{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T02:22:26Z","timestamp":1762309346033,"version":"build-2065373602"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100007289","name":"Nanjing Medical University","doi-asserted-by":"publisher","award":["CMC2024PY19"],"award-info":[{"award-number":["CMC2024PY19"]}],"id":[{"id":"10.13039\/501100007289","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Basic research project of the Changzhou medical center of Nanjing medical university"},{"DOI":"10.13039\/501100007131","name":"Changzhou Science and Technology Bureau","doi-asserted-by":"publisher","award":["CJ20240044","CQ20240133"],"award-info":[{"award-number":["CJ20240044","CQ20240133"]}],"id":[{"id":"10.13039\/501100007131","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32400969"],"award-info":[{"award-number":["32400969"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Jiangsu Province Natural Science Foundation","doi-asserted-by":"publisher","award":["BK20230636","BK20240340"],"award-info":[{"award-number":["BK20230636","BK20240340"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmaceutical and Biomedical Analysis"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.jpba.2025.117028","type":"journal-article","created":{"date-parts":[[2025,6,12]],"date-time":"2025-06-12T19:28:14Z","timestamp":1749756494000},"page":"117028","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Pharmacokinetics, tissue distribution and metabolism study of 2,3,5,4\u2032-Tetrahydroxystilbene-2-O-\u03b2-D-glucoside in a rat model of ischemic stroke using UHPLC\u2011Q\u2011TOF\u2013MS\/MS"],"prefix":"10.1016","volume":"265","author":[{"given":"Lingyu","family":"Ruan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenya","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongyan","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuheng","family":"Tao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qing","family":"Qing","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liqun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8935-4969","authenticated-orcid":false,"given":"Junsong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenhao","family":"Ge","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jpba.2025.117028_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.109923","article-title":"A review on the extraction, purification, detection, and pharmacological effects of 2, 3, 5, 4\u2019-tetrahydroxystilbene-2-O-\u03b2-d-glucoside from polygonum multiflorum","volume":"124","author":"Qian","year":"2020","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.jpba.2025.117028_bib2","article-title":"A review of pharmacology, toxicity and pharmacokinetics of 2, 3, 5, 4\u2032-tetrahydroxystilbene-2-O-\u03b2-D-Glucoside","volume":"12","author":"Wang","year":"2022","journal-title":"Front. Pharmacol."},{"issue":"3","key":"10.1016\/j.jpba.2025.117028_bib3","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.freeradbiomed.2009.02.027","article-title":"Protection by tetrahydroxystilbene glucoside against cerebral ischemia: involvement of JNK, SIRT1, and NF-\u03baB pathways and inhibition of intracellular ROS\/RNS generation","volume":"47","author":"Wang","year":"2009","journal-title":"Free Radic. Biol. Med."},{"issue":"7","key":"10.1016\/j.jpba.2025.117028_bib4","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.3390\/antiox10071112","article-title":"Activation of adenosine A1 receptor in ischemic stroke: neuroprotection by tetrahydroxy stilbene glycoside as an agonist","volume":"10","author":"Ruan","year":"2021","journal-title":"Antioxidants"},{"issue":"5","key":"10.1016\/j.jpba.2025.117028_bib5","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1161\/STROKEAHA.122.040073","article-title":"Projected global trends in ischemic stroke incidence, deaths and disability-adjusted life years from 2020 to 2030","volume":"54","author":"Pu","year":"2023","journal-title":"Stroke"},{"issue":"11","key":"10.1016\/j.jpba.2025.117028_bib6","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1001\/jama.2020.26867","article-title":"Diagnosis and management of transient ischemic attack and acute ischemic stroke: a review","volume":"325","author":"Mendelson","year":"2021","journal-title":"Jama"},{"issue":"3","key":"10.1016\/j.jpba.2025.117028_bib7","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.annemergmed.2017.06.026","article-title":"Managing patients with transient ischemic attack","volume":"71","author":"Edlow","year":"2018","journal-title":"Ann. Emerg. Med."},{"issue":"5","key":"10.1016\/j.jpba.2025.117028_bib8","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1161\/STROKEAHA.122.036946","article-title":"Neuroinflammation, stroke, blood-brain barrier dysfunction, and imaging modalities","volume":"53","author":"Candelario-Jalil","year":"2022","journal-title":"Stroke"},{"issue":"1","key":"10.1016\/j.jpba.2025.117028_bib9","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/j.jep.2011.05.049","article-title":"Pharmacokinetics and tissue distribution of 2, 3, 5, 4\u2032-tetrahydroxystilbene-2-O-\u03b2-d-glucoside from traditional Chinese Medicine polygonum multiflorum following oral administration to rats","volume":"137","author":"Lv","year":"2011","journal-title":"J. Ethnopharmacol."},{"issue":"20","key":"10.1016\/j.jpba.2025.117028_bib10","doi-asserted-by":"crossref","first-page":"1602","DOI":"10.2174\/1381612829666230707121415","article-title":"Recent update on pharmacokinetics and drug metabolism in CNS-based drug discovery","volume":"29","author":"Sanap","year":"2023","journal-title":"Curr. Pharm. Des."},{"issue":"5","key":"10.1016\/j.jpba.2025.117028_bib11","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/j.apsb.2018.04.003","article-title":"Drug metabolism in drug discovery and development","volume":"8","author":"Zhang","year":"2018","journal-title":"Acta Pharm. Sin. B"},{"issue":"51","key":"10.1016\/j.jpba.2025.117028_bib12","doi-asserted-by":"crossref","first-page":"18645","DOI":"10.1021\/acs.analchem.3c02924","article-title":"Current practices in LC-MS untargeted metabolomics: a scoping review on the use of pooled quality control samples","volume":"95","author":"Broeckling","year":"2023","journal-title":"Anal. Chem."},{"issue":"2","key":"10.1016\/j.jpba.2025.117028_bib13","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1021\/ac403385y","article-title":"Comparison of information-dependent acquisition, SWATH, and MSAll techniques in metabolite identification study employing ultrahigh-performance liquid chromatography\u2013quadrupole time-of-flight mass spectrometry","volume":"86","author":"Zhu","year":"2014","journal-title":"Anal. Chem."},{"issue":"8","key":"10.1016\/j.jpba.2025.117028_bib14","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1038\/nbt.3597","article-title":"Sharing and community curation of mass spectrometry data with global natural products social molecular networking","volume":"34","author":"Wang","year":"2016","journal-title":"Nat. Biotechnol."},{"issue":"1","key":"10.1016\/j.jpba.2025.117028_bib15","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1161\/01.STR.20.1.84","article-title":"Reversible middle cerebral artery occlusion without craniectomy in rats","volume":"20","author":"Longa","year":"1989","journal-title":"Stroke"},{"issue":"10","key":"10.1016\/j.jpba.2025.117028_bib16","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.3390\/metabo13101047","article-title":"Biomarker discovery for hepatocellular carcinoma in patients with liver cirrhosis using untargeted metabolomics and lipidomics studies","volume":"13","author":"Rashid","year":"2023","journal-title":"Metabolites"},{"issue":"29","key":"10.1016\/j.jpba.2025.117028_bib17","doi-asserted-by":"crossref","first-page":"7043","DOI":"10.1007\/s00216-024-05608-y","article-title":"Metabolic fate of the natural anticancer agent cucurbitacin B: an LC\u2013MS\/MS-enabled profiling of its major phase I and II conjugates in vivo","volume":"416","author":"Liu","year":"2024","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.jpba.2025.117028_bib18","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.jpba.2017.03.016","article-title":"Rapid profiling and pharmacokinetic studies of major compounds in crude extract from polygonum multiflorum by UHPLC-Q-TOF-MS and UPLC\u2013MS\/MS","volume":"140","author":"Wang","year":"2017","journal-title":"J. Pharm. Biomed. Anal."},{"issue":"25","key":"10.1016\/j.jpba.2025.117028_bib19","doi-asserted-by":"crossref","first-page":"7773","DOI":"10.1021\/acs.jafc.2c00572","article-title":"A systematic strategy for the characterization of 2, 3, 5, 4\u2032-tetrahydroxystilbene-2-O-\u03b2-D-glucoside metabolites in vivo by ultrahigh performance liquid chromatography coupled with a q exactive-orbitrap mass system","volume":"70","author":"Huang","year":"2022","journal-title":"J. Agric. Food Chem."},{"issue":"5","key":"10.1016\/j.jpba.2025.117028_bib20","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1002\/jssc.201200668","article-title":"Pharmacokinetics of 2, 3, 5, 4\u2032-tetrahydroxystilbene-2-O-\u03b2-D-glucoside in rat using ultra-performance LC-quadrupole TOF-MS","volume":"36","author":"Zhao","year":"2013","journal-title":"J. Sep. Sci."},{"issue":"11-12","key":"10.1016\/j.jpba.2025.117028_bib21","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/j.drudis.2012.01.017","article-title":"Reactions and enzymes in the metabolism of drugs and other xenobiotics","volume":"17","author":"Testa","year":"2012","journal-title":"Drug Discov. Today"},{"issue":"4","key":"10.1016\/j.jpba.2025.117028_bib22","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1080\/03602530500251220","article-title":"Phase I and phase II drug metabolism: terminology that we should phase out?","volume":"37","author":"David Josephy","year":"2005","journal-title":"Drug Metab. Rev."},{"issue":"6","key":"10.1016\/j.jpba.2025.117028_bib23","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1080\/10826076.2012.673209","volume":"36","author":"Zhao","year":"2013","journal-title":"J. Liq. Chromatogr. Relat. Technol."},{"issue":"5","key":"10.1016\/j.jpba.2025.117028_bib24","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1038\/sj.bjp.0703898","article-title":"Glucuronide and glucoside conjugation of mycophenolic acid by human liver, kidney and intestinal microsomes","volume":"132","author":"Shipkova","year":"2001","journal-title":"Br. J. Pharmacol."},{"issue":"7","key":"10.1016\/j.jpba.2025.117028_bib25","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1111\/j.1745-7254.2005.00091.x","article-title":"Phase II metabolites of etofesalamide in filamentous fungi","volume":"26","author":"Huang","year":"2005","journal-title":"Acta Pharmacol. Sin."},{"issue":"3","key":"10.1016\/j.jpba.2025.117028_bib26","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1093\/glycob\/cww114","article-title":"Rapid screening of sugar-nucleotide donor specificities of putative glycosyltransferases","volume":"27","author":"Sheikh","year":"2017","journal-title":"Glycobiology"},{"issue":"4","key":"10.1016\/j.jpba.2025.117028_bib27","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1016\/j.bbrc.2003.11.179","article-title":"Structures of human purine nucleoside phosphorylase complexed with inosine and ddi","volume":"313","author":"Canduri","year":"2004","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"1","key":"10.1016\/j.jpba.2025.117028_bib28","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/0014-2999(74)90180-0","article-title":"Inhibition by aspirin of ribose conjugation in the metabolism of histamine","volume":"29","author":"Beaven","year":"1974","journal-title":"Eur. J. Pharmacol."},{"issue":"10","key":"10.1016\/j.jpba.2025.117028_bib29","doi-asserted-by":"crossref","first-page":"2869","DOI":"10.1021\/ac0499017","article-title":"Derivatization for LC-electrospray ionization-MS: a tool for improving reversed-phase separation and ESI responses of bases, ribosides, and intact nucleotides","volume":"76","author":"Nordstr\u00f6m","year":"2004","journal-title":"Anal. Chem."},{"issue":"1","key":"10.1016\/j.jpba.2025.117028_bib30","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1093\/neuonc\/2.1.45","article-title":"The blood-brain and blood-tumor barriers: a review of strategies for increasing drug delivery","volume":"2","author":"Groothuis","year":"2000","journal-title":"Neuro. Oncol."},{"issue":"3","key":"10.1016\/j.jpba.2025.117028_bib31","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1124\/dmd.114.061093","article-title":"Inflammation-induced phenoconversion of polymorphic drug metabolizing enzymes: hypothesis with implications for personalized medicine","volume":"43","author":"Shah","year":"2015","journal-title":"Drug Metab. Dispos."},{"issue":"2","key":"10.1016\/j.jpba.2025.117028_bib32","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1038\/clpt.1993.127","article-title":"The pharmacokinetics of morphine and morphine glucuronides in kidney failure","volume":"54","author":"Osborne","year":"1993","journal-title":"Clin. Pharmacol. Ther."},{"issue":"2","key":"10.1016\/j.jpba.2025.117028_bib33","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1517\/17425255.2012.652615","article-title":"Pharmacokinetics of alteplase in the treatment of ischaemic stroke","volume":"8","author":"Acheampong","year":"2012","journal-title":"Expert Opin. Drug Metab. Toxicol."},{"key":"10.1016\/j.jpba.2025.117028_bib34","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1007\/s13318-017-0435-9","article-title":"Pharmacokinetic study of piracetam in focal cerebral ischemic rats","volume":"43","author":"Paliwal","year":"2018","journal-title":"Eur. J. Drug Metab. Pharmacokinet."},{"issue":"11","key":"10.1016\/j.jpba.2025.117028_bib35","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1038\/aps.2017.114","article-title":"Pharmacokinetic and metabolomic analyses of the neuroprotective effects of Salvianolic acid A in a rat ischemic stroke model","volume":"38","author":"Feng","year":"2017","journal-title":"Acta Pharmacol. Sin."}],"container-title":["Journal of Pharmaceutical and Biomedical Analysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0731708525003693?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0731708525003693?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T02:18:58Z","timestamp":1762309138000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0731708525003693"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":35,"alternative-id":["S0731708525003693"],"URL":"https:\/\/doi.org\/10.1016\/j.jpba.2025.117028","relation":{},"ISSN":["0731-7085"],"issn-type":[{"type":"print","value":"0731-7085"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pharmacokinetics, tissue distribution and metabolism study of 2,3,5,4\u2032-Tetrahydroxystilbene-2-O-\u03b2-D-glucoside in a rat model of ischemic stroke using UHPLC\u2011Q\u2011TOF\u2013MS\/MS","name":"articletitle","label":"Article Title"},{"value":"Journal of Pharmaceutical and Biomedical Analysis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpba.2025.117028","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"117028"}}