{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T22:29:20Z","timestamp":1765232960761,"version":"3.44.0"},"reference-count":86,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,9,8]],"date-time":"2020-09-08T00:00:00Z","timestamp":1599523200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Jornal de Pediatria"],"published-print":{"date-parts":[[2021,3]]},"DOI":"10.1016\/j.jped.2020.08.004","type":"journal-article","created":{"date-parts":[[2020,9,11]],"date-time":"2020-09-11T16:33:12Z","timestamp":1599841992000},"page":"140-159","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":35,"title":["Multisystem inflammatory syndrome associated with COVID-19 from the pediatric emergency physician's point of view"],"prefix":"10.1016","volume":"97","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0674-3767","authenticated-orcid":false,"given":"Hany","family":"Simon Junior","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4803-5272","authenticated-orcid":false,"given":"Tania Miyuki Shimoda","family":"Sakano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6284-1054","authenticated-orcid":false,"given":"Regina Maria","family":"Rodrigues","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6831-8651","authenticated-orcid":false,"given":"Adriana Pasmanik","family":"Eisencraft","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7631-3714","authenticated-orcid":false,"given":"Vitor Emanoel Lemos de","family":"Carvalho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5695-9331","authenticated-orcid":false,"given":"Claudio","family":"Schvartsman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5898-4052","authenticated-orcid":false,"given":"Amelia Gorete Afonso da Costa","family":"Reis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jped.2020.08.004_bib0005","unstructured":"World Health Organization. Responding to community spread of COVID-19: interim guidance. Available from: https:\/\/www.who.int\/publications\/i\/item\/responding-to-community-spread-of-covid-19 [cited 7.3.20]."},{"key":"10.1016\/j.jped.2020.08.004_bib0010","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.3201\/eid2605.200146","article-title":"Risk for transportation of coronavirus disease from Wuhan to other cities in China","volume":"26","author":"Du","year":"2020","journal-title":"Emerg Infect Dis"},{"key":"10.1016\/j.jped.2020.08.004_bib0015","first-page":"157","article-title":"WHO declares COVID-19 a pandemic","volume":"91","author":"Cucinotta","year":"2020","journal-title":"Acta Biomed"},{"key":"10.1016\/j.jped.2020.08.004_bib0020","doi-asserted-by":"crossref","first-page":"1648","DOI":"10.1161\/CIRCULATIONAHA.120.046941","article-title":"COVID-19 and cardiovascular disease","volume":"2019","author":"Clerkin","year":"2020","journal-title":"Circulation"},{"key":"10.1016\/j.jped.2020.08.004_bib0025","article-title":"Angiotensin-converting enzyme 2 (ACE2) is a key modulator of the renin angiotensin system in health and disease","author":"Tikellis","year":"2012","journal-title":"Int J Pept. 2012"},{"key":"10.1016\/j.jped.2020.08.004_bib0030","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1007\/s00134-020-05985-9","article-title":"Angiotensin-converting enzyme 2 (ACE2) as a SARS-CoV-2 receptor: molecular mechanisms and potential therapeutic target","volume":"46","author":"Zhang","year":"2020","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.jped.2020.08.004_bib0035","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.jped.2020.04.001","article-title":"The intriguing features of COVID-19 in children and its impact on the pandemic","volume":"96","author":"Safadi","year":"2020","journal-title":"J Pediatr (Rio J)"},{"key":"10.1016\/j.jped.2020.08.004_bib0040","doi-asserted-by":"crossref","first-page":"100433","DOI":"10.1016\/j.eclinm.2020.100433","article-title":"COVID-19 in 7780 pediatric patients: a systematic review","volume":"24","author":"Hoang","year":"2020","journal-title":"Eclinical MEDICINE"},{"key":"10.1016\/j.jped.2020.08.004_bib0045","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1097\/INF.0000000000002660","article-title":"Coronavirus infections in children including COVID-19: an overview of the epidemiology, clinical features, diagnosis, treatment and prevention options in children","volume":"39","author":"Zimmermann","year":"2020","journal-title":"Pediatr Infect Dis J"},{"key":"10.1016\/j.jped.2020.08.004_bib0050","doi-asserted-by":"crossref","first-page":"e1947","DOI":"10.6061\/clinics\/2020\/e1947","article-title":"Why is SARS-CoV-2 infection milder among children?","volume":"75","author":"Palmeira","year":"2020","journal-title":"Clinics (Sao Paulo)"},{"key":"10.1016\/j.jped.2020.08.004_bib0055","unstructured":"New York State. Childhood inflammatory disease related to COVID-19. Available from: http:\/\/coronavirus.heath.ny.gov\/childhood-inflammatory-disease-related-covid-19."},{"key":"10.1016\/j.jped.2020.08.004_bib0060","unstructured":"Royal College of Paediatrics and Childrens Health. Guidance: Paediatric multisystem inflammatory syndrome temporally associated with COVID-19. Available from: https:\/\/www.rcpch.ac.uk\/sites\/default\/files\/2020-05\/COVID-19-Paediatric-multisystem-%20inflammatory%20syndrome-20200501.pdf [cited 21.7.20]."},{"key":"10.1016\/j.jped.2020.08.004_bib0065","doi-asserted-by":"crossref","first-page":"e2020192","DOI":"10.1590\/1984-0462\/2020\/38\/2020192","article-title":"The challenging and unpredictable spectrum of COVID-19 in children and adolescents","volume":"39","author":"Safadi","year":"2021","journal-title":"Rev Paul Pediatr"},{"key":"10.1016\/j.jped.2020.08.004_bib0070","doi-asserted-by":"crossref","first-page":"e001295","DOI":"10.1136\/rmdopen-2020-001295","article-title":"Storm, typhoon, cyclone or hurricane in patients with COVID-19? Beware of the same storm that has a different origin","volume":"6","author":"Alunno","year":"2020","journal-title":"RMD Open"},{"key":"10.1016\/j.jped.2020.08.004_bib0075","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1007\/s00281-017-0629-x","article-title":"Pathogenic human coronavirus infections: causes and consequences of cytokine storm and immunopathology","volume":"39","author":"Channappanavar","year":"2017","journal-title":"Semin Immunopathol"},{"key":"10.1016\/j.jped.2020.08.004_bib0080","doi-asserted-by":"crossref","first-page":"2366","DOI":"10.1182\/blood-2004-10-4166","article-title":"Chemokine up-regulation in SARS-coronavirus \u2013 infected, monocyte-derived human dendritic cells","volume":"106","author":"Law","year":"2005","journal-title":"Blood"},{"key":"10.1016\/j.jped.2020.08.004_bib0085","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1001\/jama.2020.10374","article-title":"Multisystem inflammatory syndrome related to COVID-19 in previously healthy children and adolescents in New York City","volume":"324","author":"Cheung","year":"2020","journal-title":"JAMA"},{"key":"10.1016\/j.jped.2020.08.004_bib0090","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1093\/cid\/ciaa248","article-title":"Dysregulation of immune response in patients with COVID-19 in Wuhan, China","volume":"71","author":"Qin","year":"2020","journal-title":"Clin Infect Dis. Clin Infect Dis"},{"key":"10.1016\/j.jped.2020.08.004_bib0095","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1186\/s12879-020-05681-5","article-title":"Correlation analysis between disease severity and inflammation-related parameters in patients with COVID-19 pneumonia","volume":"20","author":"Gong","year":"2020","journal-title":"BMC Infect Dis"},{"key":"10.1016\/j.jped.2020.08.004_bib0100","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1055\/s-2008-1066020","article-title":"Metabolic modulation of inflammation-induced activation of coagulation","volume":"34","author":"Levi","year":"2008","journal-title":"Semin Thromb Hemost"},{"key":"10.1016\/j.jped.2020.08.004_bib0105","series-title":"Acute and chronic inflammation","article-title":"Robbins and Cotran pathologic basis of disease","author":"Kumar","year":"2005"},{"key":"10.1016\/j.jped.2020.08.004_bib0110","doi-asserted-by":"crossref","first-page":"827","DOI":"10.3389\/fimmu.2020.00827","article-title":"Reduction and functional exhaustion of t cells in patients with coronavirus disease 2019 (COVID-19)","volume":"11","author":"Diao","year":"2020","journal-title":"Front Immunol"},{"key":"10.1016\/j.jped.2020.08.004_bib0115","doi-asserted-by":"crossref","first-page":"2620","DOI":"10.1172\/JCI137244","article-title":"Clinical and immunological features of severe and moderate coronavirus disease 2019","volume":"130","author":"Chen","year":"2020","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jped.2020.08.004_bib0120","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.jaut.2007.11.003","article-title":"New functions for an iron storage protein: the role of ferritin in immunity and autoimmunity","volume":"30","author":"Recalcati","year":"2008","journal-title":"J Autoimmun"},{"key":"10.1016\/j.jped.2020.08.004_bib0125","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1097\/PCC.0b013e3181a1ae08","article-title":"Secondary hemophagocytic lymphohistiocytosis and severe sepsis\/systemic inflammatory response syndrome\/multiorgan dysfunction syndrome\/macrophage activation syndrome share common intermediate phenotypes on a spectrum of inflammation","volume":"10","author":"Castillo","year":"2009","journal-title":"Pediatr Crit Care Med"},{"key":"10.1016\/j.jped.2020.08.004_bib0130","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1016\/S0140-6736(20)30628-0","article-title":"COVID-19: consider cytokine storm syndromes and immunosuppression","volume":"395","author":"Mehta","year":"2020","journal-title":"Lancet"},{"key":"10.1016\/j.jped.2020.08.004_bib0135","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1186\/1741-7015-11-185","article-title":"The hyperferritinemic syndrome: macrophage activation syndrome, Still's disease, septic shock and catastrophic antiphospholipid syndrome","volume":"11","author":"Ros\u00e1rio","year":"2013","journal-title":"BMC Med"},{"key":"10.1016\/j.jped.2020.08.004_bib0140","doi-asserted-by":"crossref","first-page":"m1710","DOI":"10.1136\/bmj.m1710","article-title":"Covid-19: concerns grow over inflammatory syndrome emerging in children","volume":"369","author":"Mahase","year":"2020","journal-title":"BMJ"},{"key":"10.1016\/j.jped.2020.08.004_bib0145","series-title":"Multisystem inflammatory syndrome in children and adolescents with COVID-19","first-page":"1","author":"World Health Organization","year":"2020"},{"key":"10.1016\/j.jped.2020.08.004_bib0150","doi-asserted-by":"crossref","first-page":"e927","DOI":"10.1161\/CIR.0000000000000484","article-title":"Diagnosis, treatment, and long-term management of Kawasaki disease: a scientific statement for health professionals from the American Heart Association","volume":"135","author":"McCrindle","year":"2017","journal-title":"Circulation"},{"key":"10.1016\/j.jped.2020.08.004_bib0155","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1056\/NEJMe2023158","article-title":"Childhood multisystem inflammatory syndrome \u2013 a new challenge in the pandemic","volume":"383","author":"Levin","year":"2020","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jped.2020.08.004_bib0160","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1056\/NEJMc2003717","article-title":"Detection of COVID-19 in children in early January 2020 in Wuhan, China","volume":"382","author":"Liu","year":"2020","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jped.2020.08.004_bib0165","first-page":"125","article-title":"Epidemiology and clinical features of coronavirus disease 2019 in children","volume":"63","author":"Choi","year":"2020","journal-title":"Korean J Pediatr"},{"key":"10.1016\/j.jped.2020.08.004_bib0170","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1001\/jamapediatrics.2020.1467","article-title":"Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in children and adolescents: a systematic review","volume":"174","author":"Castagnoli","year":"2020","journal-title":"JAMA Pediatr"},{"key":"10.1016\/j.jped.2020.08.004_bib0175","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1016\/S0140-6736(20)31094-1","article-title":"Hyperinflammatory shock in children during COVID-19 pandemic","volume":"395","author":"Riphagen","year":"2020","journal-title":"Lancet"},{"key":"10.1016\/j.jped.2020.08.004_bib0180","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1161\/CIRCULATIONAHA.120.048360","article-title":"Acute heart failure in multisystem inflammatory syndrome in children (MIS-C) in the context of global SARS-CoV-2 pandemic Running","volume":"142","author":"Belhadjer","year":"2020","journal-title":"Circulation"},{"key":"10.1016\/j.jped.2020.08.004_bib0185","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1056\/NEJMoa2021680","article-title":"Multisystem inflammatory syndrome in U.S. children and adolescents","volume":"383","author":"Feldstein","year":"2020","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jped.2020.08.004_bib0190","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1056\/NEJMoa2021756","article-title":"Multisystem inflammatory syndrome in children in New York State","volume":"383","author":"Dufort","year":"2020","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jped.2020.08.004_bib0195","first-page":"e202687","article-title":"Neurologic and radiographic findings associated with COVID-19 infection in children","author":"Abdel-Mannan","year":"2020","journal-title":"JAMA Neurol"},{"key":"10.1016\/j.jped.2020.08.004_bib0200","doi-asserted-by":"crossref","first-page":"1771","DOI":"10.1016\/S0140-6736(20)31103-X","article-title":"An outbreak of severe Kawasaki-like disease at the Italian epicentre of the SARS-CoV-2 epidemic: an observational cohort study","volume":"395","author":"Verdoni","year":"2020","journal-title":"Lancet"},{"key":"10.1016\/j.jped.2020.08.004_bib0205","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1001\/jama.2020.10369","article-title":"Clinical characteristics of 58 children with a pediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2","volume":"324","author":"Whittaker","year":"2020","journal-title":"JAMA"},{"year":"2020","series-title":"Paediatric inflammatory multisystem syndrome and SARS-CoV-2 infection in children","author":"European Centre for Disease Prevention and Control","key":"10.1016\/j.jped.2020.08.004_bib0210"},{"key":"10.1016\/j.jped.2020.08.004_bib0215","doi-asserted-by":"crossref","first-page":"e00512","DOI":"10.1128\/JCM.00512-20","article-title":"Laboratory diagnosis of COVID-19: current issues and challenges","volume":"58","author":"Tang","year":"2020","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.jped.2020.08.004_bib0220","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1007\/s12098-020-03292-1","article-title":"COVID-19 in children: clinical approach and management","volume":"87","author":"Sankar","year":"2020","journal-title":"Indian J Pediatr"},{"year":"2020","series-title":"EXTRA! COVID-19: the impact on pediatric","author":"Walker","key":"10.1016\/j.jped.2020.08.004_bib0225"},{"key":"10.1016\/j.jped.2020.08.004_bib0230","doi-asserted-by":"crossref","first-page":"2033","DOI":"10.1086\/430355","article-title":"Antigenic Cross-reactivity between severe acute respiratory syndrome-associated coronavirus and human coronaviruses 229E and OC43","volume":"191","author":"Che","year":"2005","journal-title":"J Infect Dis"},{"key":"10.1016\/j.jped.2020.08.004_bib0235","doi-asserted-by":"crossref","first-page":"m2094","DOI":"10.1136\/bmj.m2094","article-title":"Kawasaki-like multisystem inflammatory syndrome in children during the covid-19 pandemic in Paris, France: prospective observational study","volume":"369","author":"Toubiana","year":"2020","journal-title":"BMJ"},{"key":"10.1016\/j.jped.2020.08.004_bib0240","doi-asserted-by":"crossref","first-page":"e2010895","DOI":"10.1001\/jamanetworkopen.2020.10895","article-title":"Clinical and immune features of hospitalized pediatric patients with coronavirus disease 2019 (COVID-19) in Wuhan, China","volume":"3","author":"Wu","year":"2020","journal-title":"JAMA Netw Open"},{"key":"10.1016\/j.jped.2020.08.004_bib0245","unstructured":"Rodrigues C, Carvalho AP De, Berezin EN, Coser E, Marques SR, Fonseca AR, et al. Nota de alerta: s\u00edndrome inflamat\u00f3ria multissist\u00eamica em crian\u00e7as e adolescentes provavelmente associada \u00e0 COVID-19: uma apresenta\u00e7\u00e3o aguda, grave e potencialmente fatal. Available from: https:\/\/www.sbp.com.br\/imprensa\/detalhe\/nid\/sindrome-inflamatoria-multissistemica-em-criancas-e-adolescentes-provavelmente-associada-a-covid-19-uma-apresentacao-aguda-grave-e-potencialmente-fatal\/."},{"year":"2020","series-title":"Emergency preparedness and response multisystem inflammatory syndrome in children (MIS-C) associated with coronavirus disease 2019","author":"Centers for Disease Control and Prevention","key":"10.1016\/j.jped.2020.08.004_bib0250"},{"key":"10.1016\/j.jped.2020.08.004_bib0255","first-page":"2019","article-title":"Correspondence hyperinflammatory","volume":"6736","author":"Riphagen","year":"2020","journal-title":"Lancet"},{"key":"10.1016\/j.jped.2020.08.004_bib0260","doi-asserted-by":"crossref","first-page":"e27","DOI":"10.1016\/S2213-2600(20)30120-X","article-title":"COVID-19 outbreak: less stethoscope, more ultrasound","volume":"8","author":"Buonsenso","year":"2020","journal-title":"Lancet Respir Med"},{"key":"10.1016\/j.jped.2020.08.004_bib0265","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1111\/anae.15082","article-title":"Point-of-care lung ultrasound in patients with COVID-19 \u2013 a narrative review","volume":"75","author":"Smith","year":"2020","journal-title":"Anaesthesia"},{"key":"10.1016\/j.jped.2020.08.004_bib0270","doi-asserted-by":"crossref","first-page":"1504","DOI":"10.1016\/j.ajem.2020.04.048","article-title":"Cardiovascular complications in COVID-19","volume":"38","author":"Long","year":"2020","journal-title":"Am J Emerg Med"},{"key":"10.1016\/j.jped.2020.08.004_bib0275","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/j.jcyt.2020.04.100","article-title":"Emerging trends in COVID-19 treatment: learning from inflammatory conditions associated with cellular therapies","volume":"22","author":"Cancio","year":"2020","journal-title":"Cytotherapy"},{"key":"10.1016\/j.jped.2020.08.004_bib0280","doi-asserted-by":"crossref","first-page":"102537","DOI":"10.1016\/j.autrev.2020.102537","article-title":"The role of cytokines including interleukin-6 in COVID-19 induced pneumonia and macrophage activation syndrome-like disease","volume":"19","author":"Mcgonagle","year":"2020","journal-title":"Autoimmun Rev"},{"year":"2020","series-title":"The national institutes of health COVID-19 treatment guidelines panel provides recommendations for dexamethasone in patients with COVID-19","author":"Health","key":"10.1016\/j.jped.2020.08.004_bib0285"},{"key":"10.1016\/j.jped.2020.08.004_bib0290","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1186\/s13613-020-00690-8","article-title":"Acute myocarditis and multisystem inflammatory emerging disease following SARS-CoV-2 infection in critically ill children","volume":"10","author":"Grimaud","year":"2020","journal-title":"Ann Intensive Care"},{"key":"10.1016\/j.jped.2020.08.004_bib0295","doi-asserted-by":"crossref","first-page":"e20201711","DOI":"10.1542\/peds.2020-1711","article-title":"SARS-CoV-2-induced Kawasaki-like hyperinflammatory syndrome: a novel COVID phenotype in children","author":"Licciardi","year":"2020","journal-title":"Pediatrics."},{"key":"10.1016\/j.jped.2020.08.004_bib0300","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.jpeds.2020.06.044","article-title":"Characteristics, cardiac involvement, and outcomes of multisystem inflammatory disease of childhood (MIS-C) associated with SARS-CoV-2 infection","volume":"224","author":"Capone","year":"2020","journal-title":"J Pediatr"},{"key":"10.1016\/j.jped.2020.08.004_bib0305","doi-asserted-by":"crossref","DOI":"10.3949\/ccjm.87a.ccc039","article-title":"New spectrum of COVID-19 manifestations in children: Kawasaki-like syndrome and hyperinflammatory response","author":"Panupattanapong","year":"2020","journal-title":"Cleve Clin J Med"},{"key":"10.1016\/j.jped.2020.08.004_bib0310","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/j.healun.2020.03.012","article-title":"COVID-19 illness in native and immunosuppressed states: a clinical-therapeutic staging proposal","volume":"39","author":"Siddiqi","year":"2020","journal-title":"J Heart Lung Transplant"},{"key":"10.1016\/j.jped.2020.08.004_bib0315","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.1053\/j.gastro.2020.05.079","article-title":"Gastrointestinal symptoms as a major presentation component of a novel multisystem inflammatory syndrome in children (MIS-C) that is related to COVID-19: a single center experience of 44 cases","volume":"159","author":"Miller","year":"2020","journal-title":"Gastroenterology."},{"key":"10.1016\/j.jped.2020.08.004_bib0320","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1093\/jpids\/piaa069","article-title":"Multisystem inflammatory syndrome in children during the COVID-19 pandemic: a case series OUP accepted manuscript","volume":"9","author":"Chiotos","year":"2020","journal-title":"J Pediatric Infect Dis Soc"},{"key":"10.1016\/j.jped.2020.08.004_bib0325","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1586\/1744666X.2015.1044980","article-title":"The immunomodulatory effects of intravenous immunoglobulin therapy in Kawasaki disease","volume":"11","author":"Burns","year":"2015","journal-title":"Expert Rev Clin Immunol"},{"key":"10.1016\/j.jped.2020.08.004_bib0330","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/S0140-6736(20)30317-2","article-title":"Clinical evidence does not support corticosteroid treatment for 2019-n Cov lung injury","volume":"395","author":"Russell","year":"2020","journal-title":"Lancet"},{"key":"10.1016\/j.jped.2020.08.004_bib0335","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/j.jinf.2020.03.037","article-title":"The pathogenesis and treatment of the \u2018cytokine storm\u2019 in COVID-19","volume":"80","author":"Ye","year":"2020","journal-title":"J Infect"},{"key":"10.1016\/j.jped.2020.08.004_bib0340","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1001\/jamapediatrics.2016.2055","article-title":"Coronary artery complication in Kawasaki disease and the importance of early intervention a systematic review and meta-analysis","volume":"170","author":"Chen","year":"2016","journal-title":"JAMA Pediatr"},{"key":"10.1016\/j.jped.2020.08.004_bib0345","first-page":"672","article-title":"European consensus-based recommendations for the diagnosis and treatment of Kawasaki disease \u2013 the SHARE initiative","volume":"58","author":"De Graeff","year":"2019","journal-title":"Rheumatol (United Kingdom)"},{"key":"10.1016\/j.jped.2020.08.004_bib0350","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1097\/CCM.0000000000001402","article-title":"Interleukin-1 receptor blockade is associated with reduced mortality in sepsis patients with features of the macrophage activation syndrome: re-analysis of a prior Phase III trial","volume":"44","author":"Shakoory","year":"2016","journal-title":"Crit Care Med"},{"year":"2020","series-title":"Clinical guidance for pediatric patients with multisystem inflammatory syndrome in children (MIS-C) associated with SARS-CoV-2 and hyperinflammation in COVID-19","author":"American College of Reumatology","key":"10.1016\/j.jped.2020.08.004_bib0355"},{"key":"10.1016\/j.jped.2020.08.004_bib0360","doi-asserted-by":"crossref","first-page":"2419","DOI":"10.1097\/CCM.0b013e3182982add","article-title":"Antitumor necrosis factor therapy is associated with improved survival in clinical sepsis trials: a meta-analysis","volume":"41","author":"Qiu","year":"2013","journal-title":"Crit Care Med"},{"key":"10.1016\/j.jped.2020.08.004_bib0365","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1016\/S0140-6736(20)31022-9","article-title":"Remdesivir in adults with severe COVID-19: a randomised, double-blind, placebo-controlled, multicentre trial","volume":"395","author":"Wang","year":"2020","journal-title":"Lancet"},{"key":"10.1016\/j.jped.2020.08.004_bib0370","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.1056\/NEJMoa2007764","article-title":"Remdesivir for the treatment of COVID-19 \u2013 preliminary report","volume":"383","author":"Beigel","year":"2020","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jped.2020.08.004_bib0375","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1056\/NEJMoa2001282","article-title":"A trial of lopinavir-ritonavir in adults hospitalized with severe covid-19","volume":"382","author":"Cao","year":"2020","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jped.2020.08.004_bib0380","doi-asserted-by":"crossref","first-page":"2033","DOI":"10.1182\/blood.2020006000","article-title":"COVID-19 and its implications for thrombosis and anticoagulation","volume":"135","author":"Connors","year":"2020","journal-title":"Blood"},{"key":"10.1016\/j.jped.2020.08.004_bib0385","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1111\/jth.14844","article-title":"Pathological evidence of pulmonary thrombotic phenomena in severe COVID-19","volume":"18","author":"Dolhnikoff","year":"2020","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.jped.2020.08.004_bib0390","doi-asserted-by":"crossref","first-page":"1858","DOI":"10.1093\/eurheartj\/ehaa254","article-title":"Acute pulmonary embolism and COVID-19 pneumonia: a random association?","volume":"41","author":"Danzi","year":"2020","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jped.2020.08.004_bib0395","doi-asserted-by":"crossref","first-page":"102569","DOI":"10.1016\/j.autrev.2020.102569","article-title":"Immunomodulatory therapy for the management of severe COVID-19. Beyond the anti-viral therapy: a comprehensive review","volume":"19","author":"Alijotas-Reig","year":"2020","journal-title":"Autoimmun Rev"},{"key":"10.1016\/j.jped.2020.08.004_bib0400","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1111\/jth.14817","article-title":"Anticoagulant treatment is associated with decreased mortality in severe coronavirus disease 2019 patients with coagulopathy","volume":"18","author":"Tang","year":"2020","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.jped.2020.08.004_bib0405","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1111\/jth.14810","article-title":"ISTH interim guidance on recognition and management of coagulopathy in COVID-19","volume":"18","author":"Thachil","year":"2020","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.jped.2020.08.004_bib0410","doi-asserted-by":"crossref","first-page":"S77","DOI":"10.1097\/PCC.0000000000000623","article-title":"Pediatric cardiac intensive care society 2014 consensus statement: pharmacotherapies in cardiac critical care anticoagulation and thrombolysis","volume":"17","author":"Giglia","year":"2016","journal-title":"Pediatr Crit Care Med"},{"key":"10.1016\/j.jped.2020.08.004_bib0415","unstructured":"Stanford University. Coronavirus Antiviral Research Database. Available from: covdb.stanford.edu\/search [cited 21.7.20]."},{"key":"10.1016\/j.jped.2020.08.004_bib0420","first-page":"CD013600","article-title":"Convalescent plasma or hyperimmune immunoglobulin for people with COVID-19: a rapid review","volume":"5","author":"Valk","year":"2020","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.jped.2020.08.004_bib0425","first-page":"29","article-title":"Extracorporeal life support organization COVID-19 interim guidelines","author":"Shekar","year":"2020","journal-title":"ASAIO J"},{"key":"10.1016\/j.jped.2020.08.004_bib0430","doi-asserted-by":"crossref","first-page":"eS737","DOI":"10.1378\/chest.11-2308","article-title":"Antithrombotic therapy in neonates and children","volume":"141","author":"Monagle","year":"2012","journal-title":"Chest"}],"container-title":["Jornal de Pediatria"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021755720302035?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021755720302035?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T23:20:41Z","timestamp":1758151241000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021755720302035"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3]]},"references-count":86,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,3]]}},"alternative-id":["S0021755720302035"],"URL":"https:\/\/doi.org\/10.1016\/j.jped.2020.08.004","relation":{},"ISSN":["0021-7557"],"issn-type":[{"type":"print","value":"0021-7557"}],"subject":[],"published":{"date-parts":[[2021,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Multisystem inflammatory syndrome associated with COVID-19 from the pediatric emergency physician's point of view","name":"articletitle","label":"Article Title"},{"value":"Jornal de Pediatria","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jped.2020.08.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Sociedade Brasileira de Pediatria. Published by Elsevier Editora Ltda.","name":"copyright","label":"Copyright"}]}}