{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T22:34:07Z","timestamp":1790030047851,"version":"4.0.1"},"reference-count":30,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2015,5,26]],"date-time":"2015-05-26T00:00:00Z","timestamp":1432598400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004916","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado do Amazonas","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004916","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Jornal de Pediatria"],"published-print":{"date-parts":[[2015,9]]},"DOI":"10.1016\/j.jped.2014.12.001","type":"journal-article","created":{"date-parts":[[2015,6,6]],"date-time":"2015-06-06T06:01:15Z","timestamp":1433570475000},"page":"485-492","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"title":["Diagnostic implications of associated defects in patients with typical orofacial clefts"],"prefix":"10.1016","volume":"91","author":[{"given":"Isabella L.","family":"Monlle\u00f3","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda G.R.","family":"de Barros","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marshall I.B.","family":"Fontes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana K.M.","family":"de Andrade","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gisele","family":"de M. Brito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diogo L.L.","family":"do Nascimento","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vera L.","family":"Gil-da-Silva-Lopes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jped.2014.12.001_bib0155","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1146\/annurev-genom-090711-163729","article-title":"The evolution of human genetic studies of cleft lip and cleft palate","volume":"13","author":"Marazita","year":"2012","journal-title":"Annu Rev Genomics Hum Genet"},{"key":"10.1016\/j.jped.2014.12.001_bib0160","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1002\/ajmg.c.31381","article-title":"Genetics of cleft lip and cleft palate","volume":"163","author":"Leslie","year":"2013","journal-title":"Am J Med Genet C Semin Med Genet"},{"key":"10.1016\/j.jped.2014.12.001_bib0165","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1038\/nrg2933","article-title":"Cleft lip and palate: understanding genetic and environmental influences","volume":"12","author":"Dixon","year":"2011","journal-title":"Nat Rev Genet"},{"key":"10.1016\/j.jped.2014.12.001_bib0170","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1177\/0022034511402083","article-title":"Global oral health inequalities: challenges in the prevention and management of orofacial clefts and potential solutions","volume":"23","author":"Mossey","year":"2011","journal-title":"Adv Dent Res"},{"key":"10.1016\/j.jped.2014.12.001_bib0175","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.ejmg.2014.04.003","article-title":"Genetics of cleft lip and\/or cleft palate: association with other common anomalies","volume":"57","author":"Set\u00f3-Salvia","year":"2014","journal-title":"Eur J Med Genet"},{"key":"10.1016\/j.jped.2014.12.001_bib0180","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.jped.2013.03.013","article-title":"Avan\u00e7ando e priorizando a pesquisa sobre fissuras orais no Brasil","volume":"89","author":"Wehby","year":"2013","journal-title":"J Pediatr (Rio J)"},{"key":"10.1016\/j.jped.2014.12.001_bib0185","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1597\/04-085r2.1","article-title":"Oral clefts with associated anomalies: methodological issues","volume":"43","author":"Wyszynski","year":"2006","journal-title":"Cleft Palate Craniofac J"},{"key":"10.1016\/j.jped.2014.12.001_bib0190","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1597\/09-217","article-title":"Prevalence at birth of cleft lip with or without cleft palate. Data from the International Perinatal Database of Typical Oral Clefts (IPDTOC)","volume":"48","author":"IPDTOC Working Group","year":"2011","journal-title":"Cleft Palate Craniofac J"},{"key":"10.1016\/j.jped.2014.12.001_bib0195","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/641570","article-title":"Implementing the Brazilian database on orofacial clefts","author":"Monlle\u00f3","year":"2013","journal-title":"Plast Surg Int"},{"key":"10.1016\/j.jped.2014.12.001_bib0200","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/S0022-3476(87)80543-7","article-title":"Predictive value of minor anomalies. I. Association with major malformations","volume":"110","author":"Leppig","year":"1987","journal-title":"J Pediatr"},{"key":"10.1016\/j.jped.2014.12.001_bib0205","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1002\/ajmg.a.20249","article-title":"Phenotypic abnormalities: terminology and classification","volume":"123A","author":"Merks","year":"2003","journal-title":"Am J Med Genet A"},{"key":"10.1016\/j.jped.2014.12.001_bib0210","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1111\/j.1741-4520.2010.00310.x","article-title":"Value of the small cohort study including a physical examination for minor structural defects in identifying new human teratogens","volume":"51","author":"Chambers","year":"2011","journal-title":"Congenit Anom (Kyoto)"},{"key":"10.1016\/j.jped.2014.12.001_bib0215","first-page":"S44","article-title":"Paper 5: surveillance of multiple congenital anomalies: implementation of a computer algorithm in European registers for classification of cases","volume":"91","author":"Garne","year":"2001","journal-title":"Birth Defects Res Part A"},{"key":"10.1016\/j.jped.2014.12.001_bib0220","series-title":"Addressing the global challenges of craniofacial anomalies","author":"World Health Organization (WHO)","year":"2006"},{"key":"10.1016\/j.jped.2014.12.001_bib0225","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1590\/S0102-311X2006000500004","article-title":"Anomalias craniofaciais: descri\u00e7\u00e3o e avalia\u00e7\u00e3o das caracter\u00edsticas gerais da aten\u00e7\u00e3o no Sistema \u00danico de Sa\u00fade","volume":"22","author":"Monlleo","year":"2006","journal-title":"Cad Saude Publica"},{"key":"10.1016\/j.jped.2014.12.001_bib0230","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1597\/11-069","article-title":"Local strategies to address health needs of individuals with orofacial clefts in Alagoas, Brazil","volume":"50","author":"Fontes","year":"2013","journal-title":"Cleft Palate Craniofac J"},{"key":"10.1016\/j.jped.2014.12.001_bib0235","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1007\/s12687-012-0096-y","article-title":"Genetic services and testing in Brazil","volume":"4","author":"Horovitz","year":"2013","journal-title":"J Community Genet"},{"key":"10.1016\/j.jped.2014.12.001_bib0240","first-page":"224","article-title":"Gravidez na adolesc\u00eancia e fatores associados com baixo peso ao nascer","volume":"30","author":"dos Santos","year":"2008","journal-title":"Rev Bras Ginecol Obstet"},{"key":"10.1016\/j.jped.2014.12.001_bib0245","doi-asserted-by":"crossref","first-page":"168","DOI":"10.4067\/S0034-98872014000200004","article-title":"La edad de la mujer como factor de riesgo de mortalidad materna, fetal, neonatal e infantil","volume":"142","author":"Donoso","year":"2014","journal-title":"Rer Med Chile"},{"key":"10.1016\/j.jped.2014.12.001_bib0250","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1111\/1471-0528.12659","article-title":"Advanced maternal age and pregnancy outcomes: a multicountry assessment","volume":"21","author":"Laopaiboon","year":"2014","journal-title":"BJOG"},{"key":"10.1016\/j.jped.2014.12.001_bib0255","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1597\/09-264","article-title":"Congenital anomalies associated with cleft lip and palate \u2013 an analysis of 1623 consecutive patients","volume":"48","author":"Sekhon","year":"2011","journal-title":"Cleft Palate Craniofac J"},{"key":"10.1016\/j.jped.2014.12.001_bib0260","first-page":"61","article-title":"Heterogeneity of oral clefts in relation to associated congenital anomalies","volume":"49","author":"Matulevi\u010dien\u0117","year":"2013","journal-title":"Medicina (Kaunas)"},{"key":"10.1016\/j.jped.2014.12.001_bib0265","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/j.bjoms.2011.08.001","article-title":"The incidence of congenital anomalies associated with cleft palate\/cleft lip and palate in neonates in the Konya region, Turkey","volume":"50","author":"Altunhan","year":"2012","journal-title":"Br J Oral Maxillofac Surg"},{"key":"10.1016\/j.jped.2014.12.001_bib0270","first-page":"352","article-title":"Structural birth defects associated with oral clefts in Hawaii, 1986 to 2001","volume":"43","author":"Mathias","year":"2006","journal-title":"Cleft Palate Craniofac J"},{"key":"10.1016\/j.jped.2014.12.001_bib0275","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1002\/ajmg.a.32854","article-title":"Orofacial clefts in the National Birth Defects Prevention Study, 1997\u20132004","volume":"149A","author":"Genisca","year":"2009","journal-title":"Am J Med Genet Part A"},{"key":"10.1016\/j.jped.2014.12.001_bib0280","doi-asserted-by":"crossref","first-page":"1588","DOI":"10.1002\/ajmg.a.34046","article-title":"Associated anomalies among infants with oral clefts at birth and during a 1-year follow-up","volume":"155","author":"Rittler","year":"2011","journal-title":"Am J Med Genet Part A"},{"key":"10.1016\/j.jped.2014.12.001_bib0285","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/1472-6831-5-4","article-title":"Oral clefts with associated anomalies: findings in the Hungarian Congenital Abnormality Registry","volume":"5","author":"S\u00e1rk\u00f6zi","year":"2005","journal-title":"BMC Oral Health"},{"key":"10.1016\/j.jped.2014.12.001_bib0290","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1002\/ajmg.1320200404","article-title":"Anomalies associated with cleft lip, cleft palate, or both","volume":"20","author":"Shprintzen","year":"1985","journal-title":"Am J Med Genet"},{"key":"10.1016\/j.jped.2014.12.001_bib0295","first-page":"163","article-title":"Prevention of oro-facial clefts in developing world","volume":"2","author":"Oginni","year":"2012","journal-title":"Ann Max Surg"},{"key":"10.1016\/j.jped.2014.12.001_bib0300","doi-asserted-by":"crossref","DOI":"10.1590\/S1806-83242014.50000008","article-title":"Risk factors and the prevention of oral clefts","volume":"28","author":"Gil-da-Silva-Lopes","year":"2014","journal-title":"Braz Oral Res"}],"container-title":["Jornal de Pediatria"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021755715000650?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021755715000650?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T16:02:43Z","timestamp":1762185763000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021755715000650"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9]]},"references-count":30,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2015,9]]}},"alternative-id":["S0021755715000650"],"URL":"https:\/\/doi.org\/10.1016\/j.jped.2014.12.001","relation":{},"ISSN":["0021-7557"],"issn-type":[{"value":"0021-7557","type":"print"}],"subject":[],"published":{"date-parts":[[2015,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Diagnostic implications of associated defects in patients with typical orofacial clefts","name":"articletitle","label":"Article Title"},{"value":"Jornal de Pediatria","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jped.2014.12.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Sociedade Brasileira de Pediatria. Published by Elsevier Editora Ltda.","name":"copyright","label":"Copyright"}]}}