{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T03:55:41Z","timestamp":1779335741836,"version":"3.51.4"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000928","name":"Welch Foundation","doi-asserted-by":"publisher","award":["Y-0026"],"award-info":[{"award-number":["Y-0026"]}],"id":[{"id":"10.13039\/100000928","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmaceutical and Biomedical Analysis"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1016\/j.jpba.2024.116420","type":"journal-article","created":{"date-parts":[[2024,8,16]],"date-time":"2024-08-16T06:49:53Z","timestamp":1723790993000},"page":"116420","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Chiral superficially porous stationary phases for enantiomeric separation of condensed 1,4-dihydropyridine derivatives"],"prefix":"10.1016","volume":"251","author":[{"given":"Reza","family":"Salehi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siddharth Jaya Sajeevan","family":"J","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryan Jacob","family":"Burk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alain","family":"Berthod","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miyase G\u00f6zde","family":"G\u00fcnd\u00fcz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel W.","family":"Armstrong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jpba.2024.116420_bib1","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1126\/science.3704640","article-title":"Separation of drug stereoisomers by the formation of beta-cyclodextrin inclusion complexes","volume":"232","author":"Armstrong","year":"1986","journal-title":"Science"},{"key":"10.1016\/j.jpba.2024.116420_bib2","unstructured":"Food and Drug Administration, Development of new stereoisomeric drugs, FDA Guidance Documents, May 1992. https:\/\/www.fda.gov\/regulatory-information\/search-fda-guidance-documents\/development-new-stereoisomeric-drugs."},{"key":"10.1016\/j.jpba.2024.116420_bib3","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1021\/ac202892w","article-title":"Chiral separations: a review of current topics and trends","volume":"84","author":"Ward","year":"2012","journal-title":"Anal. Chem."},{"key":"10.1016\/j.jpba.2024.116420_bib4","doi-asserted-by":"crossref","unstructured":"V. Schurig, Differentiation of Enantiomers, Topics in Current Chemistry, 340 & 341, Springer, Heidelberg, 2013. DOI 10.1007\/978-3-319-03716-8.","DOI":"10.1007\/978-3-319-03239-9"},{"key":"10.1016\/j.jpba.2024.116420_bib5","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/0021-9673(93)80142-U","article-title":"Enantiomeric separation of fluorescent 6-aminoquinolyl-N-hydroxysuccinimidyl carbamate, tagged amino acids","volume":"641","author":"Pawlowska","year":"1993","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.jpba.2024.116420_bib6","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1002\/(SICI)1520-636X(1996)8:1<88::AID-CHIR15>3.0.CO;2-O","article-title":"Capillary electrophoretic enantiomeric separations using the glycopeptide antibiotic, teicoplanin","volume":"8","author":"Rundlett","year":"1996","journal-title":"Chirality"},{"key":"10.1016\/j.jpba.2024.116420_bib7","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/S0021-9673(00)00805-0","article-title":"Enantioselective reversed-phase and non-aqueous capillary electrochromatography using a teicoplanin chiral stationary phase","volume":"897","author":"Karlsson","year":"2000","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.jpba.2024.116420_bib8","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/S0021-9673(02)00390-4","article-title":"Effects of temperature on retention of chiral compounds on a ristocetin A chiral stationary phase","volume":"958","author":"P\u00e9ter","year":"2002","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.jpba.2024.116420_bib9","doi-asserted-by":"crossref","first-page":"10215","DOI":"10.1021\/ac902257a","article-title":"Development of new HPLC chiral stationary phases based on native and derivatized cyclofructans","volume":"81","author":"Sung","year":"2009","journal-title":"Anal. Chem."},{"key":"10.1016\/j.jpba.2024.116420_bib10","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1080\/15422119.2017.1326939","article-title":"Chiral stationary phases based on small molecules: an update of the last 17 years","volume":"47","author":"Fernandes","year":"2018","journal-title":"Sep. Purif. Rev."},{"key":"10.1016\/j.jpba.2024.116420_bib11","unstructured":"U. Woiwode, S. Neubauer, M. Kaupert, W. Lindner, M. L\u00e4mmerhofer, Trends in Enantioselective High Performance Liquid Chromatography, LCGC Int. 30 (2017) 34-42."},{"key":"10.1016\/j.jpba.2024.116420_bib12","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1002\/chir.22526","article-title":"Superficially porous particle based hydroxypropyl-\u03b2-cyclodextrin stationary phase for high-efficiency enantiomeric separations","volume":"27","author":"Spudeit","year":"2015","journal-title":"Chirality"},{"key":"10.1016\/j.jpba.2024.116420_bib13","doi-asserted-by":"crossref","first-page":"8821","DOI":"10.1021\/acs.analchem.6b02260","article-title":"Salient sub-second enantioseparations","volume":"88","author":"Wahab","year":"2016","journal-title":"Anal. Chem."},{"key":"10.1016\/j.jpba.2024.116420_bib14","doi-asserted-by":"crossref","first-page":"3545","DOI":"10.1021\/acs.analchem.6b04834","article-title":"Ultrafast chiral chromatography as the second dimension in two-dimensional liquid chromatography experiments","volume":"89","author":"Barhate","year":"2017","journal-title":"Anal. Chem."},{"key":"10.1016\/j.jpba.2024.116420_bib15","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1039\/C6CC08512A","article-title":"Ultrafast chiral separations for high throughput enantiopurity analysis","volume":"53","author":"Barhate","year":"2017","journal-title":"Chem. Comm."},{"key":"10.1016\/j.jpba.2024.116420_bib16","unstructured":"Azyp L.L.C., Chiral phase WhelkoShell, 2024. https:\/\/www.azypusa.com\/chiral-spp\/."},{"key":"10.1016\/j.jpba.2024.116420_bib17","doi-asserted-by":"crossref","first-page":"29253","DOI":"10.1039\/D2RA04589C","article-title":"1,4-Dihydropyridine: synthetic advances, medicinal and insecticidal properties","volume":"12","author":"Makam","year":"2022","journal-title":"RSC Adv."},{"key":"10.1016\/j.jpba.2024.116420_bib18","doi-asserted-by":"crossref","first-page":"6315","DOI":"10.3390\/cimb46070377","article-title":"The EVolving Role of Calcium Channel Blockers in Hypertension Management: Pharmacological and Clinical Considerations","volume":"46","author":"Jones","year":"2024","journal-title":"Curr. Issues Mol. Biol."},{"key":"10.1016\/j.jpba.2024.116420_bib19","unstructured":"F. Bossert, W. Vater, 4-aryl-1,4-Dihydropyridines, US patent 3485847, filled March 14, 1968; granted to Bayer AG on Dec. 23, 1969."},{"key":"10.1016\/j.jpba.2024.116420_bib20","unstructured":"World Health Organization, WHO Model List of Essential Medicines - 22nd list, 2021, Download at: https:\/\/apps.who.int\/iris\/rest\/bitstreams\/1374779\/retrieve, consulted on April 28, 2024."},{"key":"10.1016\/j.jpba.2024.116420_bib21","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1007\/s11030-018-9886-4","article-title":"R. 5-oxo-hexahydroquinoline: an attractive scaffold with diverse biological activities","volume":"23","author":"Ranjbar","year":"2019","journal-title":"Mol. Divers."},{"key":"10.1016\/j.jpba.2024.116420_bib22","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1007\/s00424-013-1376-z","article-title":"Synthesis and evaluation of 1,4-dihydropyridine derivatives with calcium channel blocking activity","volume":"466","author":"Bladen","year":"2014","journal-title":"Pfl\u00fcgers Arch. Eur. J. Physiol."},{"key":"10.1016\/j.jpba.2024.116420_bib23","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1007\/s00424-014-1566-3","article-title":"1,4-Dihydropyridine derivatives with T-type calcium channel blocking activity attenuate inflammatory and neuropathic pain","volume":"467","author":"Bladen","year":"2015","journal-title":"Pfl\u00fcgers Arch. Eur. J. Physiol."},{"key":"10.1016\/j.jpba.2024.116420_bib24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ejmech.2018.05.032","article-title":"Binding mechanism investigations guiding the synthesis of novel condensed 1,4-dihydropyridine derivatives with L-\/T-type calcium channel blocking activity","volume":"155","author":"Schaller","year":"2018","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.jpba.2024.116420_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2022.114787","article-title":"Focusing on C-4 position of Hantzsch 1,4-dihydropyridines: molecular modifications, enantioseparation, and binding mechanism to L- and T-type calcium channels","volume":"244","author":"Akman","year":"2022","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.jpba.2024.116420_bib26","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.curtheres.2010.02.005","article-title":"Tolerability and effectiveness of (S)-amlodipine compared with racemic amlodipine in hypertension: a systematic review and meta-analysis","volume":"71","author":"Liu","year":"2010","journal-title":"Curr. Ther. Res."},{"key":"10.1016\/j.jpba.2024.116420_bib27","doi-asserted-by":"crossref","first-page":"1804","DOI":"10.1021\/acs.analchem.1c04585","article-title":"Enantioselective UHPLC screening combined with in silico modeling for streamlined development of ultrafast enantiopurity assays","volume":"94","author":"Losacco","year":"2022","journal-title":"Anal. Chem."},{"key":"10.1016\/j.jpba.2024.116420_bib28","doi-asserted-by":"crossref","first-page":"729","DOI":"10.2298\/JSC151206035G","article-title":"Synthesis, structural characterization and myorelaxant activity of 4-naphthylhexahydroquinoline derivatives containing different ester groups","volume":"81","author":"G\u00fcnd\u00fcz","year":"2016","journal-title":"J. Serb. Chem. Soc."},{"key":"10.1016\/j.jpba.2024.116420_bib29","unstructured":"S.J. Sajeevan J, R. Salehi, R.J. Burk, A. Berthod, M.G. G\u00fcnd\u00fcz, D.W. Armstrong, Enantiomeric Separation of Fifteen New Hexahydroquinoline Derivatives, J. Sep. Sci. submitted (2024)."},{"key":"10.1016\/j.jpba.2024.116420_bib30","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/0021-9673(94)80367-6","article-title":"Evolution of chiral stationary phase design in the Pirkle laboratory","volume":"666","author":"Welch","year":"1994","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.jpba.2024.116420_bib31","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1016\/j.ejmech.2007.04.012","article-title":"Evaluation of myorelaxant activity of 7-substituted hexahydroquinoline derivatives in isolated rabbit gastric fundus","volume":"43","author":"G\u00fcnd\u00fcz","year":"2008","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.jpba.2024.116420_bib32","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1002\/ddr.21024","article-title":"Synthesis and myorelaxant activity of fused of 1,4-dihydropyridines on isolated rabbit gastric fundus","volume":"73","author":"Safak","year":"2012","journal-title":"Drug Dev. Res."},{"key":"10.1016\/j.jpba.2024.116420_bib33","doi-asserted-by":"crossref","DOI":"10.1149\/1945-7111\/abaa6c","article-title":"Electrochemical studies of newly synthesized 1,4-Dihydropyridine-based hexahydroquinoline derivatives","volume":"167","author":"Tavakkoli","year":"2020","journal-title":"J. Electrochem. Soc."},{"key":"10.1016\/j.jpba.2024.116420_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2019.103187","article-title":"Discovery of Michael acceptor containing 1,4-dihydropyridines as first covalent inhibitors of L-\/T-type calcium channels","volume":"91","author":"Ayg\u00fcn Cevher","year":"2019","journal-title":"Bioorg. Chem."}],"container-title":["Journal of Pharmaceutical and Biomedical Analysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0731708524004606?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0731708524004606?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,3,17]],"date-time":"2025-03-17T06:15:56Z","timestamp":1742192156000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0731708524004606"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":34,"alternative-id":["S0731708524004606"],"URL":"https:\/\/doi.org\/10.1016\/j.jpba.2024.116420","relation":{},"ISSN":["0731-7085"],"issn-type":[{"value":"0731-7085","type":"print"}],"subject":[],"published":{"date-parts":[[2024,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Chiral superficially porous stationary phases for enantiomeric separation of condensed 1,4-dihydropyridine derivatives","name":"articletitle","label":"Article Title"},{"value":"Journal of Pharmaceutical and Biomedical Analysis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpba.2024.116420","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"116420"}}