{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T16:09:19Z","timestamp":1778515759545,"version":"3.51.4"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T00:00:00Z","timestamp":1785196800000},"content-version":"am","delay-in-days":239,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100012574","name":"University of Alaska Fairbanks","doi-asserted-by":"publisher","award":["NNX13AB28A"],"award-info":[{"award-number":["NNX13AB28A"]}],"id":[{"id":"10.13039\/100012574","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["2P20GM103395"],"award-info":[{"award-number":["2P20GM103395"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005714","name":"Established Program to Stimulate Competitive Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005714","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000006","name":"Office of Naval Research","doi-asserted-by":"publisher","award":["N00014-23-1-2003"],"award-info":[{"award-number":["N00014-23-1-2003"]}],"id":[{"id":"10.13039\/100000006","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009896","name":"U.S. Navy","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009896","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmaceutical and Biomedical Analysis"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.jpba.2025.117079","type":"journal-article","created":{"date-parts":[[2025,7,23]],"date-time":"2025-07-23T06:48:32Z","timestamp":1753253312000},"page":"117079","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Formulation insights into competitive binding of N6-cyclohexyladenosine and 8-(p-sulfophenyl)theophylline with hydroxypropyl-\u03b2-cyclodextrin"],"prefix":"10.1016","volume":"266","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4216-7805","authenticated-orcid":false,"given":"Seungil","family":"Cho","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7632-2765","authenticated-orcid":false,"given":"Carl","family":"Murphy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Green","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2436-5720","authenticated-orcid":false,"given":"Kelly","family":"Drew","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jpba.2025.117079_bib1","doi-asserted-by":"crossref","first-page":"114891","DOI":"10.1016\/j.expneurol.2024.114891","article-title":"N6-cyclohexyladenosine is better than meperidine and buspirone at suppressing metabolism during TTM32 but does not improve outcome after cardiac arrest","volume":"380","author":"Laughlin","year":"2024","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.jpba.2025.117079_bib2","doi-asserted-by":"crossref","first-page":"10752","DOI":"10.1523\/JNEUROSCI.1240-11.2011","article-title":"Season primes the brain in an arctic hibernator to facilitate entrance into torpor mediated by adenosine A1 receptors","volume":"31","author":"Jinka","year":"2011","journal-title":"J. Neurosci."},{"key":"10.1016\/j.jpba.2025.117079_bib3","doi-asserted-by":"crossref","first-page":"2145","DOI":"10.1016\/S0002-9440(10)64686-X","article-title":"Hibernation, a model of neuroprotection","volume":"158","author":"Zhou","year":"2001","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.jpba.2025.117079_bib4","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1038\/sj.bjp.0706043","article-title":"Role of central and peripheral adenosine receptors in the cardiovascular responses to intraperitoneal injections of adenosine A1 and A2A subtype receptor agonists","volume":"144","author":"Schindler","year":"2005","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.jpba.2025.117079_bib5","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/BF02896926","article-title":"Cerebral ischemia in gerbils: postischemic administration of cyclohexyl adenosine and 8-sulfophenyl-theophylline","volume":"2","author":"von Lubitz","year":"1990","journal-title":"J. Mol. Neurosci."},{"key":"10.1016\/j.jpba.2025.117079_bib6","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/S0022-3565(25)22608-8","article-title":"Antagonism of the cardiovascular effects of adenosine by caffeine or 8-(p-sulfophenyl)theophylline","volume":"240","author":"Evoniuk","year":"1987","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.jpba.2025.117079_bib7","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1021\/acschemneuro.5b00056","article-title":"Translating drug-induced hibernation to therapeutic hypothermia","volume":"6","author":"Jinka","year":"2015","journal-title":"ACS Chem. Neurosci."},{"key":"10.1016\/j.jpba.2025.117079_bib8","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1002\/cpt.1943","article-title":"Understanding the effect of hydroxypropyl-\u03b2-cyclodextrin on fenebrutinib absorption in an itraconazole\u2013fenebrutinib drug\u2013drug interaction study","volume":"108","author":"Durk","year":"2020","journal-title":"Clin. Pharmacol. Ther."},{"key":"10.1016\/j.jpba.2025.117079_bib9","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1111\/jphp.12427","article-title":"Pharmacokinetics of cyclodextrins and drugs after oral and parenteral administration of drug\/cyclodextrin complexes","volume":"68","author":"Loftsson","year":"2016","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.jpba.2025.117079_bib10","doi-asserted-by":"crossref","first-page":"72","DOI":"10.4103\/0975-7406.67003","article-title":"Cyclodextrins in delivery systems: applications","volume":"2","author":"Tiwari","year":"2010","journal-title":"J. Pharm. Bioallied Sci."},{"key":"10.1016\/j.jpba.2025.117079_bib11","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.3390\/molecules23051161","article-title":"Solubility of cyclodextrins and drug\/cyclodextrin complexes","volume":"23","author":"Saokham","year":"2018","journal-title":"Molecules"},{"key":"10.1016\/j.jpba.2025.117079_bib12","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.3390\/molecules23051204","article-title":"Characterization of cyclodextrin\/volatile inclusion complexes: a review","volume":"23","author":"Kfoury","year":"2018","journal-title":"Molecules"},{"key":"10.1016\/j.jpba.2025.117079_bib13","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.chroma.2003.11.092","article-title":"Determination of binding constants by affinity chromatography","volume":"1037","author":"Winzor","year":"2004","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.jpba.2025.117079_bib14","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1002\/1522-2683(200105)22:7<1419::AID-ELPS1419>3.0.CO;2-V","article-title":"Methods for the determination of binding constants by capillary electrophoresis","volume":"22","author":"Rundlett","year":"2001","journal-title":"Electrophoresis"},{"key":"10.1016\/j.jpba.2025.117079_bib15","doi-asserted-by":"crossref","first-page":"3875","DOI":"10.1021\/j100011a065","article-title":"Capillary electrophoresis as a method for determining binding constants: application to the binding of cyclodextrins and nitrophenolates","volume":"99","author":"Penn","year":"1995","journal-title":"J. Phys. Chem."},{"key":"10.1016\/j.jpba.2025.117079_bib16","doi-asserted-by":"crossref","first-page":"7777","DOI":"10.1021\/acs.analchem.6b01796","article-title":"Analysis of trinitrophenylated adenosine and inosine by capillary electrophoresis and \u03b3-cyclodextrin-enhanced fluorescence detection","volume":"88","author":"Stephen","year":"2016","journal-title":"Anal. Chem."},{"key":"10.1016\/j.jpba.2025.117079_bib17","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1007\/s10858-022-00402-3","article-title":"The measurement of binding affinities by NMR chemical shift perturbation","volume":"76","author":"Hobbs","year":"2022","journal-title":"J. Biomol. NMR"},{"key":"10.1016\/j.jpba.2025.117079_bib18","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1002\/cphc.201701253","article-title":"Investigating protein\u2013ligand interactions by solution nuclear magnetic resonance spectroscopy","volume":"19","author":"Becker","year":"2018","journal-title":"ChemPhysChem"},{"key":"10.1016\/j.jpba.2025.117079_bib19","doi-asserted-by":"crossref","DOI":"10.1038\/srep24826","article-title":"Two-dimensional NMR lineshape analysis","volume":"6","author":"Waudby","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jpba.2025.117079_bib20","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1111\/j.2042-7158.1997.tb06021.x","article-title":"Measurement of molecular association in drug: Cyclodextrin inclusion complexes with improved 1H NMR studies","volume":"49","author":"Loukas","year":"1997","journal-title":"J. Pharm. Pharm."},{"key":"10.1016\/j.jpba.2025.117079_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2024.122167","article-title":"Solving the puzzle of 2-hydroxypropyl \u03b2-cyclodextrin: detailed assignment of the substituent distribution by NMR spectroscopy","volume":"338","author":"Kalydi","year":"2024","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.jpba.2025.117079_bib22","unstructured":"Product Information, Cayman Chemical (n.d.). \u3008https:\/\/cdn.caymanchem.com\/cdn\/insert\/28427.pdf\u3009 (Accessed 9 March 2025)."},{"key":"10.1016\/j.jpba.2025.117079_bib23","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0107493","article-title":"1H NMR metabolomic biomarkers of poor outcome after hemorrhagic shock are absent in hibernators","volume":"9","author":"Bogren","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.jpba.2025.117079_bib24","doi-asserted-by":"crossref","first-page":"259","DOI":"10.3390\/biomedicines8080259","article-title":"Small molecules in the venom of the scorpion Hormurus waigiensis","volume":"8","author":"Evans","year":"2020","journal-title":"Biomedicines"},{"key":"10.1016\/j.jpba.2025.117079_bib25","unstructured":"1H NMR Spectrum (1D, 600 MHz, H2O, experimental) (HMDB0001889), HMDB (n.d.). \u3008https:\/\/hmdb.ca\/spectra\/nmr_one_d\/148533\u3009 (Accessed 11 March 2025)."},{"key":"10.1016\/j.jpba.2025.117079_bib26","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1152\/physiolgenomics.00028.2007","article-title":"Quantitative analysis of liver metabolites in three stages of the circannual hibernation cycle in 13-lined ground squirrels by NMR","volume":"31","author":"Serkova","year":"2007","journal-title":"Physiol. Genom."},{"key":"10.1016\/j.jpba.2025.117079_bib27","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/0014-5793(95)00062-E","article-title":"An exact mathematical expression for describing competitive binding of two different ligands to a protein molecule","volume":"360","author":"Wang","year":"1995","journal-title":"FEBS Lett."},{"key":"10.1016\/j.jpba.2025.117079_bib28","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1021\/ja01538a030","article-title":"Adenine-metal complexes","volume":"80","author":"Harkins","year":"1958","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.jpba.2025.117079_bib29","doi-asserted-by":"crossref","DOI":"10.3390\/ma11101971","article-title":"2-hydroxypropyl-\u03b2-cyclodextrin aggregates: Identification and development of analytical techniques","volume":"11","author":"S\u00e1 Couto","year":"2018","journal-title":"Materials"},{"key":"10.1016\/j.jpba.2025.117079_bib30","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2113690119","article-title":"Direct measurement of the viscoelectric effect in water","volume":"119","author":"Jin","year":"2022","journal-title":"PNAS"},{"key":"10.1016\/j.jpba.2025.117079_bib31","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1016\/j.jasms.2005.06.010","article-title":"Protonated adenine: tautomers, solvated clusters, and dissociation mechanisms","volume":"16","author":"Turecek","year":"2005","journal-title":"J. Am. Soc. Mass Spectrom."},{"key":"10.1016\/j.jpba.2025.117079_bib32","doi-asserted-by":"crossref","first-page":"10173","DOI":"10.1021\/acs.jpclett.3c01666","article-title":"Effect of protonation on the molecular structure of adenosine 5\u2032-triphosphate: a combined theoretical and near edge x-ray absorption fine structure study","volume":"14","author":"Mattioli","year":"2023","journal-title":"J. Phys. Chem. Lett."},{"key":"10.1016\/j.jpba.2025.117079_bib33","first-page":"72","article-title":"Blood volume in the rat","volume":"26","author":"Lee","year":"1985","journal-title":"J. Nucl. Med."},{"key":"10.1016\/j.jpba.2025.117079_bib34","doi-asserted-by":"crossref","first-page":"5547","DOI":"10.1073\/pnas.77.9.5547","article-title":"Adenosine receptors in brain membranes: binding of N6-cyclohexyl[3H]adenosine and 1,3-diethyl-8-[3H]phenylxanthine","volume":"77","author":"Bruns","year":"1980","journal-title":"Proc. Natl. Acad. Sci. USA"}],"container-title":["Journal of Pharmaceutical and Biomedical Analysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0731708525004200?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0731708525004200?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T15:21:06Z","timestamp":1778512866000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0731708525004200"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":34,"alternative-id":["S0731708525004200"],"URL":"https:\/\/doi.org\/10.1016\/j.jpba.2025.117079","relation":{},"ISSN":["0731-7085"],"issn-type":[{"value":"0731-7085","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Formulation insights into competitive binding of N6-cyclohexyladenosine and 8-(p-sulfophenyl)theophylline with hydroxypropyl-\u03b2-cyclodextrin","name":"articletitle","label":"Article Title"},{"value":"Journal of Pharmaceutical and Biomedical Analysis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpba.2025.117079","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"117079"}}