{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T22:08:40Z","timestamp":1790114920590,"version":"4.0.1"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82004093"],"award-info":[{"award-number":["82004093"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmaceutical and Biomedical Analysis"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.jpba.2026.117675","type":"journal-article","created":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T06:49:22Z","timestamp":1784962162000},"page":"117675","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Characterization of the components and metabolites of ethanol extracts of psoralea fructus in the plasma and tissues of rats based on ultrahigh performance liquid chromatography-quadrupole time-of-flight mass spectrometry"],"prefix":"10.1016","volume":"281","author":[{"given":"Xiaojuan","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huihui","family":"Zhuang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanyan","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunfei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jpba.2026.117675_bib1","first-page":"61","article-title":"Identification of psoraleae fructus illegally added in mixed wine and mixed tea based on high resolution mass spectrometry library and diagnostic ratio of characteristic components","volume":"38","author":"Gao","year":"2022","journal-title":"Food Mach."},{"key":"10.1016\/j.jpba.2026.117675_bib2","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1002\/ptr.6006","article-title":"Psoralea corylifolia L.: Ethnobotanical, biological, and chemical aspects: A review","volume":"32","author":"Alam","year":"2018","journal-title":"Phytother. Res."},{"key":"10.1016\/j.jpba.2026.117675_bib3","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1142\/S0192415X16500038","article-title":"The Chemical Constituents and Bioactivities of Psoralea corylifolia Linn.: A Review","volume":"44","author":"Zhang","year":"2016","journal-title":"Am. J. Chin. Med."},{"key":"10.1016\/j.jpba.2026.117675_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpba.2025.117209","article-title":"Systematic characterization of the prototypes and metabolites of Psoraleae Fructus in mice by high-resolution liquid chromatography\/ mass spectrometry","volume":"268","author":"Wang","year":"2026","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jpba.2026.117675_bib5","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.jpba.2015.03.026","article-title":"Identification of metabolites of PSORALEAE FRUCTUS in rats by ultra performance liquid chromatography coupled with quadrupole time-of-flight tandem mass spectrometry analysis","volume":"112","author":"Wang","year":"2015","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jpba.2026.117675_bib6","first-page":"1055","article-title":"Fabrication of psoralen-loaded lipid-polymer hybrid nanoparticles and their reversal effect on drug resistance of cancer cells","volume":"40","author":"Yuan","year":"2018","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.jpba.2026.117675_bib7","doi-asserted-by":"crossref","first-page":"14001","DOI":"10.1038\/s41598-018-32438-7","article-title":"Psoralen induced cell cycle arrest by modulating Wnt\/\u03b2-catenin pathway in breast cancer cells","volume":"8","author":"Wang","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jpba.2026.117675_bib8","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.phymed.2017.12.002","article-title":"Plasma pharmacokinetics and cerebral nuclei distribution of major constituents of Psoraleae fructus in rats after oral administration","volume":"38","author":"Yang","year":"2018","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jpba.2026.117675_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.jchromb.2021.122974","article-title":"Study on pharmacokinetics of eight active compounds from Bufei-Huoxue Capsule based on UHPLC-MS\/MS","volume":"1184","author":"Men","year":"2021","journal-title":"J. Chromatogr. B."},{"key":"10.1016\/j.jpba.2026.117675_bib10","first-page":"976","article-title":"Scientific connotation of attenuation of Psoralea corylifolia by \u2018Leigong processing method","volume":"37","author":"Lv","year":"2020","journal-title":"Tianjin. J. Tradit. Chin. Med."},{"key":"10.1016\/j.jpba.2026.117675_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpba.2025.116915","article-title":"Integrated electronic eye, electronic nose and high performance liquid chromatography for identification of raw and salt-processed Psoralea corylifolia, Fruct","volume":"263","author":"Zhu","year":"2025","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jpba.2026.117675_bib12","first-page":"439","article-title":"Comparative chemical characters of pseudostellaria heterophylla from geographical origins of China","volume":"15","author":"Sha","year":"2023","journal-title":"Chin. Herb. Med."},{"key":"10.1016\/j.jpba.2026.117675_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.chroma.2023.464488","article-title":"Chemical composition and absorption characteristics of Angong Niuhuang pill based on two-dimensional ultra-high-performance liquid chromatography-quadrupole Orbitrap high-resolution mass spectrometry","volume":"1712","author":"Wang","year":"2023","journal-title":"J. Chromatogr. A."},{"key":"10.1016\/j.jpba.2026.117675_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpba.2025.116996","article-title":"A pharmacokinetic study of four bone-protective compounds after oral administration of WSZG extract in primary breast cancer mice","volume":"265","author":"Ning","year":"2025","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jpba.2026.117675_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpba.2024.116519","article-title":"Comparative profiling of the absorbed compounds and metabolites, and pharmacokinetic studies of Danshen-Chuanxiong herb pair in rat plasma and brain using liquid chromatography-tandem mass spectrometry","volume":"252","author":"Guo","year":"2025","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jpba.2026.117675_bib16","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.jpba.2017.06.059","article-title":"Metabolite identification of AZD8055 in Sprague-Dawley rats after a single oral administration using ultra-performance liquid chromatography and mass spectrometry","volume":"145","author":"Rashid","year":"2017","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jpba.2026.117675_bib17","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1002\/mas.21607","article-title":"Strategies and challenges in method development and validation for the absolute quantification of endogenous biomarker metabolites using liquid chromatography-tandem mass spectrometry","volume":"40","author":"Khamis","year":"2021","journal-title":"Mass. Spectrom. Rev."},{"key":"10.1016\/j.jpba.2026.117675_bib18","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1002\/pca.3317","article-title":"Exploration of the profiles of steroidal saponins from Rhizoma Paridis and their metabolites in rats by UPLC-Q-TOF-MS\/MS","volume":"35","author":"Wu","year":"2024","journal-title":"Phytochem. Anal."},{"key":"10.1016\/j.jpba.2026.117675_bib19","article-title":"The signaling pathways of selected traditional Chinese medicine prescriptions and their metabolites in the treatment of diabetic cardiomyopathy: a review","volume":"15","author":"Li","year":"2024","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jpba.2026.117675_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpha.2024.100994","article-title":"Software-aided efficient identification of the components of compound formulae and their metabolites in rats by UHPLC\/IM-QTOF-MS and an in-house high-definition MS2 library: Sishen formula as a case","volume":"14","author":"Hong","year":"2024","journal-title":"J. Pharm. Anal."},{"key":"10.1016\/j.jpba.2026.117675_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2020.112607","article-title":"Metabolomic analysis of Cyrtopodium glutiniferum extract by UHPLC-MS\/MS and in vitro antiproliferative and genotoxicity assessment","volume":"253","author":"Ara\u00fajo-Lima","year":"2020","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jpba.2026.117675_bib22","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1002\/pca.2963","article-title":"Chemical characterisation and quantification of the major constituents in the Chinese herbal formula Jian-Pi-Yi-Shen pill by UPLC-Q-TOF-MS\/MS and HPLC-QQQ-MS\/MS","volume":"31","author":"Wang","year":"2020","journal-title":"Phytochem. Anal."},{"key":"10.1016\/j.jpba.2026.117675_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2021.111735","article-title":"Systematic investigation of the pharmacological mechanism for renal protection by the leaves of Eucommia ulmoides Oliver using UPLC-Q-TOF\/MS combined with network pharmacology analysis","volume":"140","author":"Huang","year":"2021","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.jpba.2026.117675_bib24","doi-asserted-by":"crossref","first-page":"3905","DOI":"10.1007\/s00216-022-04034-2","article-title":"Study on the metabolic process of synthetic cannabinoids 4F-MDMB-BINACA and 4F-MDMB-BICA in human liver microsome and zebrafish model via UHPLC-QE Orbitrap MS","volume":"414","author":"Li","year":"2022","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.jpba.2026.117675_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpba.2022.114679","article-title":"Rapid screening and identification of metabolites of murpanicin in rats by UHPLC\/Q-TOF-MS\/MS combined with diagnostic fragment ions (DFIs) and multiple mass defect filter","volume":"213","author":"Yuan","year":"2022","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jpba.2026.117675_bib26","doi-asserted-by":"crossref","DOI":"10.1002\/jssc.202300233","article-title":"Chemical components characterization and in vivo metabolites profiling of Lingbao Huxin Dan by gas chromatography-mass spectrometry and ultra-high-performance liquid chromatography-andem quadrupole time-of-flight mass spectrometry","volume":"47","author":"Huang","year":"2024","journal-title":"J. Sep. Sci."},{"key":"10.1016\/j.jpba.2026.117675_bib27","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2024.1363678","article-title":"Integrated chemical characterization, metabolite profiling, and pharmacokinetics analysis of Zhijun Tangshen decoction by UPLC-Q\/TOF-MS","volume":"15","author":"Tong","year":"2024","journal-title":"Front. Pharm."},{"key":"10.1016\/j.jpba.2026.117675_bib28","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.foodchem.2013.02.068","article-title":"Identification of in vitro and in vivo metabolites of isoimperatorin using liquid chromatography\/mass spectrometry","volume":"141","author":"Shi","year":"2013","journal-title":"Food Chem."},{"key":"10.1016\/j.jpba.2026.117675_bib29","doi-asserted-by":"crossref","first-page":"2110","DOI":"10.1124\/dmd.110.034553","article-title":"The effects of single nucleotide polymorphisms in CYP2A13 on metabolism of 5-methoxypsoralen","volume":"38","author":"Goto","year":"2010","journal-title":"Drug. Metab. Dispos."},{"key":"10.1016\/j.jpba.2026.117675_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2021.112300","article-title":"Identification and pharmacokinetics of bioavailable anti-resorptive phytochemicals after oral administration of Psoralea corylifolia L","volume":"144","author":"Lee","year":"2021","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.jpba.2026.117675_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2019.152874","article-title":"Multiorgan toxicity induced by EtOH extract of Fructus Psoraleae in Wistar rats","volume":"58","author":"Wang","year":"2019","journal-title":"PHYTOMEDICINE"},{"key":"10.1016\/j.jpba.2026.117675_bib32","doi-asserted-by":"crossref","first-page":"154","DOI":"10.3390\/toxins10040154","article-title":"Bavachinin Induces Oxidative Damage in HepaRG Cells through p38\/JNK MAPK Pathways","volume":"10","author":"Wang","year":"2018","journal-title":"Toxins (Basel)"},{"key":"10.1016\/j.jpba.2026.117675_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2020.107352","article-title":"Psoralidin, a major component of Psoraleae Fructus, induces inflammasome activation and idiosyncratic liver injury","volume":"92","author":"Wang","year":"2021","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.jpba.2026.117675_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2022.115593","article-title":"Discovery of bakuchiol as an AIM2 inflammasome activator and cause of hepatotoxicity","volume":"298","author":"Liu","year":"2022","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jpba.2026.117675_bib35","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.fct.2017.11.048","article-title":"Metabolic detoxification of bakuchiol is mediated by oxidation of CYP 450s in liver microsomes","volume":"111","author":"Hu","year":"2018","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.jpba.2026.117675_bib36","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.jpba.2014.03.024","article-title":"Metabolites profile of Xian-Ling-Gu-Bao capsule, a traditional Chinese medicine prescription, in rats by ultra performance liquid chromatography coupled with quadrupole time-of-flight tandem mass spectrometry analysis","volume":"96","author":"Geng","year":"2014","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jpba.2026.117675_bib37","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.682823","article-title":"Five constituents contributed to the Psoraleae Fructus-induced hepatotoxicity via mitochondrial dysfunction and apoptosis","volume":"12","author":"Guo","year":"2021","journal-title":"Front. Pharmacol."}],"container-title":["Journal of Pharmaceutical and Biomedical Analysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0731708526003432?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0731708526003432?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T21:44:54Z","timestamp":1790113494000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0731708526003432"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":37,"alternative-id":["S0731708526003432"],"URL":"https:\/\/doi.org\/10.1016\/j.jpba.2026.117675","relation":{},"ISSN":["0731-7085"],"issn-type":[{"value":"0731-7085","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Characterization of the components and metabolites of ethanol extracts of psoralea fructus in the plasma and tissues of rats based on ultrahigh performance liquid chromatography-quadrupole time-of-flight mass spectrometry","name":"articletitle","label":"Article Title"},{"value":"Journal of Pharmaceutical and Biomedical Analysis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpba.2026.117675","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"117675"}}