{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T21:42:37Z","timestamp":1785447757965,"version":"3.56.0"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,11,3]],"date-time":"2020-11-03T00:00:00Z","timestamp":1604361600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Jornal de Pediatria"],"published-print":{"date-parts":[[2021,3]]},"DOI":"10.1016\/j.jped.2020.10.007","type":"journal-article","created":{"date-parts":[[2020,11,8]],"date-time":"2020-11-08T01:12:18Z","timestamp":1604797938000},"page":"S34-S38","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"S1","title":["Failure of immunological competence: when to suspect?"],"prefix":"10.1016","volume":"97","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6981-2352","authenticated-orcid":false,"given":"Fernanda","family":"Pinto-Mariz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jped.2020.10.007_bib0005","first-page":"24","article-title":"Human inborn errors of immunity: 2019 update on the classification from the International Union of Immunological Societies Expert Committee","volume":"40","author":"Tangye","year":"2020","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jped.2020.10.007_bib0010","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1111\/j.1440-1754.2011.02080.x","article-title":"Recurrent infection in children: when and how to investigate for primary immunodeficiency?","volume":"48","author":"Gray","year":"2012","journal-title":"J Paediatr Child Health"},{"key":"10.1016\/j.jped.2020.10.007_bib0015","doi-asserted-by":"crossref","first-page":"779","DOI":"10.3390\/nu9070779","article-title":"Respiratory tract infections and the role of biologically active polysaccharides in their management and prevention","volume":"9","author":"Jesenak","year":"2017","journal-title":"Nutrients"},{"key":"10.1016\/j.jped.2020.10.007_bib0020","doi-asserted-by":"crossref","first-page":"S61","DOI":"10.1186\/s13223-018-0290-5","article-title":"Primary immunodeficiency","volume":"14","author":"McCusker","year":"2018","journal-title":"Allergy Asthma Clin Immunol"},{"key":"10.1016\/j.jped.2020.10.007_bib0025","series-title":"Primary Immunodeficiency Diseases: Definition, Diagnosis, and Management","author":"Rezaei","year":"2017"},{"key":"10.1016\/j.jped.2020.10.007_bib0030","series-title":"User\u2019s Guide to the Medical Literature\u2013Essentials of Evidence-Based Clinical Practice","author":"Guyatt","year":"2014"},{"key":"10.1016\/j.jped.2020.10.007_bib0035","unstructured":"BRAGID\u2013Grupo Brasileiro de Imunodefici\u00eancias. [Cited 2020 September 30] Available From: http:\/\/www.bragid.org.br\/."},{"key":"10.1016\/j.jped.2020.10.007_bib0040","unstructured":"Immune Deficiency Foundation. [Cited 2020 September 30] Available From: https:\/\/primaryimmune.org\/."},{"key":"10.1016\/j.jped.2020.10.007_bib0045","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1007\/s10875-013-9954-6","article-title":"Attending to warning signs of primary immunodeficiency diseases across the range of clinical practice","volume":"34","author":"Costa-Carvalho","year":"2014","journal-title":"J Clin Immunol"},{"key":"10.1016\/j.jped.2020.10.007_bib0050","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1111\/j.1399-3038.2010.01084.x","article-title":"A proposal of warning signs for primary immunodeficiencies in the first year of life","volume":"22","author":"Carneiro-Sampaio","year":"2011","journal-title":"Pediatr Allergy Immunol"},{"key":"10.1016\/j.jped.2020.10.007_bib0055","first-page":"184","article-title":"Severe combined immunodeficiency in Brazil: management, prognosis, and BCG-associated complications","volume":"24","author":"Mazzucchelli","year":"2014","journal-title":"J InvestigAllergol Clin Immunol"},{"key":"10.1016\/j.jped.2020.10.007_bib0060","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1016\/j.jaci.2014.02.028","article-title":"BCG vaccination in patients with severe combined immunodeficiency: complications, risks, and vaccination policies","volume":"133","author":"Marciano","year":"2014","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jped.2020.10.007_bib0065","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1542\/peds.2010-3680","article-title":"Clinical features that identify children with primary immunodeficiency diseases","volume":"127","author":"Subbarayan","year":"2011","journal-title":"Pediatrics"},{"key":"10.1016\/j.jped.2020.10.007_bib0070","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1111\/j.1749-6632.2011.06206.x","article-title":"Ten warning signs of primary immunodeficiency: a new paradigm is needed for the 21st century","volume":"1238","author":"Arkwright","year":"2011","journal-title":"Ann NY Acad Sci"},{"key":"10.1016\/j.jped.2020.10.007_bib0075","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1111\/j.1399-3038.2011.01167.x","article-title":"Clinical characteristics of pediatric patients evaluated for primary immunodeficiency","volume":"22","author":"MacGinnitie","year":"2011","journal-title":"Pediatr Allergy Immunol"},{"key":"10.1016\/j.jped.2020.10.007_bib0080","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1007\/s10875-015-0149-1","article-title":"The Duesseldorf warning signs for primary immunodeficiency: is it time to change the rules?","volume":"35","author":"Lankisch","year":"2015","journal-title":"J Clin Immunol"},{"key":"10.1016\/j.jped.2020.10.007_bib0085","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1007\/s40629-014-0030-4","article-title":"Immunodeficiency in adults a practical guide for the allergist","volume":"23","author":"Hausmann","year":"2014","journal-title":"Allergo J Int"},{"key":"10.1016\/j.jped.2020.10.007_bib0090","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.aller.2014.09.002","article-title":"Doctors\u2019 awareness concerning primary immunodeficiencies in Brazil","volume":"43","author":"Dantas","year":"2015","journal-title":"Allergol Immunopathol (Madr)"},{"key":"10.1016\/j.jped.2020.10.007_bib0095","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1097\/ACI.0000000000000583","article-title":"Rheumatologic and autoimmune manifestations in primary immune deficiency","volume":"19","author":"Kitcharoensakkul","year":"2019","journal-title":"Curr Opin Allergy Clin Immunol"},{"key":"10.1016\/j.jped.2020.10.007_bib0100","doi-asserted-by":"crossref","first-page":"2912","DOI":"10.3389\/fimmu.2018.02912","article-title":"Current Understanding and future research priorities in malignancy associated with inborn errors of immunity and DNA repair disorders: the perspective of an interdisciplinary working group","volume":"9","author":"Bomken","year":"2018","journal-title":"Front Immunol"},{"key":"10.1016\/j.jped.2020.10.007_bib0105","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1016\/j.iac.2015.07.008","article-title":"Primary immunodeficiency masquerading as allergic disease","volume":"35","author":"Chan","year":"2015","journal-title":"Immunol Allergy Clin North Am"},{"key":"10.1016\/j.jped.2020.10.007_bib0110","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1007\/s40257-019-00440-y","article-title":"Autoinflammatory disorders: a review and update on pathogenesis and treatment","volume":"20","author":"Havnaer","year":"2019","journal-title":"Am J Clin Dermatol"},{"key":"10.1016\/j.jped.2020.10.007_bib0115","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1007\/s10875-020-00758-x","article-title":"Human inborn errors of immunity: 2019 update of the IUIS phenotypical classification","volume":"40","author":"Bousfiha","year":"2020","journal-title":"J Clin Immunol"},{"key":"10.1016\/j.jped.2020.10.007_bib0120","first-page":"108","article-title":"European Society for Immunodeficiencies (ESID) members. Patient-centred screening for primary immunodeficiency, a multi-stage diagnostic protocol designed for non-immunologists: 2011 update","volume":"167","author":"de Vries","year":"2012","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.jped.2020.10.007_bib0125","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.gtc.2019.02.004","article-title":"Primary immunodeficiency and the gut","volume":"48","author":"Schwimmer","year":"2019","journal-title":"Gastroenterol Clin N Am"},{"key":"10.1016\/j.jped.2020.10.007_bib0130","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/s12016-018-8689-9","article-title":"Gastrointestinal disorders associated with primary immunodeficiency diseases","volume":"57","author":"Hartono","year":"2019","journal-title":"Clin Rev Allergy Immunol"},{"key":"10.1016\/j.jped.2020.10.007_bib0135","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1111\/all.13681","article-title":"Skin disorders are prominent features in primary immunodeficiency diseases: a systematic overview of current data","volume":"74","author":"de Wit","year":"2019","journal-title":"Allergy"},{"key":"10.1016\/j.jped.2020.10.007_bib0140","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1186\/s12931-018-0923-8","article-title":"Primary immunodeficiency diseases in lung disease: warning signs, diagnosis and management","volume":"19","author":"Soler-Palac\u00edn","year":"2018","journal-title":"Respir Res"},{"key":"10.1016\/j.jped.2020.10.007_bib0145","first-page":"7","article-title":"Neurological manifestations of primary immunodeficiencies","volume":"12","author":"Chavoshzadeh","year":"2018","journal-title":"Iran J Child Neurol"},{"key":"10.1016\/j.jped.2020.10.007_bib0150","doi-asserted-by":"crossref","first-page":"586","DOI":"10.3389\/fimmu.2019.00586","article-title":"Primary and secondary immunodeficiency diseases in oncohaematology: warning signs, diagnosis, and management","volume":"10","author":"S\u00e1nchez-Ram\u00f3n","year":"2019","journal-title":"Front Immunol"},{"key":"10.1016\/j.jped.2020.10.007_bib0155","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1097\/ACI.0000000000000583","article-title":"Rheumatologic and autoimmune manifestations in primary immune deficiency","volume":"19","author":"Kitcharoensakkul","year":"2019","journal-title":"Curr Opin Allergy Clin Immunol"}],"container-title":["Jornal de Pediatria"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021755720302242?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021755720302242?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T23:21:19Z","timestamp":1758151279000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021755720302242"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3]]},"references-count":31,"alternative-id":["S0021755720302242"],"URL":"https:\/\/doi.org\/10.1016\/j.jped.2020.10.007","relation":{},"ISSN":["0021-7557"],"issn-type":[{"value":"0021-7557","type":"print"}],"subject":[],"published":{"date-parts":[[2021,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Failure of immunological competence: when to suspect?","name":"articletitle","label":"Article Title"},{"value":"Jornal de Pediatria","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jped.2020.10.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Published by Elsevier Editora Ltda. on behalf of Sociedade Brasileira de Pediatria.","name":"copyright","label":"Copyright"}]}}