{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T02:37:11Z","timestamp":1755225431728,"version":"3.43.0"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,6,5]],"date-time":"2025-06-05T00:00:00Z","timestamp":1749081600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003748","name":"Swedish Society for Medical Research","doi-asserted-by":"publisher","award":["S17\\u20130092"],"award-info":[{"award-number":["S17\\u20130092"]}],"id":[{"id":"10.13039\/501100003748","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Swedish Research Council","doi-asserted-by":"publisher","award":["2021\\u201301628","2020\\u201302367","2024\\u201303166"],"award-info":[{"award-number":["2021\\u201301628","2020\\u201302367","2024\\u201303166"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016408","name":"Goran Gustafsson's Foundations","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016408","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012538","name":"Swedish Cancer Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012538","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002794","name":"Swedish Cancer Society","doi-asserted-by":"publisher","award":["243519Pj01H","21 1634 Pj 01\\u2009H","23 2776 Pj"],"award-info":[{"award-number":["243519Pj01H","21 1634 Pj 01\\u2009H","23 2776 Pj"]}],"id":[{"id":"10.13039\/501100002794","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmaceutical and Biomedical Analysis"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.jpba.2025.117012","type":"journal-article","created":{"date-parts":[[2025,6,5]],"date-time":"2025-06-05T21:02:01Z","timestamp":1749157321000},"page":"117012","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Mapping the polar metabolome in Huh-7 liver cancer cells reveal the role of atorvastatin in enhancing chemotherapeutic efficacy of doxorubicin"],"prefix":"10.1016","volume":"265","author":[{"given":"Maria","family":"Kopsida","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lotta","family":"Regtop","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans","family":"Lennern\u00e4s","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mikael","family":"Hedeland","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Femke","family":"Heindryckx","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mikael K.R.","family":"Engskog","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jpba.2025.117012_bib1","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1186\/s12935-018-0538-7","article-title":"Resistance a major hindrance to chemotherapy in hepatocellular carcinoma: an insight","volume":"18","author":"Lohitesh","year":"2018","journal-title":"Cancer Cell Int"},{"key":"10.1016\/j.jpba.2025.117012_bib2","doi-asserted-by":"crossref","first-page":"13051","DOI":"10.3390\/ijms222313051","article-title":"Limitations and Possibilities of Transarterial Chemotherapeutic Treatment of Hepatocellular Carcinoma","volume":"22","author":"Ebeling Barbier","year":"2021","journal-title":"Int J. Mol. Sci."},{"key":"10.1016\/j.jpba.2025.117012_bib3","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.tibs.2010.05.003","article-title":"Glutamine addiction: a new therapeutic target in cancer","volume":"35","author":"Wise","year":"2010","journal-title":"Trends Biochem Sci."},{"key":"10.1016\/j.jpba.2025.117012_bib4","doi-asserted-by":"crossref","first-page":"7463","DOI":"10.3390\/ijms24087463","article-title":"Metabolic Reprogramming of HCC: A New Microenvironment for Immune Responses","volume":"24","author":"Foglia","year":"2023","journal-title":"Int J. Mol. Sci."},{"key":"10.1016\/j.jpba.2025.117012_bib5","doi-asserted-by":"crossref","DOI":"10.1001\/archneurol.2010.199","article-title":"3-Hydroxy-3-methylglutaryl\u2013Coenzyme A Reductase Inhibitors in the Treatment of Central Nervous System Diseases","volume":"67","author":"Willey","year":"2010","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.jpba.2025.117012_bib6","doi-asserted-by":"crossref","first-page":"2259","DOI":"10.1038\/s41598-020-58264-4","article-title":"Nuclear Translocation of Glutaminase GLS2 in Human Cancer Cells Associates with Proliferation Arrest and Differentiation","volume":"10","author":"L\u00f3pez de la Oliva","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jpba.2025.117012_bib7","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1016\/j.tcb.2020.02.005","article-title":"Nitrogen Metabolism in Cancer and Immunity","volume":"30","author":"Kurmi","year":"2020","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.jpba.2025.117012_bib8","doi-asserted-by":"crossref","first-page":"659","DOI":"10.3390\/cells12040659","article-title":"Doxorubicin\u2014An Agent with Multiple Mechanisms of Anticancer Activity","volume":"12","author":"Kciuk","year":"2023","journal-title":"Cells"},{"key":"10.1016\/j.jpba.2025.117012_bib9","doi-asserted-by":"crossref","first-page":"268","DOI":"10.3390\/metabo10070268","article-title":"Metabolic Signatures of Tumor Responses to Doxorubicin Elucidated by Metabolic Profiling in Ovo","volume":"10","author":"Achkar","year":"2020","journal-title":"Metabolites"},{"key":"10.1016\/j.jpba.2025.117012_bib10","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.ejca.2022.11.025","article-title":"Metabolic switch in cancer \u2013 Survival of the fittest","volume":"180","author":"Raskov","year":"2023","journal-title":"Eur. J. Cancer"},{"key":"10.1016\/j.jpba.2025.117012_bib11","doi-asserted-by":"crossref","first-page":"802","DOI":"10.3390\/ph16060802","article-title":"Recent Advances in Doxorubicin Formulation to Enhance Pharmacokinetics and Tumor Targeting","volume":"16","author":"Lee","year":"2023","journal-title":"Pharmaceuticals"},{"key":"10.1016\/j.jpba.2025.117012_bib12","doi-asserted-by":"crossref","first-page":"4787","DOI":"10.3390\/cancers15194787","article-title":"Unraveling the Anticancer Potential of Statins: Mechanisms and Clinical Significance","volume":"15","author":"Zaky","year":"2023","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.jpba.2025.117012_bib13","doi-asserted-by":"crossref","first-page":"16067","DOI":"10.3390\/ijms160716067","article-title":"Mevalonate Pathway Blockade, Mitochondrial Dysfunction and Autophagy: A Possible Link","volume":"16","author":"Tricarico","year":"2015","journal-title":"Int J. Mol. Sci."},{"key":"10.1016\/j.jpba.2025.117012_bib14","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2022.1074911","article-title":"PPAR\u03b1: An emerging target of metabolic syndrome, neurodegenerative and cardiovascular diseases","volume":"13","author":"Lin","year":"2022","journal-title":"Front Endocrinol. (Lausanne)"},{"key":"10.1016\/j.jpba.2025.117012_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2024.110680","article-title":"Longitudinal cohort study highlights cancer-preventive benefits of lipid-lowering drugs","volume":"27","author":"Yuan","year":"2024","journal-title":"IScience"},{"key":"10.1016\/j.jpba.2025.117012_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2021.173919","article-title":"Synergistic potential of dual andrographolide and melatonin targeting of metastatic colon cancer cells: Using the Chou-Talalay combination index method","volume":"897","author":"Banerjee","year":"2021","journal-title":"Eur. J. Pharm."},{"key":"10.1016\/j.jpba.2025.117012_bib17","doi-asserted-by":"crossref","first-page":"3675","DOI":"10.1038\/s41467-024-48009-6","article-title":"MetaboAnalystR 4.0: a unified LC-MS workflow for global metabolomics","volume":"15","author":"Pang","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jpba.2025.117012_bib18","doi-asserted-by":"crossref","first-page":"D622","DOI":"10.1093\/nar\/gkab1062","article-title":"HMDB 5.0: the Human Metabolome Database for 2022","volume":"50","author":"Wishart","year":"2022","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.jpba.2025.117012_bib19","doi-asserted-by":"crossref","first-page":"D478","DOI":"10.1093\/nar\/gkt1067","article-title":"SMPDB 2.0: Big Improvements to the Small Molecule Pathway Database","volume":"42","author":"Jewison","year":"2014","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.jpba.2025.117012_bib20","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1007\/s11306-014-0656-8","article-title":"Metabolite identification: are you sure? And how do your peers gauge your confidence?","volume":"10","author":"Creek","year":"2014","journal-title":"Metabolomics"},{"key":"10.1016\/j.jpba.2025.117012_bib21","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1021\/acs.molpharmaceut.6b00886","article-title":"In Vivo Drug Delivery Performance of Lipiodol-Based Emulsion or Drug-Eluting Beads in Patients with Hepatocellular Carcinoma","volume":"14","author":"Lilienberg","year":"2017","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.jpba.2025.117012_bib22","doi-asserted-by":"crossref","first-page":"648","DOI":"10.3390\/ph15060648","article-title":"Novel Effects of Statins on Cancer via Autophagy","volume":"15","author":"Mengual","year":"2022","journal-title":"Pharmaceuticals"},{"key":"10.1016\/j.jpba.2025.117012_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.molmet.2023.101846","article-title":"Inhibiting the endoplasmic reticulum stress response enhances the effect of doxorubicin by altering the lipid metabolism of liver cancer cells","volume":"79","author":"Kopsida","year":"2024","journal-title":"Mol. Metab."},{"key":"10.1016\/j.jpba.2025.117012_bib24","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-019-49484-4","article-title":"Pre-treatment with the CDK4\/6 inhibitor palbociclib improves the efficacy of paclitaxel in TNBC cells","volume":"9","author":"Cretella","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jpba.2025.117012_bib25","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.3390\/cells10071717","article-title":"In Vitro Cell Toxicity and Intracellular Uptake of Doxorubicin Exposed as a Solution or Liposomes: Implications for Treatment of Hepatocellular Carcinoma","volume":"10","author":"Kullenberg","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.jpba.2025.117012_bib26","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.cmet.2022.01.007","article-title":"The hallmarks of cancer metabolism: Still emerging","volume":"34","author":"Pavlova","year":"2022","journal-title":"Cell Metab."},{"key":"10.1016\/j.jpba.2025.117012_bib27","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1186\/s13046-018-0872-6","article-title":"Liver cancer cell lines distinctly mimic the metabolic gene expression pattern of the corresponding human tumours","volume":"37","author":"Nwosu","year":"2018","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1016\/j.jpba.2025.117012_bib28","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1186\/s12964-022-00981-6","article-title":"Elevation of spermine remodels immunosuppressive microenvironment through driving the modification of PD-L1 in hepatocellular carcinoma","volume":"20","author":"Shi","year":"2022","journal-title":"Cell Commun. Signal."},{"key":"10.1016\/j.jpba.2025.117012_bib29","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1007\/s10456-017-9567-4","article-title":"A new key player in VEGF-dependent angiogenesis in human hepatocellular carcinoma: dimethylarginine dimethylaminohydrolase 1","volume":"20","author":"Buijs","year":"2017","journal-title":"Angiogenesis"},{"key":"10.1016\/j.jpba.2025.117012_bib30","doi-asserted-by":"crossref","DOI":"10.1002\/ctm2.686","article-title":"Protein arginine methyltransferase 3 promotes glycolysis and hepatocellular carcinoma growth by enhancing arginine methylation of lactate dehydrogenase A","volume":"12","author":"Lei","year":"2022","journal-title":"Clin. Transl. Med"},{"key":"10.1016\/j.jpba.2025.117012_bib31","doi-asserted-by":"crossref","first-page":"617","DOI":"10.4251\/wjgo.v15.i4.617","article-title":"Lipid metabolism of hepatocellular carcinoma impacts targeted therapy and immunotherapy","volume":"15","author":"Feng","year":"2023","journal-title":"World J. Gastrointest. Oncol."},{"key":"10.1016\/j.jpba.2025.117012_bib32","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1186\/s40170-023-00328-w","article-title":"A HIF-1\u03b1 inhibitor combined with palmitic acid and L-carnitine treatment can prevent the fat metabolic reprogramming under hypoxia and induce apoptosis in hepatocellular carcinoma cells","volume":"11","author":"Matsufuji","year":"2023","journal-title":"Cancer Metab."},{"key":"10.1016\/j.jpba.2025.117012_bib33","doi-asserted-by":"crossref","first-page":"36","DOI":"10.3390\/metabo9020036","article-title":"Function, Detection and Alteration of Acylcarnitine Metabolism in Hepatocellular Carcinoma","volume":"9","author":"Li","year":"2019","journal-title":"Metabolites"},{"key":"10.1016\/j.jpba.2025.117012_bib34","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/j.jhep.2022.11.017","article-title":"Decreased propionyl-CoA metabolism facilitates metabolic reprogramming and promotes hepatocellular carcinoma","volume":"78","author":"Sun","year":"2023","journal-title":"J. Hepatol."},{"key":"10.1016\/j.jpba.2025.117012_bib35","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2022\/9394381","article-title":"A Meta-Analysis of Statin Use and Risk of Hepatocellular Carcinoma","volume":"2022","author":"Wang","year":"2022","journal-title":"Can. J. Gastroenterol. Hepatol."}],"container-title":["Journal of Pharmaceutical and Biomedical Analysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S073170852500353X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S073170852500353X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,8,13]],"date-time":"2025-08-13T11:30:21Z","timestamp":1755084621000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S073170852500353X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":35,"alternative-id":["S073170852500353X"],"URL":"https:\/\/doi.org\/10.1016\/j.jpba.2025.117012","relation":{},"ISSN":["0731-7085"],"issn-type":[{"type":"print","value":"0731-7085"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mapping the polar metabolome in Huh-7 liver cancer cells reveal the role of atorvastatin in enhancing chemotherapeutic efficacy of doxorubicin","name":"articletitle","label":"Article Title"},{"value":"Journal of Pharmaceutical and Biomedical Analysis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpba.2025.117012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"117012"}}