{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T03:04:09Z","timestamp":1789787049522,"version":"4.0.1"},"reference-count":20,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T00:00:00Z","timestamp":1786665600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmaceutical and Biomedical Analysis"],"published-print":{"date-parts":[[2027,1]]},"DOI":"10.1016\/j.jpba.2026.117705","type":"journal-article","created":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T23:32:59Z","timestamp":1786404779000},"page":"117705","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Development and evaluation of a Raman detector for non-destructive identification and quantitation of cytostatic drugs in different primary packaging containers"],"prefix":"10.1016","volume":"282","author":[{"given":"Philipp","family":"Siegmund","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Klinken-Uth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Michel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael C.","family":"Hacker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f6rg","family":"Breitkreutz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bj\u00f6rn","family":"Fischer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.jpba.2026.117705_bib1","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1002\/ijc.33588","article-title":"Cancer statistics for the year 2020: an overview","volume":"149","author":"Ferlay","year":"2021","journal-title":"Int. J. Cancer"},{"issue":"1","key":"10.1016\/j.jpba.2026.117705_bib2","first-page":"10","article-title":"Cancer statistics, 2025","volume":"75","author":"Siegel","year":"2025","journal-title":"CA Cancer J. Clin."},{"issue":"5","key":"10.1016\/j.jpba.2026.117705_bib3","doi-asserted-by":"crossref","first-page":"3044","DOI":"10.3390\/curroncol29050247","article-title":"Immune checkpoint inhibitors in cancer therapy","volume":"29","author":"Shiravand","year":"2022","journal-title":"Curr. Oncol."},{"issue":"4","key":"10.1016\/j.jpba.2026.117705_bib4","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1056\/NEJMoa011795","article-title":"CHOP chemotherapy plus rituximab compared with CHOP alone in elderly patients with diffuse large-B-cell lymphoma","volume":"346","author":"Coiffier","year":"2002","journal-title":"N. Engl. J. Med."},{"issue":"1","key":"10.1016\/j.jpba.2026.117705_bib5","doi-asserted-by":"crossref","first-page":"2707","DOI":"10.1038\/s41598-021-81662-1","article-title":"Cyclophosphamide exposure assessed with the biomarker phosphoramide mustard-hemoglobin in breast cancer patients: the TailorDose I study","volume":"11","author":"Gernaat","year":"2021","journal-title":"Sci. Rep."},{"issue":"2","key":"10.1016\/j.jpba.2026.117705_bib6","doi-asserted-by":"crossref","first-page":"C540","DOI":"10.1152\/ajpcell.00331.2022","article-title":"Barriers and opportunities for gemcitabine in pancreatic cancer therapy","volume":"324","author":"Beutel","year":"2023","journal-title":"Am. J. Physiol. Cell. Physiol."},{"key":"10.1016\/j.jpba.2026.117705_bib7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00280-016-3003-0","article-title":"Pharmacokinetics and pharmacogenetics of Gemcitabine as a mainstay in adult and pediatric oncology: an EORTC-PAMM perspective","volume":"78","author":"Ciccolini","year":"2016","journal-title":"Cancer Chemother. Pharmacol."},{"issue":"1","key":"10.1016\/j.jpba.2026.117705_bib8","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.clon.2006.10.010","article-title":"Chemotherapy dosing part I: scientific basis for current practice and use of body surface area","volume":"19","author":"Kaestner","year":"2007","journal-title":"Clin. Oncol."},{"issue":"5","key":"10.1016\/j.jpba.2026.117705_bib9","doi-asserted-by":"crossref","first-page":"e295","DOI":"10.1200\/JOP.17.00007","article-title":"Intravenous chemotherapy compounding errors in a follow-up pan-Canadian observational study","volume":"14","author":"Gilbert","year":"2018","journal-title":"J. Oncol. Pract."},{"issue":"5","key":"10.1016\/j.jpba.2026.117705_bib10","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1016\/j.jpba.2009.03.007","article-title":"Quantitative and qualitative control of cytotoxic preparations by HPLC-UV","volume":"49","author":"Delmas","year":"2009","journal-title":"a Cent. Parenter. Prep. Unit. J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jpba.2026.117705_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpba.2022.115034","article-title":"Development and application of a liquid chromatography coupled to mass spectrometry method for the simultaneous determination of 23 antineoplastic drugs at trace levels","volume":"221","author":"Fleury-Souverain","year":"2022","journal-title":"J. Pharm. Biomed. Anal."},{"issue":"12","key":"10.1016\/j.jpba.2026.117705_bib12","doi-asserted-by":"crossref","first-page":"2010","DOI":"10.1016\/j.ejca.2014.04.014","article-title":"Review of therapeutic drug monitoring of anticancer drugs part 1\u2013cytotoxics","volume":"50","author":"Paci","year":"2014","journal-title":"Eur. J. Cancer"},{"key":"10.1016\/j.jpba.2026.117705_bib13","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2022.1015200","article-title":"Therapeutic drug monitoring for cytotoxic anticancer drugs: Principles and evidence-based practices","volume":"12","author":"Smita","year":"2022","journal-title":"Front. Oncol."},{"key":"10.1016\/j.jpba.2026.117705_bib14","doi-asserted-by":"crossref","first-page":"2587","DOI":"10.1007\/s00216-021-03223-9","article-title":"Quality control of cytostatic drug preparations\u2014comparison of workflow and performance of Raman\/UV and high-performance liquid chromatography coupled with diode array detection (HPLC-DAD)","volume":"413","author":"Reinders","year":"2021","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.jpba.2026.117705_bib15","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.talanta.2016.07.025","article-title":"Discrimination and quantification of two isomeric antineoplastic drugs by rapid and non-invasive analytical control using a handheld Raman spectrometer","volume":"161","author":"L\u00ea","year":"2016","journal-title":"Talanta"},{"key":"10.1016\/j.jpba.2026.117705_bib16","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/j.talanta.2018.11.062","article-title":"Quantification of gemcitabine intravenous drugs by direct measurement in chemotherapy plastic bags using a handheld Raman spectrometer","volume":"196","author":"L\u00ea","year":"2019","journal-title":"Talanta"},{"key":"10.1016\/j.jpba.2026.117705_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.talanta.2021.122137","article-title":"In situ Analytical Quality Control of chemotherapeutic solutions in infusion bags by Raman spectroscopy","volume":"228","author":"Makki","year":"2021","journal-title":"Talanta"},{"key":"10.1016\/j.jpba.2026.117705_bib18","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.ejps.2017.09.046","article-title":"Rapid discrimination and quantification analysis of five antineoplastic drugs in aqueous solutions using Raman spectroscopy","volume":"111","author":"L\u00ea","year":"2018","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.jpba.2026.117705_bib19","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.jpba.2016.12.020","article-title":"Quantitative determinations using portable Raman","volume":"136","author":"Navin","year":"2017","journal-title":"Spectrosc. J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jpba.2026.117705_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpba.2025.117031","article-title":"Handheld spatially offset Raman spectroscopy for rapid non-invasive detection of ethylene glycol and diethylene glycol in medicinal syrups","volume":"265","author":"Banerjee","year":"2025","journal-title":"J. Pharm. Biomed. Anal."}],"container-title":["Journal of Pharmaceutical and Biomedical Analysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0731708526003730?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0731708526003730?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T02:33:09Z","timestamp":1789785189000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0731708526003730"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2027,1]]},"references-count":20,"alternative-id":["S0731708526003730"],"URL":"https:\/\/doi.org\/10.1016\/j.jpba.2026.117705","relation":{},"ISSN":["0731-7085"],"issn-type":[{"value":"0731-7085","type":"print"}],"subject":[],"published":{"date-parts":[[2027,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Development and evaluation of a Raman detector for non-destructive identification and quantitation of cytostatic drugs in different primary packaging containers","name":"articletitle","label":"Article Title"},{"value":"Journal of Pharmaceutical and Biomedical Analysis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpba.2026.117705","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"117705"}}