{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T21:33:02Z","timestamp":1793309582502,"version":"4.5.0"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2024QH152"],"award-info":[{"award-number":["ZR2024QH152"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2025QC292"],"award-info":[{"award-number":["ZR2025QC292"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmaceutical and Biomedical Analysis"],"published-print":{"date-parts":[[2027,1]]},"DOI":"10.1016\/j.jpba.2026.117731","type":"journal-article","created":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T23:21:14Z","timestamp":1790205674000},"page":"117731","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["A dual-domain analytical strategy for holistic quality evaluation of Citrus aurantium L. flowers by maximum-absorbance HPLC-DAD fingerprinting, HS-GC-IMS, and binary evaluation"],"prefix":"10.1016","volume":"283","author":[{"given":"Lin","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiangshan","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengting","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuting","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruiqing","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6763-9077","authenticated-orcid":false,"given":"Dandan","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jpba.2026.117731_bib1","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1002\/ptr.7261","article-title":"Citrus flavonoids as potential therapeutic agents: a review","volume":"36","author":"Alam","year":"2022","journal-title":"Phytother. Res."},{"key":"10.1016\/j.jpba.2026.117731_bib2","doi-asserted-by":"crossref","first-page":"4019","DOI":"10.3390\/nu14194019","article-title":"The safety and efficacy of Citrus aurantium (Bitter Orange) extracts and p-synephrine: a systematic review and meta-analysis","volume":"14","author":"Koncz","year":"2022","journal-title":"Nutrients"},{"key":"10.1016\/j.jpba.2026.117731_bib3","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/s11325-024-03215-w","article-title":"The effectiveness of aromatic extract on insomnia: a meta-analysis","volume":"29","author":"Zhen","year":"2024","journal-title":"Sleep. Breath."},{"key":"10.1016\/j.jpba.2026.117731_bib4","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1024\/0300-9831\/a000710","article-title":"Citrus peel derived poly-methoxylated flavones (PMF), International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung","volume":"93","author":"Vajdi","year":"2023","journal-title":"Int. J. Vitam. Nutr. Res."},{"key":"10.1016\/j.jpba.2026.117731_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2024.118503","article-title":"Phytochemistry, pharmacological properties and pharmacokinetics of Citri Reticulatae Pericarpium: a systematic review","volume":"333","author":"Zhang","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jpba.2026.117731_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2026.121227","article-title":"Salvia plebeia R.Br.: a comprehensive review of its ethnopharmacology, phytochemistry, pharmacological activities, quality control, and current applications","volume":"361","author":"Wang","year":"2026","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jpba.2026.117731_bib7","doi-asserted-by":"crossref","first-page":"6463","DOI":"10.3390\/molecules27196463","article-title":"Application of HPLC fingerprint combined with chemical pattern recognition and multi-component determination in quality evaluation of Echinacea purpurea (L.) Moench","volume":"27","author":"Lv","year":"2022","journal-title":"Molecules"},{"key":"10.1016\/j.jpba.2026.117731_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.fochx.2023.100653","article-title":"Novel application of HS-GC-IMS for characteristic fingerprints and flavor compound variations in Citrus reticulatae pericarpium during storage with different Aspergillus niger fermentation","volume":"18","author":"Zhang","year":"2023","journal-title":"Food Chem. X"},{"key":"10.1016\/j.jpba.2026.117731_bib9","doi-asserted-by":"crossref","first-page":"7113","DOI":"10.3390\/molecules26237113","article-title":"Characteristic volatile fingerprints of four chrysanthemum teas determined by HS-GC-IMS","volume":"26","author":"Wang","year":"2021","journal-title":"Molecules"},{"key":"10.1016\/j.jpba.2026.117731_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.crfs.2024.100755","article-title":"Integrated HS-GC-IMS and UPLC-Q-Orbitrap HRMS-based metabolomics revealed the characteristics and differential volatile and nonvolatile metabolites of different citrus peels","volume":"8","author":"Wang","year":"2024","journal-title":"Curr. Res. Food Sci."},{"key":"10.1016\/j.jpba.2026.117731_bib11","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.jpba.2018.08.044","article-title":"13)C NMR-based metabolic fingerprinting of Citrus-type crude drugs","volume":"161","author":"Tsujimoto","year":"2018","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jpba.2026.117731_bib12","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1055\/a-1529-8339","article-title":"Quality control of herbal medicines: from traditional techniques to state-of-the-art approaches","volume":"87","author":"Klein-Junior","year":"2021","journal-title":"Planta Med."},{"key":"10.1016\/j.jpba.2026.117731_bib13","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1002\/pca.3089","article-title":"Breaking the challenge of polyherbal quality control using UV and HPLC fingerprints combined with multivariate analysis","volume":"33","author":"Roshan","year":"2022","journal-title":"Phytochem. Anal."},{"key":"10.1016\/j.jpba.2026.117731_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2022.135371","article-title":"A comprehensive quality control evaluation for standard decoction of Smilax glabra Roxb based on HPLC-MS-UV\/CAD methods combined with chemometrics analysis and network pharmacology","volume":"410","author":"Shi","year":"2023","journal-title":"Food Chem."},{"key":"10.1016\/j.jpba.2026.117731_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpba.2021.114574","article-title":"Holistic quality evaluation of commercial Agastache rugosa by multiple chromatographic and chemometric analysis","volume":"210","author":"Hou","year":"2022","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jpba.2026.117731_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.microc.2025.113211","article-title":"Spectral and chromatographic fingerprint-based qualitative and quantitative evaluation strategy combined with chemometrics for quality control of functional red yeast","volume":"212","author":"Yang","year":"2025","journal-title":"Microchem. J."},{"key":"10.1016\/j.jpba.2026.117731_bib17","article-title":"Integrative quantitative and qualitative analysis for the quality evaluation and monitoring of Danshen medicines from different sources using HPLC-DAD and NIR combined with chemometrics","volume":"13","author":"Li","year":"2022","journal-title":"Front. Plant. Sci."},{"key":"10.1016\/j.jpba.2026.117731_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpba.2020.113636","article-title":"Comprehensive evaluation of NAODESHENG by combining UPLC quantitative fingerprint and antioxidant activity","volume":"193","author":"Liao","year":"2021","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jpba.2026.117731_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpba.2020.113215","article-title":"Quality assessment of herbal medicines based on chemical fingerprints combined with chemometrics approach: a review","volume":"185","author":"Li","year":"2020","journal-title":"J. Pharma. Biomed. Anal."},{"key":"10.1016\/j.jpba.2026.117731_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpba.2025.117308","article-title":"Integrating multi-wavelength HPLC fingerprinting and electrochemical profiling with chemometrics for comprehensive quality assessment of Kangfuxin Liquid","volume":"270","author":"Li","year":"2026","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jpba.2026.117731_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpba.2023.115741","article-title":"Qualitative and quantitative evaluations of Chuanxiong dispensing granules by using chemical fingerprint in combination with chemometrics methods","volume":"236","author":"Huang","year":"2023","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jpba.2026.117731_bib22","article-title":"E-Nose and HS-SPME-GC-MS unveiling the scent signature of Ligusticum chuanxiong and its medicinal relatives","volume":"16","author":"Xu","year":"2025","journal-title":"Front. Plant. Sci."},{"key":"10.1016\/j.jpba.2026.117731_bib23","doi-asserted-by":"crossref","first-page":"313","DOI":"10.3390\/ph17030313","article-title":"HPLC fingerprint analysis of Cibotii rhizoma from different regions and identification of common peaks by LC-MS","volume":"17","author":"Guo","year":"2024","journal-title":"Pharmaceuticals"},{"key":"10.1016\/j.jpba.2026.117731_bib24","first-page":"317","article-title":"Difference analysis of different parts of chicory based on HPLC fingerprint and multi-component content determination","volume":"14","author":"Yan","year":"2022","journal-title":"Chin. Herb. Med."},{"key":"10.1016\/j.jpba.2026.117731_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpba.2022.115075","article-title":"Study on quality control of Zuojin pill by HPLC fingerprint with quantitative analysis of multi-components by single marker method and antioxidant activity analysis","volume":"225","author":"Wang","year":"2023","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jpba.2026.117731_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2026.149285","article-title":"Full-Spectrum HPLC-DAD digitization combines chemical and antioxidant fingerprints for quality control of big red robe tea","volume":"515","author":"Zhang","year":"2026","journal-title":"Food Chem."},{"key":"10.1016\/j.jpba.2026.117731_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.chroma.2025.466399","article-title":"Full-spectrum HPLC fingerprint with binary evaluation system and chemometrics for herbal medicine quality-efficacy control","volume":"1761","author":"Wu","year":"2025","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.jpba.2026.117731_bib28","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1039\/C9AN01643K","article-title":"Defining a standardized methodology for the determination of the antioxidant capacity: case study of Pistacia atlantica leaves","volume":"145","author":"Ben Ahmed","year":"2020","journal-title":"Analyst"},{"key":"10.1016\/j.jpba.2026.117731_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2022.134823","article-title":"Characterization of the aroma profiles of cold and hot break tomato pastes by GC-O-MS, GC \u00d7 GC-O-TOF-MS, and GC-IMS","volume":"405","author":"Li","year":"2023","journal-title":"Food Chem."},{"key":"10.1016\/j.jpba.2026.117731_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodres.2024.114964","article-title":"Combining with E-nose, GC-MS, GC-IMS and chemometrics to explore volatile characteristics during the different stages of Zanthoxylum bungeanum maxim fruits","volume":"195","author":"Feng","year":"2024","journal-title":"Food Res. Int."},{"key":"10.1016\/j.jpba.2026.117731_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.chroma.2025.465826","article-title":"An quality evaluation method based on three-dimensional integration and machine learning: advanced data processing","volume":"1747","author":"Zhang","year":"2025","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.jpba.2026.117731_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2023.137744","article-title":"Quality assessment of Red Yeast Rice by fingerprint and fingerprint-effect relationship combined with antioxidant activity","volume":"438","author":"Yang","year":"2024","journal-title":"Food Chem."},{"key":"10.1016\/j.jpba.2026.117731_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2022.132531","article-title":"Plant flavonoids: classification, distribution, biosynthesis, and antioxidant activity","volume":"383","author":"Shen","year":"2022","journal-title":"Food Chem."},{"key":"10.1016\/j.jpba.2026.117731_bib34","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1016\/j.neunet.2023.11.045","article-title":"Deep kernel principal component analysis for multi-level feature learning","volume":"170","author":"Tonin","year":"2024","journal-title":"Neural Netw."},{"key":"10.1016\/j.jpba.2026.117731_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2021.130055","article-title":"Characteristic fingerprints and volatile flavor compound variations in Liuyang Douchi during fermentation via HS-GC-IMS and HS-SPME-GC-MS","volume":"361","author":"Chen","year":"2021","journal-title":"Food Chem."},{"key":"10.1016\/j.jpba.2026.117731_bib36","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1177\/1747493018778713","article-title":"Multisociety consensus quality improvement revised consensus statement for endovascular therapy of acute ischemic stroke","volume":"13","author":"Sacks","year":"2018","journal-title":"Int. J. Stroke"},{"key":"10.1016\/j.jpba.2026.117731_bib37","volume":"262","author":"Ma","year":"2025","journal-title":"J. Pharm. Biomed. Anal."}],"container-title":["Journal of Pharmaceutical and Biomedical Analysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0731708526003997?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0731708526003997?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T21:25:36Z","timestamp":1793309136000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0731708526003997"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2027,1]]},"references-count":37,"alternative-id":["S0731708526003997"],"URL":"https:\/\/doi.org\/10.1016\/j.jpba.2026.117731","relation":{},"ISSN":["0731-7085"],"issn-type":[{"value":"0731-7085","type":"print"}],"subject":[],"published":{"date-parts":[[2027,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A dual-domain analytical strategy for holistic quality evaluation of Citrus aurantium L. flowers by maximum-absorbance HPLC-DAD fingerprinting, HS-GC-IMS, and binary evaluation","name":"articletitle","label":"Article Title"},{"value":"Journal of Pharmaceutical and Biomedical Analysis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpba.2026.117731","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"117731"}}