{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T15:47:42Z","timestamp":1790869662429,"version":"4.1.0"},"reference-count":30,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,3,20]],"date-time":"2020-03-20T00:00:00Z","timestamp":1584662400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Jornal de Pediatria"],"published-print":{"date-parts":[[2021,1]]},"DOI":"10.1016\/j.jped.2019.10.012","type":"journal-article","created":{"date-parts":[[2020,4,22]],"date-time":"2020-04-22T02:45:15Z","timestamp":1587523515000},"page":"22-29","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"title":["Effect of prednisolone on language function in children with autistic spectrum disorder: a randomized clinical trial"],"prefix":"10.1016","volume":"97","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7532-1093","authenticated-orcid":false,"given":"Adriana Rocha","family":"Brito","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7324-4781","authenticated-orcid":false,"given":"Giselle de Paula Teixeira","family":"Vairo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5394-226X","authenticated-orcid":false,"given":"Ana Paula Botelho Henriques","family":"Dias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0067-983X","authenticated-orcid":false,"given":"Beni","family":"Olej","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3516-485X","authenticated-orcid":false,"given":"Osvaldo Jos\u00e9 Moreira","family":"Nascimento","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4419-6992","authenticated-orcid":false,"given":"Marcio Moacyr","family":"Vasconcelos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jped.2019.10.012_bib0155","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1542\/pir.35.2.62","article-title":"The clinician's guide to autism","volume":"35","author":"Harrington","year":"2014","journal-title":"Pediatr Rev"},{"key":"10.1016\/j.jped.2019.10.012_bib0160","series-title":"Diagnostic and statistical manual of mental disorders \u2013 fifth edition","author":"American Psychiatric Association (APA)","year":"2013"},{"key":"10.1016\/j.jped.2019.10.012_bib0165","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1055\/s-0039-1692964","article-title":"A review of language, executive function, and intervention in autism spectrum disorder","volume":"40","author":"Friedman","year":"2019","journal-title":"Semin Speech Lang"},{"key":"10.1016\/j.jped.2019.10.012_bib0170","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.braindev.2012.03.015","article-title":"Pharmacotherapy of autism spectrum disorders","volume":"35","author":"Benvenuto","year":"2013","journal-title":"Brain Dev"},{"key":"10.1016\/j.jped.2019.10.012_bib0175","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.jaac.2013.10.013","article-title":"Practice parameter for the assessment and treatment of children and adolescents with autism spectrum disorder","volume":"53","author":"Volkmar","year":"2014","journal-title":"J Am Acad Child Adolesc Psychiatry"},{"key":"10.1016\/j.jped.2019.10.012_bib0180","doi-asserted-by":"crossref","first-page":"S124","DOI":"10.1542\/peds.2015-2851K","article-title":"Pharmacologic treatment of severe irritability and problem behaviors in autism: a systematic review and meta-analysis","volume":"137","author":"Fung","year":"2016","journal-title":"Pediatrics"},{"key":"10.1016\/j.jped.2019.10.012_bib0185","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1007\/s10803-013-1899-3","article-title":"Nasal oxytocin for social deficits in childhood autism: a randomized controlled trial","volume":"44","author":"Dadds","year":"2014","journal-title":"J Autism Dev Disord"},{"key":"10.1016\/j.jped.2019.10.012_bib0190","doi-asserted-by":"crossref","first-page":"e202","DOI":"10.1038\/tp.2012.124","article-title":"A randomised controlled trial of bumetanide in the treatment of autism in children","volume":"2","author":"Lemonnier","year":"2012","journal-title":"Transl Psychiatry"},{"key":"10.1016\/j.jped.2019.10.012_bib0195","doi-asserted-by":"crossref","first-page":"131","DOI":"10.4103\/abr.abr_100_18","article-title":"Efficacy of memantine as adjunct therapy for autism spectrum disorder in children aged <14 years","volume":"7","author":"Karahmadi","year":"2018","journal-title":"Adv Biomed Res"},{"key":"10.1016\/j.jped.2019.10.012_bib0200","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1016\/j.pnpbp.2010.07.005","article-title":"Double-blind, placebo-controlled trial of risperidone plus topiramate in children with autistic disorder","volume":"34","author":"Rezaei","year":"2010","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"10.1016\/j.jped.2019.10.012_bib0205","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1002\/sctm.16-0474","article-title":"Autologous cord blood infusions are safe and feasible in young children with autism spectrum disorder: results of a single-center phase I open-label trial","volume":"6","author":"Dawson","year":"2017","journal-title":"Stem Cells Transl Med"},{"key":"10.1016\/j.jped.2019.10.012_bib0210","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1097\/00004583-199508000-00022","article-title":"Case study: corticosteroid treatment of language regression in pervasive developmental disorder","volume":"34","author":"Stefanatos","year":"1995","journal-title":"J Am Acad Child Adolesc Psychiatry"},{"key":"10.1016\/j.jped.2019.10.012_bib0215","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1067\/mpd.2000.105355","article-title":"Response to steroid therapy in autism secondary to autoimmune lymphoproliferative syndrome","volume":"136","author":"Shenoy","year":"2000","journal-title":"J Pediatr"},{"key":"10.1016\/j.jped.2019.10.012_bib0220","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1186\/1471-2377-14-70","article-title":"Corticosteroid therapy in regressive autism: a retrospective study of effects on the frequency modulated auditory evoked response (FMAER), language and behavior","volume":"14","author":"Duffy","year":"2014","journal-title":"BMC Neurol"},{"key":"10.1016\/j.jped.2019.10.012_bib0225","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.nurt.2010.05.008","article-title":"Immune therapy in autism: historical experience and future directions with immunomodulatory therapy","volume":"7","author":"Chez","year":"2010","journal-title":"Neurotherapeutics"},{"key":"10.1016\/j.jped.2019.10.012_bib0230","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1159\/000492113","article-title":"Neuroimmune alterations in autism: a translational analysis focusing on the animal model of autism induced by prenatal exposure to valproic acid","volume":"25","author":"Deckmann","year":"2018","journal-title":"Neuroimmunomodulation"},{"key":"10.1016\/j.jped.2019.10.012_bib0235","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.bbi.2011.08.007","article-title":"The role of immune dysfunction in the pathophysiology of autism","volume":"26","author":"Onore","year":"2012","journal-title":"Brain Behav Immun"},{"key":"10.1016\/j.jped.2019.10.012_bib0240","doi-asserted-by":"crossref","first-page":"751","DOI":"10.3389\/fpsyt.2018.00751","article-title":"Characterizing the interplay between autism spectrum disorder and comorbid medical conditions: an integrative review","volume":"9","author":"Tye","year":"2019","journal-title":"Front Psychiatry"},{"key":"10.1016\/j.jped.2019.10.012_bib0245","first-page":"203","article-title":"Steroids: pharmacology, complications, and practice delivery issues","volume":"14","author":"Ericson-Neilsen","year":"2014","journal-title":"Ochsner J"},{"key":"10.1016\/j.jped.2019.10.012_bib0250","first-page":"9","article-title":"Speech-stimulating substances in autism spectrum disorders","author":"Castillo","year":"2019","journal-title":"Behav Sci (Basel)"},{"key":"10.1016\/j.jped.2019.10.012_bib0255","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.jcomdis.2008.01.002","article-title":"Further defining the language impairment of autism: is there a specific language impairment subtype?","volume":"41","author":"Whitehouse","year":"2008","journal-title":"J Commun Disord"},{"key":"10.1016\/j.jped.2019.10.012_bib0260","doi-asserted-by":"crossref","first-page":"S159","DOI":"10.1016\/j.ijporl.2003.08.016","article-title":"Language development in autism","volume":"67S1","author":"Boucher","year":"2003","journal-title":"Int J Pediatr Otorhinolaryngol"},{"key":"10.1016\/j.jped.2019.10.012_bib0265","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1590\/S0021-75572008000700004","article-title":"Childhood autism: translation and validation of the Childhood Autism Rating Scale for use in Brazil","volume":"84","author":"Pereira","year":"2008","journal-title":"J Pediatr (Rio J)"},{"key":"10.1016\/j.jped.2019.10.012_bib0270","first-page":"15","article-title":"Assessment of pragmatic language in verbal and nonverbal autistic children","volume":"36","author":"Dias","year":"2016","journal-title":"Rev Logop Fon Audiol"},{"key":"10.1016\/j.jped.2019.10.012_bib0275","doi-asserted-by":"crossref","DOI":"10.1590\/1982-021620149713","article-title":"Linguagem receptiva e expressiva de crian\u00e7as institucionalizadas","volume":"16","author":"Franco","year":"2014","journal-title":"Rev CEFAC"},{"key":"10.1016\/j.jped.2019.10.012_bib0280","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1590\/S0104-56872006000300003","article-title":"Analyses of the communicative functions expressed by language therapists and patients of the autistic spectrum","volume":"18","author":"Miilher","year":"2006","journal-title":"Pr\u00f3-Fono R Atual Cient"},{"key":"10.1016\/j.jped.2019.10.012_bib0285","doi-asserted-by":"crossref","DOI":"10.1590\/S1516-18462009000800008","article-title":"Autismo: um estudo de habilidades comunicativas em crian\u00e7as","volume":"11","author":"Campelo","year":"2009","journal-title":"Rev CEFAC"},{"key":"10.1016\/j.jped.2019.10.012_bib0290","first-page":"43","article-title":"Calculating and reporting effect sizes on scientific papers (3): guide to report regression models and ANOVA effect sizes","volume":"4","author":"Esp\u00edrito-Santo","year":"2018","journal-title":"Port J Behav Soc Res"},{"key":"10.1016\/j.jped.2019.10.012_bib0295","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1111\/j.1535-7511.2006.00113.x","article-title":"Autism and epilepsy: what has regression got to do with it?","volume":"6","author":"Tuchman","year":"2006","journal-title":"Epilepsy Curr"},{"key":"10.1016\/j.jped.2019.10.012_bib0300","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.neubiorev.2019.03.012","article-title":"Changing conceptualizations of regression: what prospective studies reveal about the onset of autism spectrum disorder","volume":"100","author":"Ozonoff","year":"2019","journal-title":"Neurosci Biobehav Rev"}],"container-title":["Jornal de Pediatria"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021755719304656?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021755719304656?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T23:21:11Z","timestamp":1758151271000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021755719304656"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":30,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,1]]}},"alternative-id":["S0021755719304656"],"URL":"https:\/\/doi.org\/10.1016\/j.jped.2019.10.012","relation":{},"ISSN":["0021-7557"],"issn-type":[{"value":"0021-7557","type":"print"}],"subject":[],"published":{"date-parts":[[2021,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effect of prednisolone on language function in children with autistic spectrum disorder: a randomized clinical trial","name":"articletitle","label":"Article Title"},{"value":"Jornal de Pediatria","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jped.2019.10.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Sociedade Brasileira de Pediatria. Published by Elsevier Editora Ltda.","name":"copyright","label":"Copyright"}]}}