{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T20:45:52Z","timestamp":1782420352529,"version":"3.54.5"},"reference-count":188,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmaceutical and Biomedical Analysis"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.jpba.2026.117434","type":"journal-article","created":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T07:47:02Z","timestamp":1771832822000},"page":"117434","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Pharmaceutical insights into nanoscale drug delivery systems and chromatographic approaches for melanoma treatment"],"prefix":"10.1016","volume":"274","author":[{"given":"Armineh","family":"Deljavan Ghodrati","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weldejeworgis","family":"Gebrehiwot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gulin","family":"Amasya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehmet","family":"Gumustas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ceyda Tuba","family":"Sengel-Turk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jpba.2026.117434_bib1","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.imed.2022.08.004","article-title":"State-of-the-art machine learning techniques for melanoma skin cancer detection and classification: a comprehensive review","volume":"3","author":"Bhatt","year":"2023","journal-title":"Intell. Med."},{"key":"10.1016\/j.jpba.2026.117434_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpba.2022.114643","article-title":"1H NMR-based metabolomics of skin squamous cell carcinoma and peri-tumoral region tissues","volume":"212","author":"Mei","year":"2022","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jpba.2026.117434_bib3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.suc.2019.09.005","article-title":"Epidemiology and risk factors of melanoma","volume":"100","author":"Carr","year":"2020","journal-title":"Surg. Clin. North Am."},{"key":"10.1016\/j.jpba.2026.117434_bib4","doi-asserted-by":"crossref","first-page":"500","DOI":"10.5858\/arpa.2019-0561-RA","article-title":"The 2018 World Health Organization Classification of Cutaneous, mucosal, and uveal melanoma: detailed analysis of 9 distinct subtypes defined by their evolutionary pathway","volume":"144","author":"Elder","year":"2020","journal-title":"Arch. Pathol. Lab. Med."},{"key":"10.1016\/j.jpba.2026.117434_bib5","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.det.2022.07.017","article-title":"Melanoma classification and management in the era of molecular medicine","volume":"41","author":"Rashid","year":"2023","journal-title":"Dermatol. Clin."},{"key":"10.1016\/j.jpba.2026.117434_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2021.120413","article-title":"A review on liposome-based therapeutic approaches against malignant melanoma","volume":"599","author":"Mirzavi","year":"2021","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.jpba.2026.117434_bib7","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.det.2022.07.007","article-title":"Targeted therapy and immunotherapy in melanoma","volume":"41","author":"Lazaroff","year":"2023","journal-title":"Dermatol. Clin."},{"key":"10.1016\/j.jpba.2026.117434_bib8","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1038\/nrclinonc.2017.43","article-title":"Targeted agents and immunotherapies: optimizing outcomes in melanoma","volume":"14","author":"Luke","year":"2017","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.jpba.2026.117434_bib9","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.jid.2020.03.943","article-title":"Treatment of advanced melanoma in 2020 and beyond","volume":"141","author":"Jenkins","year":"2021","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.jpba.2026.117434_bib10","doi-asserted-by":"crossref","first-page":"2283","DOI":"10.1007\/s00432-018-2726-1","article-title":"Melanoma treatment: from conventional to nanotechnology","volume":"144","author":"Mishra","year":"2018","journal-title":"J. Cancer Res. Clin. Oncol."},{"key":"10.1016\/j.jpba.2026.117434_bib11","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1111\/bjd.20427","article-title":"Melanoma pathology: new approaches and classification","volume":"185","author":"Yeh","year":"2021","journal-title":"Br. J. Dermatol."},{"key":"10.1016\/j.jpba.2026.117434_bib12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.suc.2019.09.005","article-title":"Epidemiology and risk factors of melanoma","volume":"100","author":"Carr","year":"2020","journal-title":"Surg. Clin. North Am."},{"key":"10.1016\/j.jpba.2026.117434_bib13","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/s12943-022-01708-4","article-title":"Advancements in nanoparticle-based treatment approaches for skin cancer therapy","volume":"22","author":"Zeng","year":"2023","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.jpba.2026.117434_bib14","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1038\/s41379-019-0402-x","article-title":"Melanoma pathology reporting and staging","volume":"33","author":"Scolyer","year":"2020","journal-title":"Mod. Pathol."},{"key":"10.1016\/j.jpba.2026.117434_bib15","doi-asserted-by":"crossref","first-page":"500","DOI":"10.5858\/arpa.2019-0561-RA","article-title":"The 2018 World Health Organization Classification of Cutaneous, mucosal, and uveal melanoma: detailed analysis of 9 distinct subtypes defined by their evolutionary pathway","volume":"144","author":"Elder","year":"2020","journal-title":"Arch. Pathol. Lab. Med."},{"key":"10.1016\/j.jpba.2026.117434_bib16","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1038\/s41572-020-0158-0","article-title":"Uveal melanoma","volume":"6","author":"Jager","year":"2020","journal-title":"Nat. Rev. Dis. Prim."},{"key":"10.1016\/j.jpba.2026.117434_bib17","first-page":"1071","article-title":"Cutaneous melanoma: from pathogenesis to therapy (Review)","volume":"52","author":"Leonardi","year":"2018","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.jpba.2026.117434_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpba.2023.115374","article-title":"In vivo evaluation of newly synthesized 213Bi-conjugated alpha-melanocyte stimulating hormone (\u03b1-MSH) peptide analogues in melanocortin-1 receptor (MC1-R) positive experimental melanoma model","volume":"229","author":"K\u00e1lm\u00e1n-Szab\u00f3","year":"2023","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jpba.2026.117434_bib19","doi-asserted-by":"crossref","first-page":"3535","DOI":"10.3390\/ijms21103535","article-title":"Current molecular markers of melanoma and treatment targets","volume":"21","author":"Yang","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jpba.2026.117434_bib20","first-page":"107","article-title":"Recent advances in nanomaterial-based drug delivery systems for melanoma therapy","volume":"12","author":"Parhi","year":"2023","journal-title":"ADMET DMPK"},{"key":"10.1016\/j.jpba.2026.117434_bib21","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.addr.2017.09.016","article-title":"Targeted drug delivery to melanoma","volume":"127","author":"Liu","year":"2018","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.jpba.2026.117434_bib22","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1002\/pds.5248","article-title":"Survival of advanced melanoma patients treated with immunotherapy and targeted therapy: a real-world study","volume":"30","author":"Yu","year":"2021","journal-title":"Pharmacoepidemiol. Drug Saf."},{"key":"10.1016\/j.jpba.2026.117434_bib23","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1002\/cam4.1001","article-title":"A systematic review and network meta-analysis of immunotherapy and targeted therapy for advanced melanoma","volume":"6","author":"Da Silveira Nogueira Lima","year":"2017","journal-title":"Cancer Med"},{"key":"10.1016\/j.jpba.2026.117434_bib24","doi-asserted-by":"crossref","first-page":"5017","DOI":"10.3390\/jcm14145017","article-title":"Comparative meta-analysis of survival, risk, and treatment efficacy in immunotherapy for metastatic melanoma using random-, fixed-, and mixed-effects models","volume":"14","author":"Iveti\u0107","year":"2025","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.jpba.2026.117434_bib25","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.1515\/ntrev-2020-0117","article-title":"Therapeutic strategies and potential implications of silver nanoparticles in the management of skin cancer","volume":"9","author":"Dasari","year":"2020","journal-title":"Nanotechnol. Rev."},{"key":"10.1016\/j.jpba.2026.117434_bib26","doi-asserted-by":"crossref","first-page":"575","DOI":"10.3390\/pharmaceutics13040575","article-title":"BSA-silver nanoparticles: potential multimodal therapeutics for conventional and photothermal treatment of skin cancer","volume":"13","author":"Kim","year":"2021","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.jpba.2026.117434_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.canlet.2023.216148","article-title":"Novel strategies in melanoma treatment using silver nanoparticles","volume":"561","author":"Zhao","year":"2023","journal-title":"Cancer Lett."},{"key":"10.1016\/j.jpba.2026.117434_bib28","doi-asserted-by":"crossref","first-page":"5459","DOI":"10.2147\/IJN.S255874","article-title":"ICG-loaded PEGylated BSA-silver nanoparticles for effective photothermal cancer therapy","volume":"15","author":"Park","year":"2020","journal-title":"Int. J. Nanomed."},{"key":"10.1016\/j.jpba.2026.117434_bib29","doi-asserted-by":"crossref","first-page":"854","DOI":"10.3390\/ph14090854","article-title":"Retinoids delivery systems in cancer: liposomal fenretinide for neuroectodermal-derived tumors","volume":"14","author":"Bensa","year":"2021","journal-title":"Pharmaceuticals"},{"key":"10.1016\/j.jpba.2026.117434_bib30","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.3390\/pharmaceutics13101617","article-title":"Nanotechnology addressing cutaneous melanoma: the Italian landscape","volume":"13","author":"Battaglia","year":"2021","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.jpba.2026.117434_bib31","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1615\/CritRevTherDrugCarrierSyst.2021034903","article-title":"Recent advances in lipid-based nanovesicular delivery systems for melanoma therapy","volume":"38","author":"Kurakula","year":"2021","journal-title":"Crit. Rev. Ther. Drug Carr. Syst."},{"key":"10.1016\/j.jpba.2026.117434_bib32","first-page":"312","article-title":"Reversing cold tumors to hot: an immunoadjuvant-functionalized metal-organic framework for multimodal imaging-guided synergistic photo-immunotherapy","volume":"6","author":"Fan","year":"2021","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.jpba.2026.117434_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.nantod.2021.101279","article-title":"Endocytosis of abiotic nanomaterials and nanobiovectors: inhibition of membrane trafficking","volume":"40","author":"Makvandi","year":"2021","journal-title":"Nano Today"},{"key":"10.1016\/j.jpba.2026.117434_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2022.106364","article-title":"Extracellular vesicles in pancreatic cancer immune escape: emerging roles and mechanisms","volume":"183","author":"Liu","year":"2022","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.jpba.2026.117434_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.canlet.2023.216397","article-title":"Nano-drug delivery system targeting tumor microenvironment: a prospective strategy for melanoma treatment","volume":"574","author":"Xu","year":"2023","journal-title":"Cancer Lett."},{"key":"10.1016\/j.jpba.2026.117434_bib36","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.jrmge.2022.02.015","article-title":"Unified description of different soils based on the superloading and subloading concepts","volume":"15","author":"Lu","year":"2023","journal-title":"J. Rock. Mech. Geotech. Eng."},{"key":"10.1016\/j.jpba.2026.117434_bib37","doi-asserted-by":"crossref","first-page":"2176","DOI":"10.3390\/ma12132176","article-title":"Nanomaterials for wound healing and infection control","volume":"12","author":"Mihai","year":"2019","journal-title":"Materials"},{"key":"10.1016\/j.jpba.2026.117434_bib38","doi-asserted-by":"crossref","first-page":"318","DOI":"10.3390\/jcm9020318","article-title":"Nanosystems for improved targeted therapies in melanoma","volume":"9","author":"Beiu","year":"2020","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.jpba.2026.117434_bib39","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1016\/j.msec.2019.01.066","article-title":"Employment of enhanced permeability and retention effect (EPR): nanoparticle-based precision tools for targeting of therapeutic and diagnostic agent in cancer","volume":"98","author":"Kalyane","year":"2019","journal-title":"Mater. Sci. Eng. C Mater. Biol. Appl."},{"key":"10.1016\/j.jpba.2026.117434_bib40","doi-asserted-by":"crossref","first-page":"785","DOI":"10.3390\/molecules26040785","article-title":"Recent advances in nanotechnology for the treatment of melanoma","volume":"26","author":"Cassano","year":"2021","journal-title":"Molecules"},{"key":"10.1016\/j.jpba.2026.117434_bib41","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1080\/09205063.2022.2121592","article-title":"Lipid-based nanocarrier mediated CRISPR\/Cas9 delivery for cancer therapy","volume":"34","author":"Aziz","year":"2022","journal-title":"J. Biomater. Sci. Polym. Ed."},{"key":"10.1016\/j.jpba.2026.117434_bib42","article-title":"Solid lipid nanoparticles: an effective lipid-based technology for cancer treatment","volume":"86","author":"Akanda","year":"2023","journal-title":"J. Drug Deliv. Sci. Technol."},{"key":"10.1016\/j.jpba.2026.117434_bib43","doi-asserted-by":"crossref","first-page":"6801","DOI":"10.1039\/C6NR00247A","article-title":"Doxorubicin conjugated functionalizable carbon dots for nucleus targeted delivery and enhanced therapeutic efficacy","volume":"8","author":"Yang","year":"2016","journal-title":"Nanoscale"},{"key":"10.1016\/j.jpba.2026.117434_bib44","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.jpba.2018.03.021","article-title":"Development of a HILIC method for the determination of 5-fluorouracil from nano drug delivery systems and rat skin extracts","volume":"154","author":"Amasya","year":"2018","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jpba.2026.117434_bib45","doi-asserted-by":"crossref","first-page":"249","DOI":"10.2174\/1567201817666200423083807","article-title":"Nanostructured lipid carriers (NLCs) for drug delivery: role of liquid lipid (oil)","volume":"18","author":"D'Souza","year":"2021","journal-title":"Curr. Drug Deliv."},{"key":"10.1016\/j.jpba.2026.117434_bib46","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1016\/j.addr.2007.04.012","article-title":"Nanostructured lipid carriers (NLC) in cosmetic dermal products","volume":"59","author":"M\u00fcller","year":"2007","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.jpba.2026.117434_bib47","doi-asserted-by":"crossref","first-page":"S131","DOI":"10.1016\/S0169-409X(02)00118-7","article-title":"Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) in cosmetic and dermatological preparations","volume":"54","author":"M\u00fcller","year":"2002","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.jpba.2026.117434_bib48","article-title":"Nanomedicine: a pragmatic approach for tackling melanoma skin cancer","volume":"83","author":"Prajapat","year":"2023","journal-title":"J. Drug Deliv. Sci. Technol."},{"key":"10.1016\/j.jpba.2026.117434_bib49","doi-asserted-by":"crossref","first-page":"5905","DOI":"10.3390\/molecules28155905","article-title":"Exploring nanocarriers as treatment modalities for skin cancer","volume":"28","author":"Adnan","year":"2023","journal-title":"Molecules"},{"key":"10.1016\/j.jpba.2026.117434_bib50","first-page":"243","article-title":"Nanostructured lipid carriers as a drug delivery system: a comprehensive review with therapeutic applications","volume":"3","author":"Mall","year":"2024","journal-title":"Intell. Pharm."},{"key":"10.1016\/j.jpba.2026.117434_bib51","article-title":"A review on lipid-polymer hybrid nanocarriers in cancer","volume":"97","author":"Karati","year":"2024","journal-title":"J. Drug Deliv. Sci. Technol."},{"key":"10.1016\/j.jpba.2026.117434_bib52","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpba.2022.114799","article-title":"Box-Behnken design optimization and in vitro cell based evaluation of piroxicam loaded core-shell type hybrid nanocarriers for prostate cancer","volume":"216","author":"Sengel-Turk","year":"2022","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jpba.2026.117434_bib53","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2020.119246","article-title":"Antitumor activity of gemcitabine hydrochloride loaded lipid polymer hybrid nanoparticles (LPHNs): in vitro and in vivo","volume":"580","author":"Yalcin","year":"2020","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.jpba.2026.117434_bib54","doi-asserted-by":"crossref","first-page":"5905","DOI":"10.3390\/molecules28155905","article-title":"Exploring nanocarriers as treatment modalities for skin cancer","volume":"28","author":"Adnan","year":"2023","journal-title":"Molecules"},{"key":"10.1016\/j.jpba.2026.117434_bib55","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpba.2023.115751","article-title":"Liposomes characterization for market approval as pharmaceutical products: analytical methods, guidelines and standardized protocols","volume":"236","author":"Giordani","year":"2023","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jpba.2026.117434_bib56","doi-asserted-by":"crossref","first-page":"907","DOI":"10.3390\/molecules23040907","article-title":"Liposomal drug delivery systems and anticancer drugs","volume":"23","author":"Olusanya","year":"2018","journal-title":"Molecules"},{"key":"10.1016\/j.jpba.2026.117434_bib57","article-title":"Advances in liposomal drug delivery to cancer: an overview","volume":"56","author":"Saraf","year":"2020","journal-title":"J. Drug Deliv. Sci. Technol."},{"key":"10.1016\/j.jpba.2026.117434_bib58","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.jpba.2012.08.030","article-title":"Development and validation of a high performance chromatographic method for determining sumatriptan in niosomes","volume":"72","author":"C\u00f3zar-Bernal","year":"2012","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jpba.2026.117434_bib59","doi-asserted-by":"crossref","first-page":"665","DOI":"10.2174\/1570180820666221226153523","article-title":"Ethosomes: novel vesicular carriers for effective transdermal delivery of natural therapeutics","volume":"21","author":"Bhatia","year":"2024","journal-title":"Lett. Drug Des. Discov."},{"key":"10.1016\/j.jpba.2026.117434_bib60","doi-asserted-by":"crossref","first-page":"3454","DOI":"10.3390\/molecules26113454","article-title":"Quality by design for development, optimization and characterization of brucine ethosomal gel for skin cancer delivery","volume":"26","author":"Ismail","year":"2021","journal-title":"Molecules"},{"key":"10.1016\/j.jpba.2026.117434_bib61","doi-asserted-by":"crossref","DOI":"10.1016\/j.msec.2020.111651","article-title":"In vitro synergic activity of diethyldithiocarbamate and 4-nitrochalcone loaded in beeswax nanoparticles against melanoma (B16F10) cells","volume":"120","author":"Cordeiro","year":"2021","journal-title":"Mater. Sci. Eng. C"},{"key":"10.1016\/j.jpba.2026.117434_bib62","article-title":"Solid lipid-based nanoparticulate system for sustained release and enhanced in-vitro cytotoxic effect of 5-fluorouracil on skin melanoma and squamous cell carcinoma","volume":"18","author":"Ali","year":"2023","journal-title":"PLoS One"},{"key":"10.1016\/j.jpba.2026.117434_bib63","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2023.1102269","article-title":"Dacarbazine-encapsulated solid lipid nanoparticles for skin cancer: physical characterization, stability, in-vivo activity, histopathology, and immunohistochemistry","volume":"13","author":"Bhattacharya","year":"2023","journal-title":"Front. Oncol."},{"key":"10.1016\/j.jpba.2026.117434_bib64","doi-asserted-by":"crossref","first-page":"960","DOI":"10.3390\/pharmaceutics16070960","article-title":"Development and evaluation of docetaxel-loaded nanostructured lipid carriers for skin cancer therapy","volume":"16","author":"Coco\u0219","year":"2024","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.jpba.2026.117434_bib65","article-title":"Melatonin loaded nanostructured lipid carriers for the treatment of uveal melanoma","volume":"100","author":"Bonilla-Vidal","year":"2024","journal-title":"J. Drug Deliv. Sci. Technol."},{"key":"10.1016\/j.jpba.2026.117434_bib66","doi-asserted-by":"crossref","DOI":"10.1016\/j.colsurfb.2024.113875","article-title":"Ibrutinib topical delivery for melanoma treatment: the effect of nanostructured lipid carriers\u2019 composition on the controlled drug skin deposition","volume":"237","author":"Albuquerque","year":"2024","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"10.1016\/j.jpba.2026.117434_bib67","doi-asserted-by":"crossref","first-page":"6035","DOI":"10.1021\/acs.molpharmaceut.3c00309","article-title":"Fisetin-loaded nanostructured lipid carriers: formulation and evaluations against advanced and metastatic melanoma","volume":"20","author":"Kumar","year":"2023","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.jpba.2026.117434_bib68","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1080\/02652048.2023.2282971","article-title":"Quality by design endorsed atorvastatin-loaded nanostructured lipid carriers embedded in pH-responsive gel for melanoma","volume":"41","author":"Bagasariya","year":"2023","journal-title":"J. Microencapsul."},{"key":"10.1016\/j.jpba.2026.117434_bib69","doi-asserted-by":"crossref","first-page":"2315","DOI":"10.1007\/s00210-020-01942-x","article-title":"Formulation of Stattic as STAT3 inhibitor in nanostructured lipid carriers (NLCs) enhances efficacy of doxorubicin in melanoma cancer cells","volume":"393","author":"Mohammadian","year":"2020","journal-title":"Naunyn Schmiede Arch. Pharmacol."},{"key":"10.1016\/j.jpba.2026.117434_bib70","doi-asserted-by":"crossref","DOI":"10.1016\/j.colsurfb.2024.114098","article-title":"Rational design of solid lipid-polymer hybrid nanoparticles: an innovative glycoalkaloids-carrier with potential for topical melanoma treatment","volume":"242","author":"Gon\u00e7alves","year":"2024","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"10.1016\/j.jpba.2026.117434_bib71","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1080\/00914037.2020.1809406","article-title":"Lipid-polymer hybrid nanoparticles as a targeted drug delivery system for melanoma treatment","volume":"71","author":"Scopel","year":"2020","journal-title":"Int. J. Polym. Mater."},{"key":"10.1016\/j.jpba.2026.117434_bib72","doi-asserted-by":"crossref","first-page":"2615","DOI":"10.2147\/IJN.S293480","article-title":"Regression of melanoma following intravenous injection of plumbagin entrapped in transferrin-conjugated lipid-polymer hybrid nanoparticles","volume":"16","author":"Sakpakdeejaroen","year":"2021","journal-title":"Int. J. Nanomed."},{"key":"10.1016\/j.jpba.2026.117434_bib73","doi-asserted-by":"crossref","first-page":"163","DOI":"10.3390\/pharmaceutics11040163","article-title":"Co-delivery of eugenol and dacarbazine by hyaluronic acid-coated liposomes for targeted inhibition of survivin in treatment of resistant metastatic melanoma","volume":"11","author":"Mishra","year":"2019","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.jpba.2026.117434_bib74","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2019.115143","article-title":"Chitosan-coated liposomes to stabilize and enhance transdermal delivery of indocyanine green for photodynamic therapy of melanoma","volume":"224","author":"Lee","year":"2019","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.jpba.2026.117434_bib75","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1208\/s12249-020-01846-2","article-title":"Co-delivery of hispolon and doxorubicin liposomes improves efficacy against melanoma cells","volume":"21","author":"Saqr","year":"2020","journal-title":"AAPS PharmSciTech"},{"key":"10.1016\/j.jpba.2026.117434_bib76","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.3390\/pharmaceutics14061128","article-title":"pH-sensitive liposomes for enhanced cellular uptake and cytotoxicity of daunorubicin in melanoma (B16-BL6) cell lines","volume":"14","author":"Alrbyawi","year":"2022","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.jpba.2026.117434_bib77","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1021\/acsbiomaterials.3c01223","article-title":"Folic acid-modified long-circulating liposomes loaded with sulfasalazine for targeted induction of ferroptosis in melanoma","volume":"10","author":"Zhang","year":"2023","journal-title":"ACS Biomater. Sci. Eng."},{"key":"10.1016\/j.jpba.2026.117434_bib78","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/j.jconrel.2023.01.034","article-title":"Liposomal celecoxib combined with dendritic cell therapy enhances antitumor efficacy in melanoma","volume":"354","author":"Jahani","year":"2023","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jpba.2026.117434_bib79","doi-asserted-by":"crossref","first-page":"1680","DOI":"10.3390\/ph16121680","article-title":"Span 60\/cholesterol niosomal formulation as a suitable vehicle for gallic acid delivery with potent in vitro antibacterial, antimelanoma, and anti-tyrosinase activity","volume":"16","author":"Zolghadri","year":"2023","journal-title":"Pharmaceuticals"},{"key":"10.1016\/j.jpba.2026.117434_bib80","doi-asserted-by":"crossref","first-page":"2395","DOI":"10.2217\/nnm-2018-0398","article-title":"Polyethylenimine and sodium cholate-modified ethosomes complex as multidrug carriers for the treatment of melanoma through transdermal delivery","volume":"14","author":"Ma","year":"2019","journal-title":"Nanomedicine"},{"key":"10.1016\/j.jpba.2026.117434_bib81","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2020.119278","article-title":"Development and in-vitro evaluation of co-loaded berberine chloride and evodiamine ethosomes for treatment of melanoma","volume":"581","author":"Lin","year":"2020","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.jpba.2026.117434_bib82","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2022.121781","article-title":"Metformin-loaded ethosomes with promoted anti-proliferative activity in melanoma cell line B16, and wound healing aptitude: development, characterization and in vivo evaluation","volume":"621","author":"Magdy","year":"2022","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.jpba.2026.117434_bib83","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1080\/10837450.2021.2023568","article-title":"Characterization and ex vivo evaluation of curcumin nanoethosomes for melanoma treatment","volume":"27","author":"Nair","year":"2022","journal-title":"Pharm. Dev. Technol."},{"key":"10.1016\/j.jpba.2026.117434_bib84","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpba.2022.114966","article-title":"Development of salting-out extraction methodology for the determination of piroxicam from polymeric based nanocarriers and biological samples","volume":"219","author":"Tok","year":"2022","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jpba.2026.117434_bib85","doi-asserted-by":"crossref","first-page":"318","DOI":"10.3390\/jcm9020318","article-title":"Nanosystems for improved targeted therapies in melanoma","volume":"9","author":"Beiu","year":"2020","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.jpba.2026.117434_bib86","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/6158298","article-title":"Corrigendum to \u201cDrug delivery nanoparticles in skin cancers","volume":"2021","author":"Dianzani","year":"2021","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.jpba.2026.117434_bib87","doi-asserted-by":"crossref","first-page":"S305","DOI":"10.33549\/physiolres.933979","article-title":"Polymeric nanogels as drug delivery systems","volume":"67","author":"Kousalov\u00e1","year":"2018","journal-title":"Physiol. Res."},{"key":"10.1016\/j.jpba.2026.117434_bib88","doi-asserted-by":"crossref","first-page":"575","DOI":"10.2174\/1389200220666190618100030","article-title":"Nanogels for skin cancer therapy via transdermal delivery: current designs","volume":"20","author":"Tran","year":"2019","journal-title":"Curr. Drug Metab."},{"key":"10.1016\/j.jpba.2026.117434_bib89","doi-asserted-by":"crossref","first-page":"2585","DOI":"10.1021\/acsnano.9b08133","article-title":"Nanomaterials for nanotheranostics: tuning their properties according to disease needs","volume":"14","author":"Wong","year":"2020","journal-title":"ACS Nano"},{"key":"10.1016\/j.jpba.2026.117434_bib90","doi-asserted-by":"crossref","first-page":"141","DOI":"10.48175\/IJARSCT-799","article-title":"Targeted therapy in chronic diseases treatment by nanomaterial based drug delivery","author":"Bhat","year":"2021","journal-title":"Int. J. Adv. Res. Sci. Commun. Technol."},{"key":"10.1016\/j.jpba.2026.117434_bib91","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.nantod.2017.06.008","article-title":"Evolution and clinical translation of drug delivery nanomaterials","volume":"15","author":"Hassan","year":"2017","journal-title":"Nano Today"},{"key":"10.1016\/j.jpba.2026.117434_bib92","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1016\/S0731-7085(01)00683-5","article-title":"RP\u2013LC determination of 5-fluorouridine in nanoparticulate formulations, Y. Fan, M. Marioli, K. Zhang, Analytical characterization of liposomes and other lipid nanoparticles for drug delivery","volume":"28","author":"Arb\u00f3s","year":"2002","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jpba.2026.117434_bib93","doi-asserted-by":"crossref","first-page":"191","DOI":"10.2174\/2211738508666200121103110","article-title":"A current review on drug loaded nanofibers: interesting and valuable platform for skin cancer treatment","volume":"8","author":"Mehan","year":"2020","journal-title":"Pharm. Nanotechnol."},{"key":"10.1016\/j.jpba.2026.117434_bib94","article-title":"Fabrication and characterization of 5-fluorouracil loaded multilayered electrospun nanofiber for the treatment of skin cancer","volume":"86","author":"Yadav","year":"2023","journal-title":"J. Drug Deliv. Sci. Technol."},{"key":"10.1016\/j.jpba.2026.117434_bib95","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.eurpolymj.2019.08.001","article-title":"PEO-chitosan nanofibers containing carboxymethyl-hexanoyl chitosan\/dodecyl sulfate nanoparticles loaded with pyrazoline for skin cancer treatment","volume":"119","author":"Rengifo","year":"2019","journal-title":"Eur. Polym. J."},{"key":"10.1016\/j.jpba.2026.117434_bib96","article-title":"Nanofiber-based systems against skin cancers: therapeutic and protective approaches","volume":"82","author":"Maleki","year":"2023","journal-title":"J. Drug Deliv. Sci. Technol."},{"key":"10.1016\/j.jpba.2026.117434_bib97","article-title":"Magnetic nanofibers based bandage for skin cancer treatment: a non-invasive hyperthermia therapy","volume":"3","author":"Suneet","year":"2020","journal-title":"Cancer Rep."},{"key":"10.1016\/j.jpba.2026.117434_bib98","doi-asserted-by":"crossref","first-page":"11167","DOI":"10.3390\/ijms222011167","article-title":"Poly(amidoamine) dendrimers as nanocarriers for 5-fluorouracil: effectiveness of complex formation and cytotoxicity studies","volume":"22","author":"Szota","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jpba.2026.117434_bib99","article-title":"Assessment of 177Lu-labeled carboxyl-terminated polyamidoamine (PAMAM) dendrimer-RGD peptide conjugate","volume":"28","author":"Vats","year":"2021","journal-title":"J. Pept. Sci."},{"key":"10.1016\/j.jpba.2026.117434_bib100","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejps.2022.106311","article-title":"Some things old, new and borrowed: delivery of dabrafenib and vemurafenib to melanoma cells via self-assembled nanomicelles based on an amphiphilic dendrimer","volume":"180","author":"Russi","year":"2023","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.jpba.2026.117434_bib101","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1039\/D2CC05498A","article-title":"Bioengineering of BRAF and COX2 inhibitor nanogels to boost the immunotherapy of melanoma via pyroptosis","volume":"59","author":"Zhang","year":"2023","journal-title":"Chem. Commun."},{"key":"10.1016\/j.jpba.2026.117434_bib102","article-title":"Carrier-free delivery of thymopentin-regulated injectable nanogels via an enhanced cancer immunity cycle against melanoma metastasis","volume":"20","author":"Ding","year":"2023","journal-title":"Mater. Today Bio"},{"key":"10.1016\/j.jpba.2026.117434_bib103","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2023.124126","article-title":"Thermosensitive TMPO-oxidized lignocellulose\/cationic agarose hydrogel loaded with deferasirox nanoparticles for photothermal therapy in melanoma","volume":"238","author":"Veisi","year":"2023","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.jpba.2026.117434_bib104","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.1021\/acs.nanolett.3c04563","article-title":"Chemoimmunotherapeutic nanogel for pre- and postsurgical treatment of malignant melanoma by reprogramming tumor-associated macrophages","volume":"24","author":"Tang","year":"2024","journal-title":"Nano Lett."},{"key":"10.1016\/j.jpba.2026.117434_bib105","doi-asserted-by":"crossref","DOI":"10.1016\/j.jphotobiol.2020.111981","article-title":"Co-delivery of IR-768 and daunorubicin using mPEG-b-PLGA micelles for synergistic enhancement of combination therapy of melanoma","volume":"211","author":"Tokarska","year":"2020","journal-title":"J. Photochem. Photobiol. B"},{"key":"10.1016\/j.jpba.2026.117434_bib106","doi-asserted-by":"crossref","DOI":"10.3389\/fchem.2020.599740","article-title":"Design of DOX-GNRs-PNIPAM@PEG-PLA micelle with temperature and light dual-function for potent melanoma therapy","volume":"8","author":"Wang","year":"2021","journal-title":"Front. Chem."},{"key":"10.1016\/j.jpba.2026.117434_bib107","doi-asserted-by":"crossref","DOI":"10.1016\/j.pdpdt.2022.103103","article-title":"Melanoma-targeted photodynamic therapy based on hypericin-loaded multifunctional P123-spermine\/folate micelles","volume":"40","author":"De Oliveira","year":"2022","journal-title":"Photodiagn Photodyn. Ther."},{"key":"10.1016\/j.jpba.2026.117434_bib108","article-title":"O2-generating multifunctional polymeric micelles for highly efficient and selective photodynamic-photothermal therapy in melanoma","volume":"35","author":"Qin","year":"2023","journal-title":"Chin. Chem. Lett."},{"key":"10.1016\/j.jpba.2026.117434_bib109","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1039\/C9PY01596E","article-title":"Curcumin\u2013polymer conjugates with dynamic boronic acid ester linkages for selective killing of cancer cells","volume":"11","author":"Pan","year":"2020","journal-title":"Polym. Chem."},{"key":"10.1016\/j.jpba.2026.117434_bib110","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1080\/00914037.2020.1809406","article-title":"Lipid-polymer hybrid nanoparticles as a targeted drug delivery system for melanoma treatment","volume":"71","author":"Scopel","year":"2020","journal-title":"Int. J. Polym. Mater."},{"key":"10.1016\/j.jpba.2026.117434_bib111","article-title":"Codelivery of afuresertib and celecoxib by IL4RPep-1-targeting nanoparticles for effective treatment against melanoma","volume":"33","author":"Song","year":"2023","journal-title":"Appl. Mater. Today"},{"key":"10.1016\/j.jpba.2026.117434_bib112","first-page":"49190","article-title":"Nanofibers based on zein protein loaded with tungsten oxide for cancer therapy: fabrication, characterization and in vitro evaluation","volume":"13","author":"Fawal","year":"2023","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jpba.2026.117434_bib113","doi-asserted-by":"crossref","DOI":"10.1016\/j.matchemphys.2021.124381","article-title":"Novel topical and transdermal delivery of colchicine with chitosan based biocomposite nanofiberous system; formulation, optimization, characterization, ex vivo skin deposition\/permeation, and anti-melanoma evaluation","volume":"263","author":"Morad","year":"2021","journal-title":"Mater. Chem. Phys."},{"key":"10.1016\/j.jpba.2026.117434_bib114","article-title":"Anti-melanogenic activity of vanadium incorporated PVA chitosan electrospun fibers: an in vitro model","volume":"75","author":"Alipour","year":"2022","journal-title":"J. Drug Deliv. Sci. Technol."},{"key":"10.1016\/j.jpba.2026.117434_bib115","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioadv.2023.213387","article-title":"Fibrous dressing containing bioactive glass with combined chemotherapy and wound healing promotion for post-surgical treatment of melanoma","volume":"149","author":"Yuan","year":"2023","journal-title":"Biomater. Adv."},{"key":"10.1016\/j.jpba.2026.117434_bib116","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/s11671-024-03962-5","article-title":"Synergistic anticancer effect of Pistacia lentiscus essential oils and 5-fluorouracil co-loaded onto biodegradable nanofibers against melanoma and breast cancer","volume":"19","author":"Alabrahim","year":"2024","journal-title":"Discov. Nano"},{"key":"10.1016\/j.jpba.2026.117434_bib117","doi-asserted-by":"crossref","first-page":"11236","DOI":"10.1016\/j.ceramint.2024.01.024","article-title":"Electrospun nanofibers combined with Fe-doped mesoporous bioactive glass nanoparticles induce in vitro melanoma cell death","volume":"50","author":"Sadeqzadeh","year":"2024","journal-title":"Ceram. Int."},{"key":"10.1016\/j.jpba.2026.117434_bib118","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2023.123162","article-title":"PCL\/gelatin nanofibers embedded with doxorubicin-loaded mesoporous silica nanoparticles\/silver nanoparticles as an antibacterial and anti-melanoma cancer","volume":"642","author":"Tavira","year":"2023","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.jpba.2026.117434_bib119","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.ejpb.2022.12.010","article-title":"Skin absorption of inorganic nanoparticles and their toxicity: a review","volume":"182","author":"Saweres-Arg\u00fcelles","year":"2023","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.jpba.2026.117434_bib120","article-title":"Insight on nano drug delivery systems with targeted therapy in treatment of oral cancer","volume":"49","author":"Vyas","year":"2023","journal-title":"Nanomedicine"},{"key":"10.1016\/j.jpba.2026.117434_bib121","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.msec.2019.01.123","article-title":"Novel biosynthesized gold nanoparticles as anti-cancer agents against breast cancer: synthesis, biological evaluation, molecular modelling studies","volume":"99","author":"Vemuri","year":"2019","journal-title":"Mater. Sci. Eng. C"},{"key":"10.1016\/j.jpba.2026.117434_bib122","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1080\/1061186X.2017.1400553","article-title":"Recent advances in metal nanoparticles in cancer therapy","volume":"26","author":"Sharma","year":"2017","journal-title":"J. Drug Target."},{"key":"10.1016\/j.jpba.2026.117434_bib123","doi-asserted-by":"crossref","first-page":"1812","DOI":"10.1007\/s12011-020-02304-7","article-title":"Apoptotic effect and anticancer activity of biosynthesized silver nanoparticles from marine algae Chaetomorpha linum extract against human colon cancer cell HCT-116","volume":"199","author":"Acharya","year":"2020","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.jpba.2026.117434_bib124","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1007\/s40291-018-0363-7","article-title":"Advances in carbon nanotubes for malignant melanoma: a chance for treatment","volume":"22","author":"De Carvalho Lima","year":"2018","journal-title":"Mol. Diagn. Ther."},{"key":"10.1016\/j.jpba.2026.117434_bib125","article-title":"Bioanalytical strategies to evaluate cisplatin nanodelivery systems: from synthesis to incorporation in individual cells and biological response","volume":"237","author":"Gutierrez-Romero","year":"2023","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jpba.2026.117434_bib126","doi-asserted-by":"crossref","DOI":"10.1016\/j.ultras.2019.106061","article-title":"Effect of targeted gold nanoparticles size on acoustic cavitation: an in vitro study on melanoma cells","volume":"102","author":"Shanei","year":"2020","journal-title":"Ultrasonics"},{"key":"10.1016\/j.jpba.2026.117434_bib127","doi-asserted-by":"crossref","first-page":"1536","DOI":"10.3390\/nano10081536","article-title":"Preliminary assays towards melanoma cells using phototherapy with gold-based nanomaterials","volume":"10","author":"Lopes","year":"2020","journal-title":"Nanomaterials"},{"key":"10.1016\/j.jpba.2026.117434_bib128","doi-asserted-by":"crossref","DOI":"10.1016\/j.msec.2021.112086","article-title":"Single-chain antibody-decorated Au nanocages@liposomal layer nanoprobes for targeted SERS imaging and remote-controlled photothermal therapy of melanoma cancer cells","volume":"124","author":"Farahavar","year":"2021","journal-title":"Mater. Sci. Eng. C"},{"key":"10.1016\/j.jpba.2026.117434_bib129","article-title":"Localized therapy using anti-PD-L1 anchored and NIR-responsive hollow gold nanoshell (HGNS) loaded with doxorubicin (DOX) for the treatment of locally advanced melanoma","volume":"33","author":"Banstola","year":"2021","journal-title":"Nanomedicine"},{"key":"10.1016\/j.jpba.2026.117434_bib130","doi-asserted-by":"crossref","DOI":"10.1016\/j.pdpdt.2022.102991","article-title":"Simultaneous chemotherapy\/sonodynamic therapy of the melanoma cancer cells using a gold-paclitaxel nanostructure","volume":"39","author":"Zahraie","year":"2022","journal-title":"Photodiagn Photodyn. Ther."},{"key":"10.1016\/j.jpba.2026.117434_bib131","article-title":"Au\/TiO2 nanocomposite as a triple-sensitizer for 808 and 650 nm phototherapy and sonotherapy: synergistic therapy of melanoma cancer in vitro","volume":"76","author":"Perota","year":"2022","journal-title":"J. Drug Deliv. Sci. Technol."},{"key":"10.1016\/j.jpba.2026.117434_bib132","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.actbio.2022.01.051","article-title":"Photosensitizer-loaded gold nanocages for immunogenic phototherapy of aggressive melanoma","volume":"142","author":"Xie","year":"2022","journal-title":"Acta Biomater."},{"key":"10.1016\/j.jpba.2026.117434_bib133","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2019\/4528241","article-title":"Antiproliferative and antitumour effect of nongenotoxic silver nanoparticles on melanoma models","volume":"2019","author":"Valenzuela-Salas","year":"2019","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.jpba.2026.117434_bib134","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-021-92689-9","article-title":"Novel light-driven functional AgNPs induce cancer death at extra low concentrations","volume":"11","author":"Bunyatova","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jpba.2026.117434_bib135","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpap.2022.100136","article-title":"Active targeted photodynamic therapeutic effect of silver-based nanohybrids on melanoma cancer cells","volume":"11","author":"Montaseri","year":"2022","journal-title":"J. Photochem. Photobiol."},{"key":"10.1016\/j.jpba.2026.117434_bib136","doi-asserted-by":"crossref","first-page":"4245","DOI":"10.1039\/C9TB02238D","article-title":"MWCNT-mediated combinatorial photothermal ablation and chemo-immunotherapy strategy for the treatment of melanoma","volume":"8","author":"Wang","year":"2020","journal-title":"J. Mater. Chem. B"},{"key":"10.1016\/j.jpba.2026.117434_bib137","doi-asserted-by":"crossref","first-page":"2322","DOI":"10.1016\/j.ultrasmedbio.2020.05.003","article-title":"Development of a composite of polypyrrole-coated carbon nanotubes as a sonosensitizer for treatment of melanoma cancer under multi-step ultrasound irradiation","volume":"46","author":"Behzadpour","year":"2020","journal-title":"Ultrasound Med. Biol."},{"key":"10.1016\/j.jpba.2026.117434_bib138","doi-asserted-by":"crossref","first-page":"57612","DOI":"10.1038\/s41598-024-57612-y","article-title":"Exploration of the photothermal role of curcumin-loaded targeted carbon nanotubes as a potential therapy for melanoma cancer","volume":"14","author":"Kargar","year":"2024","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jpba.2026.117434_bib139","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1007\/s10337-013-2477-8","article-title":"UPLC versus HPLC on drug analysis: advantageous, applications and their validation parameters","volume":"76","author":"Gumustas","year":"2013","journal-title":"Chromatographia"},{"key":"10.1016\/j.jpba.2026.117434_bib140","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpba.2023.115751","article-title":"Liposomes characterization for market approval as pharmaceutical products: analytical methods, guidelines and standardized protocols","volume":"236","author":"Giordani","year":"2023","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jpba.2026.117434_bib141","doi-asserted-by":"crossref","first-page":"3019","DOI":"10.1007\/s11095-014-1395-2","article-title":"Self-assembled chitosan-ceramide nanoparticle for enhanced oral delivery of paclitaxel","volume":"31","author":"Battogtokh","year":"2014","journal-title":"Pharm. Res."},{"key":"10.1016\/j.jpba.2026.117434_bib142","doi-asserted-by":"crossref","first-page":"5067","DOI":"10.2147\/IJN.S117511","article-title":"Development and evaluation of nanostructured lipid carrier-based hydrogel for topical delivery of 5-fluorouracil","volume":"11","author":"Rajinikanth","year":"2016","journal-title":"Int. J. Nanomed."},{"key":"10.1016\/j.jpba.2026.117434_bib143","doi-asserted-by":"crossref","first-page":"255","DOI":"10.3390\/ijms19020255","article-title":"Solid lipid nanoparticles carrying temozolomide for melanoma treatment: preliminary in vitro and in vivo studies","volume":"19","author":"Clemente","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jpba.2026.117434_bib144","doi-asserted-by":"crossref","DOI":"10.1016\/j.pdpdt.2022.102991","article-title":"Simultaneous chemotherapy\/sonodynamic therapy of the melanoma cancer cells using a gold-paclitaxel nanostructure","volume":"39","author":"Zahraie","year":"2022","journal-title":"Photodiagn. Photodyn. Ther."},{"key":"10.1016\/j.jpba.2026.117434_bib145","doi-asserted-by":"crossref","first-page":"13015","DOI":"10.1021\/acsomega.9b00489","article-title":"Codelivery of mRNA with \u03b1-galactosylceramide using a new lipopolyplex formulation induces a strong antitumor response upon intravenous administration","volume":"4","author":"Guevara","year":"2019","journal-title":"ACS Omega"},{"key":"10.1016\/j.jpba.2026.117434_bib146","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4103\/1735-5362.278710","article-title":"Development of a RP-HPLC method for analysis of docetaxel in tumor-bearing mice plasma and tissues following injection of docetaxel-loaded pH responsive targeting polymeric micelles","volume":"15","author":"Emami","year":"2020","journal-title":"Res. Pharm. Sci."},{"key":"10.1016\/j.jpba.2026.117434_bib147","doi-asserted-by":"crossref","first-page":"960","DOI":"10.3390\/pharmaceutics16070960","article-title":"Development and evaluation of docetaxel-loaded nanostructured lipid carriers for skin cancer therapy","volume":"16","author":"Coco\u0219","year":"2024","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.jpba.2026.117434_bib148","doi-asserted-by":"crossref","first-page":"149","DOI":"10.7555\/JBR.30.20150074","article-title":"Force degradation behavior of glucocorticoid deflazacort by UPLC: isolation, identification and characterization of degradant by FTIR NMR and mass analysis","volume":"30","author":"Rajesh","year":"2016","journal-title":"J. Biomed. Res."},{"key":"10.1016\/j.jpba.2026.117434_bib149","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.3390\/pharmaceutics13101617","article-title":"Nanotechnology addressing cutaneous melanoma: the Italian landscape","volume":"13","author":"Battaglia","year":"2021","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.jpba.2026.117434_bib150","article-title":"An ultrasound assisted extraction\u2013solid-phase extraction\u2013ultra-performance liquid chromatography combined strategy for atropine determination in Atropa belladonna leaves","volume":"35","author":"Koetz","year":"2020","journal-title":"Biomed. Chromatogr."},{"key":"10.1016\/j.jpba.2026.117434_bib151","doi-asserted-by":"crossref","first-page":"776","DOI":"10.3389\/fphar.2019.00776","article-title":"Paclitaxel-loaded nanosponges inhibit growth and angiogenesis in melanoma cell models","volume":"10","author":"Clemente","year":"2019","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jpba.2026.117434_bib152","doi-asserted-by":"crossref","DOI":"10.1080\/10717544.2024.2372277","article-title":"Genistein transfersome-embedded topical delivery system for skin melanoma treatment: in vitro and ex vivo evaluations","volume":"31","author":"Motawea","year":"2024","journal-title":"Drug Deliv."},{"key":"10.1016\/j.jpba.2026.117434_bib153","doi-asserted-by":"crossref","first-page":"15546","DOI":"10.1038\/s41467-020-15546-9","article-title":"Pre-clinical modeling of cutaneous melanoma","volume":"11","author":"Rebecca","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jpba.2026.117434_bib154","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202400265","article-title":"Programmable release of chemotherapeutics from ferrocene-based injectable hydrogels slows melanoma growth","volume":"13","author":"Rothe","year":"2024","journal-title":"Adv. Healthc. Mater."},{"key":"10.1016\/j.jpba.2026.117434_bib155","article-title":"Topical delivery of seriniquinone for treatment of skin cancer and fungal infections is enabled by a liquid crystalline lamellar phase","volume":"192","author":"Miguel","year":"2023","journal-title":"Eur. J. Pharm. Sci."},{"issue":"3","key":"10.1016\/j.jpba.2026.117434_bib156","doi-asserted-by":"crossref","first-page":"379","DOI":"10.3390\/pharmaceutics16030379","article-title":"Enhanced skin permeation of 5-Fluorouracil through drug-in-adhesive topical patches","volume":"16","author":"Kim","year":"2024","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.jpba.2026.117434_bib157","doi-asserted-by":"crossref","first-page":"16878","DOI":"10.1038\/s41598-017-16878-1","article-title":"Dacarbazine nanoparticle topical delivery system for the treatment of melanoma","volume":"7","author":"Hafeez","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jpba.2026.117434_bib158","doi-asserted-by":"crossref","first-page":"2570","DOI":"10.1021\/acs.molpharmaceut.6b01119","article-title":"Self-associating poly(ethylene oxide)-block-poly(\u03b1-carboxyl-\u03b5-caprolactone) drug conjugates for the delivery of STAT3 inhibitor JSI-124: potential application in cancer immunotherapy","volume":"14","author":"Garg","year":"2017","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.jpba.2026.117434_bib159","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1080\/17425247.2017.1260119","article-title":"Fractional laser-assisted topical delivery leads to enhanced, accelerated and deeper cutaneous 5-fluorouracil uptake","volume":"14","author":"Wenande","year":"2017","journal-title":"Expert Opin. Drug Deliv."},{"key":"10.1016\/j.jpba.2026.117434_bib160","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.carbpol.2018.12.104","article-title":"LC\u2013MS\/MS study of in vivo fate of hyaluronan polymeric micelles carrying doxorubicin","volume":"209","author":"\u0160imek","year":"2019","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.jpba.2026.117434_bib161","doi-asserted-by":"crossref","first-page":"6","DOI":"10.3390\/pharmaceutics12010006","article-title":"Sulforaphane-loaded ultradeformable vesicles as a potential natural nanomedicine for the treatment of skin cancer diseases","volume":"12","author":"Cristiano","year":"2019","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.jpba.2026.117434_bib162","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1080\/02652048.2019.1701114","article-title":"Optimisation of ethosomal nanogel for topical nano-CUR and sulphoraphane delivery in effective skin cancer therapy","volume":"37","author":"Soni","year":"2019","journal-title":"J. Microencapsul."},{"key":"10.1016\/j.jpba.2026.117434_bib163","doi-asserted-by":"crossref","first-page":"4947","DOI":"10.3390\/molecules25214947","article-title":"Development of HPLC method for quantification of sinigrin from Raphanus sativus roots and evaluation of its anticancer potential","volume":"25","author":"Nair","year":"2020","journal-title":"Molecules"},{"key":"10.1016\/j.jpba.2026.117434_bib164","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1080\/17425247.2020.1731470","article-title":"Non-invasive targeted iontophoretic delivery of cetuximab to skin","volume":"17","author":"Lapteva","year":"2020","journal-title":"Expert Opin. Drug Deliv."},{"key":"10.1016\/j.jpba.2026.117434_bib165","doi-asserted-by":"crossref","first-page":"1920","DOI":"10.1021\/acs.molpharmaceut.0c00977","article-title":"Apigenin-loaded PLGA-DMSA nanoparticles: a novel strategy to treat melanoma lung metastasis","volume":"18","author":"Sen","year":"2021","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.jpba.2026.117434_bib166","doi-asserted-by":"crossref","DOI":"10.1016\/j.matchemphys.2021.124381","article-title":"Novel topical and transdermal delivery of colchicine with chitosan based biocomposite nanofiberous system; formulation, optimization, characterization, ex vivo skin deposition\/permeation, and anti-melanoma evaluation","volume":"263","author":"Morad","year":"2021","journal-title":"Mater. Chem. Phys."},{"key":"10.1016\/j.jpba.2026.117434_bib167","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202001853","article-title":"Combinatory delivery of etoposide and SICD47 in a lipid polymer hybrid delays lung tumor growth in an experimental melanoma lung metastatic model","volume":"10","author":"Abdel-Bar","year":"2021","journal-title":"Adv. Healthc. Mater."},{"key":"10.1016\/j.jpba.2026.117434_bib168","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1080\/10837450.2021.2023568","article-title":"Characterization and ex vivo evaluation of curcumin nanoethosomes for melanoma treatment","volume":"27","author":"Nair","year":"2021","journal-title":"Pharm. Dev. Technol."},{"key":"10.1016\/j.jpba.2026.117434_bib169","doi-asserted-by":"crossref","first-page":"126","DOI":"10.3390\/ph15020126","article-title":"Enhancing the bioavailability and efficacy of vismodegib for the control of skin cancer: in vitro and in vivo studies","volume":"15","author":"Salem","year":"2022","journal-title":"Pharmaceuticals"},{"key":"10.1016\/j.jpba.2026.117434_bib170","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpba.2023.115593","article-title":"Chromatographic method for dacarbazine quantification in skin permeation experiments","volume":"234","author":"Cardoso","year":"2023","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jpba.2026.117434_bib171","article-title":"Stability indicating validated high-performance liquid chromatography method for simultaneous estimation of chlorin e6 and curcumin in bulk and drug-loaded lipidic nanoformulation","volume":"6","author":"Jain","year":"2022","journal-title":"Sep. Sci."},{"key":"10.1016\/j.jpba.2026.117434_bib172","doi-asserted-by":"crossref","first-page":"2939","DOI":"10.1007\/s10571-023-01338-4","article-title":"Metastatic melanoma: a preclinical model standardization and development of a chitosan-coated nanoemulsion containing temozolomide to treat brain metastasis","volume":"43","author":"Gelsleichter","year":"2023","journal-title":"Cell. Mol. Neurobiol."},{"key":"10.1016\/j.jpba.2026.117434_bib173","doi-asserted-by":"crossref","first-page":"41532","DOI":"10.1021\/acsomega.4c05209","article-title":"Synergistic therapy of melanoma by co-delivery of dacarbazine and ferroptosis-inducing ursolic acid using biomimetic nanoparticles","volume":"9","author":"Hou","year":"2024","journal-title":"ACS Omega"},{"key":"10.1016\/j.jpba.2026.117434_bib174","article-title":"Melatonin loaded nanostructured lipid carriers for the treatment of uveal melanoma","volume":"100","author":"Bonilla-Vidal","year":"2024","journal-title":"J. Drug Deliv. Sci. Technol."},{"key":"10.1016\/j.jpba.2026.117434_bib175","doi-asserted-by":"crossref","first-page":"2210","DOI":"10.1002\/pca.3360","article-title":"Robust high-performance thin-layer chromatography (HPTLC) method for stability assessment and simultaneous quantification of epigallocatechin-3-gallate and rosmarinic acid in lipid-based nanoparticles and biological matrices","volume":"36","author":"Koli","year":"2024","journal-title":"Phytochem. Anal."},{"key":"10.1016\/j.jpba.2026.117434_bib176","doi-asserted-by":"crossref","first-page":"272","DOI":"10.3390\/chemistry6020014","article-title":"Development and validation of a chromatographic method for ibrutinib determination in human and porcine skin","volume":"6","author":"Albuquerque","year":"2024","journal-title":"Chemistry"},{"key":"10.1016\/j.jpba.2026.117434_bib177","doi-asserted-by":"crossref","DOI":"10.1016\/j.colsurfb.2024.113875","article-title":"Ibrutinib topical delivery for melanoma treatment: the effect of nanostructured lipid carriers\u2019 composition on the controlled drug skin deposition","volume":"237","author":"Albuquerque","year":"2024","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"10.1016\/j.jpba.2026.117434_bib178","doi-asserted-by":"crossref","first-page":"21568","DOI":"10.1021\/acsomega.5c00689","article-title":"Codelivery of paclitaxel and cannabidiol in lipid nanoparticles enhances cytotoxicity against melanoma cells","volume":"10","author":"De Carvalho","year":"2025","journal-title":"ACS Omega"},{"key":"10.1016\/j.jpba.2026.117434_bib179","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2025.177992","article-title":"Anti-inflammatory drug repurposing in skin diseases: ketoprofen-loaded nanoemulsion development and characterization for topical administration","volume":"1004","author":"Rodrigues","year":"2025","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.jpba.2026.117434_bib180","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2025.146330","article-title":"Development and statistical optimization of camptothecin loaded hyaluronic acid and zein polymeric nanoparticles towards the treatment of melanoma","volume":"321","author":"Batool","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.jpba.2026.117434_bib181","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1186\/s43088-025-00671-5","article-title":"Novel transferosome formulation of vemurafenib for skin cancer management: biocompatible and scalable strategies","volume":"14","author":"Aljarba","year":"2025","journal-title":"BeniSuef Univ. J. Basic Appl. Sci."},{"key":"10.1016\/j.jpba.2026.117434_bib182","article-title":"CD44-targeted hyaluronic acid coated imiquimod lipid nanocapsules foster the efficacy against skin cancer: attempt to conquer unfavorable side effects","volume":"290","author":"Aasy","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.jpba.2026.117434_bib183","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1208\/s12249-025-03072-0","article-title":"Sodium cholate-mediated ion-pairing for skin delivery of methylene blue: physicochemical characterization and influence on skin barrier and skin penetration","volume":"26","author":"Tavares","year":"2025","journal-title":"AAPS PharmSciTech"},{"key":"10.1016\/j.jpba.2026.117434_bib184","doi-asserted-by":"crossref","first-page":"296","DOI":"10.3390\/pharmaceutics17030296","article-title":"Advances in materials science for precision melanoma therapy: nanotechnology-enhanced drug delivery systems","volume":"17","author":"Moni","year":"2025","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.jpba.2026.117434_bib185","doi-asserted-by":"crossref","DOI":"10.1016\/j.canlet.2023.216397","article-title":"Nano-drug delivery system targeting tumor microenvironment: a prospective strategy for melanoma treatment","volume":"574","author":"Xu","year":"2023","journal-title":"Cancer Lett."},{"key":"10.1016\/j.jpba.2026.117434_bib186","article-title":"Targeted nanoscale drug delivery systems for melanoma therapy","volume":"86","author":"Fan","year":"2023","journal-title":"J. Drug Deliv. Sci. Technol."},{"key":"10.1016\/j.jpba.2026.117434_bib187","doi-asserted-by":"crossref","DOI":"10.1088\/1748-605X\/ad6dc3","article-title":"Nano-mediated strategy: recent advance in the application of drug delivery systems in melanoma treatment and diagnosis","volume":"19","author":"Wang","year":"2024","journal-title":"Biomed. Mater."},{"key":"10.1016\/j.jpba.2026.117434_bib188","article-title":"A critical review of bioanalytical and clinical applications of solid phase microextraction","volume":"252","author":"Sevgen","year":"2024","journal-title":"J. Pharm. Biomed. Anal."}],"container-title":["Journal of Pharmaceutical and Biomedical Analysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0731708526001020?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0731708526001020?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T06:19:01Z","timestamp":1776925141000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0731708526001020"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":188,"alternative-id":["S0731708526001020"],"URL":"https:\/\/doi.org\/10.1016\/j.jpba.2026.117434","relation":{},"ISSN":["0731-7085"],"issn-type":[{"value":"0731-7085","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pharmaceutical insights into nanoscale drug delivery systems and chromatographic approaches for melanoma treatment","name":"articletitle","label":"Article Title"},{"value":"Journal of Pharmaceutical and Biomedical Analysis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpba.2026.117434","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"117434"}}