{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T04:16:00Z","timestamp":1792815360437,"version":"4.5.0"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U24A20783"],"award-info":[{"award-number":["U24A20783"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82204587"],"award-info":[{"award-number":["82204587"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["TM202301H004"],"award-info":[{"award-number":["TM202301H004"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013152","name":"Shanghai Institute of Materia Medica, Chinese Academy of Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013152","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010876","name":"Shanghai University of Traditional Chinese Medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010876","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmaceutical and Biomedical Analysis"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.jpba.2026.117457","type":"journal-article","created":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T16:11:10Z","timestamp":1773159070000},"page":"117457","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Polysaccharide-driven quality control of Gastrodia elata Blume: A multidimensional strategy integrating LC-MS\/MS-based quantitative analysis, machine learning, and anti-neuroinflammatory bioactivity"],"prefix":"10.1016","volume":"275","author":[{"given":"Xinqin","family":"Kong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sihan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liling","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenyong","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinrui","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ningxin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiangyan","family":"Huo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huali","family":"Long","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiyan","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Menghua","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zijia","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinjun","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanying","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"13","key":"10.1016\/j.jpba.2026.117457_bib1","doi-asserted-by":"crossref","DOI":"10.3390\/foods13132154","article-title":"Fermented Gastrodia elata Bl. alleviates cognitive deficits by regulating neurotransmitters and gut microbiota in D-Gal\/AlCl(3)-induced Alzheimer's disease-like mice","volume":"13","author":"Wang","year":"2024","journal-title":"Foods"},{"key":"10.1016\/j.jpba.2026.117457_bib2","doi-asserted-by":"crossref","DOI":"10.3389\/fpls.2023.1249456","article-title":"Global metabolic profile and multiple phytometabolites in the different varieties of Gastrodia elata Blume","volume":"14","author":"Zeng","year":"2023","journal-title":"Front. Plant. Sci."},{"key":"10.1016\/j.jpba.2026.117457_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpba.2025.116954","article-title":"Unlocking the chemical blueprint of Gastrodiae Rhizoma variants and hybrids: a pseudotargeted LC-MS\/MS metabolomics approach for cultivar authentication","volume":"264","author":"Li","year":"2025","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jpba.2026.117457_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpba.2023.115282","article-title":"Holistic quality evaluation of Callicarpae Formosanae Folium by multi-chromatography-based qualitative and quantitative analysis of polysaccharides and small molecules","volume":"227","author":"Sun","year":"2023","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jpba.2026.117457_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpba.2024.116008","article-title":"A new method to comprehensively evaluate the quality of Tianma Toutong tablets by multiple fingerprints combined with quantitative analysis and prescription analysis","volume":"242","author":"Wang","year":"2024","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jpba.2026.117457_bib6","article-title":"Gastrodia elata polysaccharides: a comprehensive review of extraction, purification, characterization, structure-activity relationship and quality control applications","volume":"11","author":"Kong","year":"2025","journal-title":"Carbohydr. Polym. Tech."},{"key":"10.1016\/j.jpba.2026.117457_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2025.140084","article-title":"Extraction, purification, characteristics, bioactivities, application, and toxicity of Gastrodia R. Br. polysaccharides: a review","volume":"301","author":"Zhao","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.jpba.2026.117457_bib8","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.jep.2016.06.057","article-title":"The rhizome of Gastrodia elata Blume - an ethnopharmacological review","volume":"189","author":"Zhan","year":"2016","journal-title":"J. Ethnopharmacol."},{"issue":"6","key":"10.1016\/j.jpba.2026.117457_bib9","doi-asserted-by":"crossref","first-page":"2920","DOI":"10.1039\/D3FO05169B","article-title":"Gastrodia elata polysaccharide alleviates Parkinson's disease via inhibiting apoptotic and inflammatory signaling pathways and modulating the gut microbiota","volume":"15","author":"Gan","year":"2024","journal-title":"Food Funct."},{"key":"10.1016\/j.jpba.2026.117457_bib10","article-title":"A review of the pharmacological action and mechanism of natural plant polysaccharides in depression","volume":"15","author":"Yang","year":"2024","journal-title":"Front. Pharm."},{"key":"10.1016\/j.jpba.2026.117457_bib11","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/9965081","article-title":"Gastrodia elata Blume polysaccharides attenuate vincristine-evoked neuropathic pain through the inhibition of neuroinflammation","volume":"2021","author":"Xie","year":"2021","journal-title":"Mediat. Inflamm."},{"key":"10.1016\/j.jpba.2026.117457_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpba.2022.115016","article-title":"Recent advances in qualitative and quantitative analysis of polysaccharides in natural medicines: a critical review","volume":"220","author":"Li","year":"2022","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jpba.2026.117457_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpba.2024.116648","article-title":"Advancements in glycan analysis: high performance anion exchange chromatography-pulsed amprometric detection coupled with mass spectrometry for structural elucidation","volume":"255","author":"Yi","year":"2025","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jpba.2026.117457_bib14","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.carbpol.2016.07.077","article-title":"Qualitation and quantification of specific polysaccharides from Panax species using GC\u2013MS, saccharide mapping and HPSEC-RID-MALLS","volume":"153","author":"Cheong","year":"2016","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.jpba.2026.117457_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2021.118867","article-title":"Multi-level fingerprinting and cardiomyocyte protection evaluation for comparing polysaccharides from six Panax herbal medicines","volume":"277","author":"Liu","year":"2022","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.jpba.2026.117457_bib16","article-title":"Characterization and comparison of cardiomyocyte protection activities of non-starch polysaccharides from six ginseng root herbal medicines","volume":"253","author":"Liu","year":"2023","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.jpba.2026.117457_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpba.2023.115272","article-title":"Characterization and comparison of polysaccharides from Achyranthes bidentata, Cyathula officinalis and Achyranthes aspera by saccharides mapping","volume":"227","author":"Si","year":"2023","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jpba.2026.117457_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpba.2023.115938","article-title":"Structural identification and quantification of unreported sialylated N-glycans in bovine testicular hyaluronidase by LC-ESI-HCD-MS\/MS","volume":"240","author":"Kim","year":"2024","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jpba.2026.117457_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2021.118813","article-title":"Revealing methyl-esterification patterns of pectins by enzymatic fingerprinting: Beyond the degree of blockiness","volume":"277","author":"Jermendi","year":"2022","journal-title":"Carbohydr. Polym."},{"issue":"11","key":"10.1016\/j.jpba.2026.117457_bib20","doi-asserted-by":"crossref","first-page":"7254","DOI":"10.1021\/acs.analchem.9b00789","article-title":"Strategy for structural elucidation of polysaccharides: elucidation of a maize mucilage that harbors diazotrophic bacteria","volume":"91","author":"Amicucci","year":"2019","journal-title":"Anal. Chem."},{"key":"10.1016\/j.jpba.2026.117457_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2022.119540","article-title":"Periodate oxidation of plant polysaccharides provides polysaccharide-specific oligosaccharides","volume":"291","author":"Pandeirada","year":"2022","journal-title":"Carbohydr. Polym."},{"issue":"1","key":"10.1016\/j.jpba.2026.117457_bib22","doi-asserted-by":"crossref","first-page":"3963","DOI":"10.1038\/s41467-020-17778-1","article-title":"A nonenzymatic method for cleaving polysaccharides to yield oligosaccharides for structural analysis","volume":"11","author":"Amicucci","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jpba.2026.117457_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2020.117570","article-title":"Polysaccharide identification through oligosaccharide fingerprinting","volume":"257","author":"Nandita","year":"2021","journal-title":"Carbohydr. Polym."},{"issue":"2","key":"10.1016\/j.jpba.2026.117457_bib24","first-page":"1008","article-title":"Quantitative bottom-up glycomic analysis of polysaccharides in food matrices using liquid chromatography-tandem mass spectrometry","volume":"95","author":"Bacalzo","year":"2023","journal-title":"Anal. Chem."},{"key":"10.1016\/j.jpba.2026.117457_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2022.134517","article-title":"Explainable machine learning-assisted origin identification: chemical profiling of five lotus (Nelumbo nucifera Gaertn.) parts","volume":"404","author":"Huang","year":"2023","journal-title":"Food Chem."},{"issue":"10","key":"10.1016\/j.jpba.2026.117457_bib26","doi-asserted-by":"crossref","first-page":"3255","DOI":"10.1021\/acs.jafc.0c07899","article-title":"Volatile-based prediction of Sauvignon Blanc quality gradings with static headspace-gas chromatography-ion mobility spectrometry (SHS-GC-IMS) and interpretable machine learning techniques","volume":"69","author":"Zhu","year":"2021","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.jpba.2026.117457_bib27","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/j.ijbiomac.2021.06.157","article-title":"Structural characterization of two novel polysaccharides from Gastrodia elata and their effects on Akkermansia muciniphila","volume":"186","author":"Huo","year":"2021","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.jpba.2026.117457_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2025.139526","article-title":"In vitro and in vivo immune-enhancing effects of polysaccharides with different molecular weights and structural characteristics from Gastrodia elata Blume","volume":"295","author":"Chen","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.jpba.2026.117457_bib29","doi-asserted-by":"crossref","DOI":"10.3389\/fnut.2024.1477689","article-title":"Comparative analysis of antioxidant activity and structural changes of Gastrodiae Rhizoma polysaccharides between sulfur-fumigation and nonsulfur-fumigation","volume":"11","author":"Dai","year":"2024","journal-title":"Front. Nutr."},{"key":"10.1016\/j.jpba.2026.117457_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodres.2022.111277","article-title":"How steaming and drying processes affect the active compounds and antioxidant types of Gastrodia elata Bl. f. glauca S. chow","volume":"157","author":"Wu","year":"2022","journal-title":"Food Res. Int."},{"key":"10.1016\/j.jpba.2026.117457_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2023.138148","article-title":"E-eye and FT-NIR combined with multivariate algorithms to rapidly evaluate the dynamic changes in the quality of Gastrodia elata during steaming process","volume":"439","author":"Zhang","year":"2024","journal-title":"Food Chem."},{"key":"10.1016\/j.jpba.2026.117457_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2024.141628","article-title":"Exploration of the impact of different drying methods on the quality of Gastrodia elata: a study based on drying kinetics and multidimensional quality evaluation","volume":"464","author":"Li","year":"2025","journal-title":"Food Chem."},{"key":"10.1016\/j.jpba.2026.117457_bib33","article-title":"Integration of volatile and non-volatile metabolite profile, and in vitro digestion reveals the differences between different preparation methods on physico-chemical and biological properties of Gastrodia elata","volume":"463","author":"Li","year":"2025","journal-title":"Food Chem."},{"key":"10.1016\/j.jpba.2026.117457_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodres.2023.113136","article-title":"Mechanism underlying joint loading and controlled release of \u03b2-carotene and curcumin by octenylsuccinated Gastrodia elata starch aggregates","volume":"172","author":"Wu","year":"2023","journal-title":"Food Res. Int."},{"key":"10.1016\/j.jpba.2026.117457_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodres.2024.115110","article-title":"Comprehensive assessment of matcha qualities and visualization of constituents using hyperspectral imaging technology","volume":"196","author":"Hu","year":"2024","journal-title":"Food Res. Int."},{"key":"10.1016\/j.jpba.2026.117457_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodres.2025.115707","article-title":"Computational approaches for decoding structure-saltiness enhancement and aroma perception mechanisms of odorants: from machine learning to molecular simulation","volume":"202","author":"Ji","year":"2025","journal-title":"Food Res. Int."},{"key":"10.1016\/j.jpba.2026.117457_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodres.2025.115905","article-title":"Automated and explainable machine learning for monitoring lipid and protein oxidative damage in mutton using hyperspectral imaging","volume":"203","author":"Yi","year":"2025","journal-title":"Food Res. Int."},{"key":"10.1016\/j.jpba.2026.117457_bib38","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1186\/s13020-020-00335-9","article-title":"Recent advances of novel technologies for quality consistency assessment of natural herbal medicines and preparations","volume":"15","author":"Wei","year":"2020","journal-title":"Chin. Med."},{"issue":"6","key":"10.1016\/j.jpba.2026.117457_bib39","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1002\/pca.2969","article-title":"The combination of HPLC and biological analysis to determine the quality markers and its structural composition of Eclipta prostrata L","volume":"31","author":"Wang","year":"2020","journal-title":"Phytochem. Anal."}],"container-title":["Journal of Pharmaceutical and Biomedical Analysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0731708526001251?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0731708526001251?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T18:07:39Z","timestamp":1777572459000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0731708526001251"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":39,"alternative-id":["S0731708526001251"],"URL":"https:\/\/doi.org\/10.1016\/j.jpba.2026.117457","relation":{},"ISSN":["0731-7085"],"issn-type":[{"value":"0731-7085","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Polysaccharide-driven quality control of Gastrodia elata Blume: A multidimensional strategy integrating LC-MS\/MS-based quantitative analysis, machine learning, and anti-neuroinflammatory bioactivity","name":"articletitle","label":"Article Title"},{"value":"Journal of Pharmaceutical and Biomedical Analysis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpba.2026.117457","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"117457"}}