{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T11:38:23Z","timestamp":1788349103463,"version":"build-2803163510"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,3,26]],"date-time":"2025-03-26T00:00:00Z","timestamp":1742947200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmaceutical and Biomedical Analysis"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1016\/j.jpba.2025.116838","type":"journal-article","created":{"date-parts":[[2025,3,29]],"date-time":"2025-03-29T18:21:04Z","timestamp":1743272464000},"page":"116838","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Simultaneous analysis of various anticancer drugs by supercritical fluid chromatography-mass spectrometry. Part I: Optimization of chromatographic separation"],"prefix":"10.1016","volume":"261","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-3755-5747","authenticated-orcid":false,"given":"Nathalie","family":"Nguyen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7883-5823","authenticated-orcid":false,"given":"Davy","family":"Guillarme","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4180-5417","authenticated-orcid":false,"given":"Serge","family":"Rudaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascal","family":"Bonnabry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandrine","family":"Fleury-Souverain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jpba.2025.116838_bib1","doi-asserted-by":"crossref","first-page":"354","DOI":"10.3322\/canjclin.56.6.354","article-title":"Preventing occupational exposures to antineoplastic drugs in health care settings","volume":"56","author":"Connor","year":"2006","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.jpba.2025.116838_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpba.2022.115034","article-title":"Development and application of a liquid chromatography coupled to mass spectrometry method for the simultaneous determination of 23 antineoplastic drugs at trace levels","volume":"221","author":"Fleury-Souverain","year":"2022","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jpba.2025.116838_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2023.121944","article-title":"Antineoplastic drugs in urban wastewater: occurrence, nanofiltration treatment and toxicity screening","volume":"332","author":"Gouveia","year":"2023","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.jpba.2025.116838_bib4","doi-asserted-by":"crossref","first-page":"3737","DOI":"10.3390\/ijerph19063737","article-title":"Exposure to antineoplastic drugs in occupational settings: a systematic review of biological monitoring data","volume":"19","author":"Leso","year":"2022","journal-title":"Int. J. Environ. Res. Public. Health"},{"key":"10.1016\/j.jpba.2025.116838_bib5","doi-asserted-by":"crossref","first-page":"4952","DOI":"10.3390\/ijerph20064952","article-title":"Occupational exposure to antineoplastic drugs in twelve french health care setting: biological monitoring and surface contamination","volume":"20","author":"Ndaw","year":"2023","journal-title":"Int. J. Environ. Res. Public. Health"},{"key":"10.1016\/j.jpba.2025.116838_bib6","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1248\/bpb.b16-00760","article-title":"A novel analytical method of cisplatin using the HPLC with a naphthylethyl group bonded with silica gel (\u03c0NAP) column","volume":"40","author":"Kato","year":"2017","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.jpba.2025.116838_bib7","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.3390\/ph14121317","article-title":"Azacitidine omega-3 self-assemblies: synthesis, characterization, and potent applications for myelodysplastic syndromes","volume":"14","author":"Baroud","year":"2021","journal-title":"Pharmaceuticals"},{"key":"10.1016\/j.jpba.2025.116838_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.chroma.2020.461684","article-title":"Application of chiral and achiral supercritical fluid chromatography in pesticide analysis: a review","volume":"1634","author":"Deng","year":"2020","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.jpba.2025.116838_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.trac.2021.116486","article-title":"Supercritical fluid chromatography for pharmaceutical quality control: current challenges and perspectives","volume":"146","author":"Jambo","year":"2022","journal-title":"Trends Anal. Chem."},{"key":"10.1016\/j.jpba.2025.116838_bib10","doi-asserted-by":"crossref","DOI":"10.1002\/bmc.5035","article-title":"Application of supercritical fluid chromatography for separation and quantitation of 15 co-formulated binary anti-hypertensive medications using a single elution protocol","volume":"35","author":"Pandya","year":"2021","journal-title":"Biomed. Chromatogr."},{"key":"10.1016\/j.jpba.2025.116838_bib11","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.chroma.2015.02.031","article-title":"Accurate analysis of ginkgolides and their hydrolyzed metabolites by analytical supercritical fluid chromatography hybrid tandem mass spectrometry","volume":"1388","author":"Liu","year":"2015","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.jpba.2025.116838_bib12","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.jpba.2015.03.007","article-title":"Supercritical fluid chromatography in pharmaceutical analysis","volume":"113","author":"Desfontaine","year":"2015","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jpba.2025.116838_bib13","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.chroma.2014.12.083","article-title":"The many faces of packed column supercritical fluid chromatography \u2013 a critical review","volume":"1382","author":"Lesellier","year":"2015","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.jpba.2025.116838_bib14","doi-asserted-by":"crossref","first-page":"3803","DOI":"10.1002\/jssc.201500658","article-title":"Simultaneous quantitation of two diastereoisomers of lobaplatin in rat plasma by supercritical fluid chromatography with tandem mass spectrometry and its application to a pharmacokinetic study","volume":"38","author":"Meng","year":"2015","journal-title":"J. Sep. Sci."},{"key":"10.1016\/j.jpba.2025.116838_bib15","doi-asserted-by":"crossref","first-page":"3856","DOI":"10.1021\/ac062441s","article-title":"Supercritical fluid chromatography and high-performance liquid chromatography\/tandem mass spectrometric methods for the determination of cytarabine in mouse plasma","volume":"79","author":"Hsieh","year":"2007","journal-title":"Anal. Chem."},{"key":"10.1016\/j.jpba.2025.116838_bib16","doi-asserted-by":"crossref","first-page":"342","DOI":"10.3390\/molecules19010342","article-title":"Development of a supercritical fluid chromatography-tandem mass spectrometry method for the determination of azacitidine in rat plasma and its application to a bioavailability study","volume":"19","author":"Li","year":"2013","journal-title":"Molecules"},{"key":"10.1016\/j.jpba.2025.116838_bib17","doi-asserted-by":"crossref","first-page":"3003","DOI":"10.1039\/C7AY00779E","article-title":"Supercritical fluid (CO2) chromatography for quantitative determination of selected cancer therapeutic drugs in the presence of potential impurities in injection formulations","volume":"9","author":"Ganipisetty","year":"2017","journal-title":"Anal. Methods"},{"key":"10.1016\/j.jpba.2025.116838_bib18","article-title":"Supercritical fluid (CO2) chromatography for quantitative determination of selected cancer therapeutic drugs in the presence of potential impurities","volume":"7","author":"Ganipisetty","year":"2014","journal-title":"Anal. Methods"},{"key":"10.1016\/j.jpba.2025.116838_bib19","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.aca.2016.05.051","article-title":"Enantioselective simultaneous analysis of selected pharmaceuticals in environmental samples by ultrahigh performance supercritical fluid based chromatography tandem mass spectrometry","volume":"934","author":"Camacho-Mu\u00f1oz","year":"2016","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.jpba.2025.116838_bib20","doi-asserted-by":"crossref","first-page":"3914","DOI":"10.1002\/jssc.201700536","article-title":"Supercritical fluid chromatography coupled with tandem mass spectrometry: a high-efficiency detection technique to quantify Taxane drugs in whole-blood samples","volume":"40","author":"Jin","year":"2017","journal-title":"J. Sep. Sci."},{"key":"10.1016\/j.jpba.2025.116838_bib21","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1002\/bms.1200190604","article-title":"Supercritical fluid chromatography\/chemical ionization\/mass spectrometry of some anticancer drugs in a thermospray ion source","volume":"19","author":"Musser","year":"1990","journal-title":"Biomed. Environ. Mass Spectrom."},{"key":"10.1016\/j.jpba.2025.116838_bib22","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.jchromb.2018.03.010","article-title":"What are the current solutions for interfacing supercritical fluid chromatography and mass spectrometry?","volume":"1083","author":"Guillarme","year":"2018","journal-title":"J. Chromatogr. B Anal. Technol. Biomed. Life. Sci."},{"key":"10.1016\/j.jpba.2025.116838_bib23","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1136\/ejhpharm-2019-001983","article-title":"Wipe-sampling procedure optimisation for the determination of 23 antineoplastic drugs used in the hospital pharmacy","volume":"28","author":"Guichard","year":"2021","journal-title":"Eur. J. Hosp. Pharm. Sci. Pract."},{"key":"10.1016\/j.jpba.2025.116838_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.trac.2021.116464","article-title":"Effect of water addition to super\/sub-critical fluid mobile-phases for achiral and chiral separations","volume":"145","author":"Roy","year":"2021","journal-title":"Trends Anal. Chem."},{"key":"10.1016\/j.jpba.2025.116838_bib25","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1002\/jssc.200301672","article-title":"Elution and preliminary structure-retention modeling of polar and ionic substances in supercritical fluid chromatography using volatile ammonium salts as mobile phase additives","volume":"27","author":"Pinkston","year":"2004","journal-title":"J. Sep. Sci."},{"key":"10.1016\/j.jpba.2025.116838_bib26","doi-asserted-by":"crossref","DOI":"10.1002\/jssc.202300431","article-title":"Columns in analytical-scale supercritical fluid chromatography: from traditional to unconventional chemistries","volume":"46","author":"Plachk\u00e1","year":"2023","journal-title":"J. Sep. Sci."},{"key":"10.1016\/j.jpba.2025.116838_bib27","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.chroma.2018.05.055","article-title":"Applicability of supercritical fluid chromatography \u2013 mass spectrometry to metabolomics. I \u2013 optimization of separation conditions for the simultaneous analysis of hydrophilic and lipophilic substances","volume":"1562","author":"Desfontaine","year":"2018","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.jpba.2025.116838_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.chroma.2022.463667","article-title":"Defining a generic column set for achiral supercritical fluid chromatography applied to pharmaceuticals or natural products","volume":"1687","author":"Gros","year":"2023","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.jpba.2025.116838_bib29","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.chroma.2014.07.078","article-title":"Evaluation of stationary phases packed with superficially porous particles for the analysis of pharmaceutical compounds using supercritical fluid chromatography","volume":"1360","author":"Perrenoud","year":"2014","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.jpba.2025.116838_bib30","doi-asserted-by":"crossref","first-page":"3145","DOI":"10.1007\/s00216-017-0255-4","article-title":"Signal Enhancement in the HPLC-ESI-MS\/MS analysis of spironolactone and its metabolites using HFIP and NH4F as eluent additives","volume":"409","author":"Takkis","year":"2017","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.jpba.2025.116838_bib31","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.chroma.2015.05.010","article-title":"Ammonium fluoride as a mobile phase additive in aqueous normal phase chromatography","volume":"1401","author":"Pesek","year":"2015","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.jpba.2025.116838_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.chroma.2020.461048","article-title":"Systematic investigations of peak distortions due to additives in supercritical fluid chromatography","volume":"1621","author":"Glenne","year":"2020","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.jpba.2025.116838_bib33","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.jpba.2016.10.016","article-title":"Investigation of the effect of mobile phase composition on selectivity using a solvent-triangle based approach in achiral SFC","volume":"132","author":"Muscat Galea","year":"2017","journal-title":"J. Pharm. Biomed. Anal."}],"container-title":["Journal of Pharmaceutical and Biomedical Analysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0731708525001797?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0731708525001797?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,4,14]],"date-time":"2025-04-14T19:49:56Z","timestamp":1744660196000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0731708525001797"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":33,"alternative-id":["S0731708525001797"],"URL":"https:\/\/doi.org\/10.1016\/j.jpba.2025.116838","relation":{},"ISSN":["0731-7085"],"issn-type":[{"value":"0731-7085","type":"print"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Simultaneous analysis of various anticancer drugs by supercritical fluid chromatography-mass spectrometry. Part I: Optimization of chromatographic separation","name":"articletitle","label":"Article Title"},{"value":"Journal of Pharmaceutical and Biomedical Analysis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpba.2025.116838","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"116838"}}