{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T07:53:23Z","timestamp":1773215603909,"version":"3.50.1"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004775","name":"Natural Science Foundation of Gansu Province","doi-asserted-by":"publisher","award":["24JRRA053"],"award-info":[{"award-number":["24JRRA053"]}],"id":[{"id":"10.13039\/501100004775","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013114","name":"Yunnan Key Research and Development Program","doi-asserted-by":"publisher","award":["202203AD150003"],"award-info":[{"award-number":["202203AD150003"]}],"id":[{"id":"10.13039\/501100013114","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010870","name":"Qingdao Municipal Science and Technology Bureau","doi-asserted-by":"publisher","award":["24\\u20131\\u20134-xxgg-17-nsh"],"award-info":[{"award-number":["24\\u20131\\u20134-xxgg-17-nsh"]}],"id":[{"id":"10.13039\/501100010870","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22404169"],"award-info":[{"award-number":["22404169"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82160775"],"award-info":[{"award-number":["82160775"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003459","name":"Guizhou University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003459","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003999","name":"Science Fund for Creative Research Groups","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003999","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2024MB018"],"award-info":[{"award-number":["ZR2024MB018"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2024QB050"],"award-info":[{"award-number":["ZR2024QB050"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018531","name":"Major Science and Technology Projects in Yunnan Province","doi-asserted-by":"publisher","award":["202302AE090007"],"award-info":[{"award-number":["202302AE090007"]}],"id":[{"id":"10.13039\/501100018531","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018531","name":"Major Science and Technology Projects in Yunnan Province","doi-asserted-by":"publisher","award":["202402AA310034"],"award-info":[{"award-number":["202402AA310034"]}],"id":[{"id":"10.13039\/501100018531","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmaceutical and Biomedical Analysis"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.jpba.2025.117167","type":"journal-article","created":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T04:10:40Z","timestamp":1758946240000},"page":"117167","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Orthogonal chemical-biological profiling of bioactive components from Olea europaea L. fruits for mitigating hypoxia-induced cellular injury"],"prefix":"10.1016","volume":"267","author":[{"given":"Chengfu","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiangjuan","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xia","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenjin","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong","family":"Pei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lansheng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lichun","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3389-5552","authenticated-orcid":false,"given":"Qingli","family":"Qu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jpba.2025.117167_bib1","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1038\/s41580-020-0227-y","article-title":"Cellular adaptation to hypoxia through hypoxia inducible factors and beyond","volume":"21","author":"Lee","year":"2020","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.jpba.2025.117167_bib2","first-page":"1","article-title":"Hypoxia signaling in human health and diseases: implications and prospects for therapeutics","volume":"7","author":"Luo","year":"2022","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.jpba.2025.117167_bib3","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1038\/s41581-019-0182-z","article-title":"Mechanisms of hypoxia signalling: new implications for nephrology","volume":"15","author":"Sch\u00f6del","year":"2019","journal-title":"Nat. Rev. Nephrol."},{"key":"10.1016\/j.jpba.2025.117167_bib4","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.phymed.2017.12.008","article-title":"Antihypoxic activities of constituents from arenaria kansuensis","volume":"38","author":"Cui","year":"2018","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jpba.2025.117167_bib5","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1089\/ham.2007.3055","article-title":"Treatment of high altitude pulmonary edema at 4240 m in Nepal","volume":"8","author":"Fagenholz","year":"2007","journal-title":"High. Alt. Med. Biol."},{"key":"10.1016\/j.jpba.2025.117167_bib6","doi-asserted-by":"crossref","DOI":"10.3389\/fnut.2022.854780","article-title":"Anti-hypoxic effect of polysaccharide extract of brown seaweed sargassum dentifolium in tongue squamous cell carcinoma","volume":"9","author":"Gamal-Eldeen","year":"2022","journal-title":"Front. Nutr."},{"key":"10.1016\/j.jpba.2025.117167_bib7","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.3389\/fphar.2019.01356","article-title":"Anti-hypoxic molecular mechanisms of rhodiola crenulata extract in zebrafish as revealed by metabonomics","volume":"10","author":"Ma","year":"2019","journal-title":"Front. Pharm."},{"key":"10.1016\/j.jpba.2025.117167_bib8","doi-asserted-by":"crossref","DOI":"10.1017\/jns.2020.50","article-title":"Table olives and health: a review","volume":"9","author":"Rocha","year":"2020","journal-title":"J. Nutr. Sci."},{"key":"10.1016\/j.jpba.2025.117167_bib9","doi-asserted-by":"crossref","first-page":"2932","DOI":"10.1080\/14786419.2021.1922404","article-title":"Chemical analysis, biological and therapeutic activities of olea europaea L. Extracts","volume":"36","author":"Alesci","year":"2022","journal-title":"Nat. Prod. Res."},{"key":"10.1016\/j.jpba.2025.117167_bib10","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.3390\/antiox9111061","article-title":"Phenolic compounds obtained from olea europaea by-products and their use to improve the quality and shelf life of meat and meat products-a review","volume":"9","author":"Munekata","year":"2020","journal-title":"Antioxid. Basel Switz."},{"key":"10.1016\/j.jpba.2025.117167_bib11","doi-asserted-by":"crossref","first-page":"828","DOI":"10.3390\/antiox11050828","article-title":"Unveiling the antioxidant therapeutic functionality of sustainable olive pomace active ingredients","volume":"11","author":"Quero","year":"2022","journal-title":"Antioxidants"},{"key":"10.1016\/j.jpba.2025.117167_bib12","doi-asserted-by":"crossref","first-page":"8611","DOI":"10.1007\/s11694-024-02830-1","article-title":"Discovery of xanthine oxidase inhibitors from olea europaea L. Fruit with antioxidant activity by affinity ultrafiltration guided by molecular docking assay","volume":"18","author":"Yuan","year":"2024","journal-title":"J. Food Meas. Charact."},{"key":"10.1016\/j.jpba.2025.117167_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2024.117834","article-title":"ifanosine: olea europaea L. And hyphaene thebaica L. Combination, from traditional utilization to rational formulation: preclinical and clinical efficacy on hypertensives patients","volume":"325","author":"Zakraoui","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jpba.2025.117167_bib14","doi-asserted-by":"crossref","first-page":"4198","DOI":"10.1002\/jssc.202200541","article-title":"Pancreatic lipase and alpha-glucosidase inhibitors screening from schisandra chinensis based on spectrum-effect relationship and ultra-high-performance liquid chromatography-tandem mass spectrometry","volume":"45","author":"He","year":"2022","journal-title":"J. Sep. Sci."},{"key":"10.1016\/j.jpba.2025.117167_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpba.2024.116037","article-title":"Paper-based ligand fishing method for rapid screening and real-time capturing of \u03b1-glucosidase inhibitors from the Chinese herbs","volume":"242","author":"Chen","year":"2024","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jpba.2025.117167_bib16","first-page":"697","article-title":"Triterpenoid and steroid content of lipophilic extracts of selected medicinal plants of the Mediterranean region","volume":"28","author":"Gadouche","year":"2023","journal-title":"Mol. Basel Switz."},{"key":"10.1016\/j.jpba.2025.117167_bib17","doi-asserted-by":"crossref","first-page":"6352","DOI":"10.1039\/C9NR01292C","article-title":"Cell-membrane coated iron oxide nanoparticles for isolation and specific identification of drug leads from complex matrices","volume":"11","author":"Sherwood","year":"2019","journal-title":"Nanoscale"},{"key":"10.1016\/j.jpba.2025.117167_bib18","doi-asserted-by":"crossref","first-page":"6244","DOI":"10.1021\/acsabm.1c00552","article-title":"Identification of TrkB binders from complex matrices using a magnetic drug screening nanoplatform","volume":"4","author":"Arituluk","year":"2021","journal-title":"ACS Appl. Bio Mater."},{"key":"10.1016\/j.jpba.2025.117167_bib19","doi-asserted-by":"crossref","first-page":"3439","DOI":"10.3390\/ijms19113439","article-title":"Screening the marker components in psoralea corylifolia L. With the aids of spectrum-effect relationship and component knock-out by UPLC-MS2","volume":"19","author":"Shi","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jpba.2025.117167_bib20","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.fshw.2021.02.019","article-title":"Spectrum-effect relationship of immunologic activity of ganoderma lucidum by UPLC-MS\/MS and component knock-out method","volume":"10","author":"Li","year":"2021","journal-title":"Food Sci. Hum. Wellness"},{"key":"10.1016\/j.jpba.2025.117167_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2019.110754","article-title":"Spectrum-effect relationship of antioxidant and tyrosinase activity with malus pumila flowers by UPLC-MS\/MS and component knock-out method","volume":"133","author":"Li","year":"2019","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.jpba.2025.117167_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpba.2024.116636","article-title":"Evaluation study of congelex laxative granules based on HPLC fingerprint, multi-component content determination, and chemometrics","volume":"255","author":"Qian","year":"2025","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jpba.2025.117167_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2020.127849","article-title":"Composition, antioxidant activity, and neuroprotective effects of anthocyanin-rich extract from purple highland barley bran and its promotion on autophagy","volume":"339","author":"Zhang","year":"2021","journal-title":"Food Chem."},{"key":"10.1016\/j.jpba.2025.117167_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.chroma.2023.464098","article-title":"Evaluating the quality consistency of antiviral oral liquid by high-performance liquid chromatography five-wavelength matched average fusion fingerprint combined with electrochemical fingerprint and ultraviolet spectral quantum fingerprint","volume":"1702","author":"Fan","year":"2023","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.jpba.2025.117167_bib25","doi-asserted-by":"crossref","DOI":"10.1002\/bmc.5003","article-title":"Evaluation of the effect of dahuang-mudan decoction on TNBS-induced colitis using UPLC-QTOF\/MS-based metabolomic analysis","volume":"35","author":"Nong","year":"2021","journal-title":"Biomed. Chromatogr. BMC"},{"key":"10.1016\/j.jpba.2025.117167_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.chroma.2025.465747","article-title":"A holistic strategy for the in-depth discrimination and authentication of 16 citrus herbs and associated commercial products based on machine learning techniques and non-targeted metabolomics","volume":"1745","author":"Huang","year":"2025","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.jpba.2025.117167_bib27","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.jpba.2018.08.025","article-title":"Liquid chromatographic techniques in betacyanin isomers separation from gomphrena globosa L. Flowers for the determination of their antimicrobial activities","volume":"161","author":"Sp\u00f3rna-Kucab","year":"2018","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jpba.2025.117167_bib28","doi-asserted-by":"crossref","first-page":"4827","DOI":"10.1007\/s00216-023-04782-9","article-title":"Effective isolation of cannabidiol and cannabidiolic acid free of psychotropic phytocannabinoids from hemp extract by fast centrifugal partition chromatography","volume":"415","author":"Maly","year":"2023","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.jpba.2025.117167_bib29","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1038\/s41401-019-0228-6","article-title":"CB-dock: a web server for cavity detection-guided protein\u2013ligand blind docking","volume":"41","author":"Liu","year":"2020","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.jpba.2025.117167_bib30","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1016\/j.biocel.2008.07.012","article-title":"Cobalt induces oxidative stress in isolated liver mitochondria responsible for permeability transition and intrinsic apoptosis in hepatocyte primary cultures","volume":"41","author":"Battaglia","year":"2009","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.jpba.2025.117167_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpba.2024.116213","article-title":"An efficient method for rapid screening of triterpenoid saponins in three glycyrrhiza species using rapid resolution liquid chromatography quadrupole time-of-flight mass spectrometry combined with mass defect filtering","volume":"246","author":"Song","year":"2024","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jpba.2025.117167_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.jchromb.2023.123807","article-title":"Identification of anti-photoaging components of olea europaea leaves based on spectrum-effect relationship","volume":"1226","author":"Xu","year":"2023","journal-title":"J. Chromatogr. B"},{"key":"10.1016\/j.jpba.2025.117167_bib33","doi-asserted-by":"crossref","first-page":"1674","DOI":"10.1093\/bioinformatics\/btu104","article-title":"Improved protein\u2013ligand binding affinity prediction by using a curvature-dependent surface-area model","volume":"30","author":"Cao","year":"2014","journal-title":"Bioinformatics"},{"key":"10.1016\/j.jpba.2025.117167_bib34","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.kint.2021.03.019","article-title":"Amelioration of chronic kidney disease-associated anemia by vadadustat in mice is not dependent on erythroferrone","volume":"100","author":"Hanudel","year":"2021","journal-title":"Kidney Int"},{"key":"10.1016\/j.jpba.2025.117167_bib35","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1124\/jpet.122.001126","article-title":"Preclinical characterization of vadadustat (AKB-6548), an oral small molecule hypoxia-inducible factor prolyl-4-hydroxylase inhibitor, for the potential treatment of renal anemia","volume":"383","author":"Zuk","year":"2022","journal-title":"J. Pharmacol. Exp. Ther."}],"container-title":["Journal of Pharmaceutical and Biomedical Analysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0731708525005084?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0731708525005084?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T10:02:24Z","timestamp":1773136944000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0731708525005084"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":35,"alternative-id":["S0731708525005084"],"URL":"https:\/\/doi.org\/10.1016\/j.jpba.2025.117167","relation":{},"ISSN":["0731-7085"],"issn-type":[{"value":"0731-7085","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Orthogonal chemical-biological profiling of bioactive components from Olea europaea L. fruits for mitigating hypoxia-induced cellular injury","name":"articletitle","label":"Article Title"},{"value":"Journal of Pharmaceutical and Biomedical Analysis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpba.2025.117167","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"117167"}}