{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T04:35:56Z","timestamp":1783485356884,"version":"3.55.0"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004515","name":"The National University of Malaysia","doi-asserted-by":"publisher","award":["DIP-2023-019"],"award-info":[{"award-number":["DIP-2023-019"]}],"id":[{"id":"10.13039\/501100004515","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004515","name":"The National University of Malaysia","doi-asserted-by":"publisher","award":["GUP-2023-06"],"award-info":[{"award-number":["GUP-2023-06"]}],"id":[{"id":"10.13039\/501100004515","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmaceutical and Biomedical Analysis"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1016\/j.jpba.2025.116806","type":"journal-article","created":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T12:44:46Z","timestamp":1741783486000},"page":"116806","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Deciphering the mechanism of Annona muricata leaf extract in alloxan-nicotinamide-induced diabetic rat model with 1H-NMR-based metabolomics approach"],"prefix":"10.1016","volume":"260","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-6357-8034","authenticated-orcid":false,"given":"Siti Norliyana","family":"Zubaidi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei Lou","family":"Wong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wasim S.M.","family":"Qadi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esraa Adnan Dawoud","family":"Dawoud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2169-5000","authenticated-orcid":false,"given":"Hamizah Shahirah","family":"Hamezah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Syarul Nataqain","family":"Baharum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0870-8444","authenticated-orcid":false,"given":"Faidruz Azura","family":"Jam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faridah","family":"Abas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5096-7506","authenticated-orcid":false,"given":"Andres","family":"Moreno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6892-1995","authenticated-orcid":false,"given":"Ahmed","family":"Mediani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jpba.2025.116806_bib1","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/B978-0-444-53480-4.00015-1","article-title":"General aspects of diabetes mellitus","volume":"126","author":"Alam","year":"2014","journal-title":"Handb. Clin. Neurol."},{"key":"10.1016\/j.jpba.2025.116806_bib2","first-page":"73","article-title":"Diabetic kidney disease; review of the current knowledge","volume":"2","author":"Shahbazian","year":"2013","journal-title":"J. Ren. Inj. Prev."},{"key":"10.1016\/j.jpba.2025.116806_bib3","doi-asserted-by":"crossref","first-page":"634","DOI":"10.3390\/biology10070634","article-title":"Bioactivity of medicinal plants and extracts","volume":"10","author":"Les","year":"2021","journal-title":"Biology"},{"key":"10.1016\/j.jpba.2025.116806_bib4","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/347673","article-title":"Distribution of phenolic contents, antidiabetic potentials, antihypertensive properties, and antioxidative effects of soursop (Annona muricata L.) fruit parts in vitro","volume":"2015","author":"Adefegha","year":"2015","journal-title":"Biochem. Res. Int."},{"key":"10.1016\/j.jpba.2025.116806_bib5","doi-asserted-by":"crossref","first-page":"401","DOI":"10.26656\/fr.2017.5(1).410","article-title":"Antioxidant activities and simultaneous HPLC-DAD profiling of polyphenolic compounds from Moringa oleifera Lam. leaves grown in Bangladesh","volume":"5","author":"Ahmed","year":"2021","journal-title":"Food Res."},{"issue":"1","key":"10.1016\/j.jpba.2025.116806_bib6","first-page":"5","article-title":"Validation of analytical procedures: text and methodology","volume":"2","author":"Guideline","year":"2005","journal-title":"Q"},{"key":"10.1016\/j.jpba.2025.116806_bib7","article-title":"Breadfruit leaves extract (Artocarpus altilis) effect on pancreatic damage in diabetic type II animal model induced by alloxan\u2013nicotinamide","volume":"3","author":"Sari","year":"2020","journal-title":"Med. Cl. \u00ednica Pr. \u00e1ctica"},{"key":"10.1016\/j.jpba.2025.116806_bib8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s12010-020-03304-y","article-title":"Urinary metabolomics and biochemical analysis of antihyperglycemic effect of Ficus deltoidea Jack varieties in streptozotocin-nicotinamide\u2013induced diabetic rats","volume":"192","author":"Mohammad Noor","year":"2020","journal-title":"Appl. Biochem. Biotechnol."},{"key":"10.1016\/j.jpba.2025.116806_bib9","doi-asserted-by":"crossref","DOI":"10.3389\/fnut.2023.1192131","article-title":"Flavonoids improve type 2 diabetes mellitus and its complications: A review","volume":"10","author":"Yi","year":"2023","journal-title":"Front. Nutr."},{"key":"10.1016\/j.jpba.2025.116806_bib10","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1007\/s43450-020-00012-w","article-title":"Secondary metabolites and biological properties of Annona muricata","volume":"30","author":"Calzada","year":"2020","journal-title":"Rev. Bras. Farmacogn."},{"key":"10.1016\/j.jpba.2025.116806_bib11","doi-asserted-by":"crossref","first-page":"9835","DOI":"10.1021\/jf2015717","article-title":"Interaction of cinnamic acid derivatives with commercial hypoglycemic drugs on 2-deoxyglucose uptake in 3T3-L1 adipocytes","volume":"59","author":"Prabhakar","year":"2011","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.jpba.2025.116806_bib12","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.ceca.2019.03.009","article-title":"Astragalin augments basal calcium influx and insulin secretion in rat pancreatic islets","volume":"80","author":"Rey","year":"2019","journal-title":"Cell Calcium"},{"key":"10.1016\/j.jpba.2025.116806_bib13","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.biopha.2016.09.039","article-title":"Antidiabetic and antihyperlipidemic activity of p-coumaric acid in diabetic rats, role of pancreatic GLUT 2: In vivo approach","volume":"84","author":"Amalan","year":"2016","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.jpba.2025.116806_bib14","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1080\/13880209.2021.1961823","article-title":"Kaempferol-induced GPER upregulation attenuates atherosclerosis via the PI3K\/AKT\/Nrf2 pathway","volume":"59","author":"Feng","year":"2021","journal-title":"Pharm. Biol."},{"key":"10.1016\/j.jpba.2025.116806_bib15","article-title":"Mechanisms of kaempferol in the treatment of diabetes: A comprehensive and latest review","volume":"13","author":"Yang","year":"2022","journal-title":"Front. Endocrinol. (Lausanne)."},{"key":"10.1016\/j.jpba.2025.116806_bib16","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2022.1042044","article-title":"Chlorogenic acid improves glucose tolerance, lipid metabolism, inflammation and microbiota composition in diabetic db\/db mice","volume":"13","author":"Yan","year":"2022","journal-title":"Front. Endocrinol. (Lausanne)."},{"key":"10.1016\/j.jpba.2025.116806_bib17","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.vascn.2015.11.004","article-title":"Experimental diabetes induced by alloxan and streptozotocin: The current state of the art","volume":"78","author":"Radenkovi\u0107","year":"2016","journal-title":"J. Pharmacol. Toxicol. Methods"},{"key":"10.1016\/j.jpba.2025.116806_bib18","first-page":"58","article-title":"Model of streptozotocin-nicotinamide Induced Type 2 diabetes: a comparative review","volume":"18","author":"Rais","year":"2022","journal-title":"Curr. Diabetes Rev."},{"key":"10.1016\/j.jpba.2025.116806_bib19","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0170971","article-title":"Appropriate insulin level in selecting fortified diet-fed, streptozotocin-treated rat model of type 2 diabetes for anti-diabetic studies","volume":"12","author":"Okoduwa","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.jpba.2025.116806_bib20","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/j.ejphar.2010.08.059","article-title":"Antihyperglycaemic, antilipid peroxidative and antioxidant effects of gallic acid on streptozotocin induced diabetic Wistar rats","volume":"650","author":"Punithavathi","year":"2011","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.jpba.2025.116806_bib21","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1186\/s12882-023-03110-8","article-title":"The level of serum albumin is associated with renal prognosis and renal function decline in patients with chronic kidney disease","volume":"24","author":"Cheng","year":"2023","journal-title":"BMC Nephrol."},{"key":"10.1016\/j.jpba.2025.116806_bib22","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1111\/bcpt.12656","article-title":"Toxicity of atorvastatin on pancreas mitochondria: a justification for increased risk of diabetes mellitus","volume":"120","author":"Sadighara","year":"2017","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"key":"10.1016\/j.jpba.2025.116806_bib23","doi-asserted-by":"crossref","first-page":"3823","DOI":"10.1038\/s41598-023-45608-z","article-title":"1H NMR metabolomics insights into comparative diabesity in male and female zebrafish and the antidiabetic activity of DL-limonene","volume":"14","author":"Benchoula","year":"2024","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jpba.2025.116806_bib24","doi-asserted-by":"crossref","first-page":"106","DOI":"10.24018\/ejbio.2021.2.2.178","article-title":"Blood glucose \u2013 lowering potentials of Annona muricata leaf extract in alloxan \u2013 induced diabetic rats","volume":"2","author":"Opara","year":"2021","journal-title":"Eur. J. Biol. Biotechnol."},{"key":"10.1016\/j.jpba.2025.116806_bib25","doi-asserted-by":"crossref","first-page":"688","DOI":"10.3390\/toxics11080688","article-title":"Assessing the acute toxicological effects of Annona muricata leaf ethanol extract on rats: biochemical, histopathological, and metabolomics analyses","volume":"11","author":"Zubaidi","year":"2023","journal-title":"Toxics"},{"key":"10.1016\/j.jpba.2025.116806_bib26","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1038\/s41574-019-0242-2","article-title":"Understanding the glucoregulatory mechanisms of metformin in type 2 diabetes mellitus","volume":"15","author":"Foretz","year":"2019","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.jpba.2025.116806_bib27","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1038\/aps.2016.172","article-title":"LY333531, a PKC\u03b2 inhibitor, attenuates glomerular endothelial cell apoptosis in the early stage of mouse diabetic nephropathy via down-regulating swiprosin-1","volume":"38","author":"Wang","year":"2017","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.jpba.2025.116806_bib28","doi-asserted-by":"crossref","first-page":"539","DOI":"10.3390\/life13020539","article-title":"The mechanism of hyperglycemia-induced renal cell injury in diabetic nephropathy disease: an update","volume":"13","author":"Wu","year":"2023","journal-title":"Life"},{"key":"10.1016\/j.jpba.2025.116806_bib29","doi-asserted-by":"crossref","first-page":"164","DOI":"10.2337\/diacare.28.1.164","article-title":"Diabetic nephropathy: diagnosis, prevention, and treatment","volume":"28","author":"Gross","year":"2005","journal-title":"Diabetes Care"},{"key":"10.1016\/j.jpba.2025.116806_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2021.e08075","article-title":"Urinary metabolites of type 2 diabetes rats fed with palm oil-enriched high fat diet","volume":"7","author":"Sim","year":"2021","journal-title":"Heliyon"},{"key":"10.1016\/j.jpba.2025.116806_bib31","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2015.00022","article-title":"Lactate is always the end product of glycolysis","volume":"9","author":"Rogatzki","year":"2015","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.jpba.2025.116806_bib32","doi-asserted-by":"crossref","DOI":"10.1111\/acel.13039","article-title":"Metformin blunts muscle hypertrophy in response to progressive resistance exercise training in older adults: a randomized, double-blind, placebo-controlled, multicenter trial: The MASTERS trial","volume":"18","author":"Walton","year":"2019","journal-title":"Aging Cell"},{"key":"10.1016\/j.jpba.2025.116806_bib33","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1258\/ebm.2012.011372","article-title":"Streptozotocin\u2013nicotinamide-induced diabetes in the rat. Characteristics of the experimental model","volume":"237","author":"Szkudelski","year":"2012","journal-title":"Exp. Biol. Med."},{"key":"10.1016\/j.jpba.2025.116806_bib34","doi-asserted-by":"crossref","first-page":"10275","DOI":"10.3390\/ijms221910275","article-title":"Metabolomic approaches to investigate the effect of metformin: an overview","volume":"22","author":"Kim","year":"2021","journal-title":"Int. J. Mol. Sci."}],"container-title":["Journal of Pharmaceutical and Biomedical Analysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0731708525001475?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0731708525001475?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T22:46:49Z","timestamp":1778539609000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0731708525001475"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":34,"alternative-id":["S0731708525001475"],"URL":"https:\/\/doi.org\/10.1016\/j.jpba.2025.116806","relation":{},"ISSN":["0731-7085"],"issn-type":[{"value":"0731-7085","type":"print"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Deciphering the mechanism of Annona muricata leaf extract in alloxan-nicotinamide-induced diabetic rat model with 1H-NMR-based metabolomics approach","name":"articletitle","label":"Article Title"},{"value":"Journal of Pharmaceutical and Biomedical Analysis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpba.2025.116806","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"116806"}}