{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T14:22:00Z","timestamp":1783174920957,"version":"3.54.6"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100007613","name":"Ankara University","doi-asserted-by":"publisher","award":["21L0217001"],"award-info":[{"award-number":["21L0217001"]}],"id":[{"id":"10.13039\/100007613","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmaceutical and Biomedical Analysis"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.jpba.2026.117556","type":"journal-article","created":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T02:36:47Z","timestamp":1778812607000},"page":"117556","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Development and validation of a GC-MS method for the simultaneous determination of bisphenols, phthalate monoesters, and triclosan in human meconium for comprehensive prenatal exposure assessment"],"prefix":"10.1016","volume":"279","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9353-8867","authenticated-orcid":false,"given":"Kenan Can","family":"Tok","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2793-7154","authenticated-orcid":false,"given":"Mehmet","family":"Gumustas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6290-7466","authenticated-orcid":false,"given":"Khaled Mohamed","family":"Masoud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saadet","family":"Arsan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aslihan Gurbuz","family":"Bolkan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. Sinan","family":"Suzen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.jpba.2026.117556_bib1","doi-asserted-by":"crossref","first-page":"343","DOI":"10.3390\/suschem2020020","article-title":"Environmental contamination and human exposure to select endocrine-disrupting chemicals: a review","volume":"2","author":"Sangeetha","year":"2021","journal-title":"Sustain. Chem."},{"key":"10.1016\/j.jpba.2026.117556_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2019.108732","article-title":"Occurrence, fate and risk assessment of BPA and its substituents in wastewater treatment plant: a review","volume":"178","author":"Hu","year":"2019","journal-title":"Environ. Res."},{"key":"10.1016\/j.jpba.2026.117556_bib3","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.jpba.2012.11.030","article-title":"Preparation of magnetic molecularly imprinted polymers for bisphenol A and its analogues and their application to the assay of bisphenol A in river water","volume":"75","author":"Hiratsuka","year":"2013","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jpba.2026.117556_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpba.2019.113092","article-title":"Development and investigation of a QuEChERS-based method for determination of phthalate metabolites in human milk","volume":"181","author":"An","year":"2020","journal-title":"J. Pharm. Biomed. Anal."},{"issue":"6","key":"10.1016\/j.jpba.2026.117556_bib5","doi-asserted-by":"crossref","DOI":"10.3390\/antibiotics11060735","article-title":"Triclosan: a small molecule with controversial roles","volume":"11","author":"Sinicropi","year":"2022","journal-title":"Antibiotics"},{"issue":"8","key":"10.1016\/j.jpba.2026.117556_bib6","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1080\/10937404.2017.1399306","article-title":"Triclosan exposure, transformation, and human health effects","volume":"20","author":"Weatherly","year":"2017","journal-title":"J. Toxicol. Environ. Health Part B"},{"issue":"7","key":"10.1016\/j.jpba.2026.117556_bib7","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1016\/j.tem.2020.03.003","article-title":"Placenta disrupted: endocrine disrupting chemicals and pregnancy","volume":"31","author":"Gingrich","year":"2020","journal-title":"Trends Endocrinol. & Metab."},{"issue":"18","key":"10.1016\/j.jpba.2026.117556_bib8","doi-asserted-by":"crossref","DOI":"10.3390\/ijerph17186811","article-title":"Effects and mechanisms of phthalates\u2019 action on reproductive processes and reproductive health: a literature review","volume":"17","author":"Hlisn\u00edkov\u00e1","year":"2020","journal-title":"Int. J. Environ. Res. Public Health"},{"issue":"6","key":"10.1016\/j.jpba.2026.117556_bib9","doi-asserted-by":"crossref","first-page":"2397","DOI":"10.1007\/s00204-025-04025-z","article-title":"Mechanisms of bisphenol A and its analogs as endocrine disruptors via nuclear receptors and related signaling pathways","volume":"99","author":"Stanojevi\u0107","year":"2025","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.jpba.2026.117556_bib10","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1016\/j.envpol.2017.11.027","article-title":"Bisphenol A alternatives bisphenol S and bisphenol F interfere with thyroid hormone signaling pathway in vitro and in vivo","volume":"237","author":"Zhang","year":"2018","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.jpba.2026.117556_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2023.163068","article-title":"Adverse effects of triclosan exposure on health and potential molecular mechanisms","volume":"879","author":"Chen","year":"2023","journal-title":"Sci. Total Environ."},{"issue":"3","key":"10.1016\/j.jpba.2026.117556_bib12","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1016\/j.jaci.2012.12.1573","article-title":"Prenatal and postnatal bisphenol A exposure and asthma development among inner-city children","volume":"131","author":"Donohue","year":"2013","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.jpba.2026.117556_bib13","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.reprotox.2015.11.002","article-title":"Bisphenol A and other phenols in human placenta from children with cryptorchidism or hypospadias","volume":"59","author":"Fern\u00e1ndez","year":"2016","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.jpba.2026.117556_bib14","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.envres.2019.03.012","article-title":"Bisphenol a: a narrative review of prenatal exposure effects on adipogenesis and childhood obesity via peroxisome proliferator-activated receptor gamma","volume":"173","author":"Hoepner","year":"2019","journal-title":"Environ. Res."},{"issue":"7","key":"10.1016\/j.jpba.2026.117556_bib15","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1038\/s41366-022-01126-y","article-title":"Correction to: fetal exposure to phthalates and bisphenols and childhood general and organ fat. A population-based prospective cohort study","volume":"46","author":"Sol","year":"2022","journal-title":"Int. J. Obes."},{"issue":"1","key":"10.1016\/j.jpba.2026.117556_bib16","doi-asserted-by":"crossref","DOI":"10.1186\/s12940-021-00709-y","article-title":"Prenatal exposure to bisphenol A and autistic- and ADHD-related symptoms in children aged 2 and5 years from the Odense Child Cohort","volume":"20","author":"Hansen","year":"2021","journal-title":"Environ. Health"},{"key":"10.1016\/j.jpba.2026.117556_bib17","article-title":"Fetal exposure to bisphenols and phthalates and childhood bone mass: a population-based prospective cohort study","volume":"186","author":"van Zwol","year":"2020","journal-title":"Environ. Res."},{"issue":"6","key":"10.1016\/j.jpba.2026.117556_bib18","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1038\/pr.2017.20","article-title":"Prenatal exposure to bisphenol A and risk of allergic diseases in early life","volume":"81","author":"Zhou","year":"2017","journal-title":"Pediatr. Res."},{"issue":"1","key":"10.1016\/j.jpba.2026.117556_bib19","doi-asserted-by":"crossref","DOI":"10.1186\/s12302-024-00900-1","article-title":"Regrettable substitution? Comparative study of the effect profile of bisphenol A and eleven analogues in an in vitro test battery","volume":"36","author":"Reininger","year":"2024","journal-title":"Environ. Sci. Eur."},{"issue":"8","key":"10.1016\/j.jpba.2026.117556_bib20","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1136\/adc.2005.084129","article-title":"Meconium and neurotoxicants: searching for a prenatal exposure timing","volume":"91","author":"Ortega Garcia","year":"2006","journal-title":"Arch. Dis. Child."},{"issue":"12","key":"10.1016\/j.jpba.2026.117556_bib21","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1016\/j.annepidem.2014.09.009","article-title":"Use of meconium in perinatal epidemiology: potential benefits and pitfalls","volume":"24","author":"Park","year":"2014","journal-title":"Ann. Epidemiol."},{"issue":"1","key":"10.1016\/j.jpba.2026.117556_bib22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11419-021-00596-5","article-title":"Alternative matrices in forensic toxicology: a critical review","volume":"40","author":"de Campos","year":"2021","journal-title":"Forensic Toxicol."},{"key":"10.1016\/j.jpba.2026.117556_bib23","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.jpba.2019.04.036","article-title":"Salting out assisted liquid-liquid extraction for liquid chromatography tandem-mass spectrometry determination of amphetamine-like stimulants in meconium","volume":"172","author":"Neme\u0161kalov\u00e1","year":"2019","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jpba.2026.117556_bib24","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.jpba.2017.09.017","article-title":"Determination of phthalate diesters and monoesters in human milk and infant formula by fat extraction, size-exclusion chromatography clean-up and gas chromatography-mass spectrometry detection","volume":"148","author":"Del Bubba","year":"2018","journal-title":"J. Pharm. Biomed. Anal."},{"issue":"1","key":"10.1016\/j.jpba.2026.117556_bib25","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1007\/s00128-010-0051-8","article-title":"Determination of five phthalate monoesters in human urine using gas chromatography-mass spectrometry","volume":"85","author":"Kondo","year":"2010","journal-title":"Bull. Environ. Contam. Toxicol."},{"issue":"1","key":"10.1016\/j.jpba.2026.117556_bib26","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/S1570-0232(02)00413-0","article-title":"Simultaneous determination of phthalate di- and monoesters in poly(vinylchloride) products and human saliva by gas chromatography\u2013mass spectrometry","volume":"780","author":"Niino","year":"2002","journal-title":"J. Chromatogr. B"},{"issue":"18","key":"10.1016\/j.jpba.2026.117556_bib27","doi-asserted-by":"crossref","first-page":"3757","DOI":"10.1021\/es001860i","article-title":"Monitoring of phthalic acid monoesters in river water by solid-phase extraction and GC-MS determination","volume":"35","author":"Suzuki","year":"2001","journal-title":"Environ. Sci. Technol."},{"issue":"1","key":"10.1016\/j.jpba.2026.117556_bib28","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1080\/19440049.2017.1382730","article-title":"Solid phase extraction of large volume of water and beverage samples to improve detection limits for GC-MS analysis of bisphenol A and four other bisphenols","volume":"35","author":"Cao","year":"2017","journal-title":"Food Addit. Contam. Part A"},{"issue":"5","key":"10.1016\/j.jpba.2026.117556_bib29","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1093\/jaoacint\/qsae062","article-title":"Development and validation of a GC\u2013MS method based on solid-phase extraction and derivatization for analysis of free and glucuronide-conjugated Bisphenol F in biological samples","volume":"107","author":"Cao","year":"2024","journal-title":"J. AOAC Int."},{"key":"10.1016\/j.jpba.2026.117556_bib30","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.jchromb.2017.10.060","article-title":"Micro-QuEChERS extraction coupled to GC\u2013MS for a fast determination of Bisphenol A in human urine","volume":"1072","author":"Correia-S\u00e1","year":"2018","journal-title":"J. Chromatogr. B"},{"key":"10.1016\/j.jpba.2026.117556_bib31","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2021.694669","article-title":"Identification of the Bisphenol A (BPA) and the two analogues BPS and BPF in Cryptorchidism","volume":"12","author":"Komarowska","year":"2021","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.jpba.2026.117556_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpba.2020.113417","article-title":"A simple, inexpensive, non-enzymatic microwave-assisted method for determining bisphenol-A in urine in the form of trimethylsilyl derivative by GC\/MS with single quadrupole","volume":"188","author":"Polovkov","year":"2020","journal-title":"J. Pharm. Biomed. Anal."},{"issue":"31","key":"10.1016\/j.jpba.2026.117556_bib33","doi-asserted-by":"crossref","first-page":"4042","DOI":"10.1016\/j.jchromb.2009.10.017","article-title":"Sensitive and selective method for the determination of bisphenol-A and triclosan in serum and urine as pentafluorobenzoate-derivatives using GC\u2013ECNI\/MS","volume":"877","author":"Geens","year":"2009","journal-title":"J. Chromatogr. B"},{"key":"10.1016\/j.jpba.2026.117556_bib34","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.scitotenv.2016.02.022","article-title":"Maternal and early life exposure to phthalates: the plastics and personal-care products use in pregnancy (P4) study","volume":"551-552","author":"Arbuckle","year":"2016","journal-title":"Sci. Total Environ."},{"issue":"1","key":"10.1016\/j.jpba.2026.117556_bib35","doi-asserted-by":"crossref","DOI":"10.3390\/toxics12010075","article-title":"Multiclass determination of endocrine-disrupting chemicals in meconium: first evidence of perfluoroalkyl substances in this biological compartment","volume":"12","author":"Dom\u00ednguez-Liste","year":"2024","journal-title":"Toxics"},{"issue":"18","key":"10.1016\/j.jpba.2026.117556_bib36","doi-asserted-by":"crossref","first-page":"6651","DOI":"10.1021\/ac0608220","article-title":"Quantifying phthalate metabolites in human meconium and semen using automated off-line solid-phase extraction coupled with on-line SPE and isotope-dilution high-performance liquid chromatography\u2212Tandem Mass spectrometry","volume":"78","author":"Kato","year":"2006","journal-title":"Anal. Chem."},{"key":"10.1016\/j.jpba.2026.117556_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2021.148898","article-title":"Prenatal phthalate exposure measurement: a comparison of metabolites quantified in prenatal maternal urine and newborn's meconium","volume":"796","author":"Mathew","year":"2021","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.jpba.2026.117556_bib38","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.envres.2015.03.028","article-title":"Paraoxonase 2 gene polymorphisms and prenatal phthalates' exposure in Chinese newborns","volume":"140","author":"Xie","year":"2015","journal-title":"Environ. Res."},{"key":"10.1016\/j.jpba.2026.117556_bib39","unstructured":"ICH, ICH Guideline M10 on Bioanalytical Method Validation - Step 5. \u3008https:\/\/www.ema.europa.eu\/en\/ich-m10-bioanalytical-method-validation-scientific-guideline\u3009, 2022 (accessed 14 September 2025.)."},{"key":"10.1016\/j.jpba.2026.117556_bib40","unstructured":"FDA, Bioanalytical Method Validation Guidance for Industry. \u3008https:\/\/www.fda.gov\/regulatory-information\/search-fda-guidance-documents\/bioanalytical-method-validation-guidance-industry\u3009, 2018 (accessed 14 September 2025.)."},{"key":"10.1016\/j.jpba.2026.117556_bib41","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/j.scitotenv.2014.10.107","article-title":"Maternal and infant exposure to environmental phenols as measured in multiple biological matrices","volume":"508","author":"Arbuckle","year":"2015","journal-title":"Sci. Total Environ."},{"issue":"13","key":"10.1016\/j.jpba.2026.117556_bib42","doi-asserted-by":"crossref","first-page":"5739","DOI":"10.1021\/acs.est.3c11032","article-title":"First insight into fetal exposure to legacy and emerging plasticizers revealed by infant hair and meconium: occurrence, biotransformation, and accumulation","volume":"58","author":"Cai","year":"2024","journal-title":"Environ. Sci. Technol."},{"issue":"1","key":"10.1016\/j.jpba.2026.117556_bib43","doi-asserted-by":"crossref","DOI":"10.1210\/jendso\/bvaf208","article-title":"Intrauterine exposure to endocrine-disrupting chemicals and risk of hypospadias: a pilot study","volume":"10","author":"Tillotson","year":"2026","journal-title":"J. Endocr. Soc."}],"container-title":["Journal of Pharmaceutical and Biomedical Analysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0731708526002244?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0731708526002244?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T14:02:41Z","timestamp":1783173761000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0731708526002244"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":43,"alternative-id":["S0731708526002244"],"URL":"https:\/\/doi.org\/10.1016\/j.jpba.2026.117556","relation":{},"ISSN":["0731-7085"],"issn-type":[{"value":"0731-7085","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Development and validation of a GC-MS method for the simultaneous determination of bisphenols, phthalate monoesters, and triclosan in human meconium for comprehensive prenatal exposure assessment","name":"articletitle","label":"Article Title"},{"value":"Journal of Pharmaceutical and Biomedical Analysis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpba.2026.117556","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"117556"}}