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Lett."},{"key":"10.1016\/j.jpba.2026.117758_bib75","doi-asserted-by":"crossref","first-page":"3593","DOI":"10.1021\/acsnano.0c10035","article-title":"Ultrasensitive and highly specific lateral flow assays for point-of-care diagnosis","volume":"15","author":"Liu","year":"2021","journal-title":"ACS Nano"},{"key":"10.1016\/j.jpba.2026.117758_bib76","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.phytochem.2003.10.022","article-title":"Horseradish peroxidase: a modern view of a classic enzyme","volume":"65","author":"Veitch","year":"2004","journal-title":"Phytochemistry"},{"key":"10.1016\/j.jpba.2026.117758_bib77","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.jim.2017.11.005","article-title":"Endogenous peroxidases in sputum interfere with horse-radish peroxidase-based ELISAs","volume":"454","author":"Kim","year":"2018","journal-title":"J. Immunol. 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Soc."},{"key":"10.1016\/j.jpba.2026.117758_bib110","doi-asserted-by":"crossref","first-page":"5788","DOI":"10.3390\/molecules26195788","article-title":"Understanding the Adsorption of Peptides and Proteins onto PEGylated Gold Nanoparticles","volume":"26","author":"Perera","year":"2021","journal-title":"Molecules"},{"key":"10.1016\/j.jpba.2026.117758_bib111","doi-asserted-by":"crossref","DOI":"10.1016\/j.bios.2020.112537","article-title":"Conjugation of antibodies and aptamers on nanozymes for developing biosensors","volume":"168","author":"Tao","year":"2020","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.jpba.2026.117758_bib112","doi-asserted-by":"crossref","DOI":"10.1016\/j.bios.2020.112537","article-title":"Conjugation of antibodies and aptamers on nanozymes for developing biosensors","volume":"168","author":"Tao","year":"2020","journal-title":"Biosens. 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