{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T22:35:11Z","timestamp":1784673311029,"version":"3.55.0"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004607","name":"Guangxi Natural Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004607","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmaceutical and Biomedical Analysis"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.jpba.2026.117624","type":"journal-article","created":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T07:22:31Z","timestamp":1782199351000},"page":"117624","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Dissection of potential mechanism of Bao-Yuan tablet against Spleen-Qi Deficiency by UPLC-Q\/TOF MS and network pharmacology"],"prefix":"10.1016","volume":"280","author":[{"given":"Zi-Hao","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-Lu","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue-Dan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tian-Yun","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi-Liu","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wan-Ting","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhong-Qiao","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong-Peng","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan-Yan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1255-4222","authenticated-orcid":false,"given":"Feng-Xiang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Si-Yuan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10","key":"10.1016\/j.jpba.2026.117624_bib1","first-page":"2459","article-title":"Progress in the research of quantitative diagnostic criteria of Spleen-qi Deficiency syndrome","volume":"39","author":"Lin","year":"2022","journal-title":"J. Guangzhou Univ. Tradit. Chin. Med."},{"issue":"06","key":"10.1016\/j.jpba.2026.117624_bib2","first-page":"99","article-title":"Connotation and expansion of the spleen governing blood theory","volume":"32","author":"Li","year":"2015","journal-title":"Inf. Tradit. Chin. Med."},{"issue":"3","key":"10.1016\/j.jpba.2026.117624_bib3","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1007\/s11684-019-0705-9","article-title":"Chinmedomics facilitated quality-marker discovery of Sijunzi decoction to treat spleen qi deficiency syndrome","volume":"14","author":"Zhao","year":"2020","journal-title":"Front. Med."},{"key":"10.1016\/j.jpba.2026.117624_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2024.118058","article-title":"Bao Yuan decoction alleviates fatigue by restraining inflammation and oxidative stress via the AMPK\/CRY2\/PER1 signaling pathway","volume":"328","author":"Zheng","year":"2024","journal-title":"J. Ethnopharmacol."},{"issue":"05","key":"10.1016\/j.jpba.2026.117624_bib5","first-page":"1677","article-title":"Effects of modified Bao-Yuan Decoction on immune function in normal mice","volume":"46","author":"Hu","year":"2024","journal-title":"Chin. Tradit. Pat. Med."},{"issue":"05","key":"10.1016\/j.jpba.2026.117624_bib6","first-page":"1","article-title":"Research progress on the chemical constituents, pharmacological effects, and clinical applications of Baoyuan Decoction","volume":"2026","author":"Li","year":"2025","journal-title":"J. Jilin. Med. Coll."},{"key":"10.1016\/j.jpba.2026.117624_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.fitote.2026.107172","article-title":"Integrated serum pharmacochemistry and network pharmacology reveal the mechanisms of Baoyuan decoction formula granules against spleen deficiency syndrome","volume":"190","author":"Wu","year":"2026","journal-title":"Fitoterapia"},{"issue":"2","key":"10.1016\/j.jpba.2026.117624_bib8","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1016\/j.jep.2010.10.016","article-title":"Effects on neuroendocrinoimmune network of Lizhong Pill in the reserpine induced rats with spleen deficiency in traditional Chinese medicine","volume":"133","author":"Zhao","year":"2011","journal-title":"J. Ethnopharmacol."},{"issue":"02","key":"10.1016\/j.jpba.2026.117624_bib9","first-page":"284","article-title":"A Research Overview of Modeling Method and Model Evaluation for Animal Models of Spleen-Qi Deficiency Syndrome","volume":"39","author":"Zeng","year":"2019","journal-title":"J. Hunan Univ. Tradit. Chin. Med."},{"issue":"2","key":"10.1016\/j.jpba.2026.117624_bib10","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1016\/j.jep.2013.12.001","article-title":"Analysis of the restorative effect of Bu-zhong-yi-qi-tang in the spleen-qi deficiency rat model using 1H NMR-based metabonomics","volume":"151","author":"Zheng","year":"2014","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jpba.2026.117624_bib11","first-page":"52","article-title":"A preliminary study on the standardization of animal models for Spleen-Qi Deficiency syndrome","volume":"04","author":"Chen","year":"2001","journal-title":"Chin. J. Tradit. Chin. Med. Pharm."},{"key":"10.1016\/j.jpba.2026.117624_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpba.2022.115086","article-title":"Non-targeted characteristic filter analysis combined with in silico prediction strategies to identify the chemical components and in vivo metabolites of Dalitong Granules by UPLC-Q-TOF\/MS\/MS","volume":"222","author":"Su","year":"2023","journal-title":"J. Pharm. Biomed. Anal."},{"issue":"1","key":"10.1016\/j.jpba.2026.117624_bib13","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1080\/13880209.2024.2354341","article-title":"Comprehensive profiling of the chemical constituents in Dayuanyin decoction using UPLC-QTOF-MS combined with molecular networking","volume":"62","author":"Peng","year":"2024","journal-title":"Pharm. Biol."},{"key":"10.1016\/j.jpba.2026.117624_bib14","article-title":"Integrating UPLC-Q-TOF-MS\/MS, Feature-Based Molecular Networking, network pharmacology, and molecular docking to investigate the mechanism of Persicae Ramulus against Myocardial Ischemia","volume":"357","author":"Yu","year":"2025","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jpba.2026.117624_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2025.119994","article-title":"Exploring the pharmacological mechanism of Bu-Wang San on Alzheimer's disease through multiple GEO datasets of the human hippocampus, network pharmacology, and metabolomics based on GC-MS and UPLC-Q\/TOF-MS","volume":"350","author":"Wang","year":"2025","journal-title":"J. Ethnopharmacol."},{"issue":"3","key":"10.1016\/j.jpba.2026.117624_bib16","doi-asserted-by":"crossref","DOI":"10.1002\/bmc.4110","article-title":"A target and nontarget strategy for identification or characterization of the chemical ingredients in Chinese herb preparation Shuang-Huang-Lian oral liquid by ultra-performance liquid chromatography-quadrupole time-of-flight mass spectrometry","volume":"32","author":"Zhang","year":"2018","journal-title":"Biomed. Chromatogr."},{"key":"10.1016\/j.jpba.2026.117624_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpba.2024.116257","article-title":"Chemical profiling of Zhi-Ke-Bao pills and its potential mechanism against cough by ultra-high performance liquid chromatography coupled to quadrupole time-of-flight mass spectrometry and network pharmacology","volume":"247","author":"Chen","year":"2024","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jpba.2026.117624_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2025.119787","article-title":"Lan-Qin oral liquid alleviates influenza A virus-induced acute lung injury by regulating monocyte-derived macrophages and TLR4\/PI3K\/AKT\/NF-\u03baB signal pathways","volume":"347","author":"Chen","year":"2025","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jpba.2026.117624_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2023.116605","article-title":"A screening strategy for bioactive components of Bu-Zhong-Yi-Qi-Tang regulating spleen-qi deficiency based on \"endobiotics-targets-xenobiotics\" association network","volume":"314","author":"Hu","year":"2023","journal-title":"J. Ethnopharmacol."},{"issue":"20","key":"10.1016\/j.jpba.2026.117624_bib20","first-page":"4075","article-title":"Study on interference effect of Sijunzi decoction on brain-gut CaM \/ CaMK\u2161 of spleen Qi deficiency syndrome rats, China","volume":"40","author":"Tian","year":"2015","journal-title":"J. Chin. Mater. Med."},{"issue":"02","key":"10.1016\/j.jpba.2026.117624_bib21","first-page":"1","article-title":"Preliminary study on normalization of developing deficiency of qi of the spleen in animals-a study on changes of part of immunologic functions","author":"Zhou","year":"2003","journal-title":"Lab. Anim. Sci. Admin"},{"key":"10.1016\/j.jpba.2026.117624_bib22","article-title":"Characterization of chemical constituents and metabolites of Baoyuan Decoction in vivo and in vitro using ultra-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry","author":"Jia","year":"2026","journal-title":"World J. Tradit. Chin. Med."},{"issue":"22","key":"10.1016\/j.jpba.2026.117624_bib23","first-page":"243","article-title":"Analysis of material basis of famous classical formula Baoyuantang based on UPLC-Q-TOF-MS\/MS","volume":"30","author":"Gao","year":"2024","journal-title":"Chin. J. Exp. Tradit. Med. Formula"},{"issue":"22","key":"10.1016\/j.jpba.2026.117624_bib24","doi-asserted-by":"crossref","first-page":"4111","DOI":"10.1002\/jssc.202100360","article-title":"Comprehensive multicomponent characterization and fingerprinting analysis of lanqin oral liquid by ultra-high performance liquid chromatography coupled with ion mobility-quadrupole time-of-flight mass spectrometry","volume":"44","author":"Wang","year":"2021","journal-title":"J. Sep. Sci."},{"issue":"7","key":"10.1016\/j.jpba.2026.117624_bib25","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1007\/s00299-014-1592-9","article-title":"Past achievements, current status and future perspectives of studies on 3-hydroxy-3-methylglutaryl-CoA synthase (HMGS) in the mevalonate (MVA) pathway","volume":"33","author":"Liao","year":"2014","journal-title":"Plant. Cell. Rep."},{"issue":"10","key":"10.1016\/j.jpba.2026.117624_bib26","first-page":"2583","article-title":"Connotation of distal bleeding based on modern pathophysiological mechanism and application of Huangtu Connotation of distal bleeding based on modern pathophysiological mechanism and application of Huangtu, China","volume":"48","author":"Xiong","year":"2023","journal-title":"J. Chin. Mater. Med."},{"issue":"18","key":"10.1016\/j.jpba.2026.117624_bib27","first-page":"108","article-title":"Research progress on the syndrome of spleen failing to govern blood","volume":"25","author":"Yang","year":"2019","journal-title":"Guid. J. Tradit. Chin. Med. Pharm."},{"issue":"24","key":"10.1016\/j.jpba.2026.117624_bib28","first-page":"3281","article-title":"The effect of modified ginseng and schisandra decoction on the efficacy and inflammatory indicators of children with lobar pneumonia(lung spleen deficiency syndrome) caused by mycoplasma pneumonia infection","volume":"39","author":"You","year":"2023","journal-title":"J. Pract. Med."},{"key":"10.1016\/j.jpba.2026.117624_bib29","article-title":"Traditional Chinese medicine and lung cancer\u2014\u2014From theory to practice","volume":"137","author":"Zhang","year":"2021","journal-title":"Biomed. Pharmacother."},{"issue":"20","key":"10.1016\/j.jpba.2026.117624_bib30","first-page":"174","article-title":"Exploration of the mechanism of Shenling Baizhu Powder in treating Spleen Qi Deficiency based on network pharmacology and pharmacological experiments","volume":"22","author":"Wu","year":"2024","journal-title":"Chin. Med. Mod. Distance Educ."},{"issue":"1","key":"10.1016\/j.jpba.2026.117624_bib31","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1615\/CritRevImmunol.v30.i1.10","article-title":"Toll-like receptors and B-cell receptors synergize to induce immunoglobulin class-switch DNA recombination: relevance to microbial antibody responses","volume":"30","author":"Pone","year":"2010","journal-title":"Crit. Rev. Immunol."},{"issue":"12","key":"10.1016\/j.jpba.2026.117624_bib32","first-page":"1165","article-title":"Research on the immunomodulatory effects of Shenbai Nanosuspension in immunocompromised mice","volume":"44","author":"Zhang","year":"2025","journal-title":"J. Pharm. Res."},{"key":"10.1016\/j.jpba.2026.117624_bib33","article-title":"Protective effect of zinc gluconate on intestinal mucosal barrier injury in antibiotics and LPS-induced mice","volume":"15","author":"Wang","year":"2024","journal-title":"Front. Microbiol."},{"issue":"6","key":"10.1016\/j.jpba.2026.117624_bib34","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1136\/gut.52.6.813","volume":"52","author":"Ogasa","year":"2003","journal-title":"Gut"},{"issue":"8","key":"10.1016\/j.jpba.2026.117624_bib35","article-title":"NF-kappaB mediated transcriptional repression of acid modifying hormone gastrin","volume":"8","author":"De","year":"2017","journal-title":"PLoS. ONE"}],"container-title":["Journal of Pharmaceutical and Biomedical Analysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S073170852600292X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S073170852600292X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T10:54:24Z","timestamp":1784112864000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S073170852600292X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":35,"alternative-id":["S073170852600292X"],"URL":"https:\/\/doi.org\/10.1016\/j.jpba.2026.117624","relation":{},"ISSN":["0731-7085"],"issn-type":[{"value":"0731-7085","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dissection of potential mechanism of Bao-Yuan tablet against Spleen-Qi Deficiency by UPLC-Q\/TOF MS and network pharmacology","name":"articletitle","label":"Article Title"},{"value":"Journal of Pharmaceutical and Biomedical Analysis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpba.2026.117624","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"117624"}}