{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T19:28:18Z","timestamp":1781983698034,"version":"3.54.5"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["2024-JYB-JBZD-012"],"award-info":[{"award-number":["2024-JYB-JBZD-012"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82172760"],"award-info":[{"award-number":["82172760"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmaceutical and Biomedical Analysis"],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1016\/j.jpba.2025.116731","type":"journal-article","created":{"date-parts":[[2025,2,6]],"date-time":"2025-02-06T12:36:43Z","timestamp":1738845403000},"page":"116731","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Identification of potential drug targets for four site-specific cancers by integrating human plasma proteome with genome"],"prefix":"10.1016","volume":"258","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3422-9140","authenticated-orcid":false,"given":"Zhangjun","family":"Yun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyi","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianru","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaodan","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2921-0821","authenticated-orcid":false,"given":"Li","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jpba.2025.116731_bib1","first-page":"209","article-title":"Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.jpba.2025.116731_bib2","article-title":"Natural compounds targeting glycolysis as promising therapeutics for gastric cancer: a review","volume":"13","author":"Zhao","year":"2022","journal-title":"Front Pharm."},{"key":"10.1016\/j.jpba.2025.116731_bib3","doi-asserted-by":"crossref","first-page":"6581","DOI":"10.1073\/pnas.1701263114","article-title":"Functional proteogenomics reveals biomarkers and therapeutic targets in lymphomas","volume":"114","author":"Rolland","year":"2017","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.jpba.2025.116731_bib4","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1038\/ng.3314","article-title":"The support of human genetic evidence for approved drug indications","volume":"47","author":"Nelson","year":"2015","journal-title":"Nat. Genet"},{"key":"10.1016\/j.jpba.2025.116731_bib5","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1186\/s12967-023-04525-5","article-title":"Proteome-wide mendelian randomization study implicates therapeutic targets in common cancers","volume":"21","author":"Ren","year":"2023","journal-title":"J. Transl. Med"},{"key":"10.1016\/j.jpba.2025.116731_bib6","doi-asserted-by":"crossref","first-page":"2469","DOI":"10.1002\/ijc.33221","article-title":"Genetically predicted levels of circulating cytokines and prostate cancer risk: a Mendelian randomization study","volume":"147","author":"Sun","year":"2020","journal-title":"Int J. Cancer"},{"key":"10.1016\/j.jpba.2025.116731_bib7","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1186\/s13073-023-01229-9","article-title":"Identification of novel protein biomarkers and drug targets for colorectal cancer by integrating human plasma proteome with genome","volume":"15","author":"Sun","year":"2023","journal-title":"Genome Med"},{"key":"10.1016\/j.jpba.2025.116731_bib8","doi-asserted-by":"crossref","DOI":"10.1126\/science.abj1541","article-title":"Mapping the proteo-genomic convergence of human diseases","volume":"374","author":"Pietzner","year":"2021","journal-title":"Science"},{"key":"10.1016\/j.jpba.2025.116731_bib9","doi-asserted-by":"crossref","first-page":"1712","DOI":"10.1038\/s41588-021-00978-w","article-title":"Large-scale integration of the plasma proteome with genetics and disease","volume":"53","author":"Ferkingstad","year":"2021","journal-title":"Nat. Genet"},{"key":"10.1016\/j.jpba.2025.116731_bib10","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1038\/s41586-018-0175-2","article-title":"Genomic atlas of the human plasma proteome","volume":"558","author":"Sun","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.jpba.2025.116731_bib11","article-title":"Genetic regulation of the human plasma proteome in 54,306 UK Biobank participants","author":"Sun","year":"2022","journal-title":"bioRxiv"},{"key":"10.1016\/j.jpba.2025.116731_bib12","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1038\/s42255-020-00287-2","article-title":"Genomic and drug target evaluation of 90 cardiovascular proteins in 30,931 individuals","volume":"2","author":"Folkersen","year":"2020","journal-title":"Nat. Metab."},{"key":"10.1016\/j.jpba.2025.116731_bib13","doi-asserted-by":"crossref","first-page":"3268","DOI":"10.1038\/s41467-018-05512-x","article-title":"Genome-wide mapping of plasma protein QTLs identifies putatively causal genes and pathways for cardiovascular disease","volume":"9","author":"Yao","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jpba.2025.116731_bib14","article-title":"Connecting genetic risk to disease end points through the human blood plasma proteome","volume":"8","author":"Suhre","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jpba.2025.116731_bib15","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1093\/ije\/dyy258","article-title":"Improving the accuracy of two-sample summary-data Mendelian randomization: moving beyond the NOME assumption","volume":"48","author":"Bowden","year":"2019","journal-title":"Int J. Epidemiol."},{"key":"10.1016\/j.jpba.2025.116731_bib16","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1007\/s10654-017-0255-x","article-title":"Interpreting findings from Mendelian randomization using the MR-Egger method","volume":"32","author":"Burgess","year":"2017","journal-title":"Eur. J. Epidemiol."},{"key":"10.1016\/j.jpba.2025.116731_bib17","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1004383","article-title":"Bayesian test for colocalisation between pairs of genetic association studies using summary statistics","volume":"10","author":"Giambartolomei","year":"2014","journal-title":"PLoS Genet"},{"key":"10.1016\/j.jpba.2025.116731_bib18","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1038\/s41586-023-06592-6","article-title":"Plasma proteomic associations with genetics and health in the UK Biobank","volume":"622","author":"Sun","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.jpba.2025.116731_bib19","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1038\/s41467-018-03371-0","article-title":"Integrative analysis of omics summary data reveals putative mechanisms underlying complex traits","volume":"9","author":"Wu","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jpba.2025.116731_bib20","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1038\/ng.3506","article-title":"Integrative approaches for large-scale transcriptome-wide association studies","volume":"48","author":"Gusev","year":"2016","journal-title":"Nat. Genet"},{"key":"10.1016\/j.jpba.2025.116731_bib21","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1186\/s12916-022-02408-y","article-title":"Identification of novel proteins for lacunar stroke by integrating genome-wide association data and human brain proteomes","volume":"20","author":"Zhang","year":"2022","journal-title":"BMC Med."},{"key":"10.1016\/j.jpba.2025.116731_bib22","doi-asserted-by":"crossref","first-page":"252","DOI":"10.3389\/fphar.2015.00252","article-title":"Original insights on thrombospondin-1-related antireceptor strategies in cancer","volume":"6","author":"Jeanne","year":"2015","journal-title":"Front Pharm."},{"key":"10.1016\/j.jpba.2025.116731_bib23","doi-asserted-by":"crossref","first-page":"4893","DOI":"10.7150\/thno.36037","article-title":"CD36 tango in cancer: signaling pathways and functions","volume":"9","author":"Wang","year":"2019","journal-title":"Theranostics"},{"key":"10.1016\/j.jpba.2025.116731_bib24","doi-asserted-by":"crossref","first-page":"1822","DOI":"10.1182\/blood-2013-01-482315","article-title":"Thrombospondin-1 modulates VEGF signaling via CD36 by recruiting SHP-1 to VEGFR2 complex in microvascular endothelial cells","volume":"122","author":"Chu","year":"2013","journal-title":"Blood"},{"key":"10.1016\/j.jpba.2025.116731_bib25","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/j.ejmech.2014.07.110","article-title":"6-(Hetero)Arylpurine nucleotides as inhibitors of the oncogenic target DNPH1: synthesis, structural studies and cytotoxic activities","volume":"85","author":"Amiable","year":"2014","journal-title":"Eur. J. Med Chem."},{"key":"10.1016\/j.jpba.2025.116731_bib26","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1002\/jcb.21884","article-title":"Rcl is a novel ETV1\/ER81 target gene upregulated in breast tumors","volume":"105","author":"Shin","year":"2008","journal-title":"J. Cell Biochem"},{"key":"10.1016\/j.jpba.2025.116731_bib27","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1186\/s13058-014-0458-y","article-title":"Tumor-expressed adrenomedullin accelerates breast cancer bone metastasis","volume":"16","author":"Siclari","year":"2014","journal-title":"Breast Cancer Res"},{"key":"10.1016\/j.jpba.2025.116731_bib28","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.1248\/bpb.b18-00423","article-title":"Sema4A Responds to Hypoxia and Is Involved in Breast Cancer Progression","volume":"41","author":"Liu","year":"2018","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.jpba.2025.116731_bib29","doi-asserted-by":"crossref","DOI":"10.1042\/BSR20201054","article-title":"Prognostic value of immune checkpoint molecules in breast cancer","volume":"40","author":"Fang","year":"2020","journal-title":"Biosci. Rep."},{"key":"10.1016\/j.jpba.2025.116731_bib30","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1158\/1535-7163.MCT-16-0685","article-title":"Targeting insulin receptor in breast cancer using small engineered protein scaffolds","volume":"16","author":"Chan","year":"2017","journal-title":"Mol. Cancer Ther."},{"key":"10.1016\/j.jpba.2025.116731_bib31","doi-asserted-by":"crossref","first-page":"4592","DOI":"10.1158\/0008-5472.CAN-18-3997","article-title":"Analysis of Over 140,000 European Descendants Identifies Genetically Predicted Blood Protein Biomarkers Associated with Prostate Cancer Risk","volume":"79","author":"Wu","year":"2019","journal-title":"Cancer Res"},{"key":"10.1016\/j.jpba.2025.116731_bib32","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.eururo.2020.07.038","article-title":"Two-stage study of familial prostate cancer by whole-exome sequencing and custom capture identifies 10 novel genes associated with the risk of prostate cancer","volume":"79","author":"Schaid","year":"2021","journal-title":"Eur. Urol."},{"key":"10.1016\/j.jpba.2025.116731_bib33","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1002\/tox.22623","article-title":"Quercetin induced cell apoptosis and altered gene expression in AGS human gastric cancer cells","volume":"33","author":"Shang","year":"2018","journal-title":"Environ. Toxicol."},{"key":"10.1016\/j.jpba.2025.116731_bib34","doi-asserted-by":"crossref","DOI":"10.3390\/cancers13143582","article-title":"Allele-specific microRNA-mediated regulation of a glycolysis gatekeeper PDK1 in cancer metabolism","volume":"13","author":"Subramaniam","year":"2021","journal-title":"Cancers"}],"container-title":["Journal of Pharmaceutical and Biomedical Analysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S073170852500072X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S073170852500072X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T15:46:33Z","timestamp":1763999193000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S073170852500072X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":34,"alternative-id":["S073170852500072X"],"URL":"https:\/\/doi.org\/10.1016\/j.jpba.2025.116731","relation":{},"ISSN":["0731-7085"],"issn-type":[{"value":"0731-7085","type":"print"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Identification of potential drug targets for four site-specific cancers by integrating human plasma proteome with genome","name":"articletitle","label":"Article Title"},{"value":"Journal of Pharmaceutical and Biomedical Analysis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpba.2025.116731","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"116731"}}