{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T12:06:52Z","timestamp":1788264412801,"version":"build-2803163510"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100010096","name":"Southern Medical University","doi-asserted-by":"publisher","award":["2021A1515010737"],"award-info":[{"award-number":["2021A1515010737"]}],"id":[{"id":"10.13039\/501100010096","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010096","name":"Southern Medical University","doi-asserted-by":"publisher","award":["2024A1515011417"],"award-info":[{"award-number":["2024A1515011417"]}],"id":[{"id":"10.13039\/501100010096","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010096","name":"Southern Medical University","doi-asserted-by":"publisher","award":["yzjj2024qn07"],"award-info":[{"award-number":["yzjj2024qn07"]}],"id":[{"id":"10.13039\/501100010096","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010096","name":"Southern Medical University","doi-asserted-by":"publisher","award":["2022A1515110221"],"award-info":[{"award-number":["2022A1515110221"]}],"id":[{"id":"10.13039\/501100010096","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001747","name":"Hong Kong Baptist University","doi-asserted-by":"publisher","award":["RC\/IRCs\/17\\u201318\/04"],"award-info":[{"award-number":["RC\/IRCs\/17\\u201318\/04"]}],"id":[{"id":"10.13039\/501100001747","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmaceutical and Biomedical Analysis"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1016\/j.jpba.2025.117313","type":"journal-article","created":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T16:38:55Z","timestamp":1765211935000},"page":"117313","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["SuHeXiang Wan in the treatment of stroke: Prediction potentially active metabolites using a combination of in silico analysis and experimental viability assessment"],"prefix":"10.1016","volume":"270","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-9716-5481","authenticated-orcid":false,"given":"Lingyu","family":"Shen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9984-8439","authenticated-orcid":false,"given":"Wenxing","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2346-5826","authenticated-orcid":false,"given":"Yupeng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daogang","family":"Guan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aiping","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anqi","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jpba.2025.117313_bib1","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/S1474-4422(19)30415-6","article-title":"Advances and challenges in stroke rehabilitation","volume":"19","author":"Stinear","year":"2020","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.jpba.2025.117313_bib2","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1038\/nature13909","article-title":"Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS","volume":"515","author":"Chouchani","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.jpba.2025.117313_bib3","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.tcm.2016.06.009","article-title":"Acute stroke therapy: a review","volume":"27","author":"Peisker","year":"2017","journal-title":"Trends Cardiovasc. Med."},{"key":"10.1016\/j.jpba.2025.117313_bib4","article-title":"Traditional chinese medicine for post-stroke cognitive impairment: a systematic review and meta-analysis","volume":"13","author":"Shen","year":"2022","journal-title":"Front. Pharm."},{"key":"10.1016\/j.jpba.2025.117313_bib5","article-title":"The identification and molecular mechanism of anti-stroke traditional Chinese medicinal compounds","volume":"7","author":"Liu","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jpba.2025.117313_bib6","first-page":"875","article-title":"Study on ancient and modern application of Suhexiang Pill","volume":"28","author":"Bian","year":"2016","journal-title":"Clin. J. Tradit. Chin. Med."},{"key":"10.1016\/j.jpba.2025.117313_bib7","first-page":"132","article-title":"Suhexiang Wan in the treatment of 108 cases of acute stroke","volume":"4","author":"Leng","year":"2012","journal-title":"Tradit. Chin. Med."},{"key":"10.1016\/j.jpba.2025.117313_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2021.114467","article-title":"Post-stroke treatment of storax improves long-term outcomes of stroke in rats","volume":"280","author":"Zhou","year":"2021","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jpba.2025.117313_bib9","first-page":"1294","article-title":"Mechanism of Suhexiang Pill in treatment of ischemic stroke based on network pharmacology and molecular docking","volume":"45","author":"Shan","year":"2022","journal-title":"Drug Eval. Res."},{"key":"10.1016\/j.jpba.2025.117313_bib10","article-title":"Elucidating the synergistic effect of multiple chinese herbal prescriptions in the treatment of post-stroke neurological damage","volume":"13","author":"Xu","year":"2022","journal-title":"Front. Pharm."},{"key":"10.1016\/j.jpba.2025.117313_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpba.2023.115867","article-title":"The effective compounds and mechanisms of Cang-Fu-Dao-Tan formula in treating polycystic ovary syndrome based on UPLC\/Q-TOF-MS\/MS, network pharmacology and molecular experiments","volume":"239","author":"Hu","year":"2024","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jpba.2025.117313_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpba.2024.116061","article-title":"Deciphering the molecular mechanism of Bu Yang Huan Wu Decoction in interference with diabetic pulmonary fibrosis via regulating oxidative stress and lipid metabolism disorder","volume":"243","author":"Guo","year":"2024","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jpba.2025.117313_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpba.2025.116951","article-title":"Study on the active ingredients and mechanism of Huyang Yangkun Formula for treating premature ovarian insufficiency via chemical profiling, network pharmacology, and experimental validation","volume":"263","author":"Li","year":"2025","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jpba.2025.117313_bib14","doi-asserted-by":"crossref","first-page":"1650","DOI":"10.1038\/nprot.2016.095","article-title":"Transcript-level expression analysis of RNA-seq experiments with HISAT, StringTie and Ballgown","volume":"11","author":"Pertea","year":"2016","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.jpba.2025.117313_bib15","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkv007","article-title":"limma powers differential expression analyses for RNA-sequencing and microarray studies","volume":"43","author":"Ritchie","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jpba.2025.117313_bib16","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/1752-153X-2-5","article-title":"Pybel: a Python wrapper for the OpenBabel cheminformatics toolkit","volume":"2","author":"O'Boyle","year":"2008","journal-title":"Chem. Cent. J."},{"key":"10.1016\/j.jpba.2025.117313_bib17","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1186\/s12906-023-03990-1","article-title":"Screening of key functional components of Taohong Siwu Decoction on ischemic stroke treatment based on multiobjective optimization approach and experimental validation","volume":"23","author":"Xu","year":"2023","journal-title":"BMC Complement. Med. Ther."},{"key":"10.1016\/j.jpba.2025.117313_bib18","doi-asserted-by":"crossref","DOI":"10.7717\/peerj.2470","article-title":"Integrated analysis of ischemic stroke datasets revealed sex and age difference in anti-stroke targets","volume":"4","author":"Li","year":"2016","journal-title":"PeerJ"},{"key":"10.1016\/j.jpba.2025.117313_bib19","first-page":"736","article-title":"Different impairment of immune and inflammation functions in short and long-term after ischemic stroke","volume":"9","author":"Li","year":"2017","journal-title":"Am. J. Transl. Res."},{"key":"10.1016\/j.jpba.2025.117313_bib20","doi-asserted-by":"crossref","first-page":"15113","DOI":"10.1523\/JNEUROSCI.2890-15.2015","article-title":"Daidzein augments cholesterol homeostasis via ApoE to promote functional recovery in chronic stroke","volume":"35","author":"Kim","year":"2015","journal-title":"J. Neurosci."},{"key":"10.1016\/j.jpba.2025.117313_bib21","article-title":"Neuroprotective effect of daidzein extracted from pueraria lobate radix in a stroke model via the Akt\/mTOR\/BDNF channel","volume":"12","author":"Zheng","year":"2021","journal-title":"Front. Pharm."},{"key":"10.1016\/j.jpba.2025.117313_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2020.107268","article-title":"Syringin exerts neuroprotective effects in a rat model of cerebral ischemia through the FOXO3a\/NF-kappaB pathway","volume":"90","author":"Tan","year":"2021","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.jpba.2025.117313_bib23","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.0030128","article-title":"An unbiased cell morphology-based screen for new, biologically active small molecules","volume":"3","author":"Tanaka","year":"2005","journal-title":"PLoS Biol."},{"key":"10.1016\/j.jpba.2025.117313_bib24","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1007\/s12975-021-00912-6","article-title":"Carbonyl reductase 1 attenuates ischemic brain injury by reducing oxidative stress and neuroinflammation","volume":"12","author":"Mao","year":"2021","journal-title":"Transl. Stroke Res."},{"key":"10.1016\/j.jpba.2025.117313_bib25","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1161\/01.STR.20.2.248","article-title":"A flavonoid inhibitor of 5-lipoxygenase inhibits leukotriene production following ischemia in gerbil brain","volume":"20","author":"Ban","year":"1989","journal-title":"Stroke"},{"key":"10.1016\/j.jpba.2025.117313_bib26","doi-asserted-by":"crossref","DOI":"10.3390\/agronomy11112165","article-title":"HPLC\/MS phytochemical profiling with antioxidant activities of Echium humile Desf. Extracts: ADMET prediction and computational study targeting human peroxiredoxin 5 receptor","volume":"11","author":"Aouadi","year":"2021","journal-title":"Agronomy"},{"key":"10.1016\/j.jpba.2025.117313_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2022.115847","article-title":"Integrating network pharmacology and pharmacological evaluation to explore the protective mechanism of Ershiwuwei Zhenzhu pill in ischemic stroke","volume":"301","author":"Wang","year":"2023","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jpba.2025.117313_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2023.116507","article-title":"Network pharmacology-based prediction and validation of the active ingredients and potential mechanisms of the Huangxiong formula for treating ischemic stroke","volume":"312","author":"Zhao","year":"2023","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jpba.2025.117313_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.154934","article-title":"Elucidation of the mechanism of Yiqi Tongluo Granule against cerebral ischemia\/reperfusion injury based on a combined strategy of network pharmacology, multi-omics and molecular biology","volume":"118","author":"Yuan","year":"2023","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jpba.2025.117313_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2025.157251","article-title":"Integrating serum pharmacochemistry, network pharmacology, and metabolomics to explore the protective mechanism of Hua-Feng-Dan in ischemic stroke","volume":"148","author":"Yuan","year":"2025","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jpba.2025.117313_bib31","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1186\/s12883-019-1509-x","article-title":"Low free triiodothyronineis predicts worsen neurological outcome of patients with acute ischemic stroke: a retrospective study with bioinformatics analysis","volume":"19","author":"Zhang","year":"2019","journal-title":"BMC Neurol."},{"key":"10.1016\/j.jpba.2025.117313_bib32","doi-asserted-by":"crossref","first-page":"150","DOI":"10.2174\/1871527320666210512013648","article-title":"Arachidonic acid metabolites in neurologic disorders","volume":"21","author":"Kursun","year":"2022","journal-title":"CNS Neurol. Disord. Drug Targets"},{"key":"10.1016\/j.jpba.2025.117313_bib33","article-title":"Network pharmacology and molecular docking-based mechanism study to reveal the protective effect of salvianolic Acid C in a rat model of ischemic stroke","volume":"12","author":"Yang","year":"2021","journal-title":"Front. Pharm."},{"key":"10.1016\/j.jpba.2025.117313_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2019.e01692","article-title":"beta-Cyclodextrin complex improves the bioavailability and antitumor potential of cirsiliol, a flavone isolated from Leonotis nepetifolia (Lamiaceae)","volume":"5","author":"Oliveira","year":"2019","journal-title":"Heliyon"},{"key":"10.1016\/j.jpba.2025.117313_bib35","doi-asserted-by":"crossref","DOI":"10.3390\/cells9112481","article-title":"Drug crystal-related gastrointestinal complications involve crystal-induced release of neutrophil and monocyte extracellular traps","volume":"9","author":"Kim","year":"2020","journal-title":"Cells"}],"container-title":["Journal of Pharmaceutical and Biomedical Analysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0731708525006545?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0731708525006545?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T01:50:18Z","timestamp":1773885018000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0731708525006545"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":35,"alternative-id":["S0731708525006545"],"URL":"https:\/\/doi.org\/10.1016\/j.jpba.2025.117313","relation":{},"ISSN":["0731-7085"],"issn-type":[{"value":"0731-7085","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"SuHeXiang Wan in the treatment of stroke: Prediction potentially active metabolites using a combination of in silico analysis and experimental viability assessment","name":"articletitle","label":"Article Title"},{"value":"Journal of Pharmaceutical and Biomedical Analysis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpba.2025.117313","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"117313"}}