{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T14:20:25Z","timestamp":1781706025475,"version":"3.54.5"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004731","name":"Zhejiang Province Natural Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmaceutical and Biomedical Analysis"],"published-print":{"date-parts":[[2025,1]]},"DOI":"10.1016\/j.jpba.2024.116521","type":"journal-article","created":{"date-parts":[[2024,10,17]],"date-time":"2024-10-17T06:00:03Z","timestamp":1729144803000},"page":"116521","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Plasma-based proteomic and metabolomic characterization of lung and lymph node metastases in cervical cancer patients"],"prefix":"10.1016","volume":"253","author":[{"given":"Yue","family":"Feng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zijian","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lichao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuomin","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Ni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingkui","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanmei","family":"Lou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojuan","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jpba.2024.116521_bib1","doi-asserted-by":"crossref","first-page":"12571","DOI":"10.3390\/ijms222212571","article-title":"Cervical carcinoma: oncobiology and biomarkers","volume":"22","author":"Volkova","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jpba.2024.116521_bib2","doi-asserted-by":"crossref","first-page":"209","DOI":"10.3322\/caac.21660","article-title":"Global Cancer Statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"71","author":"Sung","year":"2021","journal-title":"Ca. Cancer J. Clin."},{"key":"10.1016\/j.jpba.2024.116521_bib3","doi-asserted-by":"crossref","DOI":"10.3802\/jgo.2016.27.e43","article-title":"Advances in diagnosis and treatment of metastatic cervical cancer","volume":"27","author":"Li","year":"2016","journal-title":"J. Gynecol. Oncol."},{"key":"10.1016\/j.jpba.2024.116521_bib4","doi-asserted-by":"crossref","first-page":"768","DOI":"10.4143\/crt.2017.141","article-title":"Survival nomograms after curative neoadjuvant chemotherapy and radical surgery for stage IB2-IIIB cervical cancer","volume":"50","author":"Marchetti","year":"2018","journal-title":"Cancer Res. Treat."},{"key":"10.1016\/j.jpba.2024.116521_bib5","doi-asserted-by":"crossref","first-page":"1856","DOI":"10.1056\/NEJMoa2112435","article-title":"Pembrolizumab for persistent, re-current, or metastatic cervical cancer","volume":"385","author":"Colombo","year":"2021","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.jpba.2024.116521_bib6","article-title":"The role of miRNAs in the invasion and metastasis of cervical cancer","volume":"39","author":"Wang","year":"2019","journal-title":"Biosci. Rep."},{"key":"10.1016\/j.jpba.2024.116521_bib7","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1128\/MMBR.66.1.39-63.2002","article-title":"Molecular biologist's guide to proteomics","volume":"66","author":"Graves","year":"2002","journal-title":"Mol. Biol. Rev."},{"key":"10.1016\/j.jpba.2024.116521_bib8","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1093\/bfgp\/3.4.382","article-title":"The dynamics of the proteome: strategies for measuring protein turnover on a proteome-wide scale","volume":"3","author":"Beynon","year":"2005","journal-title":"Brief. Funct. Genom. Prote"},{"key":"10.1016\/j.jpba.2024.116521_bib9","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/978-3-319-98758-3_4","article-title":"Metabolomics in systems biology","volume":"1102","author":"Baharum","year":"2018","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.jpba.2024.116521_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpba.2023.115806","article-title":"Plasma metabolomics and proteomics reveal novel molecular insights and biomarker panel for cholelithiasis","volume":"238","author":"Gong","year":"2024","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jpba.2024.116521_bib11","doi-asserted-by":"crossref","DOI":"10.1002\/prca.202300136","article-title":"Proteomic and metabolomic characterization of bone, liver, and lung metastases in plasma of breast cancer patients","author":"Ye","year":"2024","journal-title":"Proteom. Clin. Appl."},{"key":"10.1016\/j.jpba.2024.116521_bib12","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1186\/s12014-022-09387-5","article-title":"LC-MS\/MS based metabolomics and proteomics reveal candidate biomarkers and molecular mechanism of early IgA nephropathy","volume":"19","author":"Zhang","year":"2022","journal-title":"Clin. Proteom."},{"key":"10.1016\/j.jpba.2024.116521_bib13","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1039\/D3MO00142C","article-title":"Integrated proteomic and metabolomic analysis of plasma reveals regulatory pathways and key elements in thyroid cancer","volume":"19","author":"Sun","year":"2023","journal-title":"Mol. Omics."},{"key":"10.1016\/j.jpba.2024.116521_bib14","doi-asserted-by":"crossref","first-page":"511","DOI":"10.3390\/cancers11040511","article-title":"LC\/MS-based polar metabolite profiling identified unique biomarker signatures for cervical cancer and cervical intraepithelial neoplasia using global and targeted metabolomics","volume":"11","author":"Khan","year":"2019","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.jpba.2024.116521_bib15","first-page":"78","article-title":"Tissue-based metabolomics reveals potential biomarkers for cervical carcinoma and HPV infection","volume":"20","author":"Abudula","year":"2020","journal-title":"Bosn. J. Basic. Med. Sci."},{"key":"10.1016\/j.jpba.2024.116521_bib16","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1038\/s41392-020-00443-w","article-title":"Metabolism pathways of arachidonic acids: mechanisms and potential therapeutic targets","volume":"6","author":"Wang","year":"2021","journal-title":"Signal. Transduct. Target. Ther."},{"key":"10.1016\/j.jpba.2024.116521_bib17","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.918775","article-title":"Coagulation and complement: key innate defense participants in a seamless web","volume":"13","author":"Pryzdial","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jpba.2024.116521_bib18","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/bs.acc.2019.01.002","article-title":"Acute phase reactant serum amyloid A in inflammation and other diseases","volume":"90","author":"Zhang","year":"2019","journal-title":"Adv. Clin. Chem."},{"key":"10.1016\/j.jpba.2024.116521_bib19","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1038\/s41568-020-00320-2","article-title":"The metabolism of cancer cells during metastasis","volume":"21","author":"Bergers","year":"2021","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.jpba.2024.116521_bib20","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1038\/s41419-023-05571-z","article-title":"BACH1-induced ferroptosis drives lymphatic metastasis by repressing the biosynthesis of monounsaturated fatty acids","volume":"14","author":"Xie","year":"2023","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.jpba.2024.116521_bib21","doi-asserted-by":"crossref","first-page":"2044","DOI":"10.7150\/ijbs.92274","article-title":"Cholesterol metabolism in tumor microenvironment: cancer hallmarks and therapeutic opportunities","volume":"20","author":"Jiang","year":"2024","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.jpba.2024.116521_bib22","doi-asserted-by":"crossref","first-page":"5103","DOI":"10.1038\/s41467-021-25354-4","article-title":"Dysregulated cholesterol homeostasis results in resistance to ferroptosis increasing tumorigenicity and metastasis in cancer","volume":"12","author":"Liu","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jpba.2024.116521_bib23","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1126\/science.aaf4405","article-title":"Hypoxic control of metastasis","volume":"352","author":"Rankin","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.jpba.2024.116521_bib24","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1007\/s10456-020-09766-2","article-title":"A novel lymphatic pattern promotes metastasis of cervical cancer in a hypoxic tumour-associated macrophage-dependent manner","volume":"24","author":"Chen","year":"2021","journal-title":"Angiogenesis"},{"key":"10.1016\/j.jpba.2024.116521_bib25","article-title":"Prognostic value of complement properdin in cancer","volume":"11","author":"Mangogna","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jpba.2024.116521_bib26","doi-asserted-by":"crossref","first-page":"1538","DOI":"10.1172\/JCI82658","article-title":"Schwann cells induce cancer cell dispersion and invasion","volume":"126","author":"Deborde","year":"2016","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.jpba.2024.116521_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2021.101942","article-title":"Quiescin sulfhydryl oxidase 1 promotes sorafenib-induced ferroptosis in hepatocellular carcinoma by driving EGFR endosomal trafficking and inhibiting NRF2 activation","volume":"41","author":"Sun","year":"2021","journal-title":"Redox Biol."},{"key":"10.1016\/j.jpba.2024.116521_bib28","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1002\/jcla.21503","article-title":"Serum lipid hydroperoxide levels and paraoxonase activity in patients with lung, breast, and colorectal cancer","volume":"26","author":"Balci","year":"2012","journal-title":"J. Clin. Lab. Anal."},{"key":"10.1016\/j.jpba.2024.116521_bib29","doi-asserted-by":"crossref","first-page":"697","DOI":"10.3390\/antiox11040697","article-title":"The relationship between cancer and paraoxonase 1","volume":"11","author":"Medina-Diaz","year":"2022","journal-title":"Antioxid. (Basel)"},{"key":"10.1016\/j.jpba.2024.116521_bib30","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1111\/crj.13182","article-title":"Anti-tumour effects of Keratin 6A in lung adenocarcinoma","volume":"14","author":"Xiao","year":"2020","journal-title":"Clin. Respir. J."}],"container-title":["Journal of Pharmaceutical and Biomedical Analysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0731708524005636?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0731708524005636?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T07:18:20Z","timestamp":1733037500000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0731708524005636"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":30,"alternative-id":["S0731708524005636"],"URL":"https:\/\/doi.org\/10.1016\/j.jpba.2024.116521","relation":{},"ISSN":["0731-7085"],"issn-type":[{"value":"0731-7085","type":"print"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Plasma-based proteomic and metabolomic characterization of lung and lymph node metastases in cervical cancer patients","name":"articletitle","label":"Article Title"},{"value":"Journal of Pharmaceutical and Biomedical Analysis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpba.2024.116521","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"116521"}}