{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T21:32:56Z","timestamp":1793309576690,"version":"4.5.0"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T00:00:00Z","timestamp":1789948800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100031478","name":"NextGenerationEU","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100031478","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100024370","name":"Ministero dell'Istruzione dell'Universit\u00e0 e della Ricerca","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100024370","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmaceutical and Biomedical Analysis"],"published-print":{"date-parts":[[2027,1]]},"DOI":"10.1016\/j.jpba.2026.117744","type":"journal-article","created":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T15:22:53Z","timestamp":1790004173000},"page":"117744","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Metabolomic signatures associated with probiotic use in atopic dermatitis: An exploratory study"],"prefix":"10.1016","volume":"283","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8318-3065","authenticated-orcid":false,"given":"Maria Michela","family":"Salvatore","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Maione","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugenia Veronica","family":"Di Brizzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ludovica","family":"Fedi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabetta","family":"de Alteriis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8949-3654","authenticated-orcid":false,"given":"Anna","family":"Andolfi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Salvatore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1413-8214","authenticated-orcid":false,"given":"Giuseppe","family":"Argenziano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Guida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriella","family":"Brancaccio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilia","family":"Galdiero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jpba.2026.117744_bib1","doi-asserted-by":"crossref","first-page":"2653","DOI":"10.1007\/s13555-022-00819-6","article-title":"Burden of atopic dermatitis in adults and adolescents: a systematic literature review","volume":"12","author":"Fasseeh","year":"2022","journal-title":"Dermatol. Ther. (Heidelb. )."},{"key":"10.1016\/j.jpba.2026.117744_bib2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s13555-016-0170-1","article-title":"Systemic treatment of adult atopic dermatitis: A review","volume":"7","author":"Megna","year":"2017","journal-title":"Dermatol. Ther. (Heidelb. )."},{"key":"10.1016\/j.jpba.2026.117744_bib3","doi-asserted-by":"crossref","first-page":"3496","DOI":"10.1021\/acs.jproteome.4c00153","article-title":"Characterization of inflammatory mediators and metabolome in interstitial fluid collected with dermal open flow microperfusion before and at the end of Dupilumab treatment in atopic dermatitis","volume":"23","author":"Monedeiro","year":"2024","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.jpba.2026.117744_bib4","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1111\/jdv.15951","article-title":"The gut microbiome alterations in allergic and inflammatory skin diseases \u2013 an update","volume":"34","author":"Gerkowicz","year":"2020","journal-title":"J. Eur. Acad. Dermatol. & Venereol."},{"key":"10.1016\/j.jpba.2026.117744_bib5","series-title":"in: Probiotics, Prebiotics, Synbiotics, and Postbiotics: Human Microbiome and Human Health","first-page":"165","article-title":"Human microbiome and lifestyle disorders","author":"Gupta","year":"2023"},{"key":"10.1016\/j.jpba.2026.117744_bib6","doi-asserted-by":"crossref","DOI":"10.3389\/fnut.2021.634897","article-title":"Modulation of gut microbiota and immune system by probiotics, pre-biotics, and post-biotics","volume":"8","author":"Liu","year":"2022","journal-title":"Front. Nutr."},{"key":"10.1016\/j.jpba.2026.117744_bib7","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.2147\/JMDH.S501056","article-title":"Probiotics and synbiotics: Applications, benefits, and mechanisms for the improvement of human and ecological health","volume":"18","author":"Bhatia","year":"2025","journal-title":"J. Multidiscip. Healthc."},{"key":"10.1016\/j.jpba.2026.117744_bib8","doi-asserted-by":"crossref","first-page":"2455","DOI":"10.2147\/CCID.S388954","article-title":"The role of probiotics in skin photoaging and related mechanisms: A review","volume":"15","author":"Teng","year":"2022","journal-title":"Clin. Cosmet. Investig. Dermatol."},{"key":"10.1016\/j.jpba.2026.117744_bib9","doi-asserted-by":"crossref","first-page":"3123","DOI":"10.3390\/nu15143123","article-title":"The role of probiotics in skin health and related gut\u2013skin axis: A review","volume":"15","author":"Gao","year":"2023","journal-title":"Nutrients"},{"key":"10.1016\/j.jpba.2026.117744_bib10","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.3390\/nu13041169","article-title":"The effectiveness of probiotic Lactobacillus rhamnosus and Lactobacillus casei strains in children with atopic dermatitis and cow\u2019s milk protein allergy: A multicenter, randomized, double blind, placebo controlled study","volume":"13","author":"Cukrowska","year":"2021","journal-title":"Nutrients"},{"key":"10.1016\/j.jpba.2026.117744_bib11","doi-asserted-by":"crossref","first-page":"351","DOI":"10.2165\/11531420-000000000-00000","article-title":"Probiotic supplement reduces atopic dermatitis in preschool children: a randomized, double-blind, placebo-controlled, clinical trial","volume":"11","author":"Gerasimov","year":"2010","journal-title":"Am. J. Clin. Dermatol."},{"key":"10.1016\/j.jpba.2026.117744_bib12","doi-asserted-by":"crossref","first-page":"507","DOI":"10.3389\/fmicb.2016.00507","article-title":"Probiotics and atopic dermatitis: An overview","volume":"7","author":"Rather","year":"2016","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.jpba.2026.117744_bib13","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2023.1137275","article-title":"Lactobacillus for the treatment and prevention of atopic dermatitis: Clinical and experimental evidence","volume":"13","author":"Xie","year":"2023","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.jpba.2026.117744_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2024.142657","article-title":"Biological activities, biosynthetic capacity and metabolic interactions of lactic acid bacteria and yeast strains from traditional home-made kefir","volume":"470","author":"Salvatore","year":"2025","journal-title":"Food Chem."},{"key":"10.1016\/j.jpba.2026.117744_bib15","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.3390\/foods13071013","article-title":"Evaluation of potential probiotic properties in vitro and in vivo safety of lactic acid bacteria and yeast strains isolated from traditional home-made kefir","volume":"13","author":"Maione","year":"2024","journal-title":"Foods"},{"key":"10.1016\/j.jpba.2026.117744_bib16","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1007\/s00216-012-6117-1","article-title":"Serum metabolomics as a novel diagnostic approach for disease: a systematic review","volume":"404","author":"Zhang","year":"2012","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.jpba.2026.117744_bib17","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1080\/14737159.2019.1656530","article-title":"The applications of metabolomics in the molecular diagnostics of cancer","volume":"19","author":"Cheung","year":"2019","journal-title":"Expert. Rev. Mol. Diagn."},{"key":"10.1016\/j.jpba.2026.117744_bib18","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1373\/clinchem.2017.272344","article-title":"Use of metabolomics in improving assessment of dietary intake","volume":"64","author":"Guasch-Ferre","year":"2018","journal-title":"Clin. Chem."},{"key":"10.1016\/j.jpba.2026.117744_bib19","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1111\/jocd.14100","article-title":"Application of omics technologies in dermatological research and skin management","volume":"21","author":"Bs","year":"2022","journal-title":"J. Cosmet. Dermatol."},{"key":"10.1016\/j.jpba.2026.117744_bib20","doi-asserted-by":"crossref","first-page":"8776","DOI":"10.3390\/ijms23158776","article-title":"Current knowledge in skin metabolomics: Updates from literature review","volume":"23","author":"Paganelli","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jpba.2026.117744_bib21","first-page":"229","article-title":"Progress of metabolomics in atopic dermatitis: a systematic review, JDDG","author":"Zhang","year":"2023","journal-title":"J. Dtsch. Dermatol. Ges."},{"key":"10.1016\/j.jpba.2026.117744_bib22","doi-asserted-by":"crossref","first-page":"511","DOI":"10.3390\/metabo10120511","article-title":"The metabolomics of childhood atopic diseases: A comprehensive pathway-specific review","volume":"10","author":"Schj\u00f8dt","year":"2020","journal-title":"Metabolites"},{"key":"10.1016\/j.jpba.2026.117744_bib23","doi-asserted-by":"crossref","first-page":"3209","DOI":"10.3390\/nu12103209","article-title":"The health benefits of dietary fibre","volume":"12","author":"Barber","year":"2020","journal-title":"Nutrients"},{"key":"10.1016\/j.jpba.2026.117744_bib24","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1016\/j.cbpa.2013.06.015","article-title":"Human metabolomics: strategies to understand biology","volume":"17","author":"Ramautar","year":"2013","journal-title":"Curr. Opin. Chem. Biol."},{"key":"10.1016\/j.jpba.2026.117744_bib25","doi-asserted-by":"crossref","first-page":"1819","DOI":"10.1152\/physrev.00035.2018","article-title":"Metabolomics for investigating physiological and pathophysiological processes","author":"Wishart","year":"2019","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.jpba.2026.117744_bib26","doi-asserted-by":"crossref","first-page":"15","DOI":"10.3390\/metabo12010015","article-title":"Defining blood plasma and serum metabolome by gc-ms","volume":"12","author":"Kiseleva","year":"2022","journal-title":"Metabolites"},{"key":"10.1016\/j.jpba.2026.117744_bib27","doi-asserted-by":"crossref","first-page":"44","DOI":"10.2340\/00015555924447","article-title":"Diagnostic Features of Atopic Dermatitis","volume":"60","author":"Hanifin","year":"1980","journal-title":"Acta Derm.-Venereol."},{"key":"10.1016\/j.jpba.2026.117744_bib28","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1034\/j.1600-0625.2001.100102.x","article-title":"The eczema area and severity index (EASI): Assessment of reliability in atopic dermatitis","volume":"10","author":"Hanifin","year":"2001","journal-title":"Exp. Dermatol."},{"key":"10.1016\/j.jpba.2026.117744_bib29","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0279069","article-title":"A model for microbial interactions and metabolomic alterations in Candida glabrata-Staphylococcus epidermidis dual-species biofilms","volume":"17","author":"Salvatore","year":"2022","journal-title":"PLoS. One"},{"key":"10.1016\/j.jpba.2026.117744_bib30","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1016\/j.micinf.2007.07.004","article-title":"The bacterial metabolite 2,3-butanediol ameliorates endotoxin-induced acute lung injury in rats","volume":"9","author":"Hsieh","year":"2007","journal-title":"Microbes Infect."},{"key":"10.1016\/j.jpba.2026.117744_bib31","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1038\/s41575-025-01092-6","article-title":"Intestinal pH: a major driver of human gut microbiota composition and metabolism","volume":"22","author":"Brinck","year":"2025","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.jpba.2026.117744_bib32","first-page":"1","article-title":"Advances in lactic acid bacteria and their metabolites in fermented foods: Mechanisms of food quality enhancement, gut microbiota modulation, and future prospects","author":"Zang","year":"2025","journal-title":"Food Rev. Int."},{"key":"10.1016\/j.jpba.2026.117744_bib33","doi-asserted-by":"crossref","first-page":"196","DOI":"10.3390\/antiox9030196","article-title":"Oxidative stress and atopic dermatitis","volume":"9","author":"Bertino","year":"2020","journal-title":"Antioxidants"},{"key":"10.1016\/j.jpba.2026.117744_bib34","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/S0024-3205(01)01124-9","article-title":"Increased oxidative stress in childhood atopic dermatitis","volume":"69","author":"Omata","year":"2001","journal-title":"Life Sci."},{"key":"10.1016\/j.jpba.2026.117744_bib35","series-title":"in: Dietary Sugar, Salt and Fat in Human Health","first-page":"305","article-title":"Associations of high blood sugar with oxidative stress and inflammation in patients with type 2 diabetes","author":"Perkebunan","year":"2020"},{"key":"10.1016\/j.jpba.2026.117744_bib36","doi-asserted-by":"crossref","first-page":"2710","DOI":"10.3390\/nu15122710","article-title":"Beneficial effects of indigenous probiotics in high-cholesterol diet-induced hypercholesterolemic rats","volume":"15","author":"Puttarat","year":"2023","journal-title":"Nutrients"},{"key":"10.1016\/j.jpba.2026.117744_bib37","article-title":"The effects of probiotics on cholesterol levels in patients with metabolic syndrome: A systematic review","volume":"15","author":"Momin","year":"2023","journal-title":"Cureus"},{"issue":"e9679","key":"10.1016\/j.jpba.2026.117744_bib38","first-page":"5","article-title":"The effects of probiotics on total cholesterol: A meta-analysis of randomized controlled trials","volume":"97","author":"Wang","year":"2018","journal-title":"Med. (U. S. )"},{"key":"10.1016\/j.jpba.2026.117744_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpba.2025.117302","article-title":"Lipidome changes indicate oxidative stress, inflammation, and specific loss of glycerophosphoserine inflammatory protection in patients with lupus","volume":"270","author":"Koelmel","year":"2026","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jpba.2026.117744_bib40","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1007\/s00403-025-04385-7","article-title":"Microbiota, mind, and skin: bridging the Gut-Brain-Skin axis in psychodermatology","volume":"317","author":"Ali","year":"2025","journal-title":"Arch. Dermatol. Res."},{"key":"10.1016\/j.jpba.2026.117744_bib41","doi-asserted-by":"crossref","DOI":"10.1080\/19490976.2025.2473524","article-title":"The gut-skin axis: a bi-directional, microbiota-driven relationship with therapeutic potential","volume":"17","author":"Jimenez-Sanchez","year":"2025","journal-title":"Gut Microbes"},{"key":"10.1016\/j.jpba.2026.117744_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/j.jdsct.2026.100147","article-title":"Exploring the bidirectional skin-brain axis: Mental health, dermatology-related quality of life, and the role of probiotics","author":"de Mello","year":"2026","journal-title":"J. Dermatol. Sci. Cosmet. Technol."}],"container-title":["Journal of Pharmaceutical and Biomedical Analysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0731708526004127?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0731708526004127?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T21:25:46Z","timestamp":1793309146000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0731708526004127"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2027,1]]},"references-count":42,"alternative-id":["S0731708526004127"],"URL":"https:\/\/doi.org\/10.1016\/j.jpba.2026.117744","relation":{},"ISSN":["0731-7085"],"issn-type":[{"value":"0731-7085","type":"print"}],"subject":[],"published":{"date-parts":[[2027,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Metabolomic signatures associated with probiotic use in atopic dermatitis: An exploratory study","name":"articletitle","label":"Article Title"},{"value":"Journal of Pharmaceutical and Biomedical Analysis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jpba.2026.117744","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"117744"}}