{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T04:20:57Z","timestamp":1791606057073,"version":"4.3.4"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100005046","name":"Natural Science Foundation of Heilongjiang Province","doi-asserted-by":"publisher","award":["PL2024H196"],"award-info":[{"award-number":["PL2024H196"]}],"id":[{"id":"10.13039\/501100005046","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmaceutical and Biomedical Analysis"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.jpba.2025.117169","type":"journal-article","created":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T04:10:54Z","timestamp":1758946254000},"page":"117169","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Antidepressant efficacy and Q-markers determination of Dachaihu decoction: Combining pharmacology, correlation analysis, and network pharmacology approaches"],"prefix":"10.1016","volume":"267","author":[{"given":"Yifan","family":"Bing","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoling","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fajing","family":"Qiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiejing","family":"Sheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuo","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Zou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongyuan","family":"Qu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jpba.2025.117169_bib1","unstructured":"COVID-19Mental Disorders Collaborators, Global prevalence and burden of depressive and anxiety disorders in 204 countries and territories in 2020 due to the COVID-19 pandemic, Lancet, 2021398 (10312)) pp.1700\u20131712.."},{"key":"10.1016\/j.jpba.2025.117169_bib2","unstructured":"Institute of Depression, Blue Book of National Depression in, 2022 Beijing: Institute of Depression, 2022."},{"issue":"9","key":"10.1016\/j.jpba.2025.117169_bib3","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/S2215-0366(23)00199-2","article-title":"Comparative efficacy and tolerability of pharmacological interventions for acute bipolar depression in adults: a systematic review and network meta-analysis","volume":"10","author":"Yildiz","year":"2023","journal-title":"Lancet Psychiatry"},{"issue":"7","key":"10.1016\/j.jpba.2025.117169_bib4","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1002\/phar.2767","article-title":"Adverse effects of antidepressant medications and their management in children and adolescents","volume":"43","author":"Strawn","year":"2023","journal-title":"Pharmacotherapy"},{"key":"10.1016\/j.jpba.2025.117169_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2025.156836","article-title":"Regulation of inflammation by Chaihu-Shugan-San: targeting the IL-17\/ NF-\u03baB pathway to combat breast cancer-related depression","volume":"143","author":"Qu","year":"2025","journal-title":"Phytomedicine"},{"issue":"8","key":"10.1016\/j.jpba.2025.117169_bib6","first-page":"2064","article-title":"Progress on historical evolution, clinical application, and pharmacological effects of Dachaihu decoction and predictive analysis of its quality markers","volume":"49","author":"Ji","year":"2024","journal-title":"Chin. J. Chin. Mater. Med"},{"key":"10.1016\/j.jpba.2025.117169_bib7","doi-asserted-by":"crossref","first-page":"1497072","DOI":"10.3389\/fphar.2024.1497072","article-title":"Unveiling the therapeutic role of Dachaihu decoction in acute cholecystitis: a comprehensive systematic review and meta-analysis of its efficacy and safety","volume":"15","author":"Liu","year":"2024","journal-title":"Front Pharm."},{"issue":"Pt 1","key":"10.1016\/j.jpba.2025.117169_bib8","article-title":"Dachaihu decoction alleviates chronic pancreatitis by regulating MAPK signaling pathway: insights from network pharmacology and experimental validation","volume":"337","author":"Li","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jpba.2025.117169_bib9","article-title":"Integrating metabolomics and network pharmacology to investigate Da-Chai-Hu decoction prevents kidney injury in diabetic mice","volume":"340","author":"Wang","year":"2025","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jpba.2025.117169_bib10","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2020.584090","article-title":"Da-Chai-Hu decoction ameliorates high fat Diet-Induced nonalcoholic fatty liver disease through remodeling the gut microbiota and modulating the serum metabolism","volume":"11","author":"Cui","year":"2020","journal-title":"Front Pharm."},{"key":"10.1016\/j.jpba.2025.117169_bib11","article-title":"Study on the formula syndrome of Dachaihu decoction","author":"Zhao","year":"2023","journal-title":"Chang. Univ. Chin. Med"},{"issue":"11","key":"10.1016\/j.jpba.2025.117169_bib12","first-page":"1955","article-title":"Application of the\u201cSix Differentiations\u201dof Dachaihu decoction","volume":"33","author":"Shan","year":"2024","journal-title":"J. Emerg. Tradit. Chin. Med"},{"issue":"14","key":"10.1016\/j.jpba.2025.117169_bib13","first-page":"119","article-title":"Research progress of Dachaihu decoction in treating tumor complications","volume":"32","author":"Zhang","year":"2024","journal-title":"China's. Naturop."},{"key":"10.1016\/j.jpba.2025.117169_bib14","doi-asserted-by":"crossref","first-page":"1535451","DOI":"10.3389\/fmicb.2025.1535451","article-title":"Dachaihu decoction ameliorates abnormal behavior by regulating gut microbiota in rats with propionic acid-induced autism","volume":"16","author":"Zhang","year":"2025","journal-title":"Front Microbiol"},{"key":"10.1016\/j.jpba.2025.117169_bib15","first-page":"9","article-title":"Clinical study on the improvement of sleep quality in 40 patients with insomnia after stroke","volume":"30","author":"Xiao","year":"2024","journal-title":"J. Med Pharm. Chin. Minor."},{"key":"10.1016\/j.jpba.2025.117169_bib16","doi-asserted-by":"crossref","first-page":"1313871","DOI":"10.3389\/fphar.2024.1313871","article-title":"The effect of scutellaria baicalensis and its active ingredients on major depressive disorder: a systematic review and meta-analysis of literature in pre-clinical research","volume":"15","author":"Ma","year":"2024","journal-title":"Front Pharm."},{"key":"10.1016\/j.jpba.2025.117169_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2024.118038","article-title":"Homotherapy-for-heteropathy of bupleurum chinense DC.-Scutellaria baicalensis georgi in treating depression and colorectal cancer: a network pharmacology and animal model approach","volume":"328","author":"Sun","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jpba.2025.117169_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpba.2024.116239","article-title":"Discovery and verification of antidepressant active ingredients of raw and vinegar-processed bupleurum marginatum var. Stenophyllum based on plant metabolomics and serum pharmacology","volume":"246","author":"Qu","year":"2024","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jpba.2025.117169_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2022.175435","article-title":"Baicalin ameliorates CUMS-induced depression-like behaviors through activating AMPK\/PGC-1\u03b1 pathway and enhancing NIX-mediated mitophagy in mice","volume":"938","author":"Jin","year":"2023","journal-title":"Eur. J. Pharm."},{"issue":"5","key":"10.1016\/j.jpba.2025.117169_bib20","doi-asserted-by":"crossref","first-page":"947","DOI":"10.3390\/antiox11050947","article-title":"Baicalein exerts therapeutic effects against Endotoxin-Induced Depression-like behavior in mice by decreasing inflammatory cytokines and increasing Brain-Derived neurotrophic factor levels","volume":"11","author":"Liu","year":"2022","journal-title":"Antioxidants"},{"issue":"Pt B","key":"10.1016\/j.jpba.2025.117169_bib21","article-title":"Preliminary exploration of the antidepressant mechanism of bupleurum scorzonerifolium-Scutellaria baicalensis and its core SSa-Baicalin combination","volume":"353","author":"Bing","year":"2025","journal-title":"J. Ethnopharmacol."},{"issue":"1","key":"10.1016\/j.jpba.2025.117169_bib22","first-page":"123","article-title":"Identification of anti-inflammatory components in panax ginseng of sijunzi decoction based on spectrum-effect relationship","volume":"15","author":"Kan","year":"2022","journal-title":"Chin. Herb. Med"},{"issue":"2","key":"10.1016\/j.jpba.2025.117169_bib23","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1007\/s10695-023-01288-0","article-title":"Understanding zebrafish sleep and wakefulness physiology as an experimental model for biomedical research","volume":"50","author":"Singh","year":"2024","journal-title":"Fish. Physiol. Biochem"},{"issue":"4","key":"10.1016\/j.jpba.2025.117169_bib24","first-page":"2021","article-title":"The role of central serotonin neurons and 5-HT heteroreceptor complexes in the pathophysiology of depression: a historical perspective and future prospects","volume":"22","author":"Borroto-Escuela","year":"1927","journal-title":"Int J. Mol. Sci."},{"issue":"11","key":"10.1016\/j.jpba.2025.117169_bib25","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1176\/appi.ajp.2015.15020152","article-title":"Inflammation: depression fans the flames and feasts on the heat","volume":"172","author":"Kiecolt-Glaser","year":"2015","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.jpba.2025.117169_bib26","doi-asserted-by":"crossref","first-page":"8657616","DOI":"10.1155\/2022\/8657616","article-title":"Comparative pharmacokinetic study of three major bioactive components in the normal and different courses of Liver-Stagnation and Spleen-Deficiency syndrome depressive rats after intragastric administration of Zhi-Zi-Hou-Po decoction","volume":"2022","author":"Luo","year":"2022","journal-title":"J. Anal. Methods Chem."},{"issue":"5","key":"10.1016\/j.jpba.2025.117169_bib27","first-page":"7","article-title":"Xiaochaihu decoction combined with xiangsha liujunzi decoction on PDS of liver depression and spleen deficiency type and its effect on MTL and gas","volume":"26","author":"Wei","year":"2023","journal-title":"J. Guangxi Univ. Chin. Med"},{"issue":"1","key":"10.1016\/j.jpba.2025.117169_bib28","first-page":"77","article-title":"Antidepressant effects of aurantii fructus Immaturus\/Aurantii fructus","volume":"7","author":"Zhang","year":"2014","journal-title":"Glob. Tradit. Chin. Med"},{"issue":"16","key":"10.1016\/j.jpba.2025.117169_bib29","doi-asserted-by":"crossref","first-page":"3617","DOI":"10.3390\/molecules25163617","article-title":"Characterization of Anti-Inflammatory and antioxidant constituents from scutellaria baicalensis using LC-MS coupled with a bioassay method","volume":"25","author":"Han","year":"2020","journal-title":"Molecules"},{"key":"10.1016\/j.jpba.2025.117169_bib30","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.chroma.2016.02.079","article-title":"A targeted strategy to analyze untargeted mass spectral data: rapid chemical profiling of scutellaria baicalensis using ultra-high performance liquid chromatography coupled with hybrid quadrupole orbitrap mass spectrometry and key ion filtering","volume":"1441","author":"Qiao","year":"2016","journal-title":"J. Chromatogr. A"},{"issue":"Pt 1","key":"10.1016\/j.jpba.2025.117169_bib31","article-title":"Discovery and verification of Q-markers for promoting blood circulation and removing stasis of raw and wine-steamed vaccaria segetalis based on pharmacological evaluation combined with chemometrics","volume":"319","author":"Bing","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jpba.2025.117169_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2025.156757","article-title":"Mechanism elucidation and biochemometric-based screening of substances in schisandra chinensis leaves for alcoholic liver injury","volume":"142","author":"Bing","year":"2025","journal-title":"Phytomedicine"},{"issue":"15","key":"10.1016\/j.jpba.2025.117169_bib33","first-page":"4078","article-title":"Chemical profiling of xiaochaihu granules and characterization ofabsorbed components in rat plasma after oral administration","volume":"49","author":"Liu","year":"2024","journal-title":"Chin. J. Chin. Mater. Med"},{"issue":"09","key":"10.1016\/j.jpba.2025.117169_bib34","first-page":"179","article-title":"Analysis on components absorbed into blood of citri ReticulataePericarpium in rats based on sequential metabolism and UPLC-HRMS","volume":"29","author":"Chen","year":"2023","journal-title":"Chin. J. Exp. Tradit. Med Formul."},{"key":"10.1016\/j.jpba.2025.117169_bib35","unstructured":"S.Q. Chen, Exploring Quality Markers and Mechanisms of Action of Fructus Aurantii Immaturus Based on in vivo Processes and Network Pharmacology. Nanchang Univ, 2024."}],"container-title":["Journal of Pharmaceutical and Biomedical Analysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0731708525005102?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0731708525005102?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T13:41:41Z","timestamp":1773150101000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0731708525005102"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":35,"alternative-id":["S0731708525005102"],"URL":"https:\/\/doi.org\/10.1016\/j.jpba.2025.117169","relation":{},"ISSN":["0731-7085"],"issn-type":[{"value":"0731-7085","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Antidepressant efficacy and Q-markers determination of Dachaihu decoction: Combining pharmacology, correlation analysis, and network pharmacology approaches","name":"articletitle","label":"Article Title"},{"value":"Journal of Pharmaceutical and Biomedical Analysis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpba.2025.117169","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"117169"}}