jpba.2024.116411_bib16","doi-asserted-by":"crossref","first-page":"590","DOI":"10.3390\/antiox12030590","article-title":"Organelle-targeted fluorescent probes for sulfane sulfur species","volume":"12","author":"Roy","year":"2023","journal-title":"Antioxidants"},{"key":"10.1016\/j.jpba.2024.116411_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.talanta.2023.125293","article-title":"Development of fluorescent probes with specific recognition moiety for hydrogen polysulfide","volume":"268","author":"Zhang","year":"2024","journal-title":"Talanta"},{"key":"10.1016\/j.jpba.2024.116411_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.saa.2021.120708","article-title":"A novel lysosome-located fluorescent probe for highly selective determination of hydrogen polysulfides based on a naphthalimide derivative","volume":"268","author":"Tian","year":"2022","journal-title":"Spectrochim. Acta A: Mol. Biomol. Spectrosc."},{"key":"10.1016\/j.jpba.2024.116411_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.dyepig.2019.107877","article-title":"Rational design of a lysosomal-targeted ratiometric two-photon fluorescent probe for imaging hydrogen polysulfides in live cells","volume":"173","author":"Han","year":"2020","journal-title":"Dyes Pigments"},{"issue":"20","key":"10.1016\/j.jpba.2024.116411_bib20","doi-asserted-by":"crossref","first-page":"7638","DOI":"10.1039\/D1QM01043C","article-title":"An easily available lysosomal-targeted ratiometric fluorescent probe with aggregation induced emission characteristics for hydrogen polysulfide visualization in acute ulcerative colitis","volume":"5","author":"Xiang","year":"2021","journal-title":"Mater. Chem. Front."},{"issue":"1","key":"10.1016\/j.jpba.2024.116411_bib21","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1039\/C9BM01616C","article-title":"A new lysosome-targetable fluorescent probe for detection of endogenous hydrogen polysulfides in living cells and inflamed mouse model","volume":"8","author":"Liang","year":"2020","journal-title":"Biomater. Sci."},{"key":"10.1016\/j.jpba.2024.116411_bib22","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.aca.2018.12.051","article-title":"A new lysosome-targetable fluorescent probe with a large Stokes shift for detection of endogenous hydrogen polysulfides in living cells","volume":"1056","author":"Ren","year":"2019","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.jpba.2024.116411_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.talanta.2024.126004","article-title":"Recent progress and outlooks in rhodamine-based fluorescent probes for detection and imaging of reactive oxygen, nitrogen, and sulfur species","volume":"274","author":"Yang","year":"2024","journal-title":"Talanta"},{"key":"10.1016\/j.jpba.2024.116411_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.saa.2022.120962","article-title":"A novel flavone-based ESIPT ratiometric fluorescent probe for selective sensing and imaging of hydrogen polysulfides","volume":"271","author":"Yang","year":"2022","journal-title":"Spectrochim. Acta A: Mol. Biomol. Spectrosc."},{"key":"10.1016\/j.jpba.2024.116411_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.microc.2023.108761","article-title":"A lysosomal localized fluorescence probe for the detection of formaldehyde and its cell imaging","volume":"191","author":"Wang","year":"2023","journal-title":"Microchem. J."},{"key":"10.1016\/j.jpba.2024.116411_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.microc.2023.108449","article-title":"A novel rhodamine-based fluorescent probe for high selectively determining cysteine in lysosomes","volume":"187","author":"Li","year":"2023","journal-title":"Microchem. J."},{"key":"10.1016\/j.jpba.2024.116411_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.saa.2019.117579","article-title":"A highly selective fluorescent probe for hydrogen polysulfides in living cells based on a naphthalene derivative","volume":"227","author":"Wang","year":"2020","journal-title":"Spectrochim. Acta A: Mol. Biomol. Spectrosc."},{"key":"10.1016\/j.jpba.2024.116411_bib28","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.aca.2018.12.051","article-title":"A new lysosome-targetable fluorescent probe with a large Stokes shift for detection of endogenous hydrogen polysulfides in living cells","volume":"1056","author":"Ren","year":"2019","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.jpba.2024.116411_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.snb.2020.128564","article-title":"Two-photon imaging of hydrogen polysulfides in living cells and hippocampal tissues","volume":"322","author":"Chung","year":"2020","journal-title":"Sens. Actuators B: Chem."},{"key":"10.1016\/j.jpba.2024.116411_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.saa.2022.120962","article-title":"A novel flavone-based ESIPT ratiometric fluorescent probe for selective sensing and imaging of hydrogen polysulfides","volume":"271","author":"Yang","year":"2022","journal-title":"Spectrochim. Acta A: Mol. Biomol. Spectrosc."},{"key":"10.1016\/j.jpba.2024.116411_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.saa.2020.118650","article-title":"A FRET-based ratiometric fluorescent probe for highly selective detection of hydrogen polysulfides based on a coumarin-rhodol derivative","volume":"241","author":"Sun","year":"2020","journal-title":"Spectrochim. Acta A: Mol. Biomol.. Spectrosc."},{"issue":"23","key":"10.1016\/j.jpba.2024.116411_bib32","doi-asserted-by":"crossref","first-page":"11892","DOI":"10.1021\/acs.analchem.6b03702","article-title":"Ratiometric two-photon fluorescent probe for in vivo hydrogen polysulfides detection and imaging during lipopolysaccharide-induced acute organs injury","volume":"88","author":"Zhang","year":"2016","journal-title":"Anal. Chem."},{"key":"10.1016\/j.jpba.2024.116411_bib33","doi-asserted-by":"crossref","unstructured":"Molecular engineering of benzenesulfonyl analogs for visual hydrogen polysulfide fluorescent probes based on Nile red skeleton, Spectrochim. Acta A: Mol. Biomol. Spectrosc. 296 (2023) 122658.","DOI":"10.1016\/j.saa.2023.122658"},{"key":"10.1016\/j.jpba.2024.116411_bib34","doi-asserted-by":"crossref","unstructured":"A ratiometric fluorescent probe for monitoring the changes in the level of hydrogen polysulfides in mitochondria during stimulus-induced redox imbalance, Dyes Pigments 188 (2021) 109190.","DOI":"10.1016\/j.dyepig.2021.109190"},{"key":"10.1016\/j.jpba.2024.116411_bib35","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1039\/D0OB02253E","article-title":"A near-infrared fluorescent probe that can image endogenous hydrogen polysulfides in vivo in tumour-bearing mice","volume":"19","author":"Zhang","year":"2021","journal-title":"Org. Biomol. Chem."}],"container-title":["Journal of Pharmaceutical and Biomedical Analysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0731708524004515?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0731708524004515?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T02:13:31Z","timestamp":1762308811000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0731708524004515"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11]]},"references-count":35,"alternative-id":["S0731708524004515"],"URL":"https:\/\/doi.org\/10.1016\/j.jpba.2024.116411","relation":{},"ISSN":["0731-7085"],"issn-type":[{"value":"0731-7085","type":"print"}],"subject":[],"published":{"date-parts":[[2024,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A lysosome-located and rhodamine-based fluorescence probe for recognizing hydrogen polysulfide","name":"articletitle","label":"Article Title"},{"value":"Journal of Pharmaceutical and Biomedical Analysis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpba.2024.116411","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"116411"}}