{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:08:50Z","timestamp":1791418130289,"version":"4.3.3"},"reference-count":16,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmaceutical and Biomedical Analysis"],"published-print":{"date-parts":[[2025,1]]},"DOI":"10.1016\/j.jpba.2024.116486","type":"journal-article","created":{"date-parts":[[2024,9,24]],"date-time":"2024-09-24T16:33:58Z","timestamp":1727195638000},"page":"116486","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Optimized analysis for related substances in spiramycin based on high performance liquid chromatography with hybrid particle column and characterization of its impurities by single heartcut two-dimensional liquid chromatography coupled with quadrupole time-of-flight mass spectrometer"],"prefix":"10.1016","volume":"252","author":[{"given":"Yuan","family":"Yao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinlin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weifeng","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaozuo","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jpba.2024.116486_bib1","doi-asserted-by":"crossref","DOI":"10.2165\/00044011-199815060-00001","article-title":"Efficacy of spiramycin as an alternative to amoxicillin in the treatment of acute upper respiratory tract infections","volume":"15","author":"Bunnag","year":"1998","journal-title":"Clin. Drug Invest."},{"key":"10.1016\/j.jpba.2024.116486_bib2","article-title":"Comparison of spiramycin and clarithromycin for community-acquired lower respiratory tract infections","volume":"53","author":"Rocha","year":"1999","journal-title":"Int. J. Clin. Pract."},{"key":"10.1016\/j.jpba.2024.116486_bib3","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/s12223-017-0544-5","article-title":"Influence of dextrins on the production of spiramycin and impurity components by Streptomyces ambofaciens","volume":"63","author":"Yao","year":"2018","journal-title":"Folia Microbiol."},{"key":"10.1016\/j.jpba.2024.116486_bib4","doi-asserted-by":"crossref","DOI":"10.3390\/molecules27103202","article-title":"Anti-inflammatory effects of spiramycin in LPS-activated RAW 264.7 macrophages","volume":"27","author":"Kang","year":"2022","journal-title":"Molecules"},{"key":"10.1016\/j.jpba.2024.116486_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.actatropica.2022.106508","article-title":"Direct and indirect antiparasitic effects of chloroquine against the virulent RH strain of Toxoplasma gondii: an experimental study","volume":"232","author":"Gamea","year":"2022","journal-title":"Acta Trop."},{"key":"10.1016\/j.jpba.2024.116486_bib6","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0010268","article-title":"The powerful synergistic effect of spiramycin\/propolis loaded chitosan\/alginate nanoparticles on acute murine toxoplasmosis","volume":"16","author":"Hagras","year":"2022","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.jpba.2024.116486_bib7","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1002\/rcm.2868","article-title":"Characterization of impurities in spiramycin by liquid chromatography\/ion trap mass spectrometry","volume":"21","author":"Pendela","year":"2007","journal-title":"Rapid Commun. Mass Spectrom."},{"key":"10.1016\/j.jpba.2024.116486_bib8","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.jpba.2017.10.041","article-title":"Improved liquid chromatographic method for quality control of spiramycin using superficially porous particles","volume":"149","author":"Lin","year":"2018","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jpba.2024.116486_bib10","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.jcis.2013.09.043","article-title":"Preparation and characterization of mesoporous silicas modified with chiral selectors as stationary phase for high-performance liquid chromatography","volume":"414","author":"Perez-Quintanilla","year":"2014","journal-title":"J. Colloid Interface Sci."},{"key":"10.1016\/j.jpba.2024.116486_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.chroma.2022.463013","article-title":"Application of a hybrid zwitterionic hydrophilic interaction liquid chromatography column in metabolic profiling studies","volume":"1672","author":"Lioupi","year":"2022","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.jpba.2024.116486_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpba.2021.113933","article-title":"Identification and structural characterization of potential degraded impurities of ribociclib by time of flight -tandem mass spectrometry, and their toxicity prediction","volume":"197","author":"Sahu","year":"2021","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jpba.2024.116486_bib13","doi-asserted-by":"crossref","DOI":"10.1002\/rcm.8847","article-title":"Impurity profiling of alfentanil hydrochloride by liquid chromatography\/quadrupole time-of-flight high-resolution mass spectrometric techniques for drug enforcement","volume":"34","author":"Wang","year":"2020","journal-title":"Rapid Commun. Mass Spectrom."},{"key":"10.1016\/j.jpba.2024.116486_bib14","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.chroma.2014.04.010","article-title":"Separations by gradient elution: why are steep gradient profiles distorted and what is their impact on resolution in reversed-phase liquid chromatography","volume":"1344","author":"Gritti","year":"2014","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.jpba.2024.116486_bib15","doi-asserted-by":"crossref","first-page":"2631","DOI":"10.1002\/jssc.201100340","article-title":"An improved liquid chromatographic method for the analysis of tylosin and its impurities","volume":"34","author":"Ashenafi","year":"2011","journal-title":"J. Sep. Sci."},{"key":"10.1016\/j.jpba.2024.116486_bib16","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/j.jpba.2006.07.044","article-title":"Development of an enhanced separation of erythromycin and its related substances by liquid chromatography","volume":"43","author":"Deubel","year":"2007","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jpba.2024.116486_bib17","first-page":"275","article-title":"LC-ESI\/MS identification and reduction of impurities in spiramycin fermentation","volume":"21","author":"Li","year":"2005","journal-title":"Sheng Wu Gong\u00a0Cheng Xue Bao"}],"container-title":["Journal of Pharmaceutical and Biomedical Analysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0731708524005284?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0731708524005284?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,11,3]],"date-time":"2024-11-03T19:26:35Z","timestamp":1730661995000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0731708524005284"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":16,"alternative-id":["S0731708524005284"],"URL":"https:\/\/doi.org\/10.1016\/j.jpba.2024.116486","relation":{},"ISSN":["0731-7085"],"issn-type":[{"value":"0731-7085","type":"print"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Optimized analysis for related substances in spiramycin based on high performance liquid chromatography with hybrid particle column and characterization of its impurities by single heartcut two-dimensional liquid chromatography coupled with quadrupole time-of-flight mass spectrometer","name":"articletitle","label":"Article Title"},{"value":"Journal of Pharmaceutical and Biomedical Analysis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpba.2024.116486","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"116486"}}