{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T21:02:05Z","timestamp":1789333325150,"version":"build-2803163510"},"reference-count":22,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"name":"zhejiang provincial natural science foundation of china"},{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["LTGC23H230001"],"award-info":[{"award-number":["LTGC23H230001"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["LTGC24B050007"],"award-info":[{"award-number":["LTGC24B050007"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmaceutical and Biomedical Analysis"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.jpba.2025.117023","type":"journal-article","created":{"date-parts":[[2025,6,16]],"date-time":"2025-06-16T08:10:05Z","timestamp":1750061405000},"page":"117023","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Leveraging mass spectrometry fragmentation patterns for accelerated screening and structural elucidation of new etomidate analogues in suspect samples"],"prefix":"10.1016","volume":"265","author":[{"given":"Yilei","family":"Fan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianxin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing","family":"Ke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"9","key":"10.1016\/j.jpba.2025.117023_bib1","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1093\/jat\/bkae080","article-title":"Detection of \u201csmoke powder\u201d etomidate and its metabolite etomidate acid in blood and urine by UHPLC-MS-MS: application in authentic cases","volume":"48","author":"Zhou","year":"2024","journal-title":"J. Anal. Toxicol."},{"issue":"6","key":"10.1016\/j.jpba.2025.117023_bib2","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1213\/ANE.0b013e31828b3637","article-title":"Carboetomidate: an analog of etomidate that interacts weakly with 11\u03b2-Hydroxylase","volume":"116","author":"Shanmugasundararaj","year":"2013","journal-title":"Anesth. Analg."},{"issue":"1","key":"10.1016\/j.jpba.2025.117023_bib3","first-page":"30","article-title":"Determination of etomidate and etomidate acid in human hair by high performance liquid chromotography tandem mass spectroscopy","volume":"2","author":"Y","year":"2024","journal-title":"Labor. Prax."},{"key":"10.1016\/j.jpba.2025.117023_bib4","article-title":"Identification and characterization of etomidate and metomidate metabolites in zebrafish, HLMs and S9 fraction by quadrupole-orbitrap LC-MS\/MS for drug control","author":"Zhong","year":"2025","journal-title":"J. Chromatogr. B 250"},{"key":"10.1016\/j.jpba.2025.117023_bib5","unstructured":"Office of National Narcotics Control Commission, China Drug Situation Report 2023 Office of National Narcotics Control Comission. \u3008http:\/\/us.china-embassy.gov.cn\/eng\/zggs\/202406\/t20240620_11438701.htm\u3009, 2024 (Accessed 20 May 2025)."},{"key":"10.1016\/j.jpba.2025.117023_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.talanta.2023.124816","article-title":"Identification of new psychoactive substances and their metabolites using non-targeted detection with high-resolution mass spectrometry through diagnosing fragment ions\/neutral loss analysis","volume":"265","author":"Matey","year":"2023","journal-title":"Talanta"},{"issue":"1","key":"10.1016\/j.jpba.2025.117023_bib7","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1080\/15563650.2024.2423834","article-title":"A recent increasing occurrence of etomidate and propoxate\/isopropoxate misuse","volume":"63","author":"Cheung","year":"2024","journal-title":"Clin. Toxicol."},{"key":"10.1016\/j.jpba.2025.117023_bib8","unstructured":"United Nations Office on Drugs and Crime, April 2025 \u2013 Increasing range of drugs and new psychoactive substances found in vaping products. \u3008https:\/\/www.unodc.org\/LSS\/Announcement\/Details\/8afbc6e8-9439-4ed8-8117-30d80173590a\u3009, 2025 (Accessed 20 May 2025)."},{"key":"10.1016\/j.jpba.2025.117023_bib9","unstructured":"United Nations Office on Drugs and Crime, March 2025 - Increasing detections of etomidate and analogues on illicit drug markets is becoming a global concern. \u3008https:\/\/www.unodc.org\/LSS\/Announcement\/Details\/8774c132-4b30-477c-9ceb-46ce384223fd\u3009, 2025 (Accessed 20 May 2025)."},{"issue":"1","key":"10.1016\/j.jpba.2025.117023_bib10","first-page":"16","article-title":"1H-qNMR for the quantification of etomidate in suspicious samples","volume":"44","author":"Liu","year":"2025","journal-title":"Chin. J. Anal. Lab."},{"key":"10.1016\/j.jpba.2025.117023_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.talanta.2023.124257","article-title":"New trends of new psychoactive substances (NPS)-infused chocolate: identification and quantification of trace level of NPS in complex matrix by GC-MS and NMR","volume":"255","author":"Song","year":"2023","journal-title":"Talanta"},{"key":"10.1016\/j.jpba.2025.117023_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.jchromb.2024.124340","article-title":"Characterization of etomidate and emerging analogs in human hair using UHPLC-MS\/MS and confirmation in real forensic cases","volume":"1247","author":"Pei","year":"2024","journal-title":"J. Chromatogr. B"},{"key":"10.1016\/j.jpba.2025.117023_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.vascn.2023.107490","article-title":"A highly efficient liquid chromatography-tandem mass spectrometry (LC-MS\/MS) assay for etomidate and etomidate acid in urine, liver and kidney","volume":"125","author":"He","year":"2024","journal-title":"J. Pharmacol. Toxicol. Methods"},{"key":"10.1016\/j.jpba.2025.117023_bib14","first-page":"1","article-title":"Metabolic profile of etomidate and its three analogs in zebrafish, human liver microsomes, human urine and hair samples using UHPLC-Q exactive Orbitrap-HRMS","volume":"0","author":"Tang","year":"2025","journal-title":"Drug Test. Anal."},{"issue":"4","key":"10.1016\/j.jpba.2025.117023_bib15","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1021\/jasms.4c00049","article-title":"Identification of unique fragmentation patterns of fentanyl analog protomers using structures for lossless ion manipulations ion mobility-orbitrap mass spectrometry","volume":"35","author":"Hollerbach","year":"2024","journal-title":"J. Am. Soc. Mass Spectr."},{"issue":"18","key":"10.1016\/j.jpba.2025.117023_bib16","doi-asserted-by":"crossref","first-page":"6510","DOI":"10.3390\/molecules28186510","article-title":"Study on the mass spectrometry fragmentation patterns for rapid screening and structure identification of ketamine analogues in illicit powders","volume":"28","author":"Fan","year":"2023","journal-title":"Molecules"},{"key":"10.1016\/j.jpba.2025.117023_bib17","first-page":"1030","article-title":"Analysis on electron impact fragmentation characteristics of inda\u2043zole-3-carboxamide analogues synthetic cannabinoids","volume":"41","author":"Xu","year":"2022","journal-title":"J. Instrum. Anal."},{"key":"10.1016\/j.jpba.2025.117023_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpba.2025.116677","article-title":"Rapid determination of etomidate and its structural analogues in e-liquid byprobe electrospray ionization quadrupole time-of-flight mass spectrometry","volume":"256","author":"Lin","year":"2025","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jpba.2025.117023_bib19","doi-asserted-by":"crossref","first-page":"884","DOI":"10.3390\/toxics12120884","article-title":"Rapid screening of etomidate and its analogs in seized e-liquids using thermal desorption electrospray ionization coupled with triple quadrupole mass spectrometry","volume":"12","author":"Li","year":"2024","journal-title":"Toxics"},{"issue":"2","key":"10.1016\/j.jpba.2025.117023_bib20","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1080\/15563650.2019.1661425","article-title":"Synthetic cannabinoid receptor agonists: classification and nomenclature","volume":"58","author":"Potts","year":"2020","journal-title":"Clin. Toxicol."},{"key":"10.1016\/j.jpba.2025.117023_bib21","first-page":"557","article-title":"High resolution mass spectrometry fragmentation rules of etomidate and its structural analogues","volume":"40","author":"Fan","year":"2024","journal-title":"J. Forensic Med."},{"key":"10.1016\/j.jpba.2025.117023_bib22","doi-asserted-by":"crossref","unstructured":"X.L. Zhang, Y.X. Chen, J.L. Liu, M.C. Wang, Y.Y. Dai, K.D. Zhao, J. Gu, H.M. Zhang, A. Wurita, K. Hasegawa, Identification of a novel imidazole-derived GABA agonist isopropoxate: simultaneous detection and quantification of imidazole-derived analogs from human hairs in abused cases by LC-MS\/MS, Forensic Toxicol. https:\/\/doi.org\/10.1016\/j.toxac.2024.12.003.","DOI":"10.1016\/j.toxac.2024.12.003"}],"container-title":["Journal of Pharmaceutical and Biomedical Analysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0731708525003644?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0731708525003644?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T02:18:26Z","timestamp":1762309106000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0731708525003644"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":22,"alternative-id":["S0731708525003644"],"URL":"https:\/\/doi.org\/10.1016\/j.jpba.2025.117023","relation":{},"ISSN":["0731-7085"],"issn-type":[{"value":"0731-7085","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Leveraging mass spectrometry fragmentation patterns for accelerated screening and structural elucidation of new etomidate analogues in suspect samples","name":"articletitle","label":"Article Title"},{"value":"Journal of Pharmaceutical and Biomedical Analysis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpba.2025.117023","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"117023"}}