{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T05:47:15Z","timestamp":1777873635900,"version":"3.51.4"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81803961,82374300"],"award-info":[{"award-number":["81803961,82374300"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81803961"],"award-info":[{"award-number":["81803961"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82374300"],"award-info":[{"award-number":["82374300"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017964","name":"Tianjin Municipal Health Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100017964","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmaceutical and Biomedical Analysis"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.jpba.2026.117403","type":"journal-article","created":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T16:04:31Z","timestamp":1770739471000},"page":"117403","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Metabolomics technology combined with O2PLS analysis reveals the active components of Paeoniae Radix Alba in preventing renal damage in rheumatoid arthritis"],"prefix":"10.1016","volume":"273","author":[{"given":"Shuyi","family":"Lv","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiayi","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingqin","family":"Kang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-3371-9950","authenticated-orcid":false,"given":"Lili","family":"Song","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yubo","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jpba.2026.117403_bib1","first-page":"67","article-title":"Research progress in the pathogenesis of rheumatoid arthritis","volume":"13","author":"Wang","year":"2024","journal-title":"Rheumatol. Arthritis"},{"key":"10.1016\/j.jpba.2026.117403_bib2","doi-asserted-by":"crossref","first-page":"81","DOI":"10.3390\/biom11010081","article-title":"Endothelial dysfunction and extra-articular neurological manifestations in rheumatoid arthritis","volume":"11","author":"Maiuolo","year":"2021","journal-title":"Biomolecules"},{"key":"10.1016\/j.jpba.2026.117403_bib3","article-title":"Rheumatoid arthritis and the risk of end-stage renal disease: a nationwide, population-based study","volume":"10","author":"Suh","year":"2023","journal-title":"Front. Med. (Lausanne)"},{"key":"10.1016\/j.jpba.2026.117403_bib4","doi-asserted-by":"crossref","first-page":"481","DOI":"10.5114\/reum\/177005","article-title":"Rheumatoid arthritis - medication dosage in chronic kidney disease","volume":"61","author":"Tyczy\u0144ska","year":"2023","journal-title":"Reumatologia"},{"key":"10.1016\/j.jpba.2026.117403_bib5","first-page":"76","article-title":"Review of pharmacological actions of active ingredients in Paeonia lactiflora","volume":"56","author":"Shen","year":"2024","journal-title":"Jiangsu J. Tradit. Chin. Med."},{"key":"10.1016\/j.jpba.2026.117403_bib6","first-page":"1490","article-title":"Study on the spatio-temporal expression pattern and their correlation of monoterpene glycosides content and biosynthesis-related genes in Paeonia lactiflora Pall","volume":"40","author":"Xu","year":"2023","journal-title":"Chin. J. Mod. Appl. Pharm."},{"key":"10.1016\/j.jpba.2026.117403_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2019.153091","article-title":"Total glucosides of Paeoniae Radix Albaprotects against collagen-induced mouse arthritis via inhibiting follicular helper T cell differentiation","volume":"65","author":"Li","year":"2019","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jpba.2026.117403_bib8","first-page":"390","article-title":"Therapeutic effect of total glucosides of Paeoniae Radix Alba in rheumatoid arthritis model rats by mediating the TLR4\/NF-\u03baB signaling pathway and its mechanism","volume":"47","author":"Yan","year":"2021","journal-title":"J. Jilin Univ. (Med. Ed. )"},{"key":"10.1016\/j.jpba.2026.117403_bib9","doi-asserted-by":"crossref","first-page":"566","DOI":"10.3389\/fphar.2019.00566","article-title":"Paeoniflorin ameliorates macrophage infiltration and activation by inhibiting the TLR4 signaling pathway in diabetic nephropathy","volume":"10","author":"Shao","year":"2019","journal-title":"Front. Pharm."},{"key":"10.1016\/j.jpba.2026.117403_bib10","first-page":"35","article-title":"Therapeutic effect of total glucosides of Paeoniae Radix Alba on diabetic nephropathy rats and its influence on the expression of TGF-\u03b21 and CTGF in renal tissue","volume":"57","author":"Song","year":"2017","journal-title":"Shandong Med. J."},{"key":"10.1016\/j.jpba.2026.117403_bib11","first-page":"855","article-title":"Progress of research on relative dynamics of the pharmacodynamic material basis of traditional Chinese medicines","volume":"45","author":"Shi","year":"2021","journal-title":"Pharm. Prog."},{"key":"10.1016\/j.jpba.2026.117403_bib12","first-page":"1439","article-title":"Research on effective substances and mechanism of traditional Chinese medicine prescriptions based on metabolomics technology","volume":"43","author":"Xie","year":"2020","journal-title":"Drug Eval. Res."},{"key":"10.1016\/j.jpba.2026.117403_bib13","doi-asserted-by":"crossref","first-page":"404","DOI":"10.3390\/metabo5030404","article-title":"A metabolomic approach to target compounds from the Asteraceae family for dual COX and LOX inhibition","volume":"5","author":"Chagas-Paula","year":"2015","journal-title":"Metabolites"},{"key":"10.1016\/j.jpba.2026.117403_bib14","article-title":"Therapeutic effect of Periploca forrestii on collagen-induced arthritis in rats through JAK2\/NF-\u03baB pathway","volume":"15","author":"Zhang","year":"2024","journal-title":"Front. Pharm."},{"key":"10.1016\/j.jpba.2026.117403_bib15","first-page":"694","article-title":"Preliminary UPLC-MS metabolomics study on the anti-inflammatory effects of Paeoniae Radix Alba and Paeoniae Radix Alba","volume":"36","author":"Yang","year":"2011","journal-title":"Chin. J. Tradit. Chin. Med."},{"key":"10.1016\/j.jpba.2026.117403_bib16","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1093\/biostatistics\/kxz010","article-title":"The functional false discovery rate with applications to genomics","volume":"22","author":"Chen","year":"2021","journal-title":"Biostatistics"},{"key":"10.1016\/j.jpba.2026.117403_bib17","doi-asserted-by":"crossref","first-page":"2418","DOI":"10.1093\/bioinformatics\/bty064","article-title":"FWER and FDR control when testing multiple mediators","volume":"34","author":"Sampson","year":"2018","journal-title":"Bioinformatics"},{"key":"10.1016\/j.jpba.2026.117403_bib18","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.adj1252","article-title":"Loss of synovial tissue macrophage homeostasis precedes rheumatoid arthritis clinical onset","volume":"10","author":"Hanlon","year":"2024","journal-title":"Sci. Adv."},{"key":"10.1016\/j.jpba.2026.117403_bib19","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.amsu.2020.11.011","article-title":"Renal dysfunction among rheumatoid arthritis patients: a retrospective cohort study","volume":"60","author":"Oweis","year":"2020","journal-title":"Ann. Med. Surg. (Lond. )"},{"key":"10.1016\/j.jpba.2026.117403_bib20","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1136\/ard-2024-226156","article-title":"Disease activity of rheumatoid arthritis and kidney function decline: a large prospective registry study","volume":"84","author":"Fukui","year":"2025","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.jpba.2026.117403_bib21","doi-asserted-by":"crossref","first-page":"566","DOI":"10.3389\/fphar.2019.00566","article-title":"Paeoniflorin ameliorates macrophage infiltration and activation by inhibiting the TLR4 signaling pathway in diabetic nephropathy","volume":"10","author":"Shao","year":"2019","journal-title":"Front. Pharm."},{"key":"10.1016\/j.jpba.2026.117403_bib22","article-title":"Protective effect of paeoniflorin in diabetic nephropathy: a preclinical systematic review revealing the mechanism of action","volume":"18","author":"Zhang","year":"2023","journal-title":"PLoS One"},{"key":"10.1016\/j.jpba.2026.117403_bib23","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.704260","article-title":"UPLC\/Q-TOF MS screening and identification of antibacterial compounds in Forsythia suspensa (Thunb.) Vahl leaves","volume":"12","author":"Zhou","year":"2022","journal-title":"Front. Pharm."},{"key":"10.1016\/j.jpba.2026.117403_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpba.2023.115960","article-title":"Study on the white frost formation mechanism during storage of Phyllanthus emblica Linn. fruit based on component analysis and spatial metabolomics","volume":"241","author":"Lin","year":"2024","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jpba.2026.117403_bib25","first-page":"3412","article-title":"Study on mechanism of nourishing blood and smoothing liver effects of Paeoniae Radix Alba based on metabolomics information","volume":"48","author":"Zhao","year":"2017","journal-title":"Chin. Tradit. Herb. Drugs"},{"key":"10.1016\/j.jpba.2026.117403_bib26","doi-asserted-by":"crossref","first-page":"783","DOI":"10.3390\/antiox9090783","article-title":"Hippuric acid promotes renal fibrosis by disrupting redox homeostasis via facilitation of NRF2-KEAP1-CUL3 interactions in chronic kidney disease","volume":"9","author":"Sun","year":"2020","journal-title":"Antioxid. (Basel)"},{"key":"10.1016\/j.jpba.2026.117403_bib27","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1186\/s40168-024-01826-9","article-title":"Gut microbiota dysbiosis in hyperuricaemia promotes renal injury through the activation of NLRP3 inflammasome","volume":"12","author":"Zhou","year":"2024","journal-title":"Microbiome"},{"key":"10.1016\/j.jpba.2026.117403_bib28","doi-asserted-by":"crossref","first-page":"783","DOI":"10.3390\/antiox9090783","article-title":"Hippuric acid promotes renal fibrosis by disrupting redox homeostasis via facilitation of NRF2-KEAP1-CUL3 interactions in chronic kidney disease","volume":"9","author":"Sun","year":"2020","journal-title":"Antioxid. (Basel)"},{"key":"10.1016\/j.jpba.2026.117403_bib29","first-page":"1","article-title":"NMR-based metabolomics analysis of urine in cisplatin-induced renal injury rats before and after intervention with Panax notoginseng saponins","volume":"56","author":"Huang","year":"2016","journal-title":"Shandong Med. J."},{"key":"10.1016\/j.jpba.2026.117403_bib30","doi-asserted-by":"crossref","first-page":"7014","DOI":"10.3390\/molecules27207014","article-title":"High-throughput metabolomics integrated network pharmacology reveals the underlying mechanism of Paeoniae Radix Alba treating rheumatoid arthritis","volume":"27","author":"Liu","year":"2022","journal-title":"Molecules"},{"key":"10.1016\/j.jpba.2026.117403_bib31","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1016\/j.biotechadv.2015.04.006","article-title":"Metabolic engineering in the biotechnological production of organic acids in the tricarboxylic acid cycle of microorganisms: advances and prospects","volume":"33","author":"Yin","year":"2015","journal-title":"Biotechnol. Adv."},{"issue":"22","key":"10.1016\/j.jpba.2026.117403_bib32","doi-asserted-by":"crossref","first-page":"7337","DOI":"10.3390\/s24227337","article-title":"Integration of FTIR Spectroscopy, Volatile Compound Profiling, and Chemometric Techniques for Advanced Geographical and Varietal Analysis of Moroccan Eucalyptus Essential Oils","volume":"24","author":"El Orche","year":"2024","journal-title":"Sens. (Basel)"},{"key":"10.1016\/j.jpba.2026.117403_bib33","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1186\/s12859-018-2371-3","article-title":"Integrating omics datasets with the OmicsPLS package","volume":"19","author":"Bouhaddani","year":"2018","journal-title":"BMC Bioinforma."},{"key":"10.1016\/j.jpba.2026.117403_bib34","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1186\/s12859-021-03958-3","article-title":"Statistical integration of two omics datasets using GO2PLS","volume":"22","author":"Gu","year":"2021","journal-title":"BMC Bioinforma."},{"key":"10.1016\/j.jpba.2026.117403_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.154400","article-title":"Paeoniflorin binds to VEGFR2 to restore autophagy and inhibit apoptosis for podocyte protection in diabetic kidney disease through PI3K-AKT signaling pathway","volume":"106","author":"Wang","year":"2022","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jpba.2026.117403_bib36","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2020.580593","article-title":"Gallic acid alleviates gouty arthritis by inhibiting NLRP3 inflammasome activation and pyroptosis through enhancing Nrf2 signaling","volume":"11","author":"Lin","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jpba.2026.117403_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.etap.2022.103960","article-title":"Protective activities of ellagic acid and urolithins against kidney toxicity of environmental pollutants: A review","volume":"95","author":"Garc\u00eda-Ni\u00f1o","year":"2022","journal-title":"Environ. Toxicol. Pharm."}],"container-title":["Journal of Pharmaceutical and Biomedical Analysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0731708526000713?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0731708526000713?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T18:07:39Z","timestamp":1777572459000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0731708526000713"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":37,"alternative-id":["S0731708526000713"],"URL":"https:\/\/doi.org\/10.1016\/j.jpba.2026.117403","relation":{},"ISSN":["0731-7085"],"issn-type":[{"value":"0731-7085","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Metabolomics technology combined with O2PLS analysis reveals the active components of Paeoniae Radix Alba in preventing renal damage in rheumatoid arthritis","name":"articletitle","label":"Article Title"},{"value":"Journal of Pharmaceutical and Biomedical Analysis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpba.2026.117403","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"117403"}}