{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T21:39:24Z","timestamp":1791841164286,"version":"4.3.4"},"reference-count":15,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100013061","name":"Jilin Scientific and Technological Development Program","doi-asserted-by":"publisher","award":["20210204207YY"],"award-info":[{"award-number":["20210204207YY"]}],"id":[{"id":"10.13039\/501100013061","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmaceutical and Biomedical Analysis"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1016\/j.jpba.2025.116814","type":"journal-article","created":{"date-parts":[[2025,3,10]],"date-time":"2025-03-10T12:54:17Z","timestamp":1741611257000},"page":"116814","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["GC and HPLC-RID method development and validation for the determination of twelve related substances, including several novel compounds in tetrabenazine"],"prefix":"10.1016","volume":"260","author":[{"given":"Dong-shuo","family":"Meng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guo-jing","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shen-guo","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun-xin","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tian-quan","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2608-6941","authenticated-orcid":false,"given":"Yu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jpba.2025.116814_bib1","first-page":"583","article-title":"Huntington's disease: a tutorial review","volume":"41","author":"Burgunder","year":"2015","journal-title":"Chin. J. Nerv. Ment. Dis."},{"key":"10.1016\/j.jpba.2025.116814_bib2","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1007\/BF00194305","article-title":"The epidemiology of Huntington's disease","volume":"89","author":"Harper","year":"1992","journal-title":"Hum. Genet."},{"key":"10.1016\/j.jpba.2025.116814_bib3","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1002\/mds.25075","article-title":"The incidence and prevalence of Huntington's disease: a systematic review and meta-analysis","volume":"27","author":"Pringsheim","year":"2012","journal-title":"Mov. Disord."},{"key":"10.1016\/j.jpba.2025.116814_bib4","first-page":"80","article-title":"Tetrabenazine (Xenazine)","volume":"19","author":"Liu","year":"2009","journal-title":"Chin. J. Med. Chem."},{"key":"10.1016\/j.jpba.2025.116814_bib5","unstructured":"CDE, N.M.P.A. Notice on the Release of the First Batch of Overseas New Drugs Urgently Needed in Clinical Settings. \u3008https:\/\/www.cde.org.cn\/main\/news\/viewInfoCommon\/21de8acd6c395746b041b2ad93eb5c43\u3009."},{"key":"10.1016\/j.jpba.2025.116814_bib6","first-page":"193","article-title":"Synthetic process improvement of tetrabenazine","volume":"51","author":"Li","year":"2020","journal-title":"Chin. J. Pharm."},{"key":"10.1016\/j.jpba.2025.116814_bib7","first-page":"120","article-title":"Determination of related substances in tetrabenazine by HPLC-UV","volume":"52","author":"Xu","year":"2021","journal-title":"Chin. J. Pharm."},{"key":"10.1016\/j.jpba.2025.116814_bib8","first-page":"102","article-title":"Mannich reactions of aromaitic aldehydes with aromatic amines and aromatic ketones","volume":"21","author":"Xiao","year":"2000","journal-title":"J. Chongqing Univ. Nat. Sci. Ed."},{"key":"10.1016\/j.jpba.2025.116814_bib9","first-page":"17","article-title":"Preparation and structure confirmation of the related substances of tetrabenazine","volume":"31","author":"Li","year":"2021","journal-title":"Chin. J. Med. Chem."},{"key":"10.1016\/j.jpba.2025.116814_bib10","first-page":"e46","article-title":"Quantitative study of impurities in bedaquiline fumarate and identification, characterization of its three degradation products using HPLC, LC\/ESI\u2013MS, and NMR analyses","author":"Zhang","year":"2023","journal-title":"Pharm. Fronts 5"},{"key":"10.1016\/j.jpba.2025.116814_bib11","unstructured":"ICH Q2(R2), Validation of Analytical Procedures\uff0e \u3008https:\/\/www\u3009\uff0ecde\uff0eorg\uff0ecn\/ichWeb\/guideIch\/toGuideIch\/1\/0. (Accessed 19 October 2024)."},{"key":"10.1016\/j.jpba.2025.116814_bib12","unstructured":"L. Ding, Drug Chromatography Analysis. People's Medical Publishing House, Beijing, 2008."},{"key":"10.1016\/j.jpba.2025.116814_bib13","first-page":"46","article-title":"Simultaneous determination of low-molecular-weight carbonyl compounds in oil-containing herbs by HPLC coupled with pro-column derivatization","volume":"20","author":"Xing","year":"2013","journal-title":"Chin. J. Inf. Tradit. Chin. Med."},{"key":"10.1016\/j.jpba.2025.116814_bib14","unstructured":"FDA, Labels for NDA 021894. \u3008https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2017\/021894s013lbl.pdf\u3009. (Accessed 19 October 2024)."},{"key":"10.1016\/j.jpba.2025.116814_bib15","unstructured":"ICH M7, Assessment and Control of DNA Reactive (Mutagenic) Impurities in Pharmaceuticals to Limit Potential Carcinogenic Risk\uff0e \u3008https:\/\/www\u3009\uff0ecde\uff0eorg\uff0ecn\/ichWeb\/guideIch\/toGuideIch\/1\/0. (Accessed 19 October 2024)."}],"container-title":["Journal of Pharmaceutical and Biomedical Analysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0731708525001554?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0731708525001554?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T02:14:10Z","timestamp":1762308850000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0731708525001554"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":15,"alternative-id":["S0731708525001554"],"URL":"https:\/\/doi.org\/10.1016\/j.jpba.2025.116814","relation":{},"ISSN":["0731-7085"],"issn-type":[{"value":"0731-7085","type":"print"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"GC and HPLC-RID method development and validation for the determination of twelve related substances, including several novel compounds in tetrabenazine","name":"articletitle","label":"Article Title"},{"value":"Journal of Pharmaceutical and Biomedical Analysis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpba.2025.116814","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"116814"}}