{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T02:53:04Z","timestamp":1789181584137,"version":"build-2803163510"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100013077","name":"National Science and Technology Planning Project","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013077","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82074126"],"award-info":[{"award-number":["82074126"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020060","name":"Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization","doi-asserted-by":"publisher","award":["ZDXM-1\\u201310"],"award-info":[{"award-number":["ZDXM-1\\u201310"]}],"id":[{"id":"10.13039\/501100020060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018552","name":"Science and Technology Plan Project of Taizhou","doi-asserted-by":"publisher","award":["SSF20210068"],"award-info":[{"award-number":["SSF20210068"]}],"id":[{"id":"10.13039\/501100018552","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010023","name":"Natural Science Research of Jiangsu Higher Education Institutions of China","doi-asserted-by":"publisher","award":["21KJD360001"],"award-info":[{"award-number":["21KJD360001"]}],"id":[{"id":"10.13039\/501100010023","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmaceutical and Biomedical Analysis"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.jpba.2025.117217","type":"journal-article","created":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T07:52:31Z","timestamp":1761724351000},"page":"117217","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Compatibility mechanism of Atractylodis Macrocephalae Rhizoma and Glycyrrhizae Radix et Rhizoma in colitis treatment: Integrating pharmacokinetics, metabolomics, and network pharmacology"],"prefix":"10.1016","volume":"268","author":[{"given":"Xiaoxiao","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenwen","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meijuan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9043-8118","authenticated-orcid":false,"given":"Shu","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erxin","family":"Shang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinao","family":"Duan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.jpba.2025.117217_bib1","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1038\/s41572-020-0205-x","article-title":"Ulcerative colitis","volume":"6","author":"Kobayashi","year":"2020","journal-title":"Nat. Rev. Dis. Prim."},{"key":"10.1016\/j.jpba.2025.117217_bib2","doi-asserted-by":"crossref","DOI":"10.12688\/f1000research.20805.1","article-title":"Ulcerative colitis: recent advances in the understanding of disease pathogenesis","volume":"9","author":"Porter","year":"2020","journal-title":"F1000Res"},{"issue":"10","key":"10.1016\/j.jpba.2025.117217_bib3","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1016\/j.tips.2024.08.003","article-title":"Ulcerative colitis: clinical biomarkers, therapeutic targets, and emerging treatments","volume":"45","author":"Wangchuk","year":"2024","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.jpba.2025.117217_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2022.115084","article-title":"Potential activity of Traditional Chinese Medicine against Ulcerative colitis: a review","volume":"289","author":"Liu","year":"2022","journal-title":"J. Ethnopharmacol."},{"issue":"11","key":"10.1016\/j.jpba.2025.117217_bib5","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1016\/j.phymed.2014.07.006","article-title":"Data mining and frequency analysis for licorice as a \"Two-Face\" herb in Chinese Formulae based on Chinese Formulae Database","volume":"21","author":"Guo","year":"2014","journal-title":"Phytomedicine"},{"issue":"5","key":"10.1016\/j.jpba.2025.117217_bib6","first-page":"14","article-title":"Study on medication rules in treatment of ulcerative colitis by national TCM masters based on data mining","volume":"28","author":"Xu","year":"2021","journal-title":"Chin. J. Inf. Tradit. Chin. Med."},{"issue":"10","key":"10.1016\/j.jpba.2025.117217_bib7","doi-asserted-by":"crossref","DOI":"10.3390\/molecules28103987","article-title":"Chemical constitution, pharmacological effects and the underlying mechanism of atractylenolides: a review","volume":"28","author":"Xie","year":"2023","journal-title":"Molecules"},{"key":"10.1016\/j.jpba.2025.117217_bib8","first-page":"9129984","article-title":"Atractylenolide III improves mitochondrial function and protects against ulcerative colitis by activating AMPK\/SIRT1\/PGC-1\u03b1","author":"Han","year":"2022","journal-title":"Mediat. Inflamm."},{"issue":"7","key":"10.1016\/j.jpba.2025.117217_bib9","doi-asserted-by":"crossref","first-page":"13041","DOI":"10.3390\/molecules200713041","article-title":"Anti-Inflammatory activities of licorice extract and its active compounds, glycyrrhizic acid, liquiritin and liquiritigenin, in BV2 cells and mice liver","volume":"20","author":"Yu","year":"2015","journal-title":"Molecules"},{"issue":"1","key":"10.1016\/j.jpba.2025.117217_bib10","doi-asserted-by":"crossref","first-page":"73","DOI":"10.2174\/1566523223666230731115236","article-title":"Isoliquiritin ameliorates ulcerative colitis in rats through Caspase 3\/HMGB1\/TLR4 Dependent Signaling Pathway","volume":"24","author":"Miao","year":"2024","journal-title":"Curr. Gene Ther."},{"issue":"1","key":"10.1016\/j.jpba.2025.117217_bib11","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1021\/acs.biomac.1c01233","article-title":"Preparation of oral core-shell zein nanoparticles to improve the bioavailability of glycyrrhizic acid for the treatment of ulcerative colitis","volume":"23","author":"Wu","year":"2022","journal-title":"Biomacromolecules"},{"issue":"10","key":"10.1016\/j.jpba.2025.117217_bib12","doi-asserted-by":"crossref","first-page":"6557","DOI":"10.1039\/D3RA08025K","article-title":"A review of typical biological activities of glycyrrhetinic acid and its derivatives","volume":"14","author":"Chen","year":"2024","journal-title":"RSC Adv."},{"issue":"51","key":"10.1016\/j.jpba.2025.117217_bib13","doi-asserted-by":"crossref","first-page":"85318","DOI":"10.18632\/oncotarget.13347","article-title":"Isoliquiritigenin decreases the incidence of colitis-associated colorectal cancer by modulating the intestinal microbiota","volume":"7","author":"Wu","year":"2016","journal-title":"Oncotarget"},{"issue":"5","key":"10.1016\/j.jpba.2025.117217_bib14","first-page":"323","article-title":"Network pharmacology approaches for research of Traditional Chinese Medicines","volume":"21","author":"Li","year":"2023","journal-title":"Chin. J. Nat. Med."},{"key":"10.1016\/j.jpba.2025.117217_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.compbiomed.2024.108775","article-title":"Integrated metabolomics and serum-feces pharmacochemistry-based network pharmacology to reveal the mechanisms of an herbal prescription against ulcerative colitis","volume":"178","author":"Cheng","year":"2024","journal-title":"Comput. Biol. Med."},{"key":"10.1016\/j.jpba.2025.117217_bib16","doi-asserted-by":"crossref","first-page":"1399460","DOI":"10.3389\/fphar.2024.1399460","article-title":"Several major herb pairs containing Coptidis rhizoma: a review of key traditional uses, constituents and compatibility effects","volume":"15","author":"Li","year":"2024","journal-title":"Front. Pharmacol."},{"issue":"1","key":"10.1016\/j.jpba.2025.117217_bib17","doi-asserted-by":"crossref","first-page":"11","DOI":"10.5217\/ir.2015.13.1.11","article-title":"Intestinal permeability regulation by tight junction: implication on inflammatory bowel diseases","volume":"13","author":"Lee","year":"2015","journal-title":"Intest. Res."},{"key":"10.1016\/j.jpba.2025.117217_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpba.2024.116111","article-title":"A LC-MS-based serum pharmacochemistry approach to reveal the compatibility features of mutual promotion\/assistance herb pairs in Xijiao Dihuang decoction","volume":"243","author":"Zhou","year":"2024","journal-title":"J. Pharm. Biomed. Anal."},{"issue":"1","key":"10.1016\/j.jpba.2025.117217_bib19","first-page":"267","article-title":"Research progress on biopharmaceutical mechanism of Glycyrrhiza uralensis moderating property of herbs","volume":"52","author":"Luo","year":"2021","journal-title":"Chin. Tradit. Herb. Drugs"},{"issue":"10","key":"10.1016\/j.jpba.2025.117217_bib20","doi-asserted-by":"crossref","DOI":"10.3390\/molecules27103268","article-title":"Study on supramolecules in traditional Chinese medicine decoction","volume":"27","author":"Gao","year":"2022","journal-title":"Molecules"},{"issue":"2","key":"10.1016\/j.jpba.2025.117217_bib21","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1080\/17425255.2019.1563595","article-title":"Pharmacokinetic mechanisms underlying the detoxification effect of Glycyrrhizae Radix et Rhizoma (Gancao): drug metabolizing enzymes, transporters, and beyond","volume":"15","author":"Li","year":"2019","journal-title":"Expert Opin. Drug Metab. Toxicol."},{"issue":"5","key":"10.1016\/j.jpba.2025.117217_bib22","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0156387","article-title":"Serum Fatty Acids Are Correlated with Inflammatory Cytokines in Ulcerative Colitis","volume":"11","author":"Wiese","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.jpba.2025.117217_bib23","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.2147\/DDDT.S352467","article-title":"Gancao Xiexin decoction ameliorates ulcerative colitis in mice via modulating gut microbiota and metabolites","volume":"16","author":"Luo","year":"2022","journal-title":"Drug Des. Dev. Ther."},{"issue":"12","key":"10.1016\/j.jpba.2025.117217_bib24","doi-asserted-by":"crossref","first-page":"1606","DOI":"10.1136\/gut.2008.169078","article-title":"Linoleic acid, a dietary n-6 polyunsaturated fatty acid, and the aetiology of ulcerative colitis: a nested case-control study within a European prospective cohort study","volume":"58","author":"Tjonneland","year":"2009","journal-title":"Gut"},{"key":"10.1016\/j.jpba.2025.117217_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2020.112872","article-title":"Mechanism of Huang-lian-Jie-du decoction and its effective fraction in alleviating acute ulcerative colitis in mice: regulating arachidonic acid metabolism and glycerophospholipid metabolism","volume":"259","author":"Yuan","year":"2020","journal-title":"J. Ethnopharmacol."},{"issue":"2","key":"10.1016\/j.jpba.2025.117217_bib26","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1159\/000353694","article-title":"Leukotriene B4, an endogenous stimulator of the innate immune response against pathogens","volume":"6","author":"Le Bel","year":"2014","journal-title":"J. Innate Immun."},{"issue":"7","key":"10.1016\/j.jpba.2025.117217_bib27","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1016\/j.biocel.2013.04.005","article-title":"5-Hydroxyeicosatetraenoic acid and leukotriene D4 increase intestinal epithelial paracellular permeability","volume":"45","author":"Rodr\u00edguez-Lagunas","year":"2013","journal-title":"Int. J. Biochem. Cell Biol."},{"issue":"23","key":"10.1016\/j.jpba.2025.117217_bib28","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20236051","article-title":"Colon cancer and perturbations of the Sphingolipid metabolism","volume":"20","author":"Machala","year":"2019","journal-title":"Int. J. Mol. Sci."},{"issue":"15","key":"10.1016\/j.jpba.2025.117217_bib29","doi-asserted-by":"crossref","first-page":"3841","DOI":"10.1158\/1078-0432.CCR-15-2173","article-title":"MicroRNA MIR21 (miR-21) and PTGS2 expression in colorectal cancer and patient survival","volume":"22","author":"Mima","year":"2016","journal-title":"Clin. Cancer Res"},{"issue":"6","key":"10.1016\/j.jpba.2025.117217_bib30","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.1038\/s41385-018-0018-3","article-title":"Colonic epithelial mTORC1 promotes ulcerative colitis through COX-2-mediated Th17 responses","volume":"11","author":"Lin","year":"2018","journal-title":"Mucosal Immunol."},{"key":"10.1016\/j.jpba.2025.117217_bib31","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/s41232-017-0036-7","article-title":"Prostaglandin E(2)-EP2 signaling as a node of chronic inflammation in the colon tumor microenvironment","volume":"37","author":"Aoki","year":"2017","journal-title":"Inflamm. Regen."}],"container-title":["Journal of Pharmaceutical and Biomedical Analysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0731708525005588?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0731708525005588?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T18:07:13Z","timestamp":1777572433000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0731708525005588"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":31,"alternative-id":["S0731708525005588"],"URL":"https:\/\/doi.org\/10.1016\/j.jpba.2025.117217","relation":{},"ISSN":["0731-7085"],"issn-type":[{"value":"0731-7085","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Compatibility mechanism of Atractylodis Macrocephalae Rhizoma and Glycyrrhizae Radix et Rhizoma in colitis treatment: Integrating pharmacokinetics, metabolomics, and network pharmacology","name":"articletitle","label":"Article Title"},{"value":"Journal of Pharmaceutical and Biomedical Analysis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpba.2025.117217","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"117217"}}