{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T09:06:15Z","timestamp":1775639175838,"version":"3.50.1"},"reference-count":13,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmaceutical and Biomedical Analysis"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.jpba.2025.117249","type":"journal-article","created":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T03:57:49Z","timestamp":1762833469000},"page":"117249","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Determination and pharmacokinetic study of thyroid hormone receptor-\u03b2 agonist resmetirom in beagle dogs using HPLC-MS\/MS method"],"prefix":"10.1016","volume":"269","author":[{"given":"Songmao","family":"Liang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingxuan","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xu","family":"Gong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhe","family":"Luo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiman","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jpba.2025.117249_bib1","doi-asserted-by":"crossref","first-page":"2367","DOI":"10.1016\/j.cgh.2024.07.003","article-title":"Expert panel recommendations: practical clinical applications for initiating and monitoring resmetirom in patients with MASH\/NASH and moderate to noncirrhotic advanced fibrosis","volume":"12","author":"Noureddin","year":"2024","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"10.1016\/j.jpba.2025.117249_bib2","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1038\/s41573-024-01084-2","article-title":"Therapeutic landscape of metabolic dysfunction-associated steatohepatitis (MASH)","volume":"24","author":"Do","year":"2025","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.jpba.2025.117249_bib3","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1016\/j.jhep.2025.02.033","article-title":"Integrative metabolism in MASLD and MASH: pathophysiology and emerging mechanisms","volume":"82","author":"Steinberg","year":"2025","journal-title":"J. Hepatol."},{"key":"10.1016\/j.jpba.2025.117249_bib4","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1080\/17843286.2025.2466011","article-title":"MASH to cirrhosis: bridging the gaps in MASLD management","volume":"79","author":"Gadi","year":"2024","journal-title":"Acta Clin. Belg."},{"key":"10.1016\/j.jpba.2025.117249_bib5","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1016\/j.jhep.2024.04.031","article-title":"European Association for the Study of Diabetes (EASD), European Association for the Study of Obesity (EASO), EASL-EASD-EASO Clinical Practice Guidelines on the management of metabolic dysfunction-associated steatotic liver disease (MASLD)","volume":"81","author":"European Association for the Study of the Liver (EASL)","year":"2024","journal-title":"J. Hepatol."},{"key":"10.1016\/j.jpba.2025.117249_bib6","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1007\/s40265-024-02045-0","article-title":"Resmetirom: first approval","volume":"84","author":"Keam","year":"2024","journal-title":"Drugs"},{"key":"10.1016\/j.jpba.2025.117249_bib7","doi-asserted-by":"crossref","first-page":"19790","DOI":"10.1038\/s41598-024-70242-8","article-title":"Efficacy and safety of Resmetirom, a selective thyroid hormone receptor-\u03b2 agonist, in the treatment of metabolic dysfunction-associated steatotic liver disease (MASLD): a systematic review and meta-analysis","volume":"14","author":"Suvarna","year":"2024","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jpba.2025.117249_bib8","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1515\/jbcpp-2024-0140","article-title":"Efficacy and safety of resmetirom in MASLD and MASH: network meta-analysis of randomized clinical trials","volume":"36","author":"Ayesh","year":"2025","journal-title":"J. Basic Clin. Physiol. Pharm."},{"key":"10.1016\/j.jpba.2025.117249_bib9","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1097\/MEG.0000000000002901","article-title":"Safety and efficacy of resmetirom in metabolic dysfunction-associated steatohepatitis (MASH): a systematic review and meta-analysis","volume":"37","author":"Abbasi","year":"2025","journal-title":"Eur. J. Gastroenterol. Hepatol."},{"key":"10.1016\/j.jpba.2025.117249_bib10","unstructured":"FDA Approved Drug Products: REZDIFFRA (resmetirom) tablets, for oral use. \u3008https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2024\/217785s000lbl.pdf\u3009."},{"key":"10.1016\/j.jpba.2025.117249_bib11","doi-asserted-by":"crossref","first-page":"9703","DOI":"10.1007\/s00210-025-03880-y","article-title":"Unlocking the potential of THR-\u03b2 agonist therapies: resmetirom's chemistry, biology, and patent insights","volume":"398","author":"Dahiya","year":"2025","journal-title":"Naunyn Schmiede Arch. Pharm."},{"key":"10.1016\/j.jpba.2025.117249_bib12","doi-asserted-by":"crossref","first-page":"4048","DOI":"10.3390\/molecules29174048","article-title":"Stability evaluation and pharmacokinetic profiling of vepdegestrant in rodents using liquid chromatography-tandem mass spectrometry","volume":"29","author":"Choi","year":"2024","journal-title":"Molecules"},{"key":"10.1016\/j.jpba.2025.117249_bib13","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1097\/FTD.0000000000001245","article-title":"Simultaneous determination of ripretinib and its desmethyl metabolite in human plasma using LC-MS\/MS","volume":"46","author":"Qian","year":"2024","journal-title":"Ther. Drug Monit."}],"container-title":["Journal of Pharmaceutical and Biomedical Analysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0731708525005904?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0731708525005904?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T12:40:14Z","timestamp":1764765614000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0731708525005904"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":13,"alternative-id":["S0731708525005904"],"URL":"https:\/\/doi.org\/10.1016\/j.jpba.2025.117249","relation":{},"ISSN":["0731-7085"],"issn-type":[{"value":"0731-7085","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Determination and pharmacokinetic study of thyroid hormone receptor-\u03b2 agonist resmetirom in beagle dogs using HPLC-MS\/MS method","name":"articletitle","label":"Article Title"},{"value":"Journal of Pharmaceutical and Biomedical Analysis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpba.2025.117249","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"117249"}}