{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T10:33:16Z","timestamp":1778754796680,"version":"3.51.4"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003810","name":"Clinics Hospital of Porto Alegre","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003810","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"National Council for Scientific and Technological Development","doi-asserted-by":"publisher","award":["88887.691743\/2022-00"],"award-info":[{"award-number":["88887.691743\/2022-00"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"National Council for Scientific and Technological Development","doi-asserted-by":"publisher","award":["402199\/2023-5"],"award-info":[{"award-number":["402199\/2023-5"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"National Council for Scientific and Technological Development","doi-asserted-by":"publisher","award":["305334\/2024-7"],"award-info":[{"award-number":["305334\/2024-7"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmaceutical and Biomedical Analysis"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.jpba.2025.117046","type":"journal-article","created":{"date-parts":[[2025,7,4]],"date-time":"2025-07-04T13:29:55Z","timestamp":1751635795000},"page":"117046","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Dysregulation of cytoskeletal organization, energy metabolism, complement cascade, and coagulation associated with suicidal behavior: Insights from proteomic analyses"],"prefix":"10.1016","volume":"265","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-7502-8542","authenticated-orcid":false,"given":"Pedro Henrique","family":"Rosa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8330-3485","authenticated-orcid":false,"given":"Tain\u00e1","family":"Schons","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4057-4263","authenticated-orcid":false,"given":"Giovana","family":"Mezzomo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-1437-8674","authenticated-orcid":false,"given":"Gabriel","family":"Rocha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Prates-Baldez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-1801-1937","authenticated-orcid":false,"given":"Guilherme","family":"Carvalho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2899-0328","authenticated-orcid":false,"given":"Lucas","family":"Patusco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rianne","family":"Pulcinelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles F","family":"Ferreira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felipe B","family":"Almeida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paola Rampelotto","family":"Ziani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pedro VS","family":"Magalh\u00e3es","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adriane R.","family":"Rosa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jpba.2025.117046_bib1","volume":"2022","author":"World Health Organization","year":"2022"},{"key":"10.1016\/j.jpba.2025.117046_bib2","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/S2215-0366(14)70222-6","article-title":"The psychology of suicidal behaviour","volume":"1","author":"O\u2019Connor","year":"2014","journal-title":"Lancet Psychiatry"},{"key":"10.1016\/j.jpba.2025.117046_bib3","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1007\/s11427-017-9175-2","article-title":"Recent progress in mass spectrometry proteomics for biomedical research","volume":"60","author":"Li","year":"2017","journal-title":"Sci. China Life Sci."},{"key":"10.1016\/j.jpba.2025.117046_bib4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fnins.2012.00187","article-title":"Systems biology, bioinformatics, and biomarkers in neuropsychiatry","volume":"6","author":"Alawieh","year":"2012","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.jpba.2025.117046_bib5","doi-asserted-by":"crossref","first-page":"256","DOI":"10.3390\/genes11030256","article-title":"Differential dorsolateral prefrontal cortex proteomic profiles of suicide victims with mood disorders","volume":"11","author":"Cabello-Arreola","year":"2020","journal-title":"Genes (Basel)"},{"key":"10.1016\/j.jpba.2025.117046_bib6","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0050532","article-title":"Altered functional protein networks in the prefrontal cortex and amygdala of victims of suicide","volume":"7","author":"K\u00e9kesi","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.jpba.2025.117046_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2024.107363","article-title":"Homodimerization of CB2 cannabinoid receptor triggered by a bivalent ligand enhances cellular signaling","volume":"208","author":"Navarro","year":"2024","journal-title":"Pharm. Res"},{"key":"10.1016\/j.jpba.2025.117046_bib8","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.1101\/gr.1239303","article-title":"Cytoscape: a software environment for integrated models of biomolecular interaction networks","volume":"13","author":"Shannon","year":"2003","journal-title":"Genome Res"},{"key":"10.1016\/j.jpba.2025.117046_bib9","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1093\/bioinformatics\/btp101","article-title":"ClueGO: a Cytoscape plug-in to decipher functionally grouped gene ontology and pathway annotation networks","volume":"25","author":"Bindea","year":"2009","journal-title":"Bioinformatics"},{"key":"10.1016\/j.jpba.2025.117046_bib10","doi-asserted-by":"crossref","DOI":"10.3389\/fpsyt.2024.1429953","article-title":"Proteome analysis of the prefrontal cortex and the application of machine learning models for the identification of potential biomarkers related to suicide","volume":"15","author":"Rojo-Romero","year":"2025","journal-title":"Front. Psychiatry"},{"key":"10.1016\/j.jpba.2025.117046_bib11","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1038\/s41398-022-01896-z","article-title":"Proteomic profiling of postmortem prefrontal cortex tissue of suicide completers","volume":"12","author":"Kim","year":"2022","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.jpba.2025.117046_bib12","doi-asserted-by":"crossref","DOI":"10.1093\/ijnp\/pyaf012","article-title":"Altered proteomics in brain extracellular vesicles from depressed individuals who died by suicide implicates synaptic processes","volume":"28","author":"Ibrahim","year":"2025","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"10.1016\/j.jpba.2025.117046_bib13","doi-asserted-by":"crossref","first-page":"515","DOI":"10.2174\/1568007043336761","article-title":"The neuronal cytoskeleton as a potential therapeutical target in neurodegenerative diseases and schizophrenia","volume":"3","author":"Benitez-King","year":"2004","journal-title":"Curr. Drug Targets CNS Neurol. Disord."},{"key":"10.1016\/j.jpba.2025.117046_bib14","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.arr.2012.08.004","article-title":"A breach in the scaffold: the possible role of cytoskeleton dysfunction in the pathogenesis of major depression","volume":"12","author":"Wong","year":"2013","journal-title":"Ageing Res Rev."},{"key":"10.1016\/j.jpba.2025.117046_bib15","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1038\/mp.2014.82","article-title":"Transcriptome sequencing and genome-wide association analyses reveal lysosomal function and actin cytoskeleton remodeling in schizophrenia and bipolar disorder","volume":"20","author":"Zhao","year":"2015","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.jpba.2025.117046_bib16","doi-asserted-by":"crossref","first-page":"400","DOI":"10.18433\/jpps31458","article-title":"Research progress on vesicle cycle and neurological disorders","volume":"24","author":"Zhu","year":"2021","journal-title":"J. Pharm. Pharm. Sci."},{"key":"10.1016\/j.jpba.2025.117046_bib17","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1097\/JCP.0000000000000616","article-title":"Increased brain lactate during depressive episodes and reversal effects by lithium monotherapy in drug-naive bipolar disorder: a 3-T 1H-MRS study","volume":"37","author":"Machado-Vieira","year":"2017","journal-title":"J. Clin. Psychopharmacol."},{"key":"10.1016\/j.jpba.2025.117046_bib18","doi-asserted-by":"crossref","first-page":"211","DOI":"10.9758\/cpn.2022.20.2.211","article-title":"Potential candidates for biomarkers in bipolar disorder: a proteomic approach through systems biology","volume":"20","author":"Ziani","year":"2022","journal-title":"Clin. Psychopharmacol. Neurosci."},{"key":"10.1016\/j.jpba.2025.117046_bib19","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1093\/abm\/kaaa001","article-title":"Acute stress-induced coagulation activation in patients with remitted major depression versus healthy controls and the role of stress-specific coping","volume":"54","author":"von K\u00e4nel","year":"2020","journal-title":"Ann. Behav. Med"},{"key":"10.1016\/j.jpba.2025.117046_bib20","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.bbi.2024.03.049","article-title":"Plasma complement and coagulation proteins as prognostic factors of negative symptoms: an analysis of the NAPLS 2 and 3 studies","volume":"119","author":"Byrne","year":"2024","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.jpba.2025.117046_bib21","article-title":"A pilot study indicating the dysregulation of the complement and coagulation cascades in treated schizophrenia and bipolar disorder patients","volume":"1869","author":"Cruz","year":"2021","journal-title":"Biochim. Et. Biophys. Acta Proteins Proteom."},{"key":"10.1016\/j.jpba.2025.117046_bib22","first-page":"1","article-title":"The extrinsic coagulation pathway: a biomarker for suicidal behavior in major depressive disorder","volume":"6","author":"Yang","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jpba.2025.117046_bib23","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1161\/CIRCRESAHA.116.306853","article-title":"Cross talk pathways between coagulation and inflammation","volume":"118","author":"Foley","year":"2016","journal-title":"Circ. Res"},{"key":"10.1016\/j.jpba.2025.117046_bib24","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1055\/s-0033-1357482","article-title":"Coagulation in inflammatory diseases of the central nervous system","volume":"39","author":"Chapman","year":"2013","journal-title":"Semin Thromb. Hemost."},{"key":"10.1016\/j.jpba.2025.117046_bib25","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1001\/archpsyc.62.7.792","article-title":"A.S. Jaffe, ENRICHD investigators, effects of antidepressant medication on morbidity and mortality in depressed patients after myocardial infarction","volume":"62","author":"Taylor","year":"2005","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.jpba.2025.117046_bib26","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.psychres.2006.08.012","article-title":"Platelet serotonin and serum cholesterol concentrations in suicidal and non-suicidal male patients with a first episode of psychosis","volume":"150","author":"Marcinko","year":"2007","journal-title":"Psychiatry Res"},{"key":"10.1016\/j.jpba.2025.117046_bib27","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1038\/s41386-024-01807-4","article-title":"Identifying novel proteins for suicide attempt by integrating proteomes from brain and blood with genome-wide association data","volume":"49","author":"Zhao","year":"2024","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.jpba.2025.117046_bib28","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/708306","article-title":"Disruption in the Blood-Brain Barrier: The Missing Link between Brain and Body Inflammation in Bipolar Disorder?","volume":"2015","author":"Patel","year":"2015","journal-title":"Neural Plast."},{"key":"10.1016\/j.jpba.2025.117046_bib29","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1038\/s41386-020-00867-6","article-title":"Complement component C4 levels in the cerebrospinal fluid and plasma of patients with schizophrenia","volume":"46","author":"Gallego","year":"2021","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.jpba.2025.117046_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.blre.2019.100610","article-title":"The role of beta-2-glycoprotein I in health and disease associating structure with function: more than just APS","volume":"39","author":"McDonnell","year":"2020","journal-title":"Blood Rev."},{"key":"10.1016\/j.jpba.2025.117046_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.jneuroim.2020.577238","article-title":"Antiphospholipid syndrome presenting as treatment resistant bipolar disorder and thrombocytopenia in a young male","volume":"343","author":"Aneja","year":"2020","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.jpba.2025.117046_bib32","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.genhosppsych.2017.11.005","article-title":"Association of psychosis with antiphospholipid antibody syndrome: a systematic review of clinical studies","volume":"50","author":"Hallab","year":"2018","journal-title":"Gen. Hosp. Psychiatry"},{"key":"10.1016\/j.jpba.2025.117046_bib33","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.ijcard.2015.03.179","article-title":"SAP: structure, function, and its roles in immune-related diseases","volume":"187","author":"Xi","year":"2015","journal-title":"Int J. Cardiol."},{"key":"10.1016\/j.jpba.2025.117046_bib34","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1038\/s41386-022-01449-4","article-title":"Serum amyloid P component (SAP) modulates antidepressant effects through promoting membrane insertion of the serotonin transporter","volume":"48","author":"Su","year":"2023","journal-title":"Neuropsychopharmacology"}],"container-title":["Journal of Pharmaceutical and Biomedical Analysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0731708525003875?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0731708525003875?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T10:01:05Z","timestamp":1778752865000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0731708525003875"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":34,"alternative-id":["S0731708525003875"],"URL":"https:\/\/doi.org\/10.1016\/j.jpba.2025.117046","relation":{},"ISSN":["0731-7085"],"issn-type":[{"value":"0731-7085","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dysregulation of cytoskeletal organization, energy metabolism, complement cascade, and coagulation associated with suicidal behavior: Insights from proteomic analyses","name":"articletitle","label":"Article Title"},{"value":"Journal of Pharmaceutical and Biomedical Analysis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpba.2025.117046","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"117046"}}