{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T23:47:58Z","timestamp":1792021678999,"version":"4.4.0"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmaceutical and Biomedical Analysis"],"published-print":{"date-parts":[[2025,1]]},"DOI":"10.1016\/j.jpba.2024.116523","type":"journal-article","created":{"date-parts":[[2024,10,16]],"date-time":"2024-10-16T00:57:05Z","timestamp":1729040225000},"page":"116523","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"special_numbering":"C","title":["Low polarity fraction of Radix Bupleuri alleviates chronic unpredictable mild stress-induced depression in rats through FXR modulating bile acid homeostasis in liver, gut, and brain"],"prefix":"10.1016","volume":"253","author":[{"given":"Weiyu","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuheng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuemei","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxia","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jpba.2024.116523_bib1","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/S0140-6736(22)01012-1","article-title":"Depression in young people","volume":"400","author":"Thapar","year":"2022","journal-title":"Lancet"},{"key":"10.1016\/j.jpba.2024.116523_bib2","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1080\/13880209.2023.2228356","article-title":"Effect-enhancing and toxicity-reducing effects of Chaihu Jia Longgu Muli decoction in the treatment of multimorbidity with depression: a systematic review and meta-analysis","volume":"61","author":"Jia","year":"2023","journal-title":"Pharm. Biol."},{"key":"10.1016\/j.jpba.2024.116523_bib3","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-022-27019-8","article-title":"Integrated metabolomics and transcriptomics analysis of roots of Bupleurum chinense and B. scorzonerifolium, two sources of medicinal Chaihu","volume":"12","author":"Wan","year":"2022","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jpba.2024.116523_bib4","doi-asserted-by":"crossref","first-page":"4572","DOI":"10.1002\/ptr.7927","article-title":"Saikosaponins regulate bile acid excretion in mice liver and ileum by activating farnesoid X receptor and bile acid transporter","volume":"37","author":"Wang","year":"2023","journal-title":"Phytother. Res."},{"key":"10.1016\/j.jpba.2024.116523_bib5","article-title":"Dose-effect\/toxicity of bupleuri radix on chronic unpredictable mild stress and normal rats based on liver metabolomics","volume":"12","author":"Wang","year":"2021","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jpba.2024.116523_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2020.112806","article-title":"Multi-omics reveals the mechanisms of antidepressant-like effects of the low polarity fraction of Bupleuri Radix","volume":"256","author":"Feng","year":"2020","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jpba.2024.116523_bib7","doi-asserted-by":"crossref","first-page":"1795","DOI":"10.1016\/j.neuron.2024.02.019","article-title":"TGR5-mediated lateral hypothalamus-dCA3-dorsolateral septum circuit regulates depressive-like behavior in male mice","volume":"112","author":"Li","year":"2024","journal-title":"Neuron"},{"key":"10.1016\/j.jpba.2024.116523_bib8","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1002\/cphy.c120027","article-title":"Bile formation and secretion","author":"Boyer","year":"2013","journal-title":"Compr. Physiol."},{"key":"10.1016\/j.jpba.2024.116523_bib9","doi-asserted-by":"crossref","first-page":"2185","DOI":"10.1080\/09168451.2020.1793658","article-title":"Recent advances in regulating cholesterol and bile acid metabolism","volume":"84","author":"Sato","year":"2020","journal-title":"Biosci. Biotechnol. Biochem."},{"key":"10.1016\/j.jpba.2024.116523_bib10","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1038\/s41579-022-00805-x","article-title":"Bile acids and the gut microbiota: metabolic interactions and impacts on disease","volume":"21","author":"Collins","year":"2023","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.jpba.2024.116523_bib11","doi-asserted-by":"crossref","first-page":"6141","DOI":"10.3748\/wjg.v26.i40.6141","article-title":"Role of gut microbiota via the gut-liver-brain axis in digestive diseases","volume":"26","author":"Ding","year":"2020","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.jpba.2024.116523_bib12","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1038\/s41598-020-79916-5","article-title":"Novel FXR agonist nelumal A suppresses colitis and inflammation-related colorectal carcinogenesis","volume":"11","author":"Miyazaki","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jpba.2024.116523_bib13","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.ebiom.2018.10.030","article-title":"Dysregulated bile acid signaling contributes to the neurological impairment in murine models of acute and chronic liver failure","volume":"37","author":"Xie","year":"2018","journal-title":"EBioMedicine"},{"key":"10.1016\/j.jpba.2024.116523_bib14","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1002\/pmic.202100324","article-title":"The clinical and mechanistic roles of bile acids in depression, Alzheimer\u2019s disease, and stroke","volume":"22","author":"Lirong","year":"2022","journal-title":"Proteomics"},{"key":"10.1016\/j.jpba.2024.116523_bib15","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.bbi.2021.09.021","article-title":"From dried bear bile to molecular investigation: A systematic review of the effect of bile acids on cell apoptosis, oxidative stress and inflammation in the brain, across pre-clinical models of neurological, neurodegenerative and neuropsychiatric disorders","volume":"99","author":"Huang","year":"2022","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.jpba.2024.116523_bib16","first-page":"26","article-title":"TGR5 deficiency in excitatory neurons ameliorates Alzheimer\u2019s pathology by regulating APP processing","volume":"10","author":"Li","year":"2024","journal-title":"Sci. Adv."},{"key":"10.1016\/j.jpba.2024.116523_bib17","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1194\/jlr.R024794","article-title":"Bile acid receptors as targets for the treatment of dyslipidemia and cardiovascular disease","volume":"53","author":"Porez","year":"2012","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.jpba.2024.116523_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.plipres.2021.101094","article-title":"Bile acids and their receptors in metabolic disorders","volume":"82","author":"Fiorucci","year":"2021","journal-title":"Prog. Lipid Res."},{"key":"10.1016\/j.jpba.2024.116523_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.chom.2023.12.009","article-title":"A Gpr35-tuned gut microbe-brain metabolic axis regulates depressive-like behavior","author":"Cheng","year":"2024","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.jpba.2024.116523_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2019.109044","article-title":"Modification effects of SanWei GanJiang Powder on liver and intestinal damage through reversing bile acid homeostasis","volume":"116","author":"Li","year":"2019","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.jpba.2024.116523_bib21","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.apsb.2015.01.004","article-title":"Bile acid nuclear receptor FXR and digestive system diseases","volume":"5","author":"Ding","year":"2015","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.jpba.2024.116523_bib22","doi-asserted-by":"crossref","first-page":"11110","DOI":"10.1074\/jbc.M808747200","article-title":"FGF15\/FGFR4 integrates growth factor signaling with hepatic bile acid metabolism and insulin action","volume":"284","author":"Shin","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jpba.2024.116523_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.clinre.2021.101641","article-title":"Regulatory mechanisms of the bile salt export pump (BSEP\/ABCB11) and its role in related diseases","volume":"45","author":"Ren","year":"2021","journal-title":"Clin. Res. Hepatol. Gastroenterol."},{"key":"10.1016\/j.jpba.2024.116523_bib24","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.1085621","article-title":"Investigating bile acid-mediated cholestatic drug-induced liver injury using a mechanistic model of multidrug resistance protein 3 (MDR3) inhibition","volume":"13","author":"Beaudoin","year":"2023","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jpba.2024.116523_bib25","doi-asserted-by":"crossref","first-page":"401","DOI":"10.3748\/wjg.14.401","article-title":"Role of the intestinal barrier in inflammatory bowel disease","volume":"14","author":"Laukoetter","year":"2008","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.jpba.2024.116523_bib26","doi-asserted-by":"crossref","DOI":"10.1111\/cpr.12696","article-title":"Mechanisms of Panax ginseng action as an antidepressant","volume":"52","author":"Jin","year":"2019","journal-title":"Cell Prolif."},{"key":"10.1016\/j.jpba.2024.116523_bib27","doi-asserted-by":"crossref","first-page":"5795","DOI":"10.1002\/ptr.7237","article-title":"Orcinol glucoside improves the depressive-like behaviors of perimenopausal depression mice through modulating activity of hypothalamic-pituitary-adrenal\/ovary axis and activating BDNF-TrkB-CREB signaling pathway","volume":"35","author":"Li","year":"2021","journal-title":"Phytother. Res."},{"key":"10.1016\/j.jpba.2024.116523_bib28","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/s00253-016-8006-6","article-title":"Interaction of gut microbiota with bile acid metabolism and its influence on disease states","volume":"101","author":"Staley","year":"2017","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"10.1016\/j.jpba.2024.116523_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2022.108238","article-title":"Bile acid metabolism and signaling, the microbiota, and metabolic disease","volume":"237","author":"Cai","year":"2022","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.jpba.2024.116523_bib30","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1093\/ijnp\/pyaa039","article-title":"Farnesoid X receptor-mediated cytoplasmic translocation of CRTC2 disrupts CREB-BDNF signaling in hippocampal CA1 and leads to the development of depression-like behaviors in mice","volume":"23","author":"Hu","year":"2020","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"10.1016\/j.jpba.2024.116523_bib31","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/j.bbi.2018.06.018","article-title":"Neuroprotective effects of INT-777 against A\u03b21-42-induced cognitive impairment, neuroinflammation, apoptosis, and synaptic dysfunction in mice","volume":"73","author":"Wu","year":"2018","journal-title":"Brain. Behav. Immun."},{"key":"10.1016\/j.jpba.2024.116523_bib32","doi-asserted-by":"crossref","first-page":"1795","DOI":"10.1016\/j.neuron.2024.02.019","article-title":"TGR5-mediated lateral hypothalamus-dCA3-dorsolateral septum circuit regulates depressive-like behavior in male mice","volume":"112","author":"Li","year":"2024","journal-title":"Neuron"},{"key":"10.1016\/j.jpba.2024.116523_bib33","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1038\/s12276-021-00677-w","article-title":"Role of the gut\u2013brain axis in energy and glucose metabolism","volume":"54","author":"Wachsmuth","year":"2022","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.jpba.2024.116523_bib34","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1111\/fcp.12367","article-title":"Tauroursodeoxycholic acid produces antidepressant-like effects in a chronic unpredictable stress model of depression via attenuation of neuroinflammation, oxido-nitrosative stress, and endoplasmic reticulum stress","volume":"32","author":"Lu","year":"2018","journal-title":"Fundam. Clin. Pharmacol."}],"container-title":["Journal of Pharmaceutical and Biomedical Analysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S073170852400565X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S073170852400565X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T07:18:17Z","timestamp":1733037497000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S073170852400565X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":34,"alternative-id":["S073170852400565X"],"URL":"https:\/\/doi.org\/10.1016\/j.jpba.2024.116523","relation":{},"ISSN":["0731-7085"],"issn-type":[{"value":"0731-7085","type":"print"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Low polarity fraction of Radix Bupleuri alleviates chronic unpredictable mild stress-induced depression in rats through FXR modulating bile acid homeostasis in liver, gut, and brain","name":"articletitle","label":"Article Title"},{"value":"Journal of Pharmaceutical and Biomedical Analysis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpba.2024.116523","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"116523"}}